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公开(公告)号:US08747385B2
公开(公告)日:2014-06-10
申请号:US13468956
申请日:2012-05-10
申请人: Eugene T. Michal , Evgenia Mandrusov , Charles D. Claude , Ni Ding , Murthy Simhambhatla , Syed Faiyez Ahmed Hossainy , Srinivasan Sridharan , Paul Consigny
发明人: Eugene T. Michal , Evgenia Mandrusov , Charles D. Claude , Ni Ding , Murthy Simhambhatla , Syed Faiyez Ahmed Hossainy , Srinivasan Sridharan , Paul Consigny
IPC分类号: A61M31/00
CPC分类号: A61K9/0019 , A61K9/0024 , A61K31/7088
摘要: Methods, devices, kits and compositions to treat a myocardial infarction. In one embodiment, the method includes the prevention of remodeling of the infarct zone of the ventricle. In other embodiments, the method includes the introduction of structurally reinforcing agents. In other embodiments, agents are introduced into a ventricle to increase compliance of the ventricle. In an alternative embodiment, the prevention of remodeling includes the prevention of thinning of the ventricular infarct zone. In another embodiment, the prevention of remodeling and thinning of the infarct zone involves the cross-linking of collagen and prevention of collagen slipping. In other embodiments, the structurally reinforcing agent may be accompanied by other therapeutic agents. These agents may include but are not limited to pro-fibroblastic and angiogenic agents.
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公开(公告)号:US08383158B2
公开(公告)日:2013-02-26
申请号:US10414602
申请日:2003-04-15
申请人: Eugene T. Michal , Evgenia Mandrusov , Charles D. Claude , Ni Ding , Murthy Simhambhatla , Syed Faiyez Ahmed Hossainy , Srinivasan Sridharan , Paul Consigny
发明人: Eugene T. Michal , Evgenia Mandrusov , Charles D. Claude , Ni Ding , Murthy Simhambhatla , Syed Faiyez Ahmed Hossainy , Srinivasan Sridharan , Paul Consigny
IPC分类号: A61K9/14
CPC分类号: A61N1/3625 , A61K9/0024 , A61K31/00 , A61K31/728 , A61K31/732 , A61K31/734 , A61K31/78 , A61K31/79 , A61K36/886 , A61K38/40 , A61K41/0042 , A61K45/06 , A61K47/02 , A61K47/34 , A61K47/60 , A61K47/62 , A61K49/0404 , A61L24/043 , A61L27/20 , A61L27/50 , A61L27/54 , A61L2430/20 , A61N1/36521 , A61K2300/00
摘要: Methods, devices, kits and compositions to treat a myocardial infarction. In one embodiment, the method includes the prevention of remodeling of the infarct zone of the ventricle. In other embodiments, the method includes the introduction of structurally reinforcing agents. In other embodiments, agents are introduced into a ventricle to increase compliance of the ventricle. In an alternative embodiment, the prevention of remodeling includes the prevention of thinning of the ventricular infarct zone. In another embodiment, the prevention of remodeling and thinning of the infarct zone involves the cross-linking of collagen and prevention of collagen slipping. In other embodiments, the structurally reinforcing agent may be accompanied by other therapeutic agents. These agents may include, but are not, limited to pro-fibroblastic and angiogenic agents.
摘要翻译: 用于治疗心肌梗塞的方法,装置,试剂盒和组合物。 在一个实施例中,该方法包括防止脑室梗死区的重塑。 在其它实施方案中,该方法包括引入结构上增强剂。 在其它实施方案中,将药剂引入心室以增加心室的依从性。 在替代实施例中,预防重塑包括防止心室梗塞区变薄。 在另一个实施方案中,预防梗塞区的重塑和变薄包括胶原蛋白的交联和预防胶原蛋白滑脱。 在其它实施方案中,结构上增强剂可以伴随其它治疗剂。 这些试剂可以包括但不限于前成纤维细胞和血管生成剂。
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公开(公告)号:US07641643B2
公开(公告)日:2010-01-05
申请号:US10414767
申请日:2003-04-15
申请人: Eugene T. Michal , Evgenia Mandrusov , Charles D. Claude , Nadine Ding , Murthy Simhambhatla , Syed Faiyez Ahmed Hossainy , Srinivasan Sridharan , Paul Consigny
发明人: Eugene T. Michal , Evgenia Mandrusov , Charles D. Claude , Nadine Ding , Murthy Simhambhatla , Syed Faiyez Ahmed Hossainy , Srinivasan Sridharan , Paul Consigny
IPC分类号: A61M31/00
CPC分类号: A61N1/3625 , A61K9/0024 , A61K31/00 , A61K31/728 , A61K31/732 , A61K31/734 , A61K31/78 , A61K31/79 , A61K36/886 , A61K38/40 , A61K41/0042 , A61K45/06 , A61K47/02 , A61K47/34 , A61K47/60 , A61K47/62 , A61K49/0404 , A61L24/043 , A61L27/20 , A61L27/50 , A61L27/54 , A61L2430/20 , A61N1/36521 , A61K2300/00
摘要: Methods, devices, kits and compositions to treat a myocardial infarction. In one embodiment, the method includes the prevention of remodeling of the infarct zone of the ventricle. In other embodiments, the method includes the introduction of structurally reinforcing agents. In other embodiments, agents are introduced into a ventricle to increase compliance of the ventricle. In an alternative embodiment, the prevention of remodeling includes the prevention of thinning of the ventricular infarct zone. In another embodiment, the prevention of remodeling and thinning of the infarct zone involves the cross-linking of collagen and prevention of collagen slipping. In other embodiments, the structurally reinforcing agent may be accompanied by other therapeutic agents. These agents may include but are not limited to pro-fibroblastic and angiogenic agents.
摘要翻译: 用于治疗心肌梗塞的方法,装置,试剂盒和组合物。 在一个实施例中,该方法包括防止脑室梗死区的重塑。 在其它实施方案中,该方法包括引入结构上增强剂。 在其它实施方案中,将药剂引入心室以增加心室的依从性。 在替代实施例中,预防重塑包括防止心室梗塞区变薄。 在另一个实施方案中,预防梗塞区的重塑和变薄包括胶原蛋白的交联和预防胶原蛋白滑脱。 在其它实施方案中,结构上增强剂可以伴随其它治疗剂。 这些药剂可以包括但不限于前成纤维细胞和血管生成剂。
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公开(公告)号:US20120219521A1
公开(公告)日:2012-08-30
申请号:US13468956
申请日:2012-05-10
申请人: Eugene T. Michal , Evgenia Mandrusov , Charles D. Claude , Ni Ding , Murthy Simhambhatia , Syed Faiyez Ahmed Hossainy , Srinivasan Sridharan , Paul Consigny
发明人: Eugene T. Michal , Evgenia Mandrusov , Charles D. Claude , Ni Ding , Murthy Simhambhatia , Syed Faiyez Ahmed Hossainy , Srinivasan Sridharan , Paul Consigny
IPC分类号: A61K31/765 , A61M25/00
CPC分类号: A61K9/0019 , A61K9/0024 , A61K31/7088
摘要: Methods, devices, kits and compositions to treat a myocardial infarction. In one embodiment, the method includes the prevention of remodeling of the infarct zone of the ventricle. In other embodiments, the method includes the introduction of structurally reinforcing agents. In other embodiments, agents are introduced into a ventricle to increase compliance of the ventricle. In an alternative embodiment, the prevention of remodeling includes the prevention of thinning of the ventricular infarct zone. In another embodiment, the prevention of remodeling and thinning of the infarct zone involves the cross-linking of collagen and prevention of collagen slipping. In other embodiments, the structurally reinforcing agent may be accompanied by other therapeutic agents. These agents may include but are not limited to pro-fibroblastic and angiogenic agents.
摘要翻译: 用于治疗心肌梗塞的方法,装置,试剂盒和组合物。 在一个实施例中,该方法包括防止脑室梗死区的重塑。 在其它实施方案中,该方法包括引入结构上增强剂。 在其它实施方案中,将药剂引入心室以增加心室的依从性。 在替代实施例中,预防重塑包括防止心室梗塞区变薄。 在另一个实施方案中,预防梗塞区的重塑和变薄包括胶原蛋白的交联和预防胶原蛋白滑脱。 在其它实施方案中,结构上增强剂可以伴随其它治疗剂。 这些药剂可以包括但不限于前成纤维细胞和血管生成剂。
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公开(公告)号:US08821473B2
公开(公告)日:2014-09-02
申请号:US12632612
申请日:2009-12-07
申请人: Eugene T. Michal , Evgenia Mandrusov , Charles D. Claude , Ni Ding , Murthy Simhambhatla , Syed Faiyaz Ahmed Hossainy , Srinivasan Sridharan , Paul Consigny
发明人: Eugene T. Michal , Evgenia Mandrusov , Charles D. Claude , Ni Ding , Murthy Simhambhatla , Syed Faiyaz Ahmed Hossainy , Srinivasan Sridharan , Paul Consigny
IPC分类号: A61M31/00 , A61K31/7088 , A61K9/00
CPC分类号: A61K9/0019 , A61K9/0024 , A61K31/7088
摘要: Methods, devices, kits and compositions to treat a myocardial infarction. In one embodiment, the method includes the prevention of remodeling of the infarct zone of the ventricle. In other embodiments, the method includes the introduction of structurally reinforcing agents. In other embodiments, agents are introduced into a ventricle to increase compliance of the ventricle. In an alternative embodiment, the prevention of remodeling includes the prevention of thinning of the ventricular infarct zone. In another embodiment, the prevention of remodeling and thinning of the infarct zone involves the cross-linking of collagen and prevention of collagen slipping. In other embodiments, the structurally reinforcing agent may be accompanied by other therapeutic agents. These agents may include but are not limited to pro-fibroblastic and angiogenic agents.
摘要翻译: 用于治疗心肌梗塞的方法,装置,试剂盒和组合物。 在一个实施例中,该方法包括防止脑室梗死区的重塑。 在其它实施方案中,该方法包括引入结构上增强剂。 在其它实施方案中,将药剂引入心室以增加心室的依从性。 在替代实施例中,预防重塑包括防止心室梗塞区变薄。 在另一个实施方案中,预防梗塞区的重塑和变薄包括胶原蛋白的交联和预防胶原蛋白滑脱。 在其它实施方案中,结构上增强剂可以伴随其它治疗剂。 这些药剂可以包括但不限于前成纤维细胞和血管生成剂。
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公开(公告)号:US20100144635A1
公开(公告)日:2010-06-10
申请号:US12632612
申请日:2009-12-07
申请人: Eugene T. Michal , Evgenia Mandrusov , Charles D. Claude , Ni Ding , Murthy Simhambhatla , Syed Faiyaz Ahmed Hossainy , Srinivasan Sridharan , Paul Consigny
发明人: Eugene T. Michal , Evgenia Mandrusov , Charles D. Claude , Ni Ding , Murthy Simhambhatla , Syed Faiyaz Ahmed Hossainy , Srinivasan Sridharan , Paul Consigny
CPC分类号: A61K9/0019 , A61K9/0024 , A61K31/7088
摘要: Methods, devices, kits and compositions to treat a myocardial infarction. In one embodiment, the method includes the prevention of remodeling of the infarct zone of the ventricle. In other embodiments, the method includes the introduction of structurally reinforcing agents. In other embodiments, agents are introduced into a ventricle to increase compliance of the ventricle. In an alternative embodiment, the prevention of remodeling includes the prevention of thinning of the ventricular infarct zone. In another embodiment, the prevention of remodeling and thinning of the infarct zone involves the cross-linking of collagen and prevention of collagen slipping. In other embodiments, the structurally reinforcing agent may be accompanied by other therapeutic agents. These agents may include but are not limited to pro-fibroblastic and angiogenic agents.
摘要翻译: 用于治疗心肌梗塞的方法,装置,试剂盒和组合物。 在一个实施例中,该方法包括防止脑室梗死区的重塑。 在其它实施方案中,该方法包括引入结构上增强剂。 在其它实施方案中,将药剂引入心室以增加心室的依从性。 在替代实施例中,预防重塑包括防止心室梗塞区变薄。 在另一个实施方案中,预防梗塞区的重塑和变薄包括胶原蛋白的交联和预防胶原蛋白滑脱。 在其它实施方案中,结构上增强剂可以伴随其它治疗剂。 这些药剂可以包括但不限于前成纤维细胞和血管生成剂。
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公开(公告)号:US20050003011A1
公开(公告)日:2005-01-06
申请号:US10892050
申请日:2004-07-15
IPC分类号: A61L27/16 , A61L27/50 , A61L27/56 , A61L29/04 , B29C55/00 , B29C55/06 , B29D7/01 , B29C43/22 , A61K9/14
CPC分类号: A61L27/56 , A61L27/16 , A61L27/507 , A61L29/041 , B29C55/005 , B29C55/065 , B29D7/01 , B29K2023/0683 , B29K2105/0061 , C08L23/06
摘要: A method including forming a pseudo-gel of a semi-crystalline polymer material and a solvent. The pseudo-gel is shaped into a first form and stretched. A portion of the solvent is removed to create a second form. The second form is stretched into a microstructure including nodes interconnected by fibrils. A method including forming a first form of a pseudo-gel including an ultra-high molecular weight polyethylene material and a solvent; stretching the first form; removing the solvent to form a second form; stretching the second form into a microstructure including nodes interconnected by fibrils; and annealing the stretched second form. An apparatus including a body portion formed of a dimension suitable for a medical device application and including a polyolefin polymer including a node and a fibril microstructure. An apparatus including a body portion including an ultra-high molecular weight polyolefin material including a node and a fibril microstructure.
摘要翻译: 一种包括形成半结晶聚合物材料和溶剂的假凝胶的方法。 假凝胶成型为第一种形式并拉伸。 除去一部分溶剂以产生第二种形式。 第二种形式被拉伸成包括由原纤维相互连接的节点的微结构。 一种包括形成包含超高分子量聚乙烯材料和溶剂的第一种形式的假凝胶的方法; 拉伸第一种形式; 除去溶剂以形成第二种形式; 将第二形式拉伸成包括通过纤维互连的节点的微结构; 并退火拉伸的第二种形式。 一种装置,包括由适于医疗装置应用的尺寸形成的主体部分,并且包括包含节点和原纤维微结构的聚烯烃聚合物。 一种包括主体部分的装置,其包括包含节点和原纤维微结构的超高分子量聚烯烃材料。
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公开(公告)号:US06946173B2
公开(公告)日:2005-09-20
申请号:US10103274
申请日:2002-03-21
申请人: Florencia Lim , Chi Le Long , Charles D. Claude , Jeong S. Lee , Srinivasan Sridharan , Fernando Gonzalez , Edwin Wang
发明人: Florencia Lim , Chi Le Long , Charles D. Claude , Jeong S. Lee , Srinivasan Sridharan , Fernando Gonzalez , Edwin Wang
IPC分类号: A61L29/00 , A61F2/958 , A61L29/04 , A61L29/08 , A61L29/12 , A61M25/00 , A61M25/16 , B32B1/08 , A61M25/10 , A61M29/00
CPC分类号: A61M25/1034 , A61L29/041 , A61L29/085 , A61L29/126 , A61M25/1006 , A61M25/1025 , A61M25/1029 , A61M2025/1075 , Y10T428/13 , Y10T428/1334 , Y10T428/1352 , Y10T428/1376 , Y10T428/1386 , Y10T428/139 , Y10T428/1393 , C08L27/18
摘要: A catheter balloon formed of a polymeric material such as expanded polytetrafluoroethylene (ePTFE) bonded to a second layer formed of a low tensile set polymer and/or impregnated with a low tensile set polymer. In a presently preferred embodiment, the low tensile set polymer is a silicone-polyurethane copolymer elastomer or a diene polymer elastomer. The low tensile set polymer has high strength, low modulus, high elongation, and low tensile set. The diene or silicone-polyurethane has a low tensile set, which facilitates deflation of the balloon to a low profile deflated configuration. One aspect of the invention provides improved attachment of the diene to the ePTFE. In one embodiment, the second layer is formed of a diene mixed with a bonding promoter such as a vulcanizing agent which is covalently bonded to the diene.
摘要翻译: 由诸如膨胀聚四氟乙烯(ePTFE)的聚合物材料形成的导管球囊结合到由低拉伸凝固聚合物形成的第二层和/或用低拉伸固化聚合物浸渍。 在目前优选的实施方案中,低拉伸固化聚合物是硅氧烷 - 聚氨酯共聚物弹性体或二烯聚合物弹性体。 低强度聚合物具有高强度,低模量,高伸长率和低拉伸强度。 二烯或硅氧烷聚氨酯具有低拉伸组合,其有利于将气囊放气至低剖面放气构型。 本发明的一个方面提供了改进的二烯与ePTFE的连接。 在一个实施方案中,第二层由与二烯混合的二烯混合形成,所述二烯与粘合促进剂例如硫化剂混合。
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公开(公告)号:US09824790B2
公开(公告)日:2017-11-21
申请号:US14240788
申请日:2012-08-16
申请人: Dongshe Zhang , Aziz S. Shaikh , Srinivasan Sridharan , Himal Khatri , Hong Jiang , George E. Graddy, Jr.
发明人: Dongshe Zhang , Aziz S. Shaikh , Srinivasan Sridharan , Himal Khatri , Hong Jiang , George E. Graddy, Jr.
IPC分类号: H01L31/00 , H01B1/22 , C07F9/11 , C03C8/16 , C03C8/18 , C03C8/22 , H01L31/0224 , H01L21/22 , C03C8/10 , C03C8/08
CPC分类号: H01B1/22 , C03C8/08 , C03C8/10 , C03C8/16 , C03C8/18 , C03C8/22 , C07F9/11 , H01L21/2225 , H01L31/022425 , H01L31/022441 , Y02E10/50
摘要: Paste compositions, methods of making a paste composition, photovoltaic cells, and methods of making a photovoltaic cell contact are disclosed. The paste composition can include a conductive metal component such as aluminum, phosphate glass, phosphorus compounds such as alky! phosphate, and a vehicle. The contact can be formed on a passivation layer on a silicon wafer by applying the paste on the passivation layer and firing the paste. During firing, the metal component can fire through the passivation layer, thereby electrically contacting the silicon substrate.
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公开(公告)号:US09272497B2
公开(公告)日:2016-03-01
申请号:US13808422
申请日:2011-07-22
申请人: Chandrashekhar S. Khadilkar , Robert P. Blonski , Srinivasan Sridharan , Jackie D. Davis , John J. Maloney , James D. Walker , Andrew M. Rohn, Jr.
发明人: Chandrashekhar S. Khadilkar , Robert P. Blonski , Srinivasan Sridharan , Jackie D. Davis , John J. Maloney , James D. Walker , Andrew M. Rohn, Jr.
CPC分类号: B32B37/12 , B05D3/007 , C08K7/14 , C09D5/34 , C09D7/70 , H01L31/048 , H01L31/0481 , H01L31/0488 , H01L51/5246 , Y02E10/50 , Y10T428/1314
摘要: A glass-flake loaded organic sealant system is useful for sealing active layers such as those in electronic devices and solar cells.
摘要翻译: 玻璃片装载的有机密封剂系统可用于密封诸如电子设备和太阳能电池中的活性层的活性层。
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