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    Lid For Functionalized Microfluidic Platform And Method
    4.
    发明申请
    Lid For Functionalized Microfluidic Platform And Method 有权
    用于功能化微流控平台和方法的盖

    公开(公告)号：US20130302842A1

    公开(公告)日：2013-11-14

    申请号：US13467584

    申请日：2012-05-09

    申请人： Erwin Berthier ,  Peter Cavner ,  David John Guckenberger ,  David Beebe

    发明人： Erwin Berthier ,  Peter Cavner ,  David John Guckenberger ,  David Beebe

    IPC分类号： C12Q1/02 ,  B01L99/00

    CPC分类号： G01N33/5005 ,  A01N1/0263 ,  A01N1/0268 ,  B01L3/502715 ,  B01L7/50 ,  B01L2200/027 ,  B01L2300/044 ,  B01L2300/047 ,  B01L2300/0672 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2400/0406 ,  B01L2400/0481 ,  B01L2400/0677 ,  B01L2400/0683 ,  B01L2400/0694 ,  B01L2400/086

    摘要： A microfluidic device and method is provided for handheld diagnostics and assays. A first substance is frozen in a cryopreservation fluid in a first well of a lid. The lid includes a first surface communicating with a first port of the first well and a second surface communicating with a second port of the first well. A porous membrane is affixed to the first surface so as to overlap the first port and a non-porous membrane is affixed to the second surface so as to overlap the second port. The first substance may be dialytically freed from the cryopreservation fluid at a user desired time. Thereafter, the lid may be moved from a first position wherein the lid is spaced from a base to a second position wherein the lid is adjacent the channel in the base such that the first substance communicates with the input of the channel.

    摘要翻译： 提供了用于手持诊断和测定的微流体装置和方法。 将第一物质在盖的第一孔中的冷冻保存液中冷冻。 所述盖包括与所述第一井的第一端口连通的第一表面和与所述第一井的第二端口连通的第二表面。 将多孔膜固定在第一表面上以与第一端口重叠，并且非多孔膜固定到第二表面以与第二端口重叠。 第一物质可以在用户期望的时间透析地从冷冻保存液中除去。 此后，盖可以从第一位置移动，其中盖子与基座间隔开到第二位置，其中盖子与基座中的通道相邻，使得第一物质与通道的输入端相通。

    METHOD FOR ISOLATING WEAKLY INTERACTING MOLECULES FROM A FLUIDIC SAMPLE
    5.
    发明申请
    METHOD FOR ISOLATING WEAKLY INTERACTING MOLECULES FROM A FLUIDIC SAMPLE 有权
    从流体样品中分离弱相互作用分子的方法

    公开(公告)号：US20120178096A1

    公开(公告)日：2012-07-12

    申请号：US12987934

    申请日：2011-01-10

    申请人： David Beebe ,  Richard Burgess ,  Lindsay Strotman ,  Scott Berry

    发明人： David Beebe ,  Richard Burgess ,  Lindsay Strotman ,  Scott Berry

    IPC分类号： C12Q1/68 ,  G01N33/53 ,  G01N33/553 ,  G01N33/543

    CPC分类号： G01N33/54326 ,  G01N33/543

    摘要： Methods of isolating weakly interacting molecules in a fluidic sample using an immiscible phase filtration technique are disclosed. A complex is formed between a solid phase substrate, a molecule immobilized on the solid phase substrate, and at least one target molecule present in the fluidic sample. The complex is transferred into an immiscible phase by applying an external force to the solid phase substrate. The methods eliminate the need for complex and time consuming washing steps.

    摘要翻译： 公开了使用不混溶相过滤技术在流体样品中分离弱相互作用分子的方法。 在固相底物，固相在固相底物上的分子与存在于流体样品中的至少一种靶分子之间形成复合物。 通过向固相基质施加外力将复合物转移到不混溶相中。 该方法消除了对复杂和耗时的洗涤步骤的需要。

    Method for isolating weakly interacting molecules from a fluidic sample
    7.
    发明授权
    Method for isolating weakly interacting molecules from a fluidic sample 有权
    从流体样品中分离弱相互作用的分子的方法

    公开(公告)号：US08993243B2

    公开(公告)日：2015-03-31

    申请号：US12987934

    申请日：2011-01-10

    申请人： David Beebe ,  Richard Burgess ,  Lindsay Strotman ,  Scott Berry

    发明人： David Beebe ,  Richard Burgess ,  Lindsay Strotman ,  Scott Berry

    IPC分类号： C12Q1/68 ,  G01N33/543

    CPC分类号： G01N33/54326 ,  G01N33/543

    摘要： Methods of isolating weakly interacting molecules in a fluidic sample using an immiscible phase filtration technique are disclosed. A complex is formed between a solid phase substrate, a molecule immobilized on the solid phase substrate, and at least one target molecule present in the fluidic sample. The complex is transferred into an immiscible phase by applying an external force to the solid phase substrate. The methods eliminate the need for complex and time consuming washing steps.

    摘要翻译： 公开了使用不混溶相过滤技术在流体样品中分离弱相互作用分子的方法。 在固相底物，固相在固相底物上的分子与存在于流体样品中的至少一种靶分子之间形成复合物。 通过向固相基质施加外力将复合物转移到不混溶相中。 该方法消除了对复杂和耗时的洗涤步骤的需要。

    Device and method for alerting a runner when a new pair of running shoes is needed
    8.
    发明申请
    Device and method for alerting a runner when a new pair of running shoes is needed 有权
    当需要新的一双跑步鞋时，提醒跑步者的装置和方法

    公开(公告)号：US20060152377A1

    公开(公告)日：2006-07-13

    申请号：US11033370

    申请日：2005-01-11

    申请人： David Beebe ,  Brian Schwartz ,  Steven Pauls ,  Timothy Rand ,  Brant Kochsiek

    发明人： David Beebe ,  Brian Schwartz ,  Steven Pauls ,  Timothy Rand ,  Brant Kochsiek

    IPC分类号： G08B21/00 ,  G01N3/56 ,  G01M19/00 ,  G08B19/00

    CPC分类号： A43B3/001 ,  A43B3/0005 ,  A43B5/00 ,  A43B7/00 ,  G01N3/56

    摘要： A device and method are provided for determining the wear of a sole of a shoe. The device includes first and second sensors receivable in the sole of the shoe. The sensors are axially spaced and generate signals in response to corresponding impact forces acting thereon. A control circuit is connectable to the first and second sensors. The control circuit compares the difference between the first and second signals to a threshold and generates an alert signal in response to the difference between the first and second signal meeting the threshold.

    摘要翻译： 提供了一种用于确定鞋底的磨损的装置和方法。 该装置包括可容纳在鞋底中的第一和第二传感器。 传感器轴向间隔开并响应于作用于其上的相应冲击力产生信号。 控制电路可连接到第一和第二传感器。 控制电路将第一和第二信号之间的差异与阈值进行比较，并且响应于满足阈值的第一和第二信号之间的差异而产生报警信号。

    Micro device and method for high resolusion delivery and monitoring of stimuli to a biological object, in vitro
    10.
    发明申请
    Micro device and method for high resolusion delivery and monitoring of stimuli to a biological object, in vitro 有权
    用于高分辨率递送和监测生物对象的刺激的微装置和方法

    公开(公告)号：US20050282267A1

    公开(公告)日：2005-12-22

    申请号：US10872647

    申请日：2004-06-21

    申请人： Justin Williams ,  David Beebe ,  Stephen Johnson

    发明人： Justin Williams ,  David Beebe ,  Stephen Johnson

    IPC分类号： C12M1/34 ,  C12M1/42 ,  G01F1/64

    CPC分类号： C12M41/46 ,  C12M35/08

    摘要： A micro device and method are provided for examining and testing a slice of a biological object, such as brain tissue. The micro device includes a body defining a chamber and a channel in communication with the chamber. A stimulation fluid flows axially along a flow path in the channel and engages a user selectable region of the slice. An array of electrodes in the chamber engages the slice and allows for the multi-channel electrical recording and stimulation of the slice at each of the electrode sites.

    摘要翻译： 提供了用于检查和测试诸如脑组织的生物体的切片的微装置和方法。 微型装置包括限定腔室的主体和与腔室连通的通道。 刺激流体沿着通道中的流动路径轴向流动并且接合切片的用户可选择区域。 腔室中的电极阵列接合切片并且允许在每个电极位置处的多通道电记录和切片的刺激。