公开(公告)号：US20070174766A1

公开(公告)日：2007-07-26

申请号：US11336329

申请日：2006-01-20

申请人： Donald Rubin ,  William Neumann ,  Lauren Antonoff

发明人： Donald Rubin ,  William Neumann ,  Lauren Antonoff

IPC分类号： G06F17/00

CPC分类号： G06F17/24 ,  G06F17/218

摘要： Technology for finding and acting on hidden data contained in documents generated by a user in productivity applications is disclosed. The technology uses a user configurable document release policy file and a document inspector which parses a document file based on the configuration policy and either presents options to the user to make changes, implements changes automatically, or both, based on the policy definition. A method implemented at least in part by a computing device includes loading a user defined document policy configuration including data types identified as hidden data. A document is then parsed for the defined hidden data and a policy defined action is executed on the hidden data in the document in accordance with the document policy configuration.

摘要翻译： 公开了用于在生产率应用中发现和执行由用户生成的文档中包含的隐藏数据的技术。 该技术使用用户可配置文档发布策略文件和文档检查器，该文档检查器根据配置策略解析文档文件，并根据策略定义向用户呈现选项以进行更改，自动实现更改或同时实现更改。 至少部分地由计算设备实现的方法包括加载用户定义的文档策略配置，包括被识别为隐藏数据的数据类型。 然后根据文档策略配置对文档中的隐藏数据进行解析，并对文档中的隐藏数据执行策略定义的操作。

公开(公告)号：US20060206485A1

公开(公告)日：2006-09-14

申请号：US11079055

申请日：2005-03-14

申请人： Donald Rubin ,  Arthur Rask ,  William Neumann

发明人： Donald Rubin ,  Arthur Rask ,  William Neumann

IPC分类号： G06F17/30

CPC分类号： G06F17/30286 ,  G06F21/6227 ,  G06F2221/2113 ,  Y10S707/99939

摘要： Row level security (RLS) and cell level security (CLS) are implemented in a database to provide secure dynamic access to database data. Encryption keys are created based on either security classification meta-data tags associated with the individual fields of an incoming data stream or on the security classification of the source network. Without prior knowledge of the incoming data security classification, the present system may generate encryption keys and, if necessary, security classification meta-data on the fly.

公开(公告)号：US20060257872A1

公开(公告)日：2006-11-16

申请号：US10535523

申请日：2003-11-18

申请人： Thomas Hodge ,  Natalie McDonald ,  Michael Shaw ,  Donald Rubin ,  Anthony Sanchez

发明人： Thomas Hodge ,  Natalie McDonald ,  Michael Shaw ,  Donald Rubin ,  Anthony Sanchez

IPC分类号： C12Q1/68 ,  C12P21/06

CPC分类号： C07K14/47 ,  C12N15/113 ,  C12N15/1138 ,  C12N2310/14 ,  C12Q1/18 ,  G01N33/56983 ,  G01N2500/02

摘要： Host nucleic acids and host proteins that participate in viral infection, such as human immunodeficiency virus (HIV), influenza A, and Ebola virus, have been identified. Interfering with or disrupting the interaction between a host nucleic acid or host protein and a virus or viral protein confers an inhibition of or resistance to infection. Thus, interfering with such an interaction in a host subject can confer a therapeutic or prophylactic effect against a virus. The sequences identified can be used to identify agents that reduce or inhibit viral infection.

摘要翻译： 已经鉴定了参与病毒感染的宿主核酸和宿主蛋白，例如人类免疫缺陷病毒（HIV），甲型流感和埃博拉病毒。 干扰或破坏宿主核酸或宿主蛋白与病毒或病毒蛋白质之间的相互作用赋予对感染的抑制或抗性。 因此，干扰宿主受试者中的这种相互作用可以赋予针对病毒的治疗或预防效果。 鉴定的序列可用于鉴定减少或抑制病毒感染的试剂。

公开(公告)号：US20130323835A1

公开(公告)日：2013-12-05

申请号：US13384333

申请日：2010-07-15

申请人： Natalie Mcdonald ,  Donald Rubin ,  Thomas Hodge ,  James Murray

发明人： Natalie Mcdonald ,  Donald Rubin ,  Thomas Hodge ,  James Murray

IPC分类号： C12N15/113

CPC分类号： C12N15/1138 ,  A61K31/5375 ,  A61K31/7105 ,  C12N15/113 ,  C12N15/1136 ,  C12N15/1137 ,  C12N2310/11 ,  C12N2310/14 ,  Y02A50/382 ,  Y02A50/385 ,  Y02A50/387 ,  Y02A50/389 ,  Y02A50/393 ,  Y02A50/397 ,  Y02A50/463 ,  Y02A50/469

摘要： The present invention relates to nucleic acid sequences and cellular proteins encoded by these sequences that are involved in infection or are otherwise associated with the life cycle of one or more pathogens.

摘要翻译： 本发明涉及由这些序列编码的涉及感染或以其它方式与一种或多种病原体的生命周期相关的核酸序列和细胞蛋白质。

公开(公告)号：US20050234762A1

公开(公告)日：2005-10-20

申请号：US10826949

申请日：2004-04-16

申请人： Stephen Pinto ,  Richard Mansfield ,  Donald Rubin

发明人： Stephen Pinto ,  Richard Mansfield ,  Donald Rubin

IPC分类号： G06F15/18 ,  G06Q30/00 ,  G06F17/60

CPC分类号： G06Q30/02 ,  G06Q40/025

摘要： Models are generated using a variety of tools and features of a model generation platform. For example, in connection with a project in which a user generates a predictive model based on historical data about a system being modeled, the user is provided through a graphical user interface a structured sequence of model generation activities to be followed, the sequence including dimension reduction, model generation, model process validation, and model re-generation. Historical multi-dimensional data is received representing multiple variables to be used as an input to a predictive model of a commercial system variables are pruned for which the data is sparse or missing, and the population of variables is adjusted to represent main effects exhibited by the data and interaction and non-linear effects exhibited by the data.

摘要翻译： 使用模型生成平台的各种工具和功能生成模型。 例如，关于用户根据关于正被建模的系统的历史数据生成预测模型的项目，通过图形用户界面提供要遵循的模型生成活动的结构化序列，所述序列包括维度 减少，模型生成，模型过程验证和模型重新生成。 接收到的代表多个变量的历史多维数据被用作商业系统的预测模型的输入，修剪数据稀疏或丢失的变量，并且调节变量的总数以表示由 数据和相互作用以及数据显示的非线性效应。

公开(公告)号：US20050234753A1

公开(公告)日：2005-10-20

申请号：US10826947

申请日：2004-04-16

申请人： Stephen Pinto ,  Richard Mansfield ,  Marc Jacobs ,  Donald Rubin

发明人： Stephen Pinto ,  Richard Mansfield ,  Marc Jacobs ,  Donald Rubin

IPC分类号： G06F19/00 ,  G06Q10/00 ,  G06Q30/00 ,  G06F17/60

CPC分类号： G06Q10/04 ,  G06Q30/02 ,  G06Q40/025

摘要： Models are generated using a variety of tools and features of a model generation platform. For example, in connection with a project in which a user generates a predictive model based on historical data about a system being modeled, the user is provided through a graphical user interface a structured sequence of model generation activities to be followed, the sequence including dimension reduction, model generation, model process validation, and model re-generation. In connection with a project in which a user generates a predictive model based on historical data about a system being modeled, the user is enabled to validate the model development process with cross-validation between at least two subsets of the historical data; the validated model development process is enabled to be reapplied.

摘要翻译： 使用模型生成平台的各种工具和功能生成模型。 例如，关于用户根据关于正被建模的系统的历史数据生成预测模型的项目，通过图形用户界面提供要遵循的模型生成活动的结构化序列，所述序列包括维度 减少，模型生成，模型过程验证和模型重新生成。 关于用户根据关于正在建模的系统的历史数据生成预测模型的项目，用户能够通过历史数据的至少两个子集之间的交叉验证来验证模型开发过程; 验证的模型开发过程能够被重新应用。

公开(公告)号：US08170841B2

公开(公告)日：2012-05-01

申请号：US10826947

申请日：2004-04-16

申请人： Stephen K. Pinto ,  Richard Mansfield ,  Marc Jacobs ,  Donald Rubin

发明人： Stephen K. Pinto ,  Richard Mansfield ,  Marc Jacobs ,  Donald Rubin

IPC分类号： G06G7/60

CPC分类号： G06Q10/04 ,  G06Q30/02 ,  G06Q40/025

摘要： Models are generated using a variety of tools and features of a model generation platform. For example, in connection with a project in which a user generates a predictive model based on historical data about a system being modeled, the user is provided through a graphical user interface a structured sequence of model generation activities to be followed, the sequence including dimension reduction, model generation, model process validation, and model re-generation.In connection with a project in which a user generates a predictive model based on historical data about a system being modeled, the user is enabled to validate the model development process with cross-validation between at least two subsets of the historical data; the validated model development process is enabled to be reapplied.

摘要翻译： 使用模型生成平台的各种工具和功能生成模型。 例如，关于用户根据关于正被建模的系统的历史数据生成预测模型的项目，通过图形用户界面提供要遵循的模型生成活动的结构化序列，所述序列包括维度 减少，模型生成，模型过程验证和模型重新生成。 关于用户根据关于正在建模的系统的历史数据生成预测模型的项目，用户能够通过历史数据的至少两个子集之间的交叉验证来验证模型开发过程; 验证的模型开发过程能够被重新应用。

公开(公告)号：US20080118495A1

公开(公告)日：2008-05-22

申请号：US11666453

申请日：2005-10-27

申请人： Donald Rubin

发明人： Donald Rubin

IPC分类号： A61K31/70 ,  A01K67/027 ,  A61K38/00 ,  A61K39/395 ,  A61P43/00 ,  C12N5/00 ,  C12P21/04 ,  C12Q1/70

CPC分类号： C12Q1/18 ,  A01K2217/075 ,  A01K2267/02 ,  C12Q2600/136 ,  G01N33/5023

摘要： The present invention relates to nucleic acid sequences and cellular proteins encoded by these sequences that are involved in infection or are otherwise associated with the life cycle of a pathogen. The invention also relates to modulators of nucleic acid sequences and cellular proteins encoded by these sequences that are involved in infection or are otherwise associated with the life cycle of a pathogen.

摘要翻译： 本发明涉及由这些序列编码的涉及感染或以其他方式与病原体生命周期相关的核酸序列和细胞蛋白质。 本发明还涉及由这些序列编码的核酸序列和细胞蛋白的调节剂，其涉及感染或者与病原体的生命周期相关。

公开(公告)号：US20070254329A1

公开(公告)日：2007-11-01

申请号：US10513426

申请日：2003-05-02

申请人： Donald Rubin

发明人： Donald Rubin

IPC分类号： A61K31/711 ,  A61P31/18 ,  C07H21/04 ,  C07K14/00 ,  C12N5/00 ,  C12Q1/02

CPC分类号： C07K14/47

摘要： The present invention provides methods of identifying cellular genes used for viral, bacterial or parasitic growth. Also provided by the present invention are nucleic acids related to and methods of reducing or preventing viral, bacterial or parasitic infection.

摘要翻译： 本发明提供鉴定用于病毒，细菌或寄生生长的细胞基因的方法。 本发明还提供了与病毒，细菌或寄生虫感染相关的核酸和减少或预防病毒，细菌或寄生虫感染的方法。

公开(公告)号：US20050234763A1

公开(公告)日：2005-10-20

申请号：US10826950

申请日：2004-04-16

申请人： Stephen Pinto ,  Richard Mansfield ,  Marc Jacobs ,  Donald Rubin

发明人： Stephen Pinto ,  Richard Mansfield ,  Marc Jacobs ,  Donald Rubin

IPC分类号： G06Q10/00 ,  G06F17/60

CPC分类号： G06Q10/04 ,  G06Q30/0201

摘要： Models are generated using a variety of tools and features of a model generation platform. For example, in connection with a project in which a user generates a predictive model based on historical data about a system being modeled, the user is provided through a graphical user interface a structured sequence of model generation activities to be followed, the sequence including dimension reduction, model generation, model process validation, and model re-generation. Historical multi-dimensional data is received representing multiple source variables to be used as an input to a predictive model of a commercial system and applying transformations to the data that are selected based on the strength of measurement represented by a variable; variables are transformed into new more predictive variables, including the Bayesian renormalization of sparsely sampled variable and including the imputation of missing values for categorical or continuous variables.

摘要翻译： 使用模型生成平台的各种工具和功能生成模型。 例如，关于用户根据关于正被建模的系统的历史数据生成预测模型的项目，通过图形用户界面提供要遵循的模型生成活动的结构化序列，所述序列包括维度 减少，模型生成，模型过程验证和模型重新生成。 接收表示多个源变量的历史多维数据，以用作商业系统的预测模型的输入，并且基于由变量表示的测量强度来选择的数据进行变换; 变量被变换成新的更具预测性的变量，包括稀疏抽样变量的贝叶斯重正化，包括对分类或连续变量的缺失值的插补。