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公开(公告)号:US20200172601A1
公开(公告)日:2020-06-04
申请号:US16626163
申请日:2018-06-22
申请人: Dongkyoon Kim , Guy Cavet , University of Maryland, Baltimore , The United States Government as Represented by the Department of Veterans Affairs
发明人: Mohammad Sajadi , George K. Lewis , Anthony DeVico , Amir Dashti , Marzena E. Pazgier , William David Tolbert , Dongkyoon Kim , Guy Cavet
摘要: The present invention provides broadly neutralizing antibodies against HIV, compositions comprising the same and methods of use thereof. Specifically, the invention provides isolated anti-HIV antibodies that are capable of neutralizing at least 95% of the HIV pseudoviruses listed in Table 1 and neutralizing 100% of the HIV clade B, G and D viruses listed in Table 1 with an IC50 value of less than 50 ug/mL. Further provides are the sequences especially complementarity-determining region (CDR) sequences of antibodies disclosed.
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公开(公告)号:US20230002480A1
公开(公告)日:2023-01-05
申请号:US17677757
申请日:2022-02-22
申请人: Dongkyoon Kim , Guy Cavet , University of Maryland, Baltimore , The United States Government as Represented by the Department of Veterans Affairs
发明人: Mohammad Sajadi , George K. Lewis , Anthony DeVico , Dongkyoon Kim , Guy Cavet
摘要: The present invention provides broadly neutralizing antibodies against HIV, compositions comprising the same and methods of use thereof.
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公开(公告)号:US20200239551A1
公开(公告)日:2020-07-30
申请号:US16725596
申请日:2019-12-23
申请人: University of Maryland, Baltimore , The United States Government as Represented by the Department of Veterans Affairs
发明人: Mohammad Sajadi , George K. Lewis , Anthony DeVico
摘要: The present invention provides broadly neutralizing antibodies against HIV, compositions comprising the same and methods of use thereof.
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公开(公告)号:US20210040184A1
公开(公告)日:2021-02-11
申请号:US17015287
申请日:2020-09-09
申请人: ATRECA, INC. , UNIVERSITY OF MARYLAND, BALTIMORE , The United States of America as Represented by the Department of Veterans Affairs
发明人: Guy L. CAVET , Anthony Devico , Dongkyoon Kim , George K. Lewis , Shaun M. Lippow , Mohammad Sajadi , Katherine Williams
IPC分类号: C07K16/10
摘要: Provided herein are anti-HIV antibodies, compositions comprising such antibodies, and methods of producing the antibodies. Additionally provided are methods of treating or preventing HIV infection, or a complication of HIV infection, using the anti-HIV antibodies.
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公开(公告)号:US20210040185A1
公开(公告)日:2021-02-11
申请号:US17015290
申请日:2020-09-09
申请人: ATRECA, INC. , UNIVERSITY OF MARYLAND, BALTIMORE , The United States of America as Represented by the Department of Veterans Affairs
发明人: Guy L. CAVET , Anthony Devico , Dongkyoon Kim , George K. Lewis , Shaun M. Lippow , Mohammad Sajadi
IPC分类号: C07K16/10
摘要: Provided herein are anti-HIV antibodies, compositions comprising such antibodies, and methods of producing the antibodies. Additionally provided are methods of treating or preventing HIV infection, or a complication of HIV infection, using the anti-HIV antibodies.
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