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公开(公告)号:US20080027228A1
公开(公告)日:2008-01-31
申请号:US11825079
申请日:2007-07-03
申请人: Edward Bacon , Sankar Chatterjee , Derek Dunn , John Mallamo , Matthew Miller , Jeffry Vaught
发明人: Edward Bacon , Sankar Chatterjee , Derek Dunn , John Mallamo , Matthew Miller , Jeffry Vaught
IPC分类号: C07D221/00 , C07C231/12 , C07D231/54 , C07D333/02 , C07D277/02 , C07D207/00
CPC分类号: C07D263/34 , C07C317/44 , C07C323/60 , C07C323/63 , C07C2603/18 , C07C2603/32 , C07D207/16 , C07D207/273 , C07D207/416 , C07D211/88 , C07D213/34 , C07D219/04 , C07D231/54 , C07D233/64 , C07D261/08 , C07D263/16 , C07D263/32 , C07D275/02 , C07D277/26 , C07D277/56 , C07D307/68 , C07D311/84 , C07D333/18 , C07D335/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/06 , C07D495/04
摘要: The present invention is directed to chemical compositions of substituted thioacetamides, processes for the preparation thereof and uses of the compositions in the treatment of diseases.
摘要翻译: 本发明涉及取代的硫代乙酰胺的化学组成,其制备方法和组合物在治疗疾病中的用途。
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公开(公告)号:US20050192313A1
公开(公告)日:2005-09-01
申请号:US11116755
申请日:2005-04-28
申请人: Edward Bacon , Sankar Chatterjee , Derek Dunn , John Mallamo , Matthew Miller , Rabindranath Tripathy , Jeffry Vaught
发明人: Edward Bacon , Sankar Chatterjee , Derek Dunn , John Mallamo , Matthew Miller , Rabindranath Tripathy , Jeffry Vaught
IPC分类号: C07D295/08 , A61K31/165 , A61K31/166 , A61K31/341 , A61K31/352 , A61K31/381 , A61K31/40 , A61K31/4015 , A61K31/4025 , A61K31/415 , A61K31/421 , A61K31/422 , A61K31/426 , A61K31/427 , A61K31/4402 , A61K31/4406 , A61K31/4436 , A61K31/45 , A61K31/4535 , A61K31/5377 , A61P1/00 , A61P1/14 , A61P9/10 , A61P11/00 , A61P25/00 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/28 , A61P43/00 , C07C317/44 , C07C323/60 , C07C323/61 , C07D207/16 , C07D207/26 , C07D207/273 , C07D207/40 , C07D207/416 , C07D211/88 , C07D213/34 , C07D213/40 , C07D219/04 , C07D231/54 , C07D233/54 , C07D261/08 , C07D263/10 , C07D263/16 , C07D263/32 , C07D263/34 , C07D275/02 , C07D277/26 , C07D277/56 , C07D307/68 , C07D311/84 , C07D333/18 , C07D335/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/06 , C07D495/04 , C07D498/04 , A61K31/473 , A61K31/353 , A61K31/382
CPC分类号: C07D263/34 , C07C317/44 , C07C323/60 , C07C323/63 , C07C2603/18 , C07C2603/32 , C07D207/16 , C07D207/273 , C07D207/416 , C07D211/88 , C07D213/34 , C07D219/04 , C07D231/54 , C07D233/64 , C07D261/08 , C07D263/16 , C07D263/32 , C07D275/02 , C07D277/26 , C07D277/56 , C07D307/68 , C07D311/84 , C07D333/18 , C07D335/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/06 , C07D495/04
摘要: The present invention is directed to chemical compositions of substituted thioacetamides, processes for the preparation thereof and uses of the compositions in the treatment of diseases.
摘要翻译: 本发明涉及取代的硫代乙酰胺的化学组成,其制备方法和组合物在治疗疾病中的用途。
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公开(公告)号:US20080070956A1
公开(公告)日:2008-03-20
申请号:US11901150
申请日:2007-09-14
IPC分类号: A61K31/4196 , A61K31/10 , A61P25/00 , A61P25/28 , C07D207/12 , C07D249/08 , C07C317/00 , A61P25/16 , A61K31/40
CPC分类号: C07C317/44 , C07C317/10 , C07C317/12 , C07C317/18 , C07C317/28 , C07C321/22 , C07C323/12 , C07C323/22 , C07C323/25 , C07C323/49 , C07C323/52 , C07C323/60 , C07C323/61 , C07C323/67 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2603/18 , C07D249/12 , C07D307/38 , C07D333/18 , C07D333/22
摘要: The present invention provides compounds of the structure: wherein the constituent members are defined herein, including pharmaceutical compositions thereof and methods of treating diseases therewith.
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公开(公告)号:US20050245747A1
公开(公告)日:2005-11-03
申请号:US11104091
申请日:2005-04-12
申请人: Edward Bacon , Sankar Chatterjee , Derek Dunn , Marie-Edith Gourdel , Greg Hostetler , Mohamed Iqbal , Brigitte Lesur , Philippe Louvet , Eric Riguet , Dominique Schweizer , Christophe Yue
发明人: Edward Bacon , Sankar Chatterjee , Derek Dunn , Marie-Edith Gourdel , Greg Hostetler , Mohamed Iqbal , Brigitte Lesur , Philippe Louvet , Eric Riguet , Dominique Schweizer , Christophe Yue
IPC分类号: C07C317/10 , C07C317/44 , C07C323/65 , C07D205/04 , C07D207/16 , C07D207/325 , C07D207/333 , C07D209/10 , C07D209/48 , C07D211/74 , C07D213/34 , C07D213/40 , C07D215/12 , C07D261/08 , C07D295/185 , C07D307/38 , C07D307/79 , C07D317/56 , C07D319/18 , C07D319/20 , C07D321/10 , C07D327/08 , C07D333/18 , C07D333/28 , C07D333/54 , C07D345/00 , C07D405/12 , C07D409/12 , C07D249/16 , C07D209/18 , C07D235/04 , C07D249/08 , C07D403/02
CPC分类号: C07C317/10 , C07C317/44 , C07C323/65 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/16 , C07C2601/18 , C07D207/325 , C07D207/333 , C07D209/48 , C07D213/40 , C07D295/185 , C07D307/38 , C07D307/79 , C07D333/54
摘要: The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions that include substituted biaryl-methanesulfinyl acetamides of Formula (I): wherein Ar, Y, R1, R2, R4, R5, q and x are as defined herein; and their use in the treatment of diseases, including treatment of sleepiness associated with narcolepsy, obstructive sleep apnea, or shift work disorder; Parkinson's disease; Alzheimer's disease; attention deficit disorder; attention deficit hyperactivity disorder; depression; or fatigue associated with a neurological disease; as well as the promotion of wakefulness.
摘要翻译: 本发明涉及化学组成,其制备方法和组合物的用途。 特别地,本发明涉及包含式(I)的取代的联芳基 - 甲亚磺酰基乙酰胺的组合物:其中Ar,Y,R 1,R 2,R 2, 4,R 5,q和x如本文所定义; 及其用于治疗疾病的用途,包括治疗与发作性睡眠相关的嗜睡,阻塞性睡眠呼吸暂停或转移工作障碍; 帕金森病 阿尔茨海默氏病; 注意力缺陷障碍 注意缺陷多动障碍; 萧条; 或与神经系统疾病相关的疲劳; 以及促进觉醒。
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公开(公告)号:US20050234040A1
公开(公告)日:2005-10-20
申请号:US11103958
申请日:2005-04-12
IPC分类号: C07C317/10 , C07C317/12 , C07C317/18 , C07C317/28 , C07C317/44 , C07C321/22 , C07C323/12 , C07C323/22 , C07C323/25 , C07C323/49 , C07C323/52 , C07C323/60 , C07C323/61 , C07C323/67 , C07D249/12 , C07D307/38 , C07D333/18 , C07D333/22 , A61K31/55 , A61K31/353 , A61K31/382 , A61K31/473 , A61K31/5377
CPC分类号: C07C317/44 , C07C317/10 , C07C317/12 , C07C317/18 , C07C317/28 , C07C321/22 , C07C323/12 , C07C323/22 , C07C323/25 , C07C323/49 , C07C323/52 , C07C323/60 , C07C323/61 , C07C323/67 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2603/18 , C07D249/12 , C07D307/38 , C07D333/18 , C07D333/22
摘要: The present invention provides compounds of the structure: wherein the constituent members are defined herein, including pharmaceutical compositions thereof and methods of treating diseases therewith.
摘要翻译: 本发明提供了结构化合物:其中组成成分在本文中定义,包括其药物组合物和用其治疗疾病的方法。
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公开(公告)号:US06919367B2
公开(公告)日:2005-07-19
申请号:US10716238
申请日:2003-11-18
申请人: Edward R. Bacon , Sankar Chatterjee , Derek Dunn , John P. Mallamo , Matthew S. Miller , Rabindranath Tripathy , Jeffry L. Vaught
发明人: Edward R. Bacon , Sankar Chatterjee , Derek Dunn , John P. Mallamo , Matthew S. Miller , Rabindranath Tripathy , Jeffry L. Vaught
IPC分类号: C07D295/08 , A61K31/165 , A61K31/166 , A61K31/341 , A61K31/352 , A61K31/381 , A61K31/40 , A61K31/4015 , A61K31/4025 , A61K31/415 , A61K31/421 , A61K31/422 , A61K31/426 , A61K31/427 , A61K31/4402 , A61K31/4406 , A61K31/4436 , A61K31/45 , A61K31/4535 , A61K31/5377 , A61P1/00 , A61P1/14 , A61P9/10 , A61P11/00 , A61P25/00 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/28 , A61P43/00 , C07C317/44 , C07C323/60 , C07C323/61 , C07D207/16 , C07D207/26 , C07D207/273 , C07D207/40 , C07D207/416 , C07D211/88 , C07D213/34 , C07D213/40 , C07D219/04 , C07D231/54 , C07D233/54 , C07D261/08 , C07D263/10 , C07D263/16 , C07D263/32 , C07D263/34 , C07D275/02 , C07D277/26 , C07D277/56 , C07D307/68 , C07D311/84 , C07D333/18 , C07D335/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/06 , C07D495/04 , C07D498/04 , C07D401/02 , A61K31/44
CPC分类号: C07D263/34 , C07C317/44 , C07C323/60 , C07C323/63 , C07C2603/18 , C07C2603/32 , C07D207/16 , C07D207/273 , C07D207/416 , C07D211/88 , C07D213/34 , C07D219/04 , C07D231/54 , C07D233/64 , C07D261/08 , C07D263/16 , C07D263/32 , C07D275/02 , C07D277/26 , C07D277/56 , C07D307/68 , C07D311/84 , C07D333/18 , C07D335/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/06 , C07D495/04
摘要: The present invention is directed to chemical compositions of substituted thioacetamides, processes for the preparation thereof and uses of the compositions in the treatment of diseases.
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公开(公告)号:US08247414B2
公开(公告)日:2012-08-21
申请号:US11881001
申请日:2007-07-25
申请人: Edward R. Bacon , Nadine C. Becknell , Sankar Chatterjee , Derek Dunn , Robert L. Hudkins , Kurt A. Josef , Ming Tao , Allison L. Zulli
发明人: Edward R. Bacon , Nadine C. Becknell , Sankar Chatterjee , Derek Dunn , Robert L. Hudkins , Kurt A. Josef , Ming Tao , Allison L. Zulli
IPC分类号: C07D401/14 , C07D237/26 , C07D498/04 , C07D237/36 , A61K31/501 , A61K31/502 , A61K31/5025 , C07D403/12 , C07D237/32 , C07D237/14 , C07D237/00 , C07D413/12 , A61K31/55 , A61K31/5355
CPC分类号: C07D498/04 , C07D237/14 , C07D237/26 , C07D237/32 , C07D237/36 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D409/04 , C07D495/04
摘要: The present invention is directed to novel pyridizinone derivatives that mediate enzymatic activity. In particular, the compounds may be effective in the treatment of diseases or disease states related to the activity of the histamine H3 receptor, including, for example, neurodegenerative disorders, sleep/wake disorders, attention deficit hyperactivity disorder and cognition.
摘要翻译: 本发明涉及介导酶活性的新型吡哒嗪酮衍生物。 特别地,这些化合物可有效治疗与组胺H3受体活性相关的疾病或疾病状态,包括例如神经变性疾病,睡眠/觉醒障碍,注意力缺陷多动障碍和认知。
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公开(公告)号:US07268132B2
公开(公告)日:2007-09-11
申请号:US11116755
申请日:2005-04-28
IPC分类号: C07D211/70 , A61K31/44
CPC分类号: C07D263/34 , C07C317/44 , C07C323/60 , C07C323/63 , C07C2603/18 , C07C2603/32 , C07D207/16 , C07D207/273 , C07D207/416 , C07D211/88 , C07D213/34 , C07D219/04 , C07D231/54 , C07D233/64 , C07D261/08 , C07D263/16 , C07D263/32 , C07D275/02 , C07D277/26 , C07D277/56 , C07D307/68 , C07D311/84 , C07D333/18 , C07D335/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/06 , C07D495/04
摘要: The present invention is directed to chemical compositions of substituted thioacetamides, processes for the preparation thereof and uses of the compositions in the treatment of diseases.
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公开(公告)号:US20060276497A1
公开(公告)日:2006-12-07
申请号:US11455356
申请日:2006-06-19
申请人: Sankar Chatterjee , James Diebold , Derek Dunn , Robert Hudkins , Reddeppareddy Dandu , Gregory Wells , Allison Zulli
发明人: Sankar Chatterjee , James Diebold , Derek Dunn , Robert Hudkins , Reddeppareddy Dandu , Gregory Wells , Allison Zulli
IPC分类号: A61K31/4745 , A61K31/425 , A61K31/407 , C07D498/02 , C07D487/02
CPC分类号: C07D491/14 , C07D471/14 , C07D487/04 , C07D491/04 , C07D495/04 , C07D519/00
摘要: The present invention is directed to novel multicyclic molecules that mediate enzymatic activity. In particular, the compounds may be effective in the treatment of diseases or disease states related to the activity of PARP, VEGFR2, and MLK3 enzymes, including, for example, neurodegenerative diseases, inflammation, ischemia, and cancer.
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10.SUBSTITUTED PHENOXYPROPYLCYCLOAMINE DERIVATIVES AS HISTAMINE-3 (H3) RECEPTOR LIGANDS 审中-公开
标题翻译: 作为HISTAMINE-3(H3)受体配体的取代的羟基丙烯酰胺衍生物公开(公告)号:US20140296212A1
公开(公告)日:2014-10-02
申请号:US14177046
申请日:2014-02-10
申请人: Edward R. Bacon , Thomas R. Bailey , Sankar Chatterjee , Derek Dunn , Greg A. Hostetler , Robert L. Hudkins , Allison L. Zulli , Brigitte Lesur , Babu G. Sundar , Christophe Yue
发明人: Edward R. Bacon , Thomas R. Bailey , Sankar Chatterjee , Derek Dunn , Greg A. Hostetler , Robert L. Hudkins , Allison L. Zulli , Brigitte Lesur , Babu G. Sundar , Christophe Yue
IPC分类号: C07D403/12 , C07C217/54 , C07D211/22 , C07D209/44 , C07D215/02 , C07D207/08 , C07D217/04
CPC分类号: C07D403/12 , C07C217/54 , C07D207/06 , C07D207/08 , C07D207/10 , C07D207/27 , C07D209/44 , C07D211/14 , C07D211/22 , C07D211/38 , C07D211/46 , C07D215/02 , C07D215/06 , C07D217/04 , C07D241/08 , C07D295/108 , C07D295/185 , C07D401/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D471/04 , C07D487/04
摘要: The present invention provides compounds of formula I: their use as H3 antagonists/inverse agonists, processes for their preparation, and pharmaceutical compositions thereof.
摘要翻译: 本发明提供式I化合物:它们用作H3拮抗剂/反向激动剂,其制备方法及其药物组合物。
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