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公开(公告)号:US4227016A
公开(公告)日:1980-10-07
申请号:US865285
申请日:1977-12-28
申请人: Emmanuel Herman , Helmut Diery , Michel Soreau , Yani Christidis
发明人: Emmanuel Herman , Helmut Diery , Michel Soreau , Yani Christidis
摘要: Glyoxylic acid and hydrochloric acid are reacted with an aromatic compound having at least one substituent group selected from among the alkyl, aryl, hydroxy, alkoxy and aryloxy groups. The glyoxylic acid is used in a concentration comprised between 60 and 100% and the hydrochloric acid is used in as concentrated an aqueous solution as possible, e.g. in an organic solvent medium such as acetic acid. An acid catalyst such as zinc chloride may be used. The reaction may be carried out under pressure. The products are useful in various syntheses e.g. to produce amino acids or arylacetic acids with medicinal uses.
摘要翻译: 将乙醛酸和盐酸与具有选自烷基,芳基,羟基,烷氧基和芳氧基中的至少一个取代基的芳族化合物反应。 乙醛酸的使用浓度为60-100%,盐酸以尽可能浓的水溶液使用。 在有机溶剂介质如乙酸中。 可以使用酸催化剂如氯化锌。 反应可以在压力下进行。 该产品可用于各种合成例如 生产氨基酸或芳基乙酸与药用。