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公开(公告)号:US06495569B1
公开(公告)日:2002-12-17
申请号:US09838657
申请日:2001-04-19
申请人: Etsuo Ohshima , Hiroki Sone , Osamu Kotera , Rie Komatsu , Gregory J. LaRosa , Jay R. Luly
发明人: Etsuo Ohshima , Hiroki Sone , Osamu Kotera , Rie Komatsu , Gregory J. LaRosa , Jay R. Luly
IPC分类号: A61K314164
CPC分类号: C07D233/26
摘要: Disclosed are novel compounds and a method of treating inflammatory diseases. The method comprises administering to an individual in need an effective amount of an imidazolidine compound represented by Structural Formula (I): and physiologically or pharmaceutically acceptable salts thereof.
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公开(公告)号:US06469002B1
公开(公告)日:2002-10-22
申请号:US09838551
申请日:2001-04-19
申请人: Etsuo Ohshima , Hiroki Sone , Osamu Kotera , Rie Komatsu , Gregory J. LaRosa , Jay R. Luly
发明人: Etsuo Ohshima , Hiroki Sone , Osamu Kotera , Rie Komatsu , Gregory J. LaRosa , Jay R. Luly
IPC分类号: A61K31454
CPC分类号: C07D405/12 , C07D233/26 , C07D409/12
摘要: Disclosed are novel compounds and a method of treating inflammatory diseases. The method comprises administering to an individual in need an effective amount of an imidazolidine compound represented by Structural Formula (I): and physiologically or pharmaceutically acceptable salts thereof.
摘要翻译: 公开了新型化合物和治疗炎性疾病的方法。 该方法包括向需要的个体施用有效量的由结构式(I)表示的咪唑烷化合物及其生理学或药学上可接受的盐。
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公开(公告)号:US06509346B2
公开(公告)日:2003-01-21
申请号:US09362837
申请日:1999-07-28
申请人: Jay R. Luly , Yoshisuke Nakasato , Etsuo Ohshima , Hiroki Sone , Osamu Kotera , Geraldine C. B. Harriman
发明人: Jay R. Luly , Yoshisuke Nakasato , Etsuo Ohshima , Hiroki Sone , Osamu Kotera , Geraldine C. B. Harriman
IPC分类号: A61K314353
CPC分类号: C07D401/06 , C07D211/46 , C07D211/52 , C07D313/12 , C07D405/06 , C07D409/06 , C07D471/04 , C07D491/04 , C07D495/04
摘要: Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: and physiologically acceptable salts thereof.
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公开(公告)号:US06503926B2
公开(公告)日:2003-01-07
申请号:US09362796
申请日:1999-07-28
申请人: Jay R. Luly , Yoshisuke Nakasato , Etsuo Ohshima , Hiroki Sone , Osamu Kotera , Geraldine C. B. Harriman
发明人: Jay R. Luly , Yoshisuke Nakasato , Etsuo Ohshima , Hiroki Sone , Osamu Kotera , Geraldine C. B. Harriman
IPC分类号: A61K314545
CPC分类号: C07D451/06 , C07D213/36 , C07D213/38 , C07D401/06 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/10 , C07D491/10 , C07D495/10
摘要: Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: and physiologically acceptable salts thereof.
摘要翻译: 公开了新型化合物和治疗与异常白细胞募集和/或激活相关的疾病的方法。 该方法包括向有需要的受试者施用有效量的由其表示的化合物及其生理上可接受的盐。
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