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公开(公告)号:US20070123698A1
公开(公告)日:2007-05-31
申请号:US10584718
申请日:2004-12-27
申请人: Eishun Tsuchida , Shinji Takeoka , Keitaro Sou
发明人: Eishun Tsuchida , Shinji Takeoka , Keitaro Sou
IPC分类号: C07K14/805
CPC分类号: C07K14/805
摘要: The present invention provides a method for purifying hemoglobin from red blood cells, wherein the red blood cells are deep-frozen and preserved, and then purified.
摘要翻译: 本发明提供了一种从红细胞中纯化血红蛋白的方法,其中将红血细胞进行深冻和保存,然后进行纯化。
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公开(公告)号:US20070122469A1
公开(公告)日:2007-05-31
申请号:US11699020
申请日:2007-01-29
申请人: Eishun Tsuchida , Shinji Takeoka , Keitaro Sou , Taro Endo , Yoshiyasu Naito
发明人: Eishun Tsuchida , Shinji Takeoka , Keitaro Sou , Taro Endo , Yoshiyasu Naito
CPC分类号: A61K9/1277 , A61K9/1271 , B01J13/02
摘要: A method for preparing a vesicle dispersion wherein a water-soluble substance is encupsulated in the vesicle, which comprises successively performing: a step of dispersing at least one lipid in an aqueous medium to pre-construct a vesicle dispersion, a step of drying the pre-constructed vesicles to obtain dried vesicles, a step of re-dispersing the dried vesicles in an aqueous solution of the water-soluble substance, and a step of passing the resultant vesicle dispersion through a filter. The method enables the efficient and simple preparation of safe vesicles with a useful substance in high concentration encupsulated therein, with a narrow size distribution, in high yield.
摘要翻译: 一种制备囊泡分散体的方法,其中水溶性物质被包封在囊泡中,其包括连续地进行:将至少一种脂质分散在水性介质中以预先构建囊泡分散体的步骤, 构造的囊泡以获得干燥的囊泡,将干燥的囊泡再分散在水溶性物质的水溶液中的步骤,以及将所得囊泡分散体通过过滤器的步骤。 该方法能够高效和简单地制备具有高浓度的有效物质的安全囊泡,并以高产率具有窄尺寸分布。
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公开(公告)号:US06965049B2
公开(公告)日:2005-11-15
申请号:US10782851
申请日:2004-02-23
申请人: Eishun Tsuchida , Shinji Takeoka , Keitaro Sou , Katsura Mori
发明人: Eishun Tsuchida , Shinji Takeoka , Keitaro Sou , Katsura Mori
IPC分类号: A61K47/16 , A61K9/127 , A61K38/00 , A61K38/42 , A61K47/18 , A61P7/08 , C07C237/12 , C07K5/072 , C07C229/00
CPC分类号: C07K5/06113 , A61K9/1272 , A61K38/42 , A61K47/186 , C07C237/12
摘要: Provided is a zwitterionic lipid compound represented by formula (I) given below: In formula (I), m and n are independently integers of 1 to 4, p is an integer of 7 to 21, one R is NH3+, and each other R is H.
摘要翻译: 本发明提供下述式(I)表示的两性离子型脂质化合物:式(I)中,m和n分别为1〜4的整数,p为7〜21的整数,1个为NH 3, / SUB> + SUP>,彼此R为H.
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4.
公开(公告)号:US08916197B2
公开(公告)日:2014-12-23
申请号:US11916648
申请日:2006-06-05
CPC分类号: A61K9/0019 , A61K9/1271 , A61K51/1227 , Y10S977/906
摘要: The present invention pertains to a bone marrow-directing drug delivery material that includes at least one fine particle, wherein the fine particle includes an anionic moiety on a surface of the particle. Also disclosed are uses of the material set forth herein for the prevention, treatment, or diagnosis of a disease of bone, cartilage, bone marrow, or a joint. Also disclosed are methods of preventing, treating, or diagnosing a disease of bone, cartilage, bone marrow, or a joint in a subject, involving administering to the subject a pharmaceutically effective amount of the material of the present invention.
摘要翻译: 本发明涉及包含至少一种细颗粒的骨髓导向药物递送材料,其中细颗粒包括在颗粒表面上的阴离子部分。 还公开了本文提出的用于预防,治疗或诊断骨,软骨,骨髓或关节疾病的材料的用途。 还公开了预防,治疗或诊断受试者中骨,软骨,骨髓或关节疾病的方法,包括向受试者施用药学有效量的本发明的材料。
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5.
公开(公告)号:US20090297608A1
公开(公告)日:2009-12-03
申请号:US11916648
申请日:2006-06-05
IPC分类号: A61K9/14
CPC分类号: A61K9/0019 , A61K9/1271 , A61K51/1227 , Y10S977/906
摘要: The present invention pertains to a bone marrow-directing drug delivery material that includes at least one fine particle, wherein the fine particle includes an anionic moiety on a surface of the particle. Also disclosed are uses of the material set forth herein for the prevention, treatment, or diagnosis of a disease of bone, cartilage, bone marrow, or a joint. Also disclosed are methods of preventing, treating, or diagnosing a disease of bone, cartilage, bone marrow, or a joint in a subject, involving administering to the subject a pharmaceutically effective amount of the material of the present invention.
摘要翻译: 本发明涉及包含至少一种细颗粒的骨髓导向药物递送材料,其中细颗粒包括在颗粒表面上的阴离子部分。 还公开了本文提出的用于预防,治疗或诊断骨,软骨,骨髓或关节疾病的材料的用途。 还公开了预防,治疗或诊断受试者中骨,软骨,骨髓或关节疾病的方法,包括向受试者施用药学有效量的本发明的材料。
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公开(公告)号:US06933352B2
公开(公告)日:2005-08-23
申请号:US10083555
申请日:2002-02-27
申请人: Eishun Tsuchida , Shinji Takeoka , Keitaro Sou , Haruki Ohkawa
发明人: Eishun Tsuchida , Shinji Takeoka , Keitaro Sou , Haruki Ohkawa
IPC分类号: C07H15/02 , C07C229/26 , C07C233/47 , C07C237/22 , C07C271/22 , C07K5/02 , C07K7/02 , C07K14/00 , C08B37/00 , C08G65/333 , C08G69/10 , C08L77/00 , C08G69/44
CPC分类号: C07C237/22 , C07C229/26 , C07C233/47 , C07C271/22 , C07K5/02 , C07K5/0215 , C07K7/02 , C07K14/001
摘要: An amphiphilic compound having a dendritic branch structure represented by general formula (I): In the formula (I), R0 is a hydrophilic group; R1 and R2 are independently a hydrophobic group; and n is an integer of 1 to 4. This amphiphilic compound is capable of stably fixing a water-soluble polymer onto a surface structure by taking advantage of intermolecular interaction, thereby enabling the water-soluble polymer to be carried thereon without giving any damage to the function thereof.
摘要翻译: 具有由通式(I)表示的树枝状支链结构的两亲化合物:在式(I)中,R 0是亲水基团; R 1和R 2分别独立地是疏水基团; n是1〜4的整数。该两亲性化合物能够通过利用分子间相互作用而将水溶性聚合物稳定地固定在表面结构上,从而使水溶性聚合物能够在其上承载而不会对 其功能。
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公开(公告)号:US06949663B2
公开(公告)日:2005-09-27
申请号:US10416275
申请日:2001-11-09
申请人: Eishun Tsuchida , Shinji Takeoka , Keitaro Sou , Haruki Ohkawa , Katsura Mori
发明人: Eishun Tsuchida , Shinji Takeoka , Keitaro Sou , Haruki Ohkawa , Katsura Mori
IPC分类号: A61K9/127 , C07C69/44 , C07C69/704 , C07C233/47 , C07C237/22 , C07C323/52 , C07C323/60 , C07H13/04 , C07H15/04 , C07C233/00
CPC分类号: A61K9/1272 , C07C69/44 , C07C69/704 , C07C233/47 , C07C237/22 , C07C323/52 , C07C323/60 , C07H13/04 , C07H15/04
摘要: As a negatively charged lipid that can stably add negative charges to the surface of vesicles without side effects, the carboxyl acid-type lipid of the following general formula [1]: [wherein R1, R2 and R3 represent substituents of which one is represented by the following general formula [X]: (wherein M is a hydrogen atom or monovalent cation, and m is an integer of 1 to 5 that represents the methylene chain length), and the other two are chained hydrocarbon groups; A1, A2 and A3 are the same or different substituents selected from the group consisting of C(O)O, CONH or NHCO; and n is an integer of 1 to 3 that represents the methylene chain length) is provided.
摘要翻译: 作为能够在没有副作用的情况下能够稳定地向囊泡表面添加负电荷的带负电荷的脂质,以下通式[1]所示的羧酸型脂质:[其中R 1,R 2, > 2和R 3表示取代基,其中一个由以下通式[X]表示:(其中M是氢原子或一价阳离子,m是1的整数) 至5,表示亚甲基链长度),另外两个是链状烃基; A 1,A 2和A 3是相同或不同的选自C(O)O,CONH或NHCO的取代基 ; 并且n是表示亚甲基链长度的1〜3的整数)。
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公开(公告)号:US06864094B2
公开(公告)日:2005-03-08
申请号:US10091440
申请日:2002-03-07
申请人: Eishun Tsuchida , Hiromi Sakai , Kenichi Tomiyama , Shinji Takeoka , Keitaro Sou
发明人: Eishun Tsuchida , Hiromi Sakai , Kenichi Tomiyama , Shinji Takeoka , Keitaro Sou
CPC分类号: A61K9/0026 , A61K31/555 , A61K47/54 , A61K47/543 , A61K47/544 , A61K47/60 , A61K47/643 , A61K47/6445 , Y10T436/100833 , Y10T436/20 , Y10T436/207497 , Y10T436/25 , Y10T436/2525
摘要: The present invention provides a method for preserving an oxygen infusion containing an aqueous suspension of molecular assemblies which contain hemoglobin or a heme compound, by: a) modifying the molecular assemblies with polyoxyethylene; and b) converting the hemoglobin or the heme compound into a deoxy-form by removing oxygen from the suspension.
摘要翻译: 本发明提供了一种通过以下方式来保存含有含有血红蛋白或血红素化合物的分子组装水悬浮液的氧气输注方法:a)用聚氧乙烯改性分子组装; 和b)通过从悬浮液中除去氧而将血红蛋白或血红素化合物转化为脱氧形式。
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公开(公告)号:US20050085410A1
公开(公告)日:2005-04-21
申请号:US10927675
申请日:2004-08-27
申请人: Eishun Tsuchida , Shinji Takeoka , Teruyuki Komatsu , Toshiya Kai , Naohisa Katayama , Ippei Fukutomi , Makoto Sato
发明人: Eishun Tsuchida , Shinji Takeoka , Teruyuki Komatsu , Toshiya Kai , Naohisa Katayama , Ippei Fukutomi , Makoto Sato
IPC分类号: C07D487/22 , C07K14/76 , A61K38/40 , C07K14/765
CPC分类号: C07D487/22 , C07K14/76
摘要: The present invention provides a method of producing a complex of albumin and a deoxy form metal complex having a porphyrin structure, which includes mixing albumin and a metal complex having a porphyrin structure under a gas atmosphere substantially free of carbon monoxide and oxygen, as a method of producing an artificial oxygen carrier containing a complex of albumin and a metal complex having a porphyrin structure, under a deoxidation (nitrogen, other inert gases) atmosphere without using carbon monoxide.
摘要翻译: 本发明提供一种生产白蛋白和具有卟啉结构的脱氧形式金属络合物的复合物的方法,其包括在基本上不含一氧化碳和氧的气体气氛下混合白蛋白和具有卟啉结构的金属络合物作为方法 在不使用一氧化碳的情况下,在脱氧(氮气,其他惰性气体)气氛下制造含有白蛋白和具有卟啉结构的金属络合物的人造氧载体。
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公开(公告)号:US5472951A
公开(公告)日:1995-12-05
申请号:US28519
申请日:1993-03-09
申请人: Akihisa Saitoh , Kiyoshi Yoshimura , Takanao Suzuki , Mikimasa Takisada , Shinji Takeoka , Hiromi Sakai , Eishun Tsuchida
发明人: Akihisa Saitoh , Kiyoshi Yoshimura , Takanao Suzuki , Mikimasa Takisada , Shinji Takeoka , Hiromi Sakai , Eishun Tsuchida
IPC分类号: A61K9/127 , C07H15/04 , C07H15/06 , C07H15/10 , C07J17/00 , A61K9/10 , A61K9/133 , C07H15/00
CPC分类号: C07H15/06 , A61K9/1271 , A61K9/1272 , C07H15/04 , C07H15/10 , C07J17/005
摘要: An oligosaccharide lipid is provided which has 2 to 20 saccharide units, and has a hydrophobic group linked by an ether linkage to an anomer carbon on a reducing end group. A stabilizer for a phospholipid vesicle is also provided which comprises an oligosaccharide derivative having 2 to 20 saccharide units, and having a hydrophobic group linked by an amide linkage or an ether linkage to an anomer carbon on a reducing end group constituted of an aldose.
摘要翻译: 提供寡糖脂质,其具有2至20个糖单元,并且具有通过醚键连接至还原端基上的端基碳的疏水基团。 还提供了一种磷脂囊泡的稳定剂,其包含具有2至20个糖单元的寡糖衍生物,并且具有通过由醛糖构成的还原端基上的与酰胺键或醚键连接的端基异构体的疏水基团。
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