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公开(公告)号:US20080070956A1
公开(公告)日:2008-03-20
申请号:US11901150
申请日:2007-09-14
IPC分类号: A61K31/4196 , A61K31/10 , A61P25/00 , A61P25/28 , C07D207/12 , C07D249/08 , C07C317/00 , A61P25/16 , A61K31/40
CPC分类号: C07C317/44 , C07C317/10 , C07C317/12 , C07C317/18 , C07C317/28 , C07C321/22 , C07C323/12 , C07C323/22 , C07C323/25 , C07C323/49 , C07C323/52 , C07C323/60 , C07C323/61 , C07C323/67 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2603/18 , C07D249/12 , C07D307/38 , C07D333/18 , C07D333/22
摘要: The present invention provides compounds of the structure: wherein the constituent members are defined herein, including pharmaceutical compositions thereof and methods of treating diseases therewith.
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公开(公告)号:US20050192313A1
公开(公告)日:2005-09-01
申请号:US11116755
申请日:2005-04-28
申请人: Edward Bacon , Sankar Chatterjee , Derek Dunn , John Mallamo , Matthew Miller , Rabindranath Tripathy , Jeffry Vaught
发明人: Edward Bacon , Sankar Chatterjee , Derek Dunn , John Mallamo , Matthew Miller , Rabindranath Tripathy , Jeffry Vaught
IPC分类号: C07D295/08 , A61K31/165 , A61K31/166 , A61K31/341 , A61K31/352 , A61K31/381 , A61K31/40 , A61K31/4015 , A61K31/4025 , A61K31/415 , A61K31/421 , A61K31/422 , A61K31/426 , A61K31/427 , A61K31/4402 , A61K31/4406 , A61K31/4436 , A61K31/45 , A61K31/4535 , A61K31/5377 , A61P1/00 , A61P1/14 , A61P9/10 , A61P11/00 , A61P25/00 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/28 , A61P43/00 , C07C317/44 , C07C323/60 , C07C323/61 , C07D207/16 , C07D207/26 , C07D207/273 , C07D207/40 , C07D207/416 , C07D211/88 , C07D213/34 , C07D213/40 , C07D219/04 , C07D231/54 , C07D233/54 , C07D261/08 , C07D263/10 , C07D263/16 , C07D263/32 , C07D263/34 , C07D275/02 , C07D277/26 , C07D277/56 , C07D307/68 , C07D311/84 , C07D333/18 , C07D335/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/06 , C07D495/04 , C07D498/04 , A61K31/473 , A61K31/353 , A61K31/382
CPC分类号: C07D263/34 , C07C317/44 , C07C323/60 , C07C323/63 , C07C2603/18 , C07C2603/32 , C07D207/16 , C07D207/273 , C07D207/416 , C07D211/88 , C07D213/34 , C07D219/04 , C07D231/54 , C07D233/64 , C07D261/08 , C07D263/16 , C07D263/32 , C07D275/02 , C07D277/26 , C07D277/56 , C07D307/68 , C07D311/84 , C07D333/18 , C07D335/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/06 , C07D495/04
摘要: The present invention is directed to chemical compositions of substituted thioacetamides, processes for the preparation thereof and uses of the compositions in the treatment of diseases.
摘要翻译: 本发明涉及取代的硫代乙酰胺的化学组成,其制备方法和组合物在治疗疾病中的用途。
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公开(公告)号:US20050234040A1
公开(公告)日:2005-10-20
申请号:US11103958
申请日:2005-04-12
IPC分类号: C07C317/10 , C07C317/12 , C07C317/18 , C07C317/28 , C07C317/44 , C07C321/22 , C07C323/12 , C07C323/22 , C07C323/25 , C07C323/49 , C07C323/52 , C07C323/60 , C07C323/61 , C07C323/67 , C07D249/12 , C07D307/38 , C07D333/18 , C07D333/22 , A61K31/55 , A61K31/353 , A61K31/382 , A61K31/473 , A61K31/5377
CPC分类号: C07C317/44 , C07C317/10 , C07C317/12 , C07C317/18 , C07C317/28 , C07C321/22 , C07C323/12 , C07C323/22 , C07C323/25 , C07C323/49 , C07C323/52 , C07C323/60 , C07C323/61 , C07C323/67 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2603/18 , C07D249/12 , C07D307/38 , C07D333/18 , C07D333/22
摘要: The present invention provides compounds of the structure: wherein the constituent members are defined herein, including pharmaceutical compositions thereof and methods of treating diseases therewith.
摘要翻译: 本发明提供了结构化合物:其中组成成分在本文中定义,包括其药物组合物和用其治疗疾病的方法。
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公开(公告)号:US06919367B2
公开(公告)日:2005-07-19
申请号:US10716238
申请日:2003-11-18
申请人: Edward R. Bacon , Sankar Chatterjee , Derek Dunn , John P. Mallamo , Matthew S. Miller , Rabindranath Tripathy , Jeffry L. Vaught
发明人: Edward R. Bacon , Sankar Chatterjee , Derek Dunn , John P. Mallamo , Matthew S. Miller , Rabindranath Tripathy , Jeffry L. Vaught
IPC分类号: C07D295/08 , A61K31/165 , A61K31/166 , A61K31/341 , A61K31/352 , A61K31/381 , A61K31/40 , A61K31/4015 , A61K31/4025 , A61K31/415 , A61K31/421 , A61K31/422 , A61K31/426 , A61K31/427 , A61K31/4402 , A61K31/4406 , A61K31/4436 , A61K31/45 , A61K31/4535 , A61K31/5377 , A61P1/00 , A61P1/14 , A61P9/10 , A61P11/00 , A61P25/00 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/28 , A61P43/00 , C07C317/44 , C07C323/60 , C07C323/61 , C07D207/16 , C07D207/26 , C07D207/273 , C07D207/40 , C07D207/416 , C07D211/88 , C07D213/34 , C07D213/40 , C07D219/04 , C07D231/54 , C07D233/54 , C07D261/08 , C07D263/10 , C07D263/16 , C07D263/32 , C07D263/34 , C07D275/02 , C07D277/26 , C07D277/56 , C07D307/68 , C07D311/84 , C07D333/18 , C07D335/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/06 , C07D495/04 , C07D498/04 , C07D401/02 , A61K31/44
CPC分类号: C07D263/34 , C07C317/44 , C07C323/60 , C07C323/63 , C07C2603/18 , C07C2603/32 , C07D207/16 , C07D207/273 , C07D207/416 , C07D211/88 , C07D213/34 , C07D219/04 , C07D231/54 , C07D233/64 , C07D261/08 , C07D263/16 , C07D263/32 , C07D275/02 , C07D277/26 , C07D277/56 , C07D307/68 , C07D311/84 , C07D333/18 , C07D335/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/06 , C07D495/04
摘要: The present invention is directed to chemical compositions of substituted thioacetamides, processes for the preparation thereof and uses of the compositions in the treatment of diseases.
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公开(公告)号:US06670358B2
公开(公告)日:2003-12-30
申请号:US10014645
申请日:2001-10-26
申请人: Edward R. Bacon , Sankar Chatterjee , Derek Dunn , John P. Mallamo , Matthew S. Miller , Rabindranath Tripathy , Jeffry L. Vaught
发明人: Edward R. Bacon , Sankar Chatterjee , Derek Dunn , John P. Mallamo , Matthew S. Miller , Rabindranath Tripathy , Jeffry L. Vaught
IPC分类号: C07D21302
CPC分类号: C07D263/34 , C07C317/44 , C07C323/60 , C07C323/63 , C07C2603/18 , C07C2603/32 , C07D207/16 , C07D207/273 , C07D207/416 , C07D211/88 , C07D213/34 , C07D219/04 , C07D231/54 , C07D233/64 , C07D261/08 , C07D263/16 , C07D263/32 , C07D275/02 , C07D277/26 , C07D277/56 , C07D307/68 , C07D311/84 , C07D333/18 , C07D335/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/06 , C07D495/04
摘要: The present invention is directed to chemical compositions of substituted thioacetamides, processes for the preparation thereof and uses of the compositions in the treatment of diseases.
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公开(公告)号:US07314875B2
公开(公告)日:2008-01-01
申请号:US11103958
申请日:2005-04-12
IPC分类号: C07D265/30 , C07D211/14 , C07D207/12 , A61K31/5375 , A61K31/135
CPC分类号: C07C317/44 , C07C317/10 , C07C317/12 , C07C317/18 , C07C317/28 , C07C321/22 , C07C323/12 , C07C323/22 , C07C323/25 , C07C323/49 , C07C323/52 , C07C323/60 , C07C323/61 , C07C323/67 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2603/18 , C07D249/12 , C07D307/38 , C07D333/18 , C07D333/22
摘要: The present invention provides compounds of the structure: wherein the constituent members are defined herein, including pharmaceutical compositions thereof and methods of treating diseases therewith.
摘要翻译: 本发明提供了结构化合物:其中组成成分在本文中定义,包括其药物组合物和用其治疗疾病的方法。
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公开(公告)号:US08153667B2
公开(公告)日:2012-04-10
申请号:US11901150
申请日:2007-09-14
IPC分类号: A61K31/4196 , A61K31/40 , A61K31/381 , A61K31/34 , A61K31/10 , C07D249/08 , C07D207/00 , C07D333/00 , C07D307/00 , C07C317/00
CPC分类号: C07C317/44 , C07C317/10 , C07C317/12 , C07C317/18 , C07C317/28 , C07C321/22 , C07C323/12 , C07C323/22 , C07C323/25 , C07C323/49 , C07C323/52 , C07C323/60 , C07C323/61 , C07C323/67 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2603/18 , C07D249/12 , C07D307/38 , C07D333/18 , C07D333/22
摘要: The present invention provides compounds of the structure: wherein the constituent members are defined herein, including pharmaceutical compositions thereof and methods of treating diseases therewith.
摘要翻译: 本发明提供了结构化合物:其中组成成分在本文中定义,包括其药物组合物和用其治疗疾病的方法。
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公开(公告)号:US20050245747A1
公开(公告)日:2005-11-03
申请号:US11104091
申请日:2005-04-12
申请人: Edward Bacon , Sankar Chatterjee , Derek Dunn , Marie-Edith Gourdel , Greg Hostetler , Mohamed Iqbal , Brigitte Lesur , Philippe Louvet , Eric Riguet , Dominique Schweizer , Christophe Yue
发明人: Edward Bacon , Sankar Chatterjee , Derek Dunn , Marie-Edith Gourdel , Greg Hostetler , Mohamed Iqbal , Brigitte Lesur , Philippe Louvet , Eric Riguet , Dominique Schweizer , Christophe Yue
IPC分类号: C07C317/10 , C07C317/44 , C07C323/65 , C07D205/04 , C07D207/16 , C07D207/325 , C07D207/333 , C07D209/10 , C07D209/48 , C07D211/74 , C07D213/34 , C07D213/40 , C07D215/12 , C07D261/08 , C07D295/185 , C07D307/38 , C07D307/79 , C07D317/56 , C07D319/18 , C07D319/20 , C07D321/10 , C07D327/08 , C07D333/18 , C07D333/28 , C07D333/54 , C07D345/00 , C07D405/12 , C07D409/12 , C07D249/16 , C07D209/18 , C07D235/04 , C07D249/08 , C07D403/02
CPC分类号: C07C317/10 , C07C317/44 , C07C323/65 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/16 , C07C2601/18 , C07D207/325 , C07D207/333 , C07D209/48 , C07D213/40 , C07D295/185 , C07D307/38 , C07D307/79 , C07D333/54
摘要: The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions that include substituted biaryl-methanesulfinyl acetamides of Formula (I): wherein Ar, Y, R1, R2, R4, R5, q and x are as defined herein; and their use in the treatment of diseases, including treatment of sleepiness associated with narcolepsy, obstructive sleep apnea, or shift work disorder; Parkinson's disease; Alzheimer's disease; attention deficit disorder; attention deficit hyperactivity disorder; depression; or fatigue associated with a neurological disease; as well as the promotion of wakefulness.
摘要翻译: 本发明涉及化学组成,其制备方法和组合物的用途。 特别地,本发明涉及包含式(I)的取代的联芳基 - 甲亚磺酰基乙酰胺的组合物:其中Ar,Y,R 1,R 2,R 2, 4,R 5,q和x如本文所定义; 及其用于治疗疾病的用途,包括治疗与发作性睡眠相关的嗜睡,阻塞性睡眠呼吸暂停或转移工作障碍; 帕金森病 阿尔茨海默氏病; 注意力缺陷障碍 注意缺陷多动障碍; 萧条; 或与神经系统疾病相关的疲劳; 以及促进觉醒。
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公开(公告)号:US20080027228A1
公开(公告)日:2008-01-31
申请号:US11825079
申请日:2007-07-03
申请人: Edward Bacon , Sankar Chatterjee , Derek Dunn , John Mallamo , Matthew Miller , Jeffry Vaught
发明人: Edward Bacon , Sankar Chatterjee , Derek Dunn , John Mallamo , Matthew Miller , Jeffry Vaught
IPC分类号: C07D221/00 , C07C231/12 , C07D231/54 , C07D333/02 , C07D277/02 , C07D207/00
CPC分类号: C07D263/34 , C07C317/44 , C07C323/60 , C07C323/63 , C07C2603/18 , C07C2603/32 , C07D207/16 , C07D207/273 , C07D207/416 , C07D211/88 , C07D213/34 , C07D219/04 , C07D231/54 , C07D233/64 , C07D261/08 , C07D263/16 , C07D263/32 , C07D275/02 , C07D277/26 , C07D277/56 , C07D307/68 , C07D311/84 , C07D333/18 , C07D335/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/06 , C07D495/04
摘要: The present invention is directed to chemical compositions of substituted thioacetamides, processes for the preparation thereof and uses of the compositions in the treatment of diseases.
摘要翻译: 本发明涉及取代的硫代乙酰胺的化学组成,其制备方法和组合物在治疗疾病中的用途。
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公开(公告)号:US08471005B2
公开(公告)日:2013-06-25
申请号:US13160890
申请日:2011-06-15
申请人: Henry J. Breslin , Sankar Chatterjee , James L. Diebold , Bruce D. Dorsey , Derek D. Dunn , Diane E. Gingrich , Greg A. Hostetler , Robert L. Hudkins , Rachael Hunter , Kurt A. Josef , Joseph Lisko , Eugen F. Mesaros , Karen L. Milkiewicz , Gregory R. Ott , Babu G. Sundar , Jay P. Theroff , Tho Thieu , Rabindranath Tripathy , Theodore L. Underiner , Linda Weinberg , Gregory J. Wells , Craig A. Zificsak
发明人: Henry J. Breslin , Sankar Chatterjee , James L. Diebold , Bruce D. Dorsey , Derek D. Dunn , Diane E. Gingrich , Greg A. Hostetler , Robert L. Hudkins , Rachael Hunter , Kurt A. Josef , Joseph Lisko , Eugen F. Mesaros , Karen L. Milkiewicz , Gregory R. Ott , Babu G. Sundar , Jay P. Theroff , Tho Thieu , Rabindranath Tripathy , Theodore L. Underiner , Linda Weinberg , Gregory J. Wells , Craig A. Zificsak
IPC分类号: C07D487/04 , C07D403/12 , A61K31/53 , A61K31/5377 , A61P35/00
CPC分类号: C07D487/04
摘要: The present invention provides a compound of formula I or a salt form thereof, wherein Q1, Q2, Q3, and Q4 are as defined herein. The compound of formula I has ALK and/or JAK2 inhibitory activity, and may be used to treat proliferative disorders.
摘要翻译: 本发明提供式I化合物或其盐形式,其中Q 1,Q 2,Q 3和Q 4如本文所定义。 式I化合物具有ALK和/或JAK2抑制活性,可用于治疗增殖性疾病。
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