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公开(公告)号：US09925536B2
公开(公告)日：2018-03-27
申请号：US12670088
申请日：2008-07-23
CPC分类号： B01L3/502738 , B01L3/5027 , B01L2300/0816 , B01L2300/0887 , B01L2300/18 , B01L2400/0415 , B01L2400/0481 , B01L2400/0655 , C12Q1/6816 , C12Q1/6848 , C12Q1/703 , C12Q1/708 , C12Q2521/107 , C12Q2531/113 , C12Q2547/101 , C12Q2563/107 , C12Q2563/149 , C12Q2565/601 , C12Q2565/629
摘要： A device comprising a rigid substrate, a flexible cover element at least partially covering the substrate, a first structure formed in the substrate, adapted for accommodating liquids and adapted for releasing contents of one or more cells, spores, or viruses, the contents including the target molecules, a second structure formed in the substrate, adapted for accommodating liquids and comprising at least one binding member adapted for capturing the target molecules and for determining a value indicative for the presence and/or amount of the target molecules, a microfluidic network interconnecting at least the first structure and the second structure, and an actuator member adapted for effecting a fluid flow between the first structure and the second structure by pressing the flexible cover element against the substrate to selectively close a portion of the microfluidic network.
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公开(公告)号：US08846313B2
公开(公告)日：2014-09-30
申请号：US12513597
申请日：2007-11-06
IPC分类号： C12Q1/68 , C12M1/34 , C12P19/34 , G01N21/00 , G01N21/75 , C07H21/04 , B01L3/00 , B01J19/00 , B01L9/00 , B01L7/00
CPC分类号： C12Q1/703 , B01J19/0046 , B01J2219/00527 , B01J2219/00576 , B01J2219/00605 , B01J2219/00659 , B01J2219/00695 , B01J2219/00704 , B01J2219/0072 , B01J2219/00722 , B01L3/502738 , B01L3/502746 , B01L3/502753 , B01L3/502761 , B01L7/52 , B01L9/527 , B01L2200/0647 , B01L2200/10 , B01L2300/0636 , B01L2300/0681 , B01L2300/0816 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , C12Q1/6813 , C12Q1/6825 , C12Q1/6837 , C12Q1/701 , C12Q2600/158
摘要： A device comprising a rigid substrate, a flexible cover element at least partially covering the substrate, a first structure formed in the substrate, adapted for accommodating liquids and adapted for releasing contents of one or more cells, spores, or viruses, the contents including the target molecules, a second structure formed in the substrate, adapted for accommodating liquids and comprising at least one binding member adapted for capturing the target molecules and for determining a value indicative of the presence and/or amount of the target molecules, a micro fluidic network interconnecting at least the first structure and the second structure, and an actuator member adapted for effecting a fluid flow between the first structure and the second structure by pressing the flexible cover element against the substrate to selectively close a portion of the micro fluidic network.
摘要翻译： 一种包括刚性基底的装置，至少部分地覆盖基底的柔性覆盖元件，形成在基底中的适于容纳液体并适于释放一个或多个细胞，孢子或病毒的内容物的第一结构，所述内容物包括 目标分子，形成在基底中的第二结构，适于容纳液体，并且包括适于捕获靶分子的至少一个结合成分，并用于确定指示靶分子的存在和/或量的值;微流体网络 至少互连第一结构和第二结构，以及致动器构件，其适于通过将柔性覆盖元件压靠在衬底上来选择性地关闭微流体网络的一部分来实现第一结构和第二结构之间的流体流动。
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公开(公告)号：US20100255473A1
公开(公告)日：2010-10-07
申请号：US12670088
申请日：2008-07-23
IPC分类号： C12Q1/68
CPC分类号： B01L3/502738 , B01L3/5027 , B01L2300/0816 , B01L2300/0887 , B01L2300/18 , B01L2400/0415 , B01L2400/0481 , B01L2400/0655 , C12Q1/6816 , C12Q1/6848 , C12Q1/703 , C12Q1/708 , C12Q2521/107 , C12Q2531/113 , C12Q2547/101 , C12Q2563/107 , C12Q2563/149 , C12Q2565/601 , C12Q2565/629
摘要： A device comprising a rigid substrate, a flexible cover element at least partially covering the substrate, a first structure formed in the substrate, adapted for accommodating liquids and adapted for releasing contents of one or more cells, spores, or viruses, the contents including the target molecules, a second structure formed in the substrate, adapted for accommodating liquids and comprising at least one binding member adapted for capturing the target molecules and for determining a value indicative for the presence and/or amount of the target molecules, a microfluidic network interconnecting at least the first structure and the second structure, and an actuator member adapted for effecting a fluid flow between the first structure and the second structure by pressing the flexible cover element against the substrate to selectively close a portion of the microfluidic network.
摘要翻译： 一种包括刚性基底的装置，至少部分地覆盖基底的柔性覆盖元件，形成在基底中的适于容纳液体并适于释放一个或多个细胞，孢子或病毒的内容物的第一结构，所述内容物包括 目标分子，形成在基底中的第二结构，适于容纳液体，并且包括适于捕获靶分子的至少一个结合成分，以及用于确定指示靶分子的存在和/或量的值;互连的微流体网络 至少第一结构和第二结构，以及致动器构件，其适于通过将柔性覆盖元件压靠在衬底上来选择性地关闭微流体网络的一部分来实现第一结构和第二结构之间的流体流动。
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公开(公告)号：US20110014606A1
公开(公告)日：2011-01-20
申请号：US12513597
申请日：2007-11-06
CPC分类号： C12Q1/703 , B01J19/0046 , B01J2219/00527 , B01J2219/00576 , B01J2219/00605 , B01J2219/00659 , B01J2219/00695 , B01J2219/00704 , B01J2219/0072 , B01J2219/00722 , B01L3/502738 , B01L3/502746 , B01L3/502753 , B01L3/502761 , B01L7/52 , B01L9/527 , B01L2200/0647 , B01L2200/10 , B01L2300/0636 , B01L2300/0681 , B01L2300/0816 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , C12Q1/6813 , C12Q1/6825 , C12Q1/6837 , C12Q1/701 , C12Q2600/158
摘要： A device comprising a rigid substrate, a flexible cover element at least partially covering the substrate, a first structure formed in the substrate, adapted for accommodating liquids and adapted for releasing contents of one or more cells, spores, or viruses, the contents including the target molecules, a second structure formed in the substrate, adapted for accommodating liquids and comprising at least one binding member adapted for capturing the target molecules and for determining a value indicative of the presence and/or amount of the target molecules, a micro fluidic network interconnecting at least the first structure and the second structure, and an actuator member adapted for effecting a fluid flow between the first structure and the second structure by pressing the flexible cover element against the substrate to selectively close a portion of the micro fluidic network.
摘要翻译： 一种包括刚性基底的装置，至少部分地覆盖基底的柔性覆盖元件，形成在基底中的适于容纳液体并适于释放一个或多个细胞，孢子或病毒的内容物的第一结构，所述内容物包括 目标分子，形成在基底中的第二结构，适于容纳液体，并且包括适于捕获靶分子的至少一个结合成分，并用于确定指示靶分子的存在和/或量的值;微流体网络 至少互连第一结构和第二结构，以及致动器构件，其适于通过将柔性覆盖元件压靠在衬底上来选择性地关闭微流体网络的一部分来实现第一结构和第二结构之间的流体流动。
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公开(公告)号：US20050047973A1
公开(公告)日：2005-03-03
申请号：US10820269
申请日：2004-04-08
申请人： Torsten Schulz , Eugen Ermantraut , Thomas Ullrich , Thomas Ellinger , Joachim Fischer , Thomas Kaiser , Klaus-Peter Mobius , Siegfried Poser , Jens Tuchscheerer , Martin Zieren
发明人： Torsten Schulz , Eugen Ermantraut , Thomas Ullrich , Thomas Ellinger , Joachim Fischer , Thomas Kaiser , Klaus-Peter Mobius , Siegfried Poser , Jens Tuchscheerer , Martin Zieren
IPC分类号： G01N33/53 , B01J19/00 , B01L3/00 , B01L7/00 , C12M1/00 , C12N15/09 , C12Q1/68 , G01N33/566 , G01N37/00 , B01L9/00
CPC分类号： B01L7/52 , B01J2219/00527 , B01J2219/00531 , B01J2219/00596 , B01J2219/00605 , B01J2219/00659 , B01J2219/00722 , B01J2219/00725 , B01L3/502715 , B01L2200/025 , B01L2200/027 , B01L2200/10 , B01L2200/141 , B01L2200/147 , B01L2300/044 , B01L2300/0636 , B01L2300/0877 , B01L2300/1805
摘要： Disclosed are devices for holding a substance library carrier, and which are useful in conducting reactions in which binding between complementary molecules is measured qualitatively or quantitatively. Also disclosed are methods for conducting such reactions in the device.
摘要翻译： 公开了用于保存物质文库载体的装置，其可用于进行定性或定量测量互补分子之间的结合的反应。 还公开了在该装置中进行这种反应的方法。
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公开(公告)号：US20060078929A1
公开(公告)日：2006-04-13
申请号：US11241671
申请日：2005-09-30
申请人： Ralf Bickel , Thomas Ellinger , Eugen Ermantraut , Thomas Kaiser , Torsten Schulz , Thomas Ullrich
发明人： Ralf Bickel , Thomas Ellinger , Eugen Ermantraut , Thomas Kaiser , Torsten Schulz , Thomas Ullrich
CPC分类号： B01L7/52 , B01L3/5027 , B01L2200/147 , B01L2300/0636 , B01L2300/0654 , B01L2300/0877 , G01N21/4738 , G01N21/59
摘要： The present invention relates to a device for the amplification and for the detection of nucleic acids comprising a temperature controlling and/or regulating unit; a reaction chamber containing a support with a detection area, on which a compound library is immobilized, wherein the temperature in the reaction chamber can be controlled and/or regulated by means of the temperature controlling and regulating unit; and an optical system, by means of which the time-dependent behavior of precipitate formations on the detection area is detectable. Methods of using the device are also disclosed.
摘要翻译： 本发明涉及用于扩增和检测包含温度控制和/或调节单元的核酸的装置; 包含具有检测区域的载体的反应室，其上固定有化合物文库，其中可以通过温度控制和调节单元来控制和/或调节反应室中的温度; 以及光学系统，通过该光学系统可以检测出沉积物在检测区域上的时间依赖性。 还公开了使用该装置的方法。
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公开(公告)号：US20160237482A1
公开(公告)日：2016-08-18
申请号：US14580137
申请日：2014-12-22
申请人： Ralf Bickel , Alexandra Dworrak , Thomas Ellinger , Eugen Ermantraut , Torsten Schulz , Thomas Ullrich
发明人： Ralf Bickel , Alexandra Dworrak , Thomas Ellinger , Eugen Ermantraut , Torsten Schulz , Thomas Ullrich
IPC分类号： C12Q1/68 , G01N33/543 , G01N33/68 , G01N21/64
CPC分类号： C12Q1/6837 , B01L3/502715 , B01L7/52 , B01L7/525 , B01L2200/027 , B01L2200/028 , B01L2300/0636 , B01L2300/0654 , B01L2300/0672 , B01L2300/0816 , B01L2300/0819 , B01L2300/0877 , B01L2300/1827 , B01L2300/1838 , B01L2400/0481 , B01L2400/0487 , C12Q1/6825 , C12Q1/6832 , G01N21/6428 , G01N33/54306 , G01N33/54366 , G01N33/58 , G01N33/6845 , G01N35/00 , G01N2021/6439 , Y10T436/143333 , C12Q2563/107 , C12Q2565/102 , C12Q2565/601 , C12Q2565/629
摘要： The invention relates to devices and methods for the detection of specific interactions between probe and target molecules. In particular, the invention relates to methods for the qualitative and/or quantitative detection of targets, including: introducing a sample containing targets into a reaction chamber formed between a first surface of the device and a second surface of a device, which is preferably located opposite to the first surface, wherein the distance between the first and the second surface is variable; and detecting the targets.
摘要翻译： 本发明涉及用于检测探针和靶分子之间特异性相互作用的装置和方法。 特别地，本发明涉及用于定性和/或定量检测靶的方法，包括：将含有靶的样品引入形成在器件的第一表面和器件的第二表面之间的反应室中，反应室优选位于 与第一表面相对，其中第一和第二表面之间的距离是可变的; 并检测目标。
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公开(公告)号：US08916348B2
公开(公告)日：2014-12-23
申请号：US11593021
申请日：2006-11-06
申请人： Ralf Bickel , Alexandra Dworrak , Thomas Ellinger , Eugen Ermantraut , Torsten Schulz , Thomas Ullrich
发明人： Ralf Bickel , Alexandra Dworrak , Thomas Ellinger , Eugen Ermantraut , Torsten Schulz , Thomas Ullrich
CPC分类号： C12Q1/6837 , B01L3/502715 , B01L7/52 , B01L7/525 , B01L2200/027 , B01L2200/028 , B01L2300/0636 , B01L2300/0654 , B01L2300/0672 , B01L2300/0816 , B01L2300/0819 , B01L2300/0877 , B01L2300/1827 , B01L2300/1838 , B01L2400/0481 , B01L2400/0487 , C12Q1/6825 , C12Q1/6832 , G01N21/6428 , G01N33/54306 , G01N33/54366 , G01N33/58 , G01N33/6845 , G01N35/00 , G01N2021/6439 , Y10T436/143333 , C12Q2563/107 , C12Q2565/102 , C12Q2565/601 , C12Q2565/629
摘要： The invention relates to devices and methods for the detection of specific interactions between probe and target molecules. In particular, the invention relates to methods for the qualitative and/or quantitative detection of targets, including: introducing a sample containing targets into a reaction chamber formed between a first surface of the device and a second surface of a device, which is preferably located opposite to the first surface, wherein the distance between the first and the second surface is variable; and detecting the targets.
摘要翻译： 本发明涉及用于检测探针和靶分子之间特异性相互作用的装置和方法。 特别地，本发明涉及用于定性和/或定量检测靶的方法，包括：将含有靶的样品引入形成在器件的第一表面和器件的第二表面之间的反应室中，反应室优选位于 与第一表面相对，其中第一和第二表面之间的距离是可变的; 并检测目标。
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公开(公告)号：US20060147996A1
公开(公告)日：2006-07-06
申请号：US11284469
申请日：2005-11-22
申请人： Thomas Ullrich , Torsten Schulz , Thomas Ellinger , Siegfried Poser , Eugen Ermantraut , Ralf Ehricht
发明人： Thomas Ullrich , Torsten Schulz , Thomas Ellinger , Siegfried Poser , Eugen Ermantraut , Ralf Ehricht
CPC分类号： C12Q1/686 , B01J19/0046 , B01J2219/00457 , B01J2219/00529 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/00662 , B01J2219/00707 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B01L3/5082 , B01L9/52 , B01L2200/025 , B01L2300/0609 , B01L2300/0636 , C12Q1/6837 , C40B40/06 , C40B40/10 , C12Q2537/162 , C12Q2537/161 , C12Q2531/107 , C12Q2525/186
摘要： The invention relates to a holding device for substance libraries which can be used, more particularly, for the detection of target molecules with the aid of substance libraries. Said device comprises: (i) a holder for a substance library carrier; (ii) a substance library carrier, which can be fixed to the holder; and (iii) a detection area applied to the substance library carrier, whereon a substance library is immobilized; and wherein at least one substance library carrier can be introduced into a laboratory reaction vessel.
摘要翻译： 本发明涉及用于物质文库的保持装置，更具体地说，可用于借助物质文库检测靶分子。 所述装置包括：（i）用于物质库载体的保持器; （ii）可以固定在保持器上的物质库载体; 和（iii）应用于物质文库载体的检测区域，其中固定有物质文库; 并且其中可以将至少一种物质文库载体引入实验室反应容器中。
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公开(公告)号：US08828741B2
公开(公告)日：2014-09-09
申请号：US12092643
申请日：2006-11-06
申请人： Eugen Ermantraut , Ralf Bickel , Torsten Schulz , Thomas Ullrich
发明人： Eugen Ermantraut , Ralf Bickel , Torsten Schulz , Thomas Ullrich
IPC分类号： G01N33/537
CPC分类号： C12Q1/6837 , B01F11/0045 , B01L3/5027 , B01L3/502746 , B01L7/52 , B01L7/525 , B01L2200/027 , B01L2300/044 , B01L2300/0636 , B01L2300/0654 , B01L2300/0816 , B01L2300/0819 , B01L2300/0864 , B01L2300/0877 , B01L2300/1827 , B01L2300/1838 , B01L2400/0481 , G01N21/6452 , G01N21/6458
摘要： The present invention relates to devices and methods for the detection of analytes. In particular, the invention relates to methods for the qualitative and/or quantitative detection of analytes, comprising a microarray on a substrate, onto which probe molecules are immobilized on array elements, said microarray being disposed on a first surface of the device; and a detection chamber formed between the first surface including the microarray disposed thereon and a second surface, wherein the distance between the microarray and the second surface is variable, and wherein the second surface has a displacement structure.
摘要翻译： 本发明涉及用于检测分析物的装置和方法。 特别地，本发明涉及用于定性和/或定量检测分析物的方法，其包括在基底上的微阵列，探针分子固定在阵列元件上，所述微阵列设置在装置的第一表面上; 以及检测室，形成在包括设置在其上的微阵列的第一表面和第二表面之间，其中微阵列和第二表面之间的距离是可变的，并且其中第二表面具有位移结构。
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