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公开(公告)号：US08546357B2
公开(公告)日：2013-10-01
申请号：US13678578
申请日：2012-11-16
发明人： Tsutomu Akama , Terry William Balko , Jean Marie Defauw , Jacob J. Plattner , William Hunter White , Joseph Raymond Winkle , Yong-Kang Zhang , Yasheen Zhou
IPC分类号： A61K31/69 , A61K31/42 , C07D231/00 , C07D207/40 , C07F5/04
摘要： This invention provides novel compounds, methods of using the compounds, and pharmaceutical compositions containing the compounds.
摘要翻译： 本发明提供新化合物，使用该化合物的方法和含有这些化合物的药物组合物。
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公开(公告)号：US20130131017A1
公开(公告)日：2013-05-23
申请号：US13678578
申请日：2012-11-16
发明人： Tsutomu AKAMA , Terry William Balko , Jean Marie Defauw , Jacob J. Plattner , William Hunter White , Joseph Raymond Winkle , Yong-Kang Zhang , Yasheen Zhou
摘要： This invention provides novel compounds, methods of using the compounds, and pharmaceutical compositions containing the compounds.
摘要翻译： 本发明提供新化合物，使用该化合物的方法和含有这些化合物的药物组合物。
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公开(公告)号：US09617285B2
公开(公告)日：2017-04-11
申请号：US14760208
申请日：2014-03-06
发明人： Tsutomu Akama , Kurt Jarnagin , Jacob J. Plattner , Shon Roland Pulley , William Hunter White , Yong-Kang Zhang , Yasheen Zhou
摘要： Provided are compounds useful for controlling endoparasites both in animals and agriculture. Further provided are methods for controlling endoparasite infestations of an animal by administering an effective amount of a compound as described above, or a pharmaceutically acceptable salt thereof, to an animal, as well as formulations for controlling endoparasite infestations using the compounds described above or an acceptable salt thereof, and an acceptable carrier. The claimed compounds are described by the following Markush formula: A typical example for a compound according to above formula is: A typical example for a compound according to above formula is:
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公开(公告)号：US08853186B2
公开(公告)日：2014-10-07
申请号：US13678576
申请日：2012-11-16
发明人： Tsutomu Akama , Terry William Balko , Jean Marie Defauw , Jacob J. Plattner , William Hunter White , Joseph Raymond Winkle , Yong-Kang Zhang , Yasheen Zhou
摘要： This invention provides novel compounds, methods of using the compounds, and pharmaceutical formulations comprising the compounds.
摘要翻译： 本发明提供新化合物，使用该化合物的方法和包含该化合物的药物制剂。
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公开(公告)号：US20130131016A1
公开(公告)日：2013-05-23
申请号：US13678576
申请日：2012-11-16
发明人： Tsutomu Akama , Terry William Balko , Jean Marie Defauw , Jacob J. Plattner , William Hunter White , Joseph Raymond Winkle , Yong-Kang Zhang , Yasheen Zhou
IPC分类号： C07F5/02
摘要： This invention provides novel compounds, methods of using the compounds, and pharmaceutical formulations comprising the compounds.
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公开(公告)号：US20150353581A1
公开(公告)日：2015-12-10
申请号：US14760208
申请日：2014-03-06
发明人： Tsutomu Akama , Kurt Jarnagin , Jacob J. Plattner , Shon Roland Pulley , William Hunter White , Yong-Kang Zhang , Yasheen Zhou
IPC分类号： C07F5/02
摘要： Provided are compounds useful for controlling endoparasites both in animals and agriculture. Further provided are methods for controlling endoparasite infestations of an animal by administering an effective amount of a compound as described above, or a pharmaceutically acceptable salt thereof, to an animal, as well as formulations for controlling endoparasite infestations using the compounds described above or an acceptable salt thereof, and an acceptable carrier. The claimed compounds are described by the following Markush formula: A typical example for a compound according to above formula is: A typical example for a compound according to above formula is:
摘要翻译： 提供了用于控制动物和农业中的寄生虫的化合物。 进一步提供的是通过向动物施用有效量的上述化合物或其药学上可接受的盐，以及使用上述化合物或可接受的化合物控制内寄生虫侵染的制剂来控制动物的内寄生虫感染的方法 其盐和可接受的载体。 所要求保护的化合物由以下马库什公式描述：根据上式的化合物的典型实例是：根据上式的化合物的典型实例是：
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公开(公告)号：US20200046745A1
公开(公告)日：2020-02-13
申请号：US16595633
申请日：2019-10-08
发明人： Stephen J. Baker , Virginia Sanders , Tsutomo Akama , Carolyn Bellinger-Kawahara , Yvonne Freund , Kirk R. Maples , Jacob J. Plattner , Yong-Kang Zhang , Huchen Zhou , Vincent S. Hernandez
摘要： Methods of treating anti-inflammatory conditions through the use of boron-containing small molecules are disclosed.
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公开(公告)号：US09796735B2
公开(公告)日：2017-10-24
申请号：US14536483
申请日：2014-11-07
发明人： Stephen J. Baker , Vincent S. Hernandez , Rashmi Sharma , James A. Nieman , Tsutomu Akama , Yong-Kang Zhang , Jacob J. Plattner , Michael Richard Kevin Alley , Rajeshwar Singh , Fernando Rock
CPC分类号： C07F5/025 , A61K31/69 , Y02A50/387
摘要： The compounds are of the class of 3,7 substituted benzoxaboroles, useful for killing and/or inhibiting the growth of microorganisms.
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公开(公告)号：US20170258819A1
公开(公告)日：2017-09-14
申请号：US15599203
申请日：2017-05-18
发明人： Stephen J. BAKER , Virginia Sanders , Tsutomu Akama , Carolyn Bellinger-Kawahara , Yvonne Freund , Kirk R. Maples , Jacob J. Plattner , Yong-Kang Zhang , Huchen Zhou , Vincent S. Hernandez
CPC分类号： A61K31/69 , C07F5/027 , Y02A50/411
摘要： Methods of treating anti-inflammatory conditions through the use of boron-containing small molecules are disclosed.
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公开(公告)号：US20170066788A1
公开(公告)日：2017-03-09
申请号：US15355813
申请日：2016-11-18
发明人： Stephen J. BAKER , Tsutomu Akama , Carolyn Bellinger-Kawahara , Vincent S. Hernandez , Karin M. Hold , James J. Leyden , Kirk R. Maples , Jacob J. Plattner , Virginia Sanders , Yong-Kang Zhang
CPC分类号： C07F5/025 , A61K9/0012 , A61K31/69 , C07F5/02 , C07F5/027
摘要： This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.
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