公开(公告)号：US06984755B2

公开(公告)日：2006-01-10

申请号：US10504913

申请日：2003-02-18

Applicant: Eit Drent ,  Renata Helena Van Der Made ,  Robert Ian Pugh

Inventor： Eit Drent ,  Renata Helena Van Der Made ,  Robert Ian Pugh

IPC: C07C51/56

CPC classification number: C07C67/08 ,  C07C51/56 ,  C07C67/38 ,  C07C53/122 ,  C07C69/017 ,  C07C69/24

Abstract: A process for the preparation of an carboxylic anhydride by reaction of an ethylenically unsaturated compound with carbon monoxide and an carboxylic acid in the presence of a catalyst involving: a) a source of a group VIII metal; b) a bidentate diphosphine of formula I,  wherein R1 represents a bivalent radical that together with the phosphorus atom to which it is attached is an optionally substituted 2-phospha-tricyclo[3.3.1.1 {3,7}]-decyl group or a derivative thereof in which one or more of the carbon atoms are replaced by heteroatoms (“2-PA” group); wherein R2 and R3 independently represent univalent radicals of up to 20 atoms or jointly form a bivalent radical of up to 20 atoms; and  wherein R represents a bivalent organic bridging group; and, c) a complexing anion; wherein the complexing anion is the anion of the carboxylic acid. A process wherein the carboxylic acid is prepared in-situ and use of the carboxylic anhydride as an acylation agent.

Abstract translation: 一种通过烯属不饱和化合物与一氧化碳和羧酸在催化剂存在下反应来制备羧酸酐的方法，所述催化剂包括：a）VIII族金属源; b）式I的二齿二膦，其中R 1表示与连接的磷原子一起为任选取代的2-磷杂三环[3.3.1.1 {3， 7}] - 癸基或其衍生物，其中一个或多个碳原子被杂原子（“2-PA”基团）代替）; 其中R 2和R 3独立地表示至多20个原子的一价基团或共同形成至多20个原子的二价基团; 并且其中R表示二价有机桥基; 和c）络合阴离子; 其中络合阴离子是羧酸的阴离子。 其中羧酸原位制备并使用羧酸酐作为酰化剂的方法。

公开(公告)号：US07202193B2

公开(公告)日：2007-04-10

申请号：US10505019

申请日：2003-02-18

Applicant: Eit Drent ,  Renata Helena Van Der Made ,  Robert Ian Pugh ,  Paul Gerard Pringle

Inventor： Eit Drent ,  Renata Helena Van Der Made ,  Robert Ian Pugh ,  Paul Gerard Pringle

IPC: B01J27/185 ,  C07C51/14

CPC classification number: B01J31/2485 ,  B01J31/28 ,  B01J2231/321 ,  B01J2531/80 ,  B01J2531/822 ,  B01J2531/824 ,  B01J2531/828 ,  B01J2531/847 ,  C07C51/14 ,  C07F9/65683 ,  C07C53/122

Abstract: A process for the carbonylation of an ethylenically unsaturated compound with carbon monoxide and a co-reactant. The carbonylation reaction is carried out in the presence of a novel catalyst involving: a) a source of a group VIII metal; b)a bidentate diphosphine of formula I, wherein R1 represents a bivalent radical that together with the phosphorus atom to which it is attached is an optionally substituted 2-phospha-tricyclo[3.3.1.1{3,7}]- decyl group or a derivative thereof in which one or more of the carbon atoms are replaced by heteroatoms (“2-PA” group); wherein R2 and R3 independently represent univalent radicals of up to 20 atoms or jointly form a bivalent radical of up to 20 atoms; and wherein A1 and A2 independently represent optionally substituted alkylene groups and R represents an optionally substituted aromatic group; and, c) a source of anions.

Abstract translation: 用一氧化碳和共反应物羰基化烯属不饱和化合物的方法。 羰基化反应在新催化剂存在下进行

公开(公告)号：US07057082B2

公开(公告)日：2006-06-06

申请号：US10882932

申请日：2004-07-01

Applicant: Eit Drent ,  Michael Rolf Eberhard ,  Paul Gerald Pringle ,  Renata Helena van der Made

Inventor： Eit Drent ,  Michael Rolf Eberhard ,  Paul Gerald Pringle ,  Renata Helena van der Made

IPC: C07C2/36

CPC classification number: B01J31/248 ,  B01J23/44 ,  B01J31/1895 ,  B01J31/24 ,  B01J2231/20 ,  B01J2531/80 ,  B01J2531/824 ,  C07C2/36 ,  C07C2/406 ,  C07C41/06 ,  C07C253/30 ,  C07C2531/24 ,  C07C2531/28 ,  C07D201/08 ,  C07F9/5027 ,  C07F9/65683 ,  C07C255/19 ,  C07C11/12 ,  C07C43/15

Abstract: Process for the telomerization of a conjugated diene,wherein the conjugated diene is reacted with a compound containing an active hydrogen atom and having a formula R′—H in the presence of a telomerization catalyst based on: (a) a source of group VIII metal, (b) a bidentate ligand wherein the bidentate ligand has the general formula I R1R2M1—R—M2R3R4  (I) wherein M1 and M2 are independently P, As or Sb; R1, R2, R3 and R4 independently represent a monovalent aliphatic group; or R1, R2 and M1 together and/or R3, R4 and M2 together independently represent an optionally substituted aliphatic cyclic group with at least 5 ring atoms, of which one is the M1 or M2 atom, respectively; R represents a bivalent organic bridging group; and novel bidentate diphosphines which can be used in this process.

Abstract translation: 共轭二烯的调聚方法，其中在调聚催化剂的存在下，共轭二烯与含有活性氢原子的化合物反应并具有式R'-H，其基于：（a）VIII族金属源 ，（b）二齿配位体，其中二齿配位体具有通式I <βin-line-formula description =“In-line Formulas”end =“lead”？> R＆lt; （1）＆lt; 2＆gt; 1＆gt; -RM＆lt; 2＆gt; line-formula description =“In-line Formulas”end =“tail”？>其中M 1和M 2独立地是P，As或Sb; R 1，R 2，R 3和R 4独立地表示一价脂族基团; 或R 1，R 2和M 1一起和/或R 3，R 4， / SUP＆amp;和M＆gt; 2共同独立地表示具有至少5个环原子的任选取代的脂族环基，其中一个是M 1或M 2， / SUP>原子; R表示二价有机桥基; 和可用于该方法的新型二齿二膦。

公开(公告)号：US06794553B2

公开(公告)日：2004-09-21

申请号：US10287731

申请日：2002-11-04

Applicant: Eit Drent ,  Michael Rolf Eberhard ,  Paul Gerald Pringle ,  Renata Helena van der Made

Inventor： Eit Drent ,  Michael Rolf Eberhard ,  Paul Gerald Pringle ,  Renata Helena van der Made

IPC: C07C132

CPC classification number: B01J31/248 ,  B01J23/44 ,  B01J31/1895 ,  B01J31/24 ,  B01J2231/20 ,  B01J2531/80 ,  B01J2531/824 ,  C07C2/36 ,  C07C2/406 ,  C07C41/06 ,  C07C253/30 ,  C07C2531/24 ,  C07C2531/28 ,  C07D201/08 ,  C07F9/5027 ,  C07F9/65683 ,  C07C255/19 ,  C07C11/12 ,  C07C43/15

Abstract: Process for the telomerization of a conjugated diene, wherein the conjugated diene is reacted with a compound containing an active hydrogen atom and having a formula R′—H in the presence of a telomerization catalyst based on: (a) a source of group VIII metal, (b) a bidentate ligand wherein the bidentate ligand has the general formula I R1R2M1—R—M2R3R4  (I) wherein M1 and M2 are independently P, As or Sb; R1, R2, R3 and R4 independently represent a monovalent aliphatic group; or R1, R2 and M1 together and/or R3, R4 and M2 together independently represent an optionally substituted aliphatic cyclic group with at least 5 ring atoms, of which one is the M1 or M2 atom, respectively; R represents a bivalent organic bridging group; and novel bidentate diphosphines which can be used in this process.

Abstract translation: 共轭二烯的调聚方法，其中在调聚催化剂的存在下，共轭二烯与含有活性氢原子的化合物反应并具有式R'-H，其基于：（a）VIII族金属源 ，（b）二齿配位体中的二齿配位体具有通式I，其中M 1和M 2独立地为P，As或Sb; R 1，R 2，R 3和R 4 >独立地表示一价脂族基团;或R 1，R 2和M 1一起和/或R 3，R 4和M 2一起独立地表示任选取代的脂族环基 具有至少5个环原子，其中一个是M 1或M 2原子; R代表二价有机桥基; 和可用于该方法的新型二齿二膦。

公开(公告)号：US07135542B2

公开(公告)日：2006-11-14

申请号：US10494901

申请日：2002-11-05

Applicant: Eit Drent ,  Roelof Van Ginkel ,  Renata Helena Van Der Made

Inventor： Eit Drent ,  Roelof Van Ginkel ,  Renata Helena Van Der Made

IPC: C08G69/08

CPC classification number: B01J31/1895 ,  B01J23/44 ,  B01J31/24 ,  B01J31/2414 ,  B01J2231/321 ,  B01J2531/80 ,  B01J2531/824 ,  C07C2/406 ,  C07C67/38 ,  C07C253/30 ,  C07C2531/24 ,  C07C2531/28 ,  C07D201/08 ,  C07F9/5027 ,  C07C255/19 ,  C07C69/24

Abstract: Bidentate ligand of formula (I), R1R2M1-R-M2R3R4 wherein M1 and M2 each indenpendently represent P, As or Sb; R1, R2, R3 and R4 each independently represent the same or a different optionally substituted organic group and at least one of R1, R2, R3 and R4 contains a tertiary carbon atom through which the group is linked to M1 or M2; and R represents a bridging group based on a trimethylene group connecting M1 and M2 of which the middle carbon atom is double bonded to a non-metal element chosen from group 14, 15 or 16 of the periodic table of elements. Catalyst comprising this bidentate ligand and carbonylation process n which this catalyst is used.

Abstract translation: 式（I）的二齿配体，R 1，R 2，R 2，...，R 2，R 3， 其中M 1和M 2各自独立地表示P，As或Sb; R 1，R 2，R 3和R 4各自独立地表示相同或不同的任选取代的有机物 并且R 1，R 2，R 3和R 4中的至少一个含有叔碳原子 该基团通过其与M 1或M 2连接; 并且R表示基于连接M 1和M 2的三亚甲基的桥连基团，其中中碳原子与选自第14族的非金属元素双键结合 ，元素周期表中的15或16个。 包含该二齿配体和使用该催化剂的羰基化方法n的催化剂。

公开(公告)号：US07491859B2

公开(公告)日：2009-02-17

申请号：US11299101

申请日：2005-12-09

Applicant: Eit Drent ,  Michael Rolf Eberhard ,  Paul Gerald Pringle ,  Renata Helena van der Made

Inventor： Eit Drent ,  Michael Rolf Eberhard ,  Paul Gerald Pringle ,  Renata Helena van der Made

IPC: B01J31/18 ,  B01J31/22 ,  C07C2/32 ,  C07C2/36

CPC classification number: B01J31/248 ,  B01J23/44 ,  B01J31/1895 ,  B01J31/24 ,  B01J2231/20 ,  B01J2531/80 ,  B01J2531/824 ,  C07C2/36 ,  C07C2/406 ,  C07C41/06 ,  C07C253/30 ,  C07C2531/24 ,  C07C2531/28 ,  C07D201/08 ,  C07F9/5027 ,  C07F9/65683 ,  C07C255/19 ,  C07C11/12 ,  C07C43/15

Abstract: Process for the telomerization of a conjugated diene,wherein the conjugated diene is reacted with a compound containing an active hydrogen atom and having a formula R′—H in the presence of a telomerization catalyst based on:(a) a source of group VIII metal,(b) a bidentate ligandwherein the bidentate ligand has the general formula I R1R2M1-R-M2R3R4  (I) wherein M1 and M2 are independently P, As or Sb; R1, R2, R3 and R4 independently represent a monovalent aliphatic group; or R1, R2 and M1 together and/or R3, R4 and M2 together independently represent an optionally substituted aliphatic cyclic group with at least 5 ring atoms, of which one is the M1 or M2 atom, respectively; R represents a bivalent organic bridging group; and novel bidentate diphosphines which can be used in this process.

Abstract translation: 共轭二烯的调聚方法，其中在调聚催化剂的存在下，共轭二烯与含有活性氢原子的化合物反应并具有式R'-H，其基于：（a）VIII族金属源 ，（b）双齿配体，其中二齿配体具有通式I <βin-line-formula description =“In-line Formulas”end =“lead”→> R1R2M1-R-M2R3R4（I） line-formula description =“In-line Formulas”end =“tail”？>其中M1和M2独立地为P，As或Sb; R1，R2，R3和R4独立地表示一价脂族基团; 或R 1，R 2和M 1一起和/或R 3，R 4和M 2一起独立地表示任选取代的具有至少5个环原子的脂族环基，其中一个是分别为M1或M2原子; R表示二价有机桥基; 和可用于该方法的新型二齿二膦。

公开(公告)号：US07098369B2

公开(公告)日：2006-08-29

申请号：US10669916

申请日：2003-09-24

Applicant: Eit Drent ,  Renata Helena Van Der Made

Inventor： Eit Drent ,  Renata Helena Van Der Made

IPC: C07C29/145 ,  C07C29/16

CPC classification number: C07C29/16 ,  B01J31/0215 ,  B01J31/24 ,  C07C31/125

Abstract: A process for producing primary alcohols from secondary alcohols and/or tertiary alcohols and/or ketones, wherein the process comprises reacting a compound selected from a secondary alcohol, a tertiary alcohol, a ketone, or mixtures thereof, with carbon monoxide and hydrogen in the presence of a catalyst based on: (i) a source of Group VIII metal, (ii) a bidentate ligand having the general formula (I): R1R2M1-R-M2R3R4  (I) wherein M1 and M2 are independently P, As or Sb; R1 and R2 together represent a bivalent substituted or unsubstituted cyclic aliphatic group whereby the two free valencies are linked to M1; R3 and R4 independently represent a substituted or unsubstituted hydrocarbyl group, or together represent a bivalent or non-substituted cyclic group whereby the two free valencies are linked to M2; and R represents a bivalent aliphatic bridging group; and (iii) an acid having a pKa of 3 or less which is in excess over the Group VIII metal.

Abstract translation: 由仲醇和/或叔醇和/或酮生产伯醇的方法，其中该方法包括使选自仲醇，叔醇，酮或其混合物的化合物与一氧化碳和氢气在 基于以下的催化剂的存在：（i）第VIII族金属源，（ii）具有通式（I）的二齿配体：<？在线公式描述=“在线式”末端=“铅 “”> R“1”2“2”“”“”“”“”“”“”“”“”“”“”“”“”“”“”“”“”“”“”“”“”“ （I）<？in-line-formula description =“In-line Formulas”end =“tail”？>其中M 1和M 2 < / SUP>独立为P，As或Sb; R 1和R 2一起代表二价取代或未取代的环状脂族基，其中两个自由价与M 1连接; R 3和R 4独立地表示取代或未取代的烃基，或一起表示二价或未取代的环状基团，由此两个自由价与M ^{2 ; R表示二价脂肪族桥基; 和（iii）具有超过第Ⅷ族金属的pK _{a <3的3或更小的酸。}}

公开(公告)号：US07858787B2

公开(公告)日：2010-12-28

申请号：US11857011

申请日：2007-09-18

Applicant: Eit Drent ,  Roelof Van Ginkel ,  Willem Wabe Jager

Inventor： Eit Drent ,  Roelof Van Ginkel ,  Willem Wabe Jager

IPC: C07F9/02 ,  C07C233/00 ,  C07C45/00 ,  C07C5/00

CPC classification number: C07F9/65683 ,  B01J31/2419 ,  B01J2231/321 ,  B01J2531/845 ,  C07C1/24 ,  C07C29/16 ,  C07C11/02 ,  C07C31/125

Abstract: A process for converting an olefin having x carbon atoms into an olefin having x+1 carbon atoms wherein the process comprises the steps of: (i) reacting an olefin having x carbon atoms with carbon monoxide and hydrogen in the presence of a hydroformylation catalyst to produce an alcohol having x+1 carbon atoms, and (ii) dehydrating the alcohol produced in step (i) in the presence of a dehydration catalyst to produce an olefin having x+1 carbon atoms characterized in that the hydroformylation catalyst used in step (i) is based on: (a) a source of cobalt, and (b) a ligand which contains phosphorus and nitrogen.

Abstract translation: 将具有x个碳原子的烯烃转化为具有x + 1个碳原子的烯烃的方法，其中所述方法包括以下步骤：（i）在加氢甲酰化催化剂存在下使具有x个碳原子的烯烃与一氧化碳和氢气反应， 产生具有x + 1个碳原子的醇，和（ii）在脱水催化剂存在下使步骤（ⅰ）中产生的醇脱水以产生具有x + 1个碳原子的烯烃，其特征在于步骤（a）中使用的加氢甲酰化催化剂 i）基于：（a）钴源，和（b）含有磷和氮的配体。

公开(公告)号：US20080269520A1

公开(公告)日：2008-10-30

申请号：US11884103

申请日：2006-02-10

Applicant: Eit Drent ,  Rene Ernst ,  Willem Wabe Jager ,  Cornelia Alida Krom ,  Timothy Michael Nisbet

Inventor： Eit Drent ,  Rene Ernst ,  Willem Wabe Jager ,  Cornelia Alida Krom ,  Timothy Michael Nisbet

IPC: C07C51/14

CPC classification number: C07C51/14 ,  C07C55/14

Abstract: A process for the carbonylation of a conjugated diene to a dicarboxylic acid, comprising the steps of (a) contacting a conjugated diene with carbon monoxide and water in the presence of a catalyst system including a source of palladium, a source of an anion and a bidentate phosphine ligand, to obtain a mixture comprising an ethylenically unsaturated acid and reversible diene adducts; (b) separating the obtained reaction mixture into a gaseous stream comprising unreacted conjugated diene and carbon monoxide, a first normally liquid stream comprising at least part of the ethylenically unsaturated acid and the reversible diene adducts, and a second normally liquid stream comprising the catalyst system in admixture with the ethylenically unsaturated acid; (c) recycling the second liquid stream obtained in step (b) to step (a); (d) separating the first liquid product stream obtained in step (b) into a stream comprising the ethylenically unsaturated acid and a stream comprising the reversible diene adducts; and (e) contacting the stream comprising the ethylenically unsaturated acid obtained in step (d) with carbon monoxide and water in the presence of a second catalyst system including a source of palladium, a source of an anion and a bidentate phosphine ligand.

Abstract translation: 一种将共轭二烯羰基化成二羧酸的方法，包括以下步骤：（a）在包括钯源，阴离子源和阴离子的催化剂体系的存在下使共轭二烯与一氧化碳和水接触 二次膦配体，以获得包含烯属不饱和酸和可逆二烯加成物的混合物; （b）将获得的反应混合物分离成包含未反应的共轭二烯和一氧化碳的气流，包含至少部分烯属不饱和酸和可逆二烯加合物的第一常规液体流，以及包含催化剂体系的第二常规液流 与烯属不饱和酸的混合物; （c）将步骤（b）中获得的第二液体流循环到步骤（a）; （d）将步骤（b）中获得的第一液体产物流分离成包含烯属不饱和酸的物流和包含可逆二烯加成物的物流; 和（e）在包含钯源，阴离子源和二齿膦配体的第二催化剂体系的存在下，将包含步骤（d）中获得的烯属不饱和酸的物流与一氧化碳和水接触。

公开(公告)号：US20080194870A1

公开(公告)日：2008-08-14

申请号：US11884079

申请日：2006-02-10

Applicant: Eit Drent ,  Rene Ernst ,  Willem Wade Jager ,  Cornelia Alida Krom

Inventor： Eit Drent ,  Rene Ernst ,  Willem Wade Jager ,  Cornelia Alida Krom

IPC: C07C51/14

CPC classification number: C08G69/28 ,  C07C51/14 ,  C07C51/43 ,  Y02P20/584 ,  C07C55/14

Abstract: A process for the preparation of a dicarboxylic acid, comprising the steps of (a) contacting a conjugated diene with carbon monoxide and water in the presence of a catalyst system including a source of palladium, a source of an anion and a bidentate phosphine ligand, to obtain a mixture comprising an ethylenically unsaturated acid product; (b) reacting the mixture obtained in step (a) further with carbon monoxide and water to obtain the dicarboxylic acid in admixture with the ethylenically unsaturated acid; (c) separating the dicarboxylic acid from a liquid filtrate comprising the catalyst system; and (d) recycling at least part of the obtained liquid filtrate to step (a).

Abstract translation: 一种制备二羧酸的方法，包括以下步骤：（a）在包括钯源，阴离子源和二齿膦配体的催化剂体系的存在下，使共轭二烯与一氧化碳和水接触， 以获得包含烯属不饱和酸产物的混合物; （b）使步骤（a）中得到的混合物进一步与一氧化碳和水反应，得到与烯属不饱和酸混合的二羧酸; （c）从包含催化剂体系的液体滤液中分离二羧酸; 和（d）将至少部分获得的液体滤液再循环到步骤（a）。