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公开(公告)号：US20190233856A1
公开(公告)日：2019-08-01
申请号：US16334781
申请日：2017-10-18
申请人： Evonik Degussa GmbH
CPC分类号： C12P7/6463 , C07K14/195 , C07K14/21 , C12N9/0036 , C12N9/1029 , C12P19/44 , C12R1/385 , C12R1/39 , C12R1/40 , C12Y101/05002 , C12Y204/01159 , C12Y207/01 , C12Y207/03009
摘要： The invention relates to cells which make rhamnolipids and are genetically modified such that they have a decreased activity, compared to the wild type thereof, of an ABC glucose transporter and, compared to the wild type thereof, an increased activity of at least one non-ABC glucose transporter and to a method for producing rhamnolipids using the cells according to the invention.
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公开(公告)号：US09580720B2
公开(公告)日：2017-02-28
申请号：US14642879
申请日：2015-03-10
申请人： EVONIK DEGUSSA GMBH
CPC分类号： C12N15/78 , A01N43/16 , C12N9/1051 , C12N9/14 , C12N15/52 , C12N15/70 , C12N15/77 , C12P19/44 , C12Y306/04013 , Y02P20/52
摘要： This invention relates to cells and nucleic acids and also use thereof for producing rhamnolipids, and also methods for producing rhamnolipids.
摘要翻译： 本发明涉及细胞和核酸，以及其用于制备鼠李糖脂的用途，以及生产鼠李糖脂的方法。
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3.发明授权公开(公告)号：US09102968B2
公开(公告)日：2015-08-11
申请号：US14487736
申请日：2014-09-16
申请人： EVONIK DEGUSSA GmbH
IPC分类号： C12N9/02 , C12N9/10 , C12N1/21 , C12P19/44 , A61K31/704
CPC分类号： C12P19/44 , A61K31/704 , C12N9/0071 , C12N9/1029 , C12N9/1051 , C12P19/14
摘要： The invention relates to cells, nucleic acids, and enzymes, the use thereof for producing sophorolipids, and methods for producing sophorolipids.
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公开(公告)号：US10174353B2
公开(公告)日：2019-01-08
申请号：US15311850
申请日：2015-04-27
申请人： Evonik Degussa GmbH
发明人： Oliver Thum , Philip Engel , Christian Gehring , Steffen Schaffer , Mirja Wessel
摘要： The present invention relates to a method of preparing at least one rhamnolipid comprising: contacting a recombinant cell with a medium containing a carbon source; and culturing the cell under suitable conditions for preparation of the rhamnolipid from the carbon source by the cell, wherein the recombinant cell has been genetically modified such that, compared to the wild-type of the cell, the cell has an increased activity of at least one of the enzymes E1, E2 and E3, wherein the enzyme E1 is an α/β hydrolase, the enzyme E2 is a rhamnosyltransferase I and the enzyme E3 is a rhamnosyl-transferase II, and wherein the carbon source is a C4 molecule.
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5.发明授权公开(公告)号：US09157108B2
公开(公告)日：2015-10-13
申请号：US14487718
申请日：2014-09-16
申请人： Evonik Degussa GmbH
CPC分类号： C12P19/44 , A61K31/704 , C12N9/0071 , C12N9/1029 , C12N9/1051 , C12P19/14
摘要： The invention relates to cells, nucleic acids, and enzymes, the use thereof for producing sophorolipids, and methods for producing sophorolipids.
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6.发明授权Cells, nucleic acids, enzymes and use thereof, and methods for the production of sophorolipids 有权细胞，核酸，酶及其用途，以及生产槐糖脂的方法公开(公告)号：US09068211B2
公开(公告)日：2015-06-30
申请号：US14487786
申请日：2014-09-16
申请人： Evonik Degussa GmbH
CPC分类号： C12P19/44 , A61K31/704 , C12N9/0071 , C12N9/1029 , C12N9/1051 , C12P19/14
摘要： The invention relates to cells, nucleic acids, and enzymes, the use thereof for producing sophorolipids, and methods for producing sophorolipids.
摘要翻译： 本发明涉及细胞，核酸和酶，其用于生产槐糖脂的用途，以及生产槐糖脂的方法。
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公开(公告)号：US20190271020A1
公开(公告)日：2019-09-05
申请号：US16333719
申请日：2017-10-18
申请人： Evonik Degussa GmbH
摘要： The invention relates to cells which make rhamnolipids and are genetically modified such that they have a decreased activity, compared to the wild type thereof, of a glucose dehydrogenase and to a method for producing rhamnolipids using the cells according to the invention.
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8.发明授权公开(公告)号：US09725746B2
公开(公告)日：2017-08-08
申请号：US14649414
申请日：2013-12-18
申请人： Evonik Degussa GmbH
发明人： Steffen Schaffer , Jasmin Corthals , Mirja Wessel , Hans-Georg Hennemann , Harald Haeger , Michael Volland , Martin Roos
CPC分类号： C12P13/001 , C12N9/0008 , C12N9/0016 , C12N9/0069 , C12N9/1096 , C12N9/1288 , C12N15/52 , C12Y102/01042 , C12Y104/01001 , C12Y113/11 , C12Y207/08007 , Y02P20/582
摘要： The invention relates to a whole-cell catalyst which expresses a recombinant α-dioxygenase or the combination of a recombinant fatty acid reductase and a phosphopantetheinyl transferase which phosphopantetheinylates the fatty acid reductase, and which expresses, in addition to the α-dioxygenase and/or the combination of fatty acid reductase and phosphopantetheinyl transferase, a transaminase, wherein the phosphopantetheinyl transferase and/or transaminase is preferably recombinant; and also to a process for converting a carboxylic acid or dicarboxylic acid or a monoester thereof to an amine or diamine, comprising the steps of contacting the carboxylic acid or dicarboxylic acid or the monoester thereof with a phosphopantetheinylated fatty acid reductase or an α-dioxygenase and contacting the product with a transaminase.
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公开(公告)号：US11034938B2
公开(公告)日：2021-06-15
申请号：US16314768
申请日：2017-07-03
申请人： EVONIK DEGUSSA GMBH
发明人： Arne Skerra , Ludwig Kirmair , Steffen Schaffer , Christoph Schorsch , Mirja Wessel , Thomas Haas
摘要： There is provided a microbial cell expressing a mutant AlkB enzyme, the mutant AlkB enzyme comprising at least one point mutation in the wild type sequence of AlkB, wherein the point mutation is at amino acid position V129 and/or T136 of the wild type AlkB enzyme. There is also provided a method for producing omega-hydroxy carboxylic acid and/or ester thereof using this cell.
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公开(公告)号：US09765370B2
公开(公告)日：2017-09-19
申请号：US14390133
申请日：2013-03-25
申请人： EVONIK DEGUSSA GMBH
发明人： Hans-Georg Hennemann , Steffen Schaffer , Mirja Wessel , Markus Pötter , Jan Christoph Pfeffer , Thomas Haas , Jasmin Corthals , Eva-Maria Eckl , Silvana Roeder , Wolfgang Kroutil , Arne Skerra
CPC分类号： C12P13/06 , C12P13/005
摘要： A process for producing alanine, including culturing a cell under aerobic conditions in an aqueous phase in the presence of an inorganic nitrogen source, and then contacting the aqueous phase and the cell cultured in the aqueous phase with a hydrophobic organic phase. The cell is a prokaryotic or a lower eukaryotic cell and expresses a recombinant alanine dehydrogenase.
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