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公开(公告)号：US06391305B1
公开(公告)日：2002-05-21
申请号：US09254892
申请日：1999-06-28
IPC分类号： A61K3814
CPC分类号： C07K7/06 , A61K38/00 , C07K5/1016
摘要： Chemical conjugates which comprise oligopeptides, having amino acid sequences that are selectively proteolytically cleaved by free prostate specific antigen (PSA), hydrophilic oligopeptide blocking groups and known cytotoxic agents are disclosed. Such conjugates are useful in the treatment of prostatic cancer and benign prostatic hypertrophy (BPH).
摘要翻译： 公开了包含具有由游离前列腺特异性抗原（PSA）选择性蛋白水解切割的氨基酸序列，亲水寡肽封闭基团和已知的细胞毒性剂的寡肽的化学共轭物。 这种缀合物可用于治疗前列腺癌和良性前列腺肥大（BPH）。
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公开(公告)号：US06130204A
公开(公告)日：2000-10-10
申请号：US51342
申请日：1998-04-06
IPC分类号： C12Q1/37 , A61K38/00 , A61K45/00 , A61K47/48 , A61K49/00 , A61P13/02 , A61P15/00 , A61P35/00 , C07K5/10 , C07K5/107 , C07K7/06 , C07K7/08 , C07K14/47 , A61K38/07 , A61K38/08 , A61K38/48
CPC分类号： C07K14/47 , A61K47/48338 , C07K5/1016 , A61K38/00 , C07K2319/00 , Y10S930/28 , Y10S930/30
摘要： Oligopeptides which comprise amino acid sequences that are recognized and proteolytically cleaved by free prostate specific antigen (PSA) are described. Also described are assays which comprise such oligopeptides useful for determining free PSA protease activity in vitro and in vivo. Therapeutic agents which comprise conjugates of such oligopeptides and known cytotoxic agents are also described.
摘要翻译： PCT No.PCT / US96 / 15713 Sec。 371日期：1998年4月6日 102（e）1998年4月6日PCT PCT 1996年10月2日PCT公布。 出版物WO97 / 12624 日期：1997年4月10日描述了包含被游离前列腺特异性抗原（PSA）识别和蛋白水解切割的氨基酸序列的寡肽。 还描述了包含用于在体外和体内测定游离PSA蛋白酶活性的这种寡肽的测定法。 还描述了包含这种寡肽和已知细胞毒性剂的缀合物的治疗剂。
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公开(公告)号：US6143864A
公开(公告)日：2000-11-07
申请号：US468161
申请日：1995-06-06
IPC分类号： G01N33/566 , A61K31/195 , A61K38/00 , A61K38/08 , A61K47/48 , A61P13/08 , A61P35/00 , A61P43/00 , C07H15/24 , C07K7/06 , C07K7/08 , C07K14/47 , C07K17/08 , C12Q1/37 , G01N33/574 , A61K38/14 , C07K9/00
CPC分类号： C07K14/47 , A61K47/48238 , A61K47/48338 , A61K38/00
摘要： Oligopeptides which comprise amino acid sequences that are recognized and proteolytically cleaved by free prostate specific antigen (PSA) are described. Also described are assays which comprise such oligopeptides useful for determining free PSA protease activity in vitro and in vivo. Therapeutic agents which comprise conjugates of such oligopeptides and known cytotoxic agents are also described.
摘要翻译： 描述了包含被游离前列腺特异性抗原（PSA）识别和蛋白水解切割的氨基酸序列的寡肽。 还描述了包含用于在体外和体内测定游离PSA蛋白酶活性的这种寡肽的测定法。 还描述了包含这种寡肽和已知细胞毒性剂的缀合物的治疗剂。
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公开(公告)号：US5866679A
公开(公告)日：1999-02-02
申请号：US540412
申请日：1995-10-06
IPC分类号： C12Q1/37 , A61K38/00 , A61K45/00 , A61K47/48 , A61K49/00 , A61P13/02 , A61P15/00 , A61P35/00 , C07K5/10 , C07K5/107 , C07K7/06 , C07K7/08 , C07K14/47 , C07K5/09
CPC分类号： C07K14/47 , A61K47/48338 , C07K5/1016 , A61K38/00 , C07K2319/00 , Y10S930/28 , Y10S930/30
摘要： Oligopeptides which comprise amino acid sequences that are recognized and proteolytically cleaved by free prostate specific antigen (PSA) are described. Also described are assays which comprise such oligopeptides useful for determining free PSA protease activity in vitro and in vivo. Therapeutic agents which comprise conjugates of such oligopeptides and known cytotoxic agents are also described.
摘要翻译： 描述了包含被游离前列腺特异性抗原（PSA）识别和蛋白水解切割的氨基酸序列的寡肽。 还描述了包含用于在体外和体内测定游离PSA蛋白酶活性的这种寡肽的测定法。 还描述了包含这种寡肽和已知细胞毒性剂的缀合物的治疗剂。
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公开(公告)号：US5998362A
公开(公告)日：1999-12-07
申请号：US926412
申请日：1997-09-09
摘要： Chemical conjugates which comprise oligopeptides, having amino acid sequences that are selectively proteolytically cleaved by free prostate specific antigen (PSA), hydrophilic oligopeptide blocking groups and known cytotoxic agents are disclosed. Such conjugates are useful in the treatment of prostatic cancer and benign prostatic hypertrophy (BPH).
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公开(公告)号：US06177404B1
公开(公告)日：2001-01-23
申请号：US09051759
申请日：1998-08-03
申请人： Deborah DeFeo-Jones , Raymond E. Jones , Allen I. Oliff , Edward M. Scolnick , Victor M. Garsky
发明人： Deborah DeFeo-Jones , Raymond E. Jones , Allen I. Oliff , Edward M. Scolnick , Victor M. Garsky
IPC分类号： A61K3816
CPC分类号： A61K47/65
摘要： Novel pharmaceutical compositions useful for the treatment of benign prostatic hyperplasia which comprises novel oligopeptides, which are selectively cleaved by enzymatically active PSA, in conjugation with a cytotoxic agent are described. Methods of treating benign prostate hypertrophy are also disclosed.
摘要翻译： 描述了可用于治疗良性前列腺增生的新型药物组合物，其包含通过酶活性PSA选择性切割的与细胞毒性剂缀合的新型寡肽。 还公开了治疗良性前列腺肥大的方法。
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公开(公告)号：US5599686A
公开(公告)日：1997-02-04
申请号：US267092
申请日：1994-06-28
CPC分类号： C07K14/47 , A61K47/48338 , A61K38/00
摘要： Assays which comprise oligopeptides and which are useful for determining free PSA protease activity in vitro and in vivo are described. Such oligopeptides comprise amino acid sequences that are recognized and proteolytically cleaved by free prostrate specific antigen (PSA). Also described are assays useful in identifying inhibitors of free PSA.
摘要翻译： 描述了包含寡肽并且其可用于在体外和体内测定游离PSA蛋白酶活性的测定。 这样的寡肽包括由游离的前列腺特异性抗原（PSA）识别和蛋白水解切割的氨基酸序列。 还描述了可用于鉴定游离PSA的抑制剂的测定法。
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公开(公告)号：US4726631A
公开(公告)日：1988-02-23
申请号：US848529
申请日：1986-04-07
IPC分类号： B62D55/30
CPC分类号： B62D55/30
摘要： A track compensator for adjusting tension of an endless track on a track-laying vehicle and for absorbing changes in track tension during vehicle operation. A tension adjuster, connected to an idler wheel, adjusts the distance between a drive wheel, at one end of the track, and the idler wheel at the other end of the track. A shock absorber mounted between the vehicle and the tension adjuster absorbs stress on the track caused by debris between the track and vehicle wheels.
摘要翻译： 轨道补偿器，用于调整轨道铺放车辆上的环形轨道的张力并且用于在车辆操作期间吸收轨道张力的变化。 连接到惰轮的张力调节器调节轨道一端的驱动轮与轨道另一端的惰轮之间的距离。 安装在车辆和张力调节器之间的减震器吸收轨道和车轮之间的碎屑引起的轨道上的应力。
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公开(公告)号：US4217972A
公开(公告)日：1980-08-19
申请号：US913468
申请日：1978-06-07
申请人： Raymond E. Jones
发明人： Raymond E. Jones
CPC分类号： B66F7/18
摘要： A casing for hydraulic lifts and the like of the type buried in the ground. The part of the casing deeply buried in the ground may be subject to corrosion and electrolysis, which is quite common in many soils, and is made from a strong, fiberglas composite material. The part of the casing not subject to corrosion is metallic. Flanges connect the two parts in end-to-end sealed relation with respect to each other and the seals and guides for the plunger are carried in the metallic part of the casing. A non-metallic bulkhead is bonded to the bottom of the fiberglas composite casing and may have a port opening through its bottom wherein the lift is a semi-hydraulic lift as is common with passenger car lifts.
摘要翻译： 一种埋在地下的液压升降机等的外壳。 深埋在地下的套管部分可能会受到腐蚀和电解，这在许多土壤中很常见，并且由强力的纤维胶复合材料制成。 套管不受腐蚀的部分是金属的。 法兰将两部分相对于彼此以端对端密封的关系连接，并且用于柱塞的密封件和引导件被承载在外壳的金属部分中。 非金属隔板结合到纤维玻璃复合壳体的底部，并且可以具有通过其底部的开口，其中升降机是与客车升降机通用的半液压升降机。
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公开(公告)号：US4134475A
公开(公告)日：1979-01-16
申请号：US808116
申请日：1977-06-20
申请人： Raymond E. Jones
发明人： Raymond E. Jones
CPC分类号： B66F7/20
摘要： An adjustable pad hydraulic lift structure has a vehicle engaging and supporting pad vertically movable by a hydraulic piston, the pad being mounted on a bolster and having load transfer blocks facing downwardly for engagement with the bolster to transfer vehicle load from the pad to the bolster. Supporting and guide rods on the bolster and bearings on the pad cooperate to support the unloaded pad for adjustment into selected position over the bolster, and while supporting the unloaded pad maintaining the pad at an elevation wherein the load transfer blocks are supported free of the bolster to permit free adjustments of the pad. The supporting and guide rods are yieldable when the pad is under vehicle load to permit the load transfer blocks to engage the bolster for load transfer from the pad to the bolster.
摘要翻译： 可调节的液压提升结构具有可通过液压活塞垂直移动的车辆接合和支撑垫，所述垫安装在垫子上并且具有面向下的负载传递块以与所述垫子接合以将车辆载荷从所述垫传递到所述垫块。 支撑和引导垫子上的杆和衬垫上的轴承协同支撑卸载的垫以调节到枕垫上的选定位置，并且在支撑卸载垫时将垫保持在高度，其中负载传递块不受支撑 以允许垫的自由调节。 支撑杆和导向杆是可靠的，当垫在车辆负载下，以允许负载传递块接合垫子用于负载从垫移动到垫板。
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