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1.Ascomycin and pimecrolimus having reduced levels of desmethylascomycin and 32-deoxy-32-epichloro-desmethylascomycin respectively, and methods for preparation thereof 审中-公开
标题翻译: 分别含有去甲基微囊霉素和32-脱氧-32-表氯 - 去甲基霉菌素水平的子囊霉素和吡美莫司及其制备方法公开(公告)号:US20090082386A1
公开(公告)日:2009-03-26
申请号:US11983124
申请日:2007-11-06
申请人: Erzsebet Meszarosne Sos , Vilmos Keri , Andrea Csorvasi , Viktor Gyollai , Piroska Kovacs , Angela Simon , Jozsef Simulak
发明人: Erzsebet Meszarosne Sos , Vilmos Keri , Andrea Csorvasi , Viktor Gyollai , Piroska Kovacs , Angela Simon , Jozsef Simulak
IPC分类号: A61K31/436 , C07D267/00 , A61P17/00
CPC分类号: C07D498/18
摘要: Provided is ascomycin that has a low level of an FK523 impurity, and pimecrolimus that has a low level of a 32-deoxy-32-epichloro-FK523 impurity, methods of preparing them, and the use of such pimecrolimus for preparing a pharmaceutical composition.
摘要翻译: 提供具有低水平的FK523杂质的青霉霉素和具有低水平的32-脱氧-32-表氯 - FK523杂质的吡美莫司,其制备方法以及这种吡美莫司用于制备药物组合物的用途。
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公开(公告)号:US20090291996A1
公开(公告)日:2009-11-26
申请号:US12454776
申请日:2009-05-21
申请人: Ferenc Korodi , Piroska Kovacs , Andrea Csorvasi , Gabor Nagy
发明人: Ferenc Korodi , Piroska Kovacs , Andrea Csorvasi , Gabor Nagy
IPC分类号: A61K31/40 , C07D487/22 , G01N33/00 , A61P31/04
CPC分类号: C07K7/56 , Y10T436/147777
摘要: The present invention provides Caspofungin and salts thereof substantially free of Caspofungin C0 and salts thereof. The present invention also provides processes for the preparation of said Caspofungin and salts thereof and processes for the determination of the amount of Caspofungin C0 and salts thereof present in Caspofungin and salts thereof. The present invention further provides pharmaceutical compositions comprising said Caspofungin and salts thereof.
摘要翻译: 本发明提供了基本上不含卡泊芬净C的卡泊芬净及其盐及其盐。 本发明还提供了制备所述卡泊芬净及其盐的方法和用于测定卡泊芬净中卡泊芬净C0及其盐及其盐的方法。 本发明还提供包含所述卡泊芬净及其盐的药物组合物。
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公开(公告)号:US20090324635A1
公开(公告)日:2009-12-31
申请号:US12459198
申请日:2009-06-25
申请人: Ferenc Korodi , Piroska Kovacs , Chaim Eidelman , Avi Tovi , Hagi Alon
发明人: Ferenc Korodi , Piroska Kovacs , Chaim Eidelman , Avi Tovi , Hagi Alon
CPC分类号: G01N33/9446 , C07K7/56 , G01N2496/00 , Y10T436/105831
摘要: Provided is caspofungin free of caspofungin impurity A, methods for preparation thereof and isolation of caspofungin impurity A.
摘要翻译: 提供的卡泊芬净不含卡泊芬净杂质A,其制备方法和卡泊芬净杂质的分离。
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4.DESLORATADINE CRYSTALLINE FORMS MIXTURES HAVING A LOW LEVEL OF RESIDUAL SOLVENTS 审中-公开
标题翻译: DESLORATADINE晶体结构混合物具有低水平的残留溶剂公开(公告)号:US20100216831A1
公开(公告)日:2010-08-26
申请号:US11917839
申请日:2006-11-17
IPC分类号: A61K31/4545 , C07D401/02
CPC分类号: C07D401/04
摘要: Provided are desloratadine mixtures, comprising a low level of residual solvents and processes for the preparation thereof.
摘要翻译: 提供了地氯雷他定混合物,其包含低水平的残留溶剂及其制备方法。
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5.
公开(公告)号:US20060223841A1
公开(公告)日:2006-10-05
申请号:US11447336
申请日:2006-06-05
IPC分类号: A61K31/473 , C07D221/02
CPC分类号: C07D401/04 , A61K31/4545
摘要: Provided are stable pharmaceutical compositions of desloratadine. Also provided are processes for preparing polymorphs of desloratadine
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6.Dolasetron trifluoroacetate, polymorphs of dolasetron trifluoroacetate and process for preparation thereof 审中-公开
标题翻译: 多沙司坦三氟乙酸盐,多沙司琼三氟乙酸盐的多晶型物及其制备方法公开(公告)号:US20090062546A1
公开(公告)日:2009-03-05
申请号:US12220104
申请日:2008-07-21
IPC分类号: C07D221/22
CPC分类号: C07D455/00 , C07D471/18
摘要: Provided are crystalline forms of dolasetron trifluoroacetate, methods for their preparation, and their use in preparing dolasetron mesylate.
摘要翻译: 提供了多沙司琼三氟乙酸盐的结晶形式,其制备方法及其在制备甲磺酸多拉司琼的用途。
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7.Preparation of 1H-imidazo[4,5-c]quinolin-4-amines via 1H-imidazo[4, 5-c]quinolin-4-phtalimide intermediates 审中-公开
标题翻译: 通过1H-咪唑并[4,5-c]喹啉-4-邻苯二甲酰亚胺中间体制备1H-咪唑并[4,5-c]喹啉-4-胺公开(公告)号:US20080103310A1
公开(公告)日:2008-05-01
申请号:US11974947
申请日:2007-10-16
申请人: Janos Hajko , Csaba Szabo , Piroska Kovacs
发明人: Janos Hajko , Csaba Szabo , Piroska Kovacs
IPC分类号: C07D471/04
CPC分类号: C07D471/04
摘要: The present invention provides process for the preparation of 4-amino-1H-imidazo[4,5-c]quinolines comprising the step of reacting a 1H-imidazo[4,5-c]quinolin-4-phthalimide with an amine selected from the group consisting of: alkylamine, aralkylamine, alkyldiamine, and aralkyldiamine.
摘要翻译: 本发明提供了制备4-氨基-1H-咪唑并[4,5-c]喹啉的方法,包括使1H-咪唑并[4,5-c]喹啉-4-邻苯二甲酰亚胺与选自 由烷基胺,芳烷基胺,烷基二胺和芳烷基二胺组成的组。
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公开(公告)号:US20100256074A1
公开(公告)日:2010-10-07
申请号:US12459180
申请日:2009-06-25
申请人: Chaim Eidelman , Avi Tovi , Hagai Alon , Vitali Pirogov , Adelina Gelfond , Csilla Nemethne Racz , Ferenc Korodi , Piroska Kovacs , Amir Gold , Alexander Rudinski
发明人: Chaim Eidelman , Avi Tovi , Hagai Alon , Vitali Pirogov , Adelina Gelfond , Csilla Nemethne Racz , Ferenc Korodi , Piroska Kovacs , Amir Gold , Alexander Rudinski
CPC分类号: C07K7/56
摘要: Provided are processes for the preparation and purification of high purity aza cyclohexapeptides.
摘要翻译: 提供了用于制备和纯化高纯度氮杂环己肽的方法。
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9.
公开(公告)号:US20090030207A1
公开(公告)日:2009-01-29
申请号:US12220084
申请日:2008-07-21
IPC分类号: C07D455/00
CPC分类号: C07D455/02
摘要: The present invention provides polymorphic forms of dolasetron base and methods for their use and preparation.
摘要翻译: 本发明提供了多沙司琼碱基的多晶形式及其使用和制备方法。
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10.Stable pharmaceutical compositions of desloratadine and processes for preparation of polymorphic forms of desloratadine 审中-公开
标题翻译: 地氯雷他定的稳定药物组合物和地氯雷他定的多晶型物的制备方法公开(公告)号:US20060135547A1
公开(公告)日:2006-06-22
申请号:US11283276
申请日:2005-11-17
IPC分类号: A61K31/473 , C07D221/16
CPC分类号: C07D401/04 , A61K31/4545
摘要: Provided are stable pharmaceutical compositions of desloratadine. Also provided are processes for preparing polymorphs of desloratadine
摘要翻译: 提供地氯雷他定的稳定药物组合物。 还提供了制备地氯雷他定多晶型物的方法
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