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公开(公告)号：US20120244139A1
公开(公告)日：2012-09-27
申请号：US13506603
申请日：2012-04-30
CPC分类号： A61K38/482 , A61K38/49 , C07K2319/00 , C12N9/6421 , C12N9/6424 , C12N9/6467 , C12Y304/21109
摘要： Provided are methods for and compounds for modulating the complement system. In particular, compounds are provided that inhibit complement activation and compounds are provided that promote complement activation. The compounds are therapeutics by virtue of their effects on the complement system. Hence, the compounds that inhibit complement activation can be used for treatment of ischemic and reperfusion disorders, including myocardial infarction and stroke, sepsis, autoimmune diseases, inflammatory diseases and diseases with an inflammatory component, including Alzheimer's Disease and other neurodegenerative disorder.
摘要翻译： 提供了用于调节补体系统的方法和化合物。 特别地，提供抑制补体活化的化合物，并提供促进补体活化的化合物。 这些化合物由于其对补体系统的作用而成为治疗剂。 因此，抑制补体活化的化合物可用于治疗缺血和再灌注障碍，包括心肌梗死和中风，败血症，自身免疫性疾病，炎性疾病和具有炎性成分的疾病，包括阿尔茨海默氏病和其他神经变性疾病。
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公开(公告)号：US20140242062A1
公开(公告)日：2014-08-28
申请号：US14275772
申请日：2014-05-12
IPC分类号： A61K38/48
CPC分类号： A61K38/482 , A61K38/49 , C07K2319/00 , C12N9/6421 , C12N9/6424 , C12N9/6467 , C12Y304/21109
摘要： Provided are methods for and compounds for modulating the complement system. In particular, compounds are provided that inhibit complement activation and compounds are provided that promote complement activation. The compounds are therapeutics by virtue of their effects on the complement system. Hence, the compounds that inhibit complement activation can be used for treatment of ischemic and reperfusion disorders, including myocardial infarction and stroke, sepsis, autoimmune diseases, inflammatory diseases and diseases with an inflammatory component, including Alzheimer's Disease and other neurodegenerative disorders.
摘要翻译： 提供了用于调节补体系统的方法和化合物。 特别地，提供抑制补体活化的化合物，并提供促进补体活化的化合物。 这些化合物由于其对补体系统的作用而成为治疗剂。 因此，抑制补体活化的化合物可用于治疗缺血和再灌注障碍，包括心肌梗死和中风，败血症，自身免疫性疾病，炎症性疾病和具有炎性成分的疾病，包括阿尔茨海默病和其他神经变性疾病。
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公开(公告)号：US09795655B2
公开(公告)日：2017-10-24
申请号：US14275772
申请日：2014-05-12
CPC分类号： A61K38/482 , A61K38/49 , C07K2319/00 , C12N9/6421 , C12N9/6424 , C12N9/6467 , C12Y304/21109
摘要： Provided are methods for and compounds for modulating the complement system. In particular, compounds are provided that inhibit complement activation and compounds are provided that promote complement activation. The compounds are therapeutics by virtue of their effects on the complement system. Hence, the compounds that inhibit complement activation can be used for treatment of ischemic and reperfusion disorders, including myocardial infarction and stroke, sepsis, autoimmune diseases, inflammatory diseases and diseases with an inflammatory component, including Alzheimer's Disease and other neurodegenerative disorders.
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公开(公告)号：US20090098103A1
公开(公告)日：2009-04-16
申请号：US12082662
申请日：2008-04-11
CPC分类号： C07K14/745 , A61K38/00 , A61K38/36 , A61K45/06 , A61K2300/00
摘要： Modified factor VII polypeptides and uses thereof are provided. Such modified FVII polypeptides include Factor VIIa and other forms of Factor VII. Among modified FVII polypeptides provided are those that have altered activities, typically altered procoagulant activity, including increased procoagulant activities. Hence, such modified polypeptides are therapeutics.
摘要翻译： 提供了修饰的因子VII多肽及其用途。 这种修饰的FVII多肽包括因子VIIa和其他形式的因子VII。 所提供的经修饰的FVII多肽是那些具有改变的活性，通常改变的促凝活性，包括增加的促凝活性。 因此，这些修饰的多肽是治疗剂。
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公开(公告)号：US20100166729A9
公开(公告)日：2010-07-01
申请号：US12082662
申请日：2008-04-11
CPC分类号： C07K14/745 , A61K38/00 , A61K38/36 , A61K45/06 , A61K2300/00
摘要： Modified factor VII polypeptides and uses thereof are provided. Such modified FVII polypeptides include Factor VIIa and other forms of Factor VII. Among modified FVII polypeptides provided are those that have altered activities, typically altered procoagulant activity, including increased procoagulant activities. Hence, such modified polypeptides are therapeutics.
摘要翻译： 提供了修饰的因子VII多肽及其用途。 这种修饰的FVII多肽包括因子VIIa和其他形式的因子VII。 所提供的经修饰的FVII多肽是那些具有改变的活性，通常改变的促凝活性，包括增加的促凝活性。 因此，这些修饰的多肽是治疗剂。
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公开(公告)号：US20140234290A1
公开(公告)日：2014-08-21
申请号：US14244840
申请日：2014-04-03
CPC分类号： C12N9/6432 , A61K38/36 , A61K38/482 , A61K38/4846
摘要： Modified therapeutic proteins are provided. In particular modified Factor X polypeptides, which includes the Factor X zymogen, Factor Xa and other forms of Factor X, and uses thereof are provided.
摘要翻译： 提供了修饰的治疗蛋白质。 提供了包括因子X酶原，因子Xa和其他形式的因子X的修饰的因子X多肽及其用途。
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公开(公告)号：US20120308540A1
公开(公告)日：2012-12-06
申请号：US13373118
申请日：2011-11-03
IPC分类号： C12N9/64 , C12N15/57 , C12N15/63 , A61K35/18 , C12N5/10 , A61K38/48 , A61P7/04 , A61K35/14 , C12N9/96 , C12N15/79
CPC分类号： C12N9/644 , A61K38/4846 , A61K48/00 , C12Y304/21022
摘要： Modified Factor IX (FIX) polypeptides and uses thereof are provided. Such modified FIX polypeptides include FIXa and other forms of FIX. Among the modified FIX polypeptides provided are those that have altered activities, typically altered procoagulant activity, including increased procoagulant activities. Hence, such modified polypeptides are therapeutics.
摘要翻译： 提供了修饰因子IX（FIX）多肽及其用途。 这种修饰的FIX多肽包括FIXa和其它形式的FIX。 提供的修饰的FIX多肽中的那些是具有改变的活性，通常改变的促凝活性，包括增加的促凝活性。 因此，这些修饰的多肽是治疗剂。
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公开(公告)号：US08519103B2
公开(公告)日：2013-08-27
申请号：US12384915
申请日：2009-04-10
IPC分类号： A61K38/36 , C07K14/745 , A61P7/04
CPC分类号： C12N9/6437 , A61K38/00 , A61K48/00 , C07K2319/00 , C12N15/62 , C12Y304/21021
摘要： Modified factor VII polypeptides and uses thereof are provided. Such modified FVII polypeptides include Factor VIIa and other forms of Factor VII. Among modified FVII polypeptides provided are those that have altered activities, typically altered procoagulant activity, including increased procoagulant activities. Hence, such modified polypeptides are therapeutics.
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公开(公告)号：US20130177541A9
公开(公告)日：2013-07-11
申请号：US13373118
申请日：2011-11-03
IPC分类号： C12N9/64 , C12N15/57 , C12N15/63 , A61K35/18 , C12N5/10 , A61K38/48 , A61P7/04 , A61K35/14 , C12N9/96 , C12N15/79
CPC分类号： C12N9/644 , A61K38/4846 , A61K48/00 , C12Y304/21022
摘要： Modified Factor IX (FIX) polypeptides and uses thereof are provided. Such modified FIX polypeptides include FIXa and other forms of FIX. Among the modified FIX polypeptides provided are those that have altered activities, typically altered procoagulant activity, including increased procoagulant activities. Hence, such modified polypeptides are therapeutics.
摘要翻译： 提供了修饰因子IX（FIX）多肽及其用途。 这种修饰的FIX多肽包括FIXa和其它形式的FIX。 提供的修饰的FIX多肽中的那些是具有改变的活性，通常改变的促凝活性，包括增加的促凝活性。 因此，这些修饰的多肽是治疗剂。
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公开(公告)号：US20090291890A1
公开(公告)日：2009-11-26
申请号：US12384915
申请日：2009-04-10
CPC分类号： C12N9/6437 , A61K38/00 , A61K48/00 , C07K2319/00 , C12N15/62 , C12Y304/21021
摘要： Modified factor VII polypeptides and uses thereof are provided. Such modified FVII polypeptides include Factor VIIa and other forms of Factor VII. Among modified FVII polypeptides provided are those that have altered activities, typically altered procoagulant activity, including increased procoagulant activities. Hence, such modified polypeptides are therapeutics.
摘要翻译： 提供了修饰的因子VII多肽及其用途。 这种修饰的FVII多肽包括因子VIIa和其他形式的因子VII。 所提供的经修饰的FVII多肽是那些具有改变的活性，通常改变的促凝活性，包括增加的促凝活性。 因此，这些修饰的多肽是治疗剂。
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