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    Substituted nitrobenzophenone derivatives and a process for the preparation thereof
    6.
    发明授权
    Substituted nitrobenzophenone derivatives and a process for the preparation thereof 失效
    取代的硝基二苯甲酮衍生物及其制备方法

    公开(公告)号：US4064121A

    公开(公告)日：1977-12-20

    申请号：US603855

    申请日：1975-08-12

    申请人： Edit Toth ,  Jozsef Torley ,  Eva Palosi ,  Szaboles Szeberenyi ,  Laszlo Szporny ,  Sandor Gorog ,  Csilla Meszaros

    发明人： Edit Toth ,  Jozsef Torley ,  Eva Palosi ,  Szaboles Szeberenyi ,  Laszlo Szporny ,  Sandor Gorog ,  Csilla Meszaros

    IPC分类号： C07D295/10 ,  C07D225/02 ,  C07D211/14

    CPC分类号： C07D295/10

    摘要： New compounds of the general formula (I), ##STR1## wherein R.sub.1 and R.sub.2 each stand for a saturated or unsaturated, straight-chained or branched alkyl group, an aralkyl group, a saturated or unsaturated cycloalkyl group or an aryl group, orR.sub.1 and R.sub.2 together with the adjacent nitrogen atom may form an optionally substituted heterocyclic group optionally containing a further oxygen or nitrogen hetero atom,But if R.sub.1 stands for methyl, R.sub.2 may only stand for a group other than methyl, are prepared by reacting a compound of the general formula ##STR2## wherein X stands for halogen, with a secondary amine of the general formula (III),r.sub.1 --nh--r.sub.2 (iii)wherein R.sub.1 and R.sub.2 each have the same meanings as defined above.The new compounds of the general formula (I), as well as their pharmaceutical acceptable acid addition salts or quaternary ammonium salts are active primarily in the induction of liver microsomal enzyme, but they also possess antipyretic activity.

    摘要翻译： 通式（I）的新化合物，其中R 1和R 2各自表示饱和或不饱和的直链或支链烷基，芳烷基，饱和或不饱和环烷基或芳基 ，或R1和R2与相邻的氮原子一起可以形成任选地含有另外的氧或氮杂原子的任选取代的杂环基团，但是，R 1表示甲基，R 2可以仅代表甲基以外的基团，其通过使 通式（II）的化合物，其中X表示卤素，具有通式（III）的仲胺，R1-NH-R2（Ⅲ）其中R1和R2各自具有与上述相同的含义 。