公开(公告)号：US11819683B2

公开(公告)日：2023-11-21

申请号：US15816631

申请日：2017-11-17

申请人： EndoStim, Inc.

发明人： Paul V. Goode ,  Virender K. Sharma ,  Shai Policker

IPC分类号： A61N1/05 ,  A61N1/36 ,  A61N1/375

CPC分类号： A61N1/0507 ,  A61N1/0509 ,  A61N1/3606 ,  A61N1/36007 ,  A61N1/36031 ,  A61N1/36034 ,  A61N1/36053 ,  A61N1/3752

摘要： Systems and methods for treating a gastrointestinal condition of a patient includes minimally invasively implanting a modular stimulator system in a patient's treatment site. The modular stimulator system comprises a microstimulator module, a small power source module and a macrostimulator module that are detachably attachable to each other. For the first phase of treatment, the microstimulator module and power source are implanted with a stimulating electrode proximate a target tissue. Electrical stimulation is provided for a short period of time and treatment efficacy is evaluated through clinical results and patient reporting. If therapy is not effective, stimulation parameters can be changed and/or the implantation site can be moved. If therapy is effective, portions of the microstimulator module and/or small power source are replaced with the macrostimulator module for long term therapy of the second phase of treatment.

公开(公告)号：US11717681B2

公开(公告)日：2023-08-08

申请号：US16547216

申请日：2019-08-21

申请人： EndoStim, Inc.

发明人： Virender K. Sharma ,  Shai Policker

IPC分类号： A61N1/36 ,  A61N1/372 ,  G16H15/00 ,  G16Z99/00 ,  A61N1/00 ,  A61N1/05 ,  A61B17/34 ,  A61N1/378 ,  G16H20/60 ,  G16H30/20 ,  G16H20/40

CPC分类号： A61N1/36007 ,  A61B17/3468 ,  A61B17/3478 ,  A61N1/00 ,  A61N1/0517 ,  A61N1/3787 ,  A61N1/37205 ,  A61N1/37282 ,  G16H15/00 ,  G16Z99/00 ,  G16H20/40 ,  G16H20/60 ,  G16H30/20

摘要： Systems and methods for treating gastroesophageal reflux disease (GERD) includes minimally invasively implanting a stimulating device in a patient's esophagus in the region proximate the lower esophageal sphincter (LES). The patient is provided with a questionnaire related to his disease via an online service. The questionnaire is accessed on a mobile device, such as a cell phone, or on a computer with network access. The data from the sensors and the answers from the questionnaire are analyzed together by a health care provider using the online service. The data and answers are used to program the stimulating device, via the mobile device or computer, to optimize treatment.

公开(公告)号：US20180085576A1

公开(公告)日：2018-03-29

申请号：US15696376

申请日：2017-09-06

申请人： EndoStim, Inc.

发明人： Virender K. Sharma ,  Matt Joseph Gani ,  Paul V. Goode ,  Bevil Hogg ,  Jay Miazga ,  Shai Policker ,  Kaila Raby

IPC分类号： A61N1/36 ,  A61N1/372 ,  A61B5/145 ,  A61B5/00 ,  A61B5/053 ,  A61B5/03 ,  A61B5/11

CPC分类号： A61B5/0031 ,  A61B5/037 ,  A61B5/0538 ,  A61B5/1116 ,  A61B5/14539 ,  A61B5/4211 ,  A61B5/4836 ,  A61N1/36007 ,  A61N1/3606 ,  A61N1/36139 ,  A61N1/36157 ,  A61N1/36171 ,  A61N1/36175 ,  A61N1/37235

摘要： The present specification discloses devices and methodologies for the treatment of transient lower esophageal sphincter relaxations (tLESRs). Individuals with tLESRs may be treated by implanting a stimulation device within the patient's lower esophageal sphincter and applying electrical stimulation to the patient's lower esophageal sphincter, in accordance with certain predefined protocols. The presently disclosed devices have a simplified design because they do not require sensing systems capable of sensing when a person is engaged in a wet swallow and have improved energy storage requirements.

公开(公告)号：US09827425B2

公开(公告)日：2017-11-28

申请号：US14475736

申请日：2014-09-03

申请人： EndoStim, Inc.

发明人： Ofer Glasberg ,  Shai Policker ,  Virender K. Sharma ,  Paul V. Goode ,  Bevil Hogg

IPC分类号： A61N1/36 ,  A61B5/00

CPC分类号： A61N1/3615 ,  A61B5/4233 ,  A61B5/4238 ,  A61B5/4836 ,  A61B5/6871 ,  A61N1/36007 ,  A61N1/36132 ,  A61N1/36139 ,  A61N1/36185

摘要： Methods for electrically stimulating body tissues to improve function or reduce symptoms provide an electrical stimulation system having two or more electrodes that are capable of being switched independently from a hyperpolarizing (depolarizing) state to a hypopolarizing state. Multiple combinations of hyperpolarizing electrodes and hypopolarizing electrodes are created by polarity switching to determine a polarity configuration having the best performance as determined by symptom reporting and clinical diagnostic tests. Polarity switching is triggered manually or is programmed to be switched automatically. Determining the configuration providing electrical stimulation resulting in the greatest benefit allows the system to be operated with one or more electrodes in a hypopolarizing state, thereby reducing energy requirements, tissue tolerance, and tissue fatigue.

公开(公告)号：US20160001071A1

公开(公告)日：2016-01-07

申请号：US14665226

申请日：2015-03-23

申请人： EndoStim, Inc.

发明人： Virender K. Sharma ,  Edy Sofer ,  Paul V. Goode ,  Bevil Hogg ,  Shai Policker ,  Matthew Joseph Gani ,  Jay Miazga ,  Kaila Raby

IPC分类号： A61N1/36 ,  A61N1/05

CPC分类号： A61N1/36007 ,  A61B5/0538 ,  A61B5/1116 ,  A61B5/4836 ,  A61N1/0517 ,  A61N1/3606 ,  A61N1/36139 ,  A61N1/3614 ,  A61N1/36171 ,  A61N1/36175 ,  A61N1/36178

摘要： The present specification discloses devices and methodologies for the treatment of GERD. Individuals with GERD may be treated by implanting a stimulation device within the patient's lower esophageal sphincter and applying electrical stimulation to the patient's lower esophageal sphincter, in accordance with certain predefined protocols. The presently disclosed devices have a simplified design because they do not require sensing systems capable of sensing when a person is engaged in a wet swallow, have improved energy storage requirements, enable improved LES function while concurrently delivering additional health benefits, and enable improved LES function post stimulation termination.

公开(公告)号：US20140222106A1

公开(公告)日：2014-08-07

申请号：US14175927

申请日：2014-02-07

申请人： EndoStim, Inc.

发明人： Virender K. Sharma ,  Matt Joseph Gani ,  Paul V. Goode ,  Bevil Hogg ,  Jay Miazga ,  Shai Policker ,  Kaila Raby

IPC分类号： A61N1/36

CPC分类号： A61N1/36007 ,  A61B5/14539 ,  A61B5/6852 ,  A61B5/6861 ,  A61B5/687 ,  A61B2562/0247 ,  A61N1/0517 ,  A61N1/3606 ,  A61N1/36139 ,  A61N1/36157 ,  A61N1/36171 ,  A61N1/36175

摘要： The present specification discloses devices and methodologies for the treatment of GERD. Individuals with GERD may be treated by implanting a stimulation device within the patient's lower esophageal sphincter and applying electrical stimulation to the patient's lower esophageal sphincter, in accordance with certain predefined protocols. The presently disclosed devices have a simplified design because they do not require sensing systems capable of sensing when a person is engaged in a wet swallow and have improved energy storage requirements.

摘要翻译： 本说明书公开了用于治疗GERD的装置和方法。 具有GERD的个体可以通过在患者的下食管括约肌内植入刺激装置并且根据某些预定义的方案对患者的下食管括约肌施加电刺激来治疗。 目前公开的设备具有简化的设计，因为它们不需要能够感测人何时从事湿式吞咽并具有改进的能量存储要求的感测系统。

公开(公告)号：US20220054833A1

公开(公告)日：2022-02-24

申请号：US16547216

申请日：2019-08-21

申请人： EndoStim, Inc.

发明人： Virender K. Sharma ,  Shai Policker

IPC分类号： A61N1/36 ,  A61N1/372 ,  G16H15/00 ,  G16Z99/00 ,  A61N1/00 ,  A61N1/05 ,  A61B17/34 ,  A61N1/378

摘要： Systems and methods for treating gastroesophageal reflux disease (GERD) includes minimally invasively implanting a stimulating device in a patient's esophagus in the region proximate the lower esophageal sphincter (LES). The patient is provided with a questionnaire related to his disease via an online service. The questionnaire is accessed on a mobile device, such as a cell phone, or on a computer with network access. The data from the sensors and the answers from the questionnaire are analyzed together by a health care provider using the online service. The data and answers are used to program the stimulating device, via the mobile device or computer, to optimize treatment.

公开(公告)号：US11058876B2

公开(公告)日：2021-07-13

申请号：US15696376

申请日：2017-09-06

申请人： EndoStim, Inc.

发明人： Virender K. Sharma ,  Matt Joseph Gani ,  Paul V. Goode ,  Bevil Hogg ,  Jay Miazga ,  Shai Policker ,  Kaila Raby

IPC分类号： A61N1/36 ,  A61B5/145 ,  A61B5/00 ,  A61N1/372 ,  A61B5/03 ,  A61B5/0538 ,  A61B5/11

摘要： The present specification discloses devices and methodologies for the treatment of transient lower esophageal sphincter relaxations (tLESRs). Individuals with tLESRs may be treated by implanting a stimulation device within the patient's lower esophageal sphincter and applying electrical stimulation to the patient's lower esophageal sphincter, in accordance with certain predefined protocols. The presently disclosed devices have a simplified design because they do not require sensing systems capable of sensing when a person is engaged in a wet swallow and have improved energy storage requirements.

公开(公告)号：US10426955B2

公开(公告)日：2019-10-01

申请号：US15332861

申请日：2016-10-24

申请人： EndoStim, Inc.

发明人： Virender K. Sharma ,  Matt Joseph Gani ,  Paul V. Goode ,  Bevil Hogg ,  Jay Miazga ,  Shai Policker ,  Kaila Raby

IPC分类号： A61N1/36 ,  A61N1/372 ,  A61B5/00 ,  A61N1/05

摘要： The present specification discloses devices and methodologies for the treatment of transient lower esophageal sphincter relaxations (tLESRs). Individuals with tLESRs may be treated by implanting a stimulation device within the patient's lower esophageal sphincter and applying electrical stimulation to the patient's lower esophageal sphincter, in accordance with certain predefined protocols. The presently disclosed devices have a simplified design because they do not require sensing systems capable of sensing when a person is engaged in a wet swallow and have improved energy storage requirements.

公开(公告)号：US10058703B2

公开(公告)日：2018-08-28

申请号：US15170462

申请日：2016-06-01

申请人： EndoStim, Inc.

发明人： Virender K. Sharma ,  Shai Policker

IPC分类号： A61N1/36 ,  A61N1/372 ,  A61N1/00 ,  A61N1/05 ,  A61B17/34 ,  A61N1/378 ,  G16H15/00 ,  G06F19/00

摘要： Systems and methods for treating gastroesophageal reflux disease (GERD) includes minimally invasively implanting a stimulating device in a patient's esophagus in the region proximate the lower esophageal sphincter (LES). The patient is provided with a questionnaire related to his disease via an online service. The questionnaire is accessed on a mobile device, such as a cell phone, or on a computer with network access. The data from the sensors and the answers from the questionnaire are analyzed together by a health care provider using the online service. The data and answers are used to program the stimulating device, via the mobile device or computer, to optimize treatment.