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公开(公告)号：US5290772A
公开(公告)日：1994-03-01
申请号：US899235
申请日：1992-06-16
CPC分类号： C12R1/01 , C07H19/01 , C12P17/188
摘要： Described is a process for producing an immunosuppressant, "demethimmunomycin" (L-683,7411) a C-31 demethylated analog of L-683,590 under fermentation conditions utilizing the microorganism, Actinoplanacete sp, (Merck Culture Collection MA 6559) ATCC No. 53771. The macrolide immunosuppressant is useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow and heart transplants.
摘要翻译： 描述了在使用微生物Actinoplanacete sp（Merck Culture Collection MA 6559）ATCC No.53771的发酵条件下生产免疫抑制剂“demethimmunomycin”（L-683,71411）L-683,590的C-31去甲基化类似物的方法 大环内酯类免疫抑制剂可用于预防外来器官移植的人宿主排斥反应 骨髓和心脏移植。
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公开(公告)号：US5268370A
公开(公告)日：1993-12-07
申请号：US872741
申请日：1992-04-22
IPC分类号： C07D498/18 , C07H19/01 , C12P17/18 , C12P19/44 , A61K31/33 , C07D498/16
CPC分类号： C07D498/18 , C07H19/01 , C12P17/188 , C12P19/445
摘要： Described is a new immunosuppressant, L-683,519, a monodemethylated rearranged derivative of L-679,934, (FK-506) produced under fermentation conditions utilizing the microorganism, unidentified Actinomycete (Merck Culture Collection MA 6474) ATCC No. 53828. The macrolide immunosuppressant is useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow and heart transplants.
摘要翻译： 描述了一种新的免疫抑制剂L-683,519，L-679,934的单甲基化重排的衍生物（FK-506），其在使用微生物，不明的放线菌（Merck Culture Collection MA 6474）ATCC No.58288的发酵条件下产生。大环内酯类免疫抑制剂是 可用于预防人体宿主排斥外来器官移植物，例如 骨髓和心脏移植。
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公开(公告)号：US4981792A
公开(公告)日：1991-01-01
申请号：US213063
申请日：1988-06-29
IPC分类号： A61K31/395 , A61K35/74 , A61P37/06 , C07D213/50 , C07D213/79 , C07D493/18 , C07D498/18 , C07G99/00 , C07H19/01 , C12P17/18 , C12R1/01
CPC分类号： C07D493/18 , C07H19/01 , C12P17/18 , Y10S435/827
摘要： Described is a process for producing a new immunosuppressant, "demethomycin" (L-682,993) a C-31 demethylated analog of L-679,934 under novel fermentation conditions utilizing the microorganism, Actinoplanacete sp., (Merck Culture Collection MA 6559) ATCC No. 53771. The macrolide immunosuppressant is useful in prevent human host rejection of foreign organ transplants, e.g. bone marrow and heart transplants.
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公开(公告)号：US5252612A
公开(公告)日：1993-10-12
申请号：US905075
申请日：1992-06-24
IPC分类号： C07D498/18 , C07H19/01 , C12P1/06 , A61K35/00
CPC分类号： C07D498/18 , C07H19/01 , C12P1/06
摘要： Described is a new immunosuppressant, L-683,756, a bisdemethylated, ring rearranged derivative of L-683,590, produced under fermentation conditions utilizing the microorganism, Actinoplanacete sp. (Merck Culture Collection MA 6559) ATCC No. 53771. The macrolide immunosuppressant is useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow and heart transplants.
摘要翻译： 描述了一种新的免疫抑制剂L-683,756，L-683,590的双脱甲基化环重排衍生物，其在使用微生物Actinoplanacete sp。 （Merck Culture Collection MA 6559）ATCC No.53771.大环内酯类免疫抑制剂可用于预防异种器官移植的人宿主排斥反应。 骨髓和心脏移植。
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公开(公告)号：US5202258A
公开(公告)日：1993-04-13
申请号：US847873
申请日：1992-03-09
申请人： Shieh-Shung T. Chen , Byron H. Arison , George M. Garrity , Edward S. Inamine , Sagrario Mochales , Linda S. Wicker
发明人： Shieh-Shung T. Chen , Byron H. Arison , George M. Garrity , Edward S. Inamine , Sagrario Mochales , Linda S. Wicker
CPC分类号： C12R1/045 , Y10S436/827
摘要： Described is a new microorganism, Actinoplanacete sp., (Merck Culture Collection MA 6559) ATCC No. 53771. The microorganism acts as a demethylating agent and can produce the new immunosuppressants, "demethomycin" (L-682,993) a C-31 demethylated analog of L-679,934, and "demethimmunomycin" (L-683,742) a C-31 demethylated analog of L-683,590, under novel fermentation conditions. These macrolide immunosuppressants are useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow and heart transplants.
摘要翻译： 描述了一种新的微生物Actinoplanacete sp。（Merck Culture Collection MA 6559）ATCC No.53771.微生物作为去甲基化剂，可以产生新的免疫抑制剂“吗啡霉素”（L-682,993）C-31去甲基化的类似物 的L-679,934和“demethimmunomycin”（L-683,742）L-683,590的C-31去甲基化类似物，在新的发酵条件下。 这些大环内酯类免疫抑制剂可用于预防异种器官移植的人宿主排斥反应。 骨髓和心脏移植。
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公开(公告)号：US4975372A
公开(公告)日：1990-12-04
申请号：US297631
申请日：1989-01-13
IPC分类号： C12P17/18 , A61K31/445 , A61P37/00 , A61P37/02 , A61P37/04 , A61P37/06 , C07D498/18 , C07H19/01 , C12P1/06 , C12R1/01
CPC分类号： C07D498/18 , C07H19/01 , C12P1/06 , Y10S435/826
摘要： Described is a new immunosuppressant, L-685,487, a monodemethylated rearranged derivative of L-683,590, produced under fermentation conditions utilizing the microorganism, unidentified Actinomycete (Merck Cultrue Collection MA 6474) ATCC No. 53828. The macrolide immunosuppressant is useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow and heart transplants.
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7.发明授权
公开(公告)号：US5087702A
公开(公告)日：1992-02-11
申请号：US647945
申请日：1991-01-30
IPC分类号： C07D471/04 , C12P17/18
CPC分类号： C12P17/182 , C07D471/04
摘要： Fermentation of the microorganism Streptomyces sp. (MA6750) ATCC No. 55042 in the presence of the Angiotensin II (A II) receptor antagonist of the following structure: ##STR1## yields an analog having a shikimate sugar-like moiety attached to the tetrazole, the said analog which is also an A II antagonist useful in the treatment of hypertension and congestive heart failure and other indications known to respond to A II angatonists.
摘要翻译： 微生物发酵链霉菌Streptomyces sp。 （MA6750）ATCC No.55042在存在下列结构的血管紧张素II（AII）受体拮抗剂的情况下：产生具有连接于四唑的眨眼糖基部分的类似物，所述类似物也是 可用于治疗高血压和充血性心力衰竭的II拮抗剂和已知对A II血管炎症反应的其他适应症。
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8.发明授权
公开(公告)号：US5250422A
公开(公告)日：1993-10-05
申请号：US880870
申请日：1992-05-11
CPC分类号： C07H19/01 , C12P19/623
摘要： Incubation of 13.beta.-hydroxy ivermectin aglycone with a species of Bacillus subtilis or the incubation of 13-deoxy ivermectin aglycone with a mixed culture of a species of Bacillus subtilis and of Streptomyces griseus results in the production of 13-.beta. ivermectin monoglucopyranoside as the major product and of 5-.beta. ivermectin monoglucopyranoside as the minor product.
摘要翻译： 将13个β-羟基伊维菌素糖苷配基与一种枯草芽孢杆菌的孵育或13-脱氧伊维菌素糖苷配基与枯草芽孢杆菌和灰色链霉菌的混合培养物的孵育导致13-β-伊维菌素单吡喃葡萄糖苷的生产作为主要 产品和5-β伊维菌素单吡喃葡萄糖苷作为次要产品。
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公开(公告)号：US5138052A
公开(公告)日：1992-08-11
申请号：US666466
申请日：1991-03-05
IPC分类号： C07D498/18 , C07H19/01 , C12P17/18
CPC分类号： C07D498/18 , C07H19/01 , C12P17/188
摘要： Described is a new L-679,934 (FK-506) antagonist, L-686,292, a C-15, C-31 bisdemethylated, derivative of L-683,590, produced under fermentation conditions utilizing the microorganism, Actinoplanacete sp. (Merck Culture Collection MA 6559) ATCC No. 53771. The macrolide reverses the immunosuppressant action of L-679,934 (FK-506), and can be used diagnostically as a tool to determine the presence of FK-506 macrolide type immunosuppressants in natural product broths, distinguishing such immunosuppressants from other chemical families such as the cycloporins.
摘要翻译： 描述了一种新的L-679,934（FK-506）拮抗剂L-686,292，C-15，C-31双脱甲基化的L-683,590衍生物，其在使用微生物Actinoplanacete sp。 （Merck Culture Collection MA 6559）ATCC编号53771.大环内酯可逆转L-679,934（FK-506）的免疫抑制剂作用，可用于诊断上用于确定天然产物中FK-506大环内酯型免疫抑制剂的存在 肉汤，区分这些免疫抑制剂与其他化学家族如环保蛋白。
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公开(公告)号：US5270187A
公开(公告)日：1993-12-14
申请号：US824690
申请日：1992-01-21
CPC分类号： C12P17/188 , Y10S435/827 , Y10S435/886
摘要： Described is a process for producing a new immunosuppressant, L-682,992, a C-13, C-31 demethylated ring-rearranged analog of L-679,934, under novel fermentation conditions utilizing the microorganism, Actinoplanacete Sp., (Merck Culture Collection MA 6559) ATCC No. 53771. The macrolide immunosuppressant is useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow and heart transplants.
摘要翻译： 描述了在使用微生物Actinoplanacete Sp。（Merck Culture Collection MA 6559）的新型发酵条件下生产新的免疫抑制剂L-682,992，C-13，C-31脱甲基环重排的L-679,934类似物的方法 ）ATCC No.53771.大环内酯类免疫抑制剂可用于预防异种器官移植的人宿主排斥，例如 骨髓和心脏移植。
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