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132 条记录 (耗时 0.052 秒)

    NOVEL SIRNA STRUCTURES
    2.
    发明申请
    NOVEL SIRNA STRUCTURES 审中-公开
    新的SIRNA结构

    公开(公告)号：US20100292301A1

    公开(公告)日：2010-11-18

    申请号：US12528907

    申请日：2008-02-28

    申请人： Elena Feinstein ,  Huseyin Aygun

    发明人： Elena Feinstein ,  Huseyin Aygun

    IPC分类号： A61K31/7088 ,  C07H21/04 ,  C07K9/00

    CPC分类号： C12N15/111 ,  C12N2310/14 ,  C12N2310/311 ,  C12N2310/319 ,  C12N2310/321 ,  C12N2320/32 ,  C12N2310/3521

    摘要： The present invention provides novel compounds, compositions, methods and uses for treating microvascular disorders, eye diseases and respiratory conditions based upon inhibition of a target gene. More specifically, the present invention relates to positional motifs of modified ribonucleotides useful in the design of siRNA compounds. In particular, the ribonucleotides include modified internucleotide linkages and/or modified sugar moieties. These novel siRNA compounds may be used therapeutically to treat a variety of diseases and indications.

    摘要翻译： 本发明提供了基于靶基因的抑制来治疗微血管病症，眼病和呼吸道病症的新型化合物，组合物，方法和用途。 更具体地，本发明涉及可用于siRNA化合物设计的修饰的核糖核苷酸的位置基序。 特别地，核糖核苷酸包括修饰的核苷酸间键和/或修饰的糖部分。 这些新型siRNA化合物可用于治疗各种疾病和适应症。

    Oligoribonucleotides and methods of use thereof for treatment of alopecia, acute renal failure and other diseases
    9.
    发明授权
    Oligoribonucleotides and methods of use thereof for treatment of alopecia, acute renal failure and other diseases 有权
    寡核糖核苷酸及其用于治疗脱发，急性肾衰竭和其它疾病的方法

    公开(公告)号：US08765699B2

    公开(公告)日：2014-07-01

    申请号：US11237598

    申请日：2005-09-27

    申请人： Elena Feinstein ,  Daniel Zurr ,  Shai Ehrlich

    发明人： Elena Feinstein ,  Daniel Zurr ,  Shai Ehrlich

    IPC分类号： C12N15/113

    CPC分类号： C12N15/1135 ,  C07H21/02 ,  C12N15/113 ,  C12N2310/14 ,  C12N2320/30

    摘要： The invention relates to a double-stranded compound, preferably an oligoribonucleotide, which down-regulates the expression of a human p53 gene. The invention also relates to a pharmaceutical composition comprising the compound, or a vector capable of expressing the oligoribonucleotide compound, and a pharmaceutically acceptable carrier. The present invention also contemplates a method of treating a patient suffering from alopecia or acute renal failure or other diseases comprising administering to the patient the pharmaceutical composition in a therapeutically effective dose so as to thereby treat the patient. The alopecia may be induced by chemotherapy or radiotherapy, and the patient may be suffering from cancer, in particular breast cancer.

    摘要翻译： 本发明涉及下调人p53基因表达的双链化合物，优选寡核糖核苷酸。 本发明还涉及包含该化合物或能够表达寡核糖核苷酸化合物的载体和药学上可接受的载体的药物组合物。 本发明还考虑了治疗患有脱发或急性肾功能衰竭或其它疾病的患者的方法，包括以治疗有效剂量向患者施用药物组合物，从而治疗患者。 秃发可以通过化学疗法或放射疗法诱发，患者可能患有癌症，特别是乳腺癌。

    COMPOSITIONS AND METHODS FOR TREATING LUNG DISEASE AND INJURY
    10.
    发明申请
    COMPOSITIONS AND METHODS FOR TREATING LUNG DISEASE AND INJURY 有权
    用于治疗肺部疾病和伤害的组合物和方法

    公开(公告)号：US20140005253A1

    公开(公告)日：2014-01-02

    申请号：US14002660

    申请日：2012-03-01

    申请人： Andrew E. Gelman ,  Elena Feinstein ,  Svetlana Adamsky ,  Igor Mett ,  Hagar Kalinski ,  Sharon Avkin-Nachum

    发明人： Andrew E. Gelman ,  Elena Feinstein ,  Svetlana Adamsky ,  Igor Mett ,  Hagar Kalinski ,  Sharon Avkin-Nachum

    IPC分类号： A61K31/713

    CPC分类号： C12N15/113 ,  A61K31/713 ,  C12N15/1138 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/321 ,  C12N2310/344 ,  C12N2310/3521

    摘要： Disclosed herein are therapeutic methods for treating lung diseases, disorders and injury in a mammal, including treatment of acute respiratory distress syndrome (ARDS), acute lung injury, pulmonary fibrosis (idiopathic), bleomycin induced pulmonary fibrosis, mechanical ventilator induced lung injury, chronic obstructive pulmonary disease (COPD), chronic bronchitis, emphysema, bronchiolitis obliterans after lung transplantation and lung transplantation-induced acute graft dysfunction, including treatment, prevention or prevention of progression of primary graft failure, ischemia-reperfusion injury, reperfusion injury, reperfusion edema, allograft dysfunction, pulmonary reimplantation response, bronchiolitis obliterans after lung transplantation and/or primary graft dysfunction (PGD) after organ transplantation, in particular in lung transplantation, comprising downregulating the TLR2 gene or both the TLR2 gene and TLR4 gene. Provided herein are compositions, methods and kits for treating lung diseases, disorders and injury.

    摘要翻译： 本文公开了治疗哺乳动物肺疾病，病症和损伤的治疗方法，包括治疗急性呼吸窘迫综合征（ARDS），急性肺损伤，肺纤维化（特发性），博来霉素诱导的肺纤维化，机械通气机诱导的肺损伤，慢性 阻塞性肺疾病（COPD），慢性支气管炎，肺气肿，肺移植后闭塞性细支气管炎和肺移植引起的急性移植物功能障碍，包括治疗，预防或预防原发性移植物衰竭，缺血再灌注损伤，再灌注损伤，再灌注水肿， 同种异体移植功能障碍，肺再植入反应，肺移植后闭塞性细支气管炎和/或器官移植后特别是肺移植中的原发性移植物功能障碍（PGD），包括下调TLR2基因或TLR2基因和TLR4基因。 本文提供了用于治疗肺部疾病，病症和损伤的组合物，方法和试剂盒。