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    Coated enzyme-containing granule
    1.
    发明授权
    Coated enzyme-containing granule 失效
    包被的含酶颗粒

    公开(公告)号：US5879920A

    公开(公告)日：1999-03-09

    申请号：US577894

    申请日：1995-12-22

    申请人： Douglas A. Dale ,  Alfred L. Gaertner ,  Gene Park ,  Nathaniel T. Becker

    发明人： Douglas A. Dale ,  Alfred L. Gaertner ,  Gene Park ,  Nathaniel T. Becker

    IPC分类号： C11D1/29 ,  C11D1/72 ,  C11D3/37 ,  C11D3/386 ,  C11D17/00 ,  C12N11/02 ,  C12N11/04 ,  C12N11/14 ,  C12N9/98 ,  C11D10/00 ,  C12N11/08 ,  D06M16/00

    CPC分类号： C11D3/3707 ,  C11D17/0039 ,  C11D3/3753 ,  C11D3/3776 ,  C11D3/38672 ,  C12N11/02 ,  C12N11/04 ,  C12N11/14 ,  C11D1/29 ,  C11D1/72

    摘要： A granular enzyme composition is produced having reduced tendency to form dust and leave a residue, and improved stability and delayed release characteristics. The composition has a core, optionally coated with a vinyl polymer, a layer containing an enzyme and a vinyl polymer and optionally a plasticizer or anti-agglomeration agent, and an outer coating containing a polymer and optionally a low residue pigment and/or lubricant. Preferably, the core is a salt or sugar nonpareil, the vinyl polymer coating the core is polyvinyl alcohol and most preferably partially hydrolyzed polyvinyl alcohol, the vinyl polymer in the enzyme layer is polyvinyl pyrrolidone, and the polymer of the outer coating is polyvinyl pyrrolidone, polyvinyl alcohol which may be partially hydrolyzed, polyethylene glycol or mixtures thereof such as a mixture of polyvinyl pyrrolidone and polyvinyl alcohol or a mixture of polyvinyl pyrrolidone and polyethylene glycol. Preferably, the pigment is titanium dioxide and the lubricant is a nonionic or anionic surfactant such as a linear primary alcohol of a 9-15 carbon atom chain length alkane or alkene or an ethoxylate or ethoxysulfate derivative thereof. The enzyme can be a protease, amylase, lipase, cellulase, xylanase, oxidase, peroxidase or mixtures thereof. The composition may be produced by spray coating in a fluidized bed a solution of the enzyme and vinyl polymer onto the core to form the enzyme layer, and then spray coating in a fluidized bed a solution of polymer on the enzyme layer to form the outer coating.

    摘要翻译： 产生颗粒状酶组合物，其具有降低形成粉尘并留下残留物的倾向，以及改进的稳定性和延迟释放特性。 该组合物具有核心，任选地涂覆有乙烯基聚合物，含有酶和乙烯基聚合物的层以及任选的增塑剂或抗附聚剂，以及含有聚合物和任选的低残留颜料和/或润滑剂的外涂层。 优选地，核心是盐或糖不分散体，涂覆核心的乙烯基聚合物是聚乙烯醇，最优选部分水解的聚乙烯醇，酶层中的乙烯基聚合物是聚乙烯吡咯烷酮，外涂层的聚合物是聚乙烯吡咯烷酮， 可以部分水解的聚乙烯醇，聚乙二醇或其混合物，例如聚乙烯吡咯烷酮和聚乙烯醇的混合物，或聚乙烯吡咯烷酮和聚乙二醇的混合物。 优选地，颜料是二氧化钛，润滑剂是非离子或阴离子表面活性剂，例如9-15碳原子的链烷烃或链烯烃的直链伯醇或其乙氧基化物或乙氧基硫酸盐衍生物。 酶可以是蛋白酶，淀粉酶，脂肪酶，纤维素酶，木聚糖酶，氧化酶，过氧化物酶或其混合物。 组合物可以通过在流化床中将酶和乙烯基聚合物的溶液喷雾到芯上以形成酶层，然后在流化床中将聚合物溶液在酶层上喷涂以形成外涂层 。

    Symmetrical fluidization coater for high capacity manufacturing
    5.
    发明授权
    Symmetrical fluidization coater for high capacity manufacturing 有权
    用于大容量制造的对称流化涂布机

    公开(公告)号：US06461672B1

    公开(公告)日：2002-10-08

    申请号：US09640394

    申请日：2000-08-16

    申请人： Antti Kosola ,  Ryszard Braun ,  Nathaniel T. Becker ,  Robert L. Christensen, Jr. ,  Ville Kyläkoski ,  Alfred L. Gaertner

    发明人： Antti Kosola ,  Ryszard Braun ,  Nathaniel T. Becker ,  Robert L. Christensen, Jr. ,  Ville Kyläkoski ,  Alfred L. Gaertner

    IPC分类号： B05D700

    CPC分类号： B01J2/16 ,  B01J2/006

    摘要： A fluidized bed coating apparatus is provided and includes a fluid inlet adapted to be connected to a source of fluidizing fluid. The fluid inlet has an entrance opening having a first diameter and an exit opening downstream of the entrance opening. The exit opening has a second diameter that is larger than the first diameter. The inlet also includes an expanding inlet section, between the entrance opening and the exit opening, that has an average diameter that increases in a direction from said entrance opening to said exit opening. A fluid distribution plate is provided adjacent the exit opening and includes a plurality of through-passages to allow the even and distributed passage of a fluidizing fluid therethrough. A chamber having a chamber inlet and a chamber outlet is provided and the fluid distribution plate is positioned between the exit opening and the chamber inlet. The chamber includes at least a first diverging section having an average diameter that increases in the direction from the chamber inlet downstream toward the chamber outlet. The symmetrical design of the coater provides an evenly distributed flow of fluid that enables efficient and complete fluidization and coating of very large particle beds.

    摘要翻译： 提供了一种流化床涂覆设备，并包括适于连接到流化流体源的流体入口。 流体入口具有入口，其具有第一直径和入口开口下游的出口。 出口具有大于第一直径的第二直径。 入口还包括在入口和出口之间的扩张入口部分，其具有在从所述入口到所述出口的方向上增加的平均直径。 流体分配板邻近出口设置并且包括多个通道以允许流化流体均匀分布通过其中。 提供具有室入口和室出口的室，并且流体分配板位于出口和室入口之间。 该腔室至少包括第一发散部分，该第一发散部分具有在从腔室入口下游朝向腔室出口的方向上增加的平均直径。 涂布机的对称设计提供均匀分布的流体流动，能够高效，完全地流化和涂覆非常大的颗粒床。

    Delivery system for co-formulated enzyme and substrate
    9.
    发明授权
    Delivery system for co-formulated enzyme and substrate 有权
    配制酶和底物的输送系统

    公开(公告)号：US08834865B2

    公开(公告)日：2014-09-16

    申请号：US13132069

    申请日：2009-11-03

    申请人： Nathaniel T. Becker ,  Michael Stoner ,  Mee-Young Yoon

    发明人： Nathaniel T. Becker ,  Michael Stoner ,  Mee-Young Yoon

    IPC分类号： A61K38/54 ,  C11D3/386 ,  C11D17/00

    CPC分类号： C11D17/0039 ,  C11D3/386 ,  C11D3/38672 ,  C11D3/38681

    摘要： The invention provides methods, compositions, systems, and kits that include an enzyme/substrate co-delivery system. The liquid delivery system includes at least one enzyme encapsulated in a water-soluble polymeric matrix and a substrate for the enzyme in a carrier liquid in which the polymeric matrix is insoluble. When water is added, the polymeric matrix is solubilized and enzyme is released from the matrix, permitting catalytic action upon the substrate.

    摘要翻译： 本发明提供包括酶/底物共递送系统的方法，组合物，系统和试剂盒。 液体递送系统包括至少一种包封在水溶性聚合物基质中的酶和在其中聚合物基质不溶性的载体液体中的酶的底物。 当加入水时，聚合物基体溶解，酶从基质中释放出来，允许对基底进行催化作用。