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公开(公告)号：US20240390427A1
公开(公告)日：2024-11-28
申请号：US18403586
申请日：2024-01-03
Inventor： Geoffrey A. von Maltzahn , John Miles Milwid , Michael Travis Mee , Jacob Rosenblum Rubens , David Chess , Kyle Marvin Trudeau , Kiana Mahdaviani , Jacob Feala , James D. McCully , Douglas B. Cowan
IPC: A61K35/35 , A61K9/00 , A61K35/12 , A61K35/14 , A61K35/19 , A61K35/33 , A61K35/34 , A61K38/17 , A61P3/00 , C12N15/87 , G01N33/15
Abstract: Therapeutic chondrisome compositions and related methods are described.
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公开(公告)号：US20210187018A1
公开(公告)日：2021-06-24
申请号：US16769930
申请日：2018-12-07
Applicant: FLAGSHIP PIONEERING INNOVATIONS V, INC.
Inventor： Geoffrey A. von Maltzahn , John Miles Milwid , Jacob Rosenblum Rubens , Michael Travis Mee , Nathan Wilson Stebbins , Molly Krisann Gibson , Neal Francis Gordon , Bo Zhang , Kyle Marvin Trudeau , Brigham Jay Hartley , Tamar Rose Putiri , Kiana Mahdaviani , Jagesh Vijaykumar Shah , Michael Connor , Peter Anthony Jones
IPC: A61K35/12 , A61K38/45 , A61K9/127 , A61K39/385 , C12N15/113 , A61K39/00
Abstract: This disclosure provides, e.g., cytobiologic compositions and methods of use thereof. The cytobiologics can be used, e.g., to deliver a protein or nucleic acid to a target cell.
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公开(公告)号：US11903974B2
公开(公告)日：2024-02-20
申请号：US15779736
申请日：2016-11-30
Inventor： Geoffrey A. von Maltzahn , John Miles Milwid , Michael Travis Mee , Jacob Rosenblum Rubens , David Chess , Kyle Marvin Trudeau , Kiana Mahdaviani , Jacob Feala , James D. McCully , Douglas B. Cowan
IPC: A61K35/35 , A61K35/34 , A61K35/14 , A61K35/19 , A61K38/17 , A61K35/33 , G01N33/15 , C12N15/87 , A61K35/12 , A61P3/00 , A61K9/00
CPC classification number: A61K35/35 , A61K35/12 , A61K35/14 , A61K35/19 , A61K35/33 , A61K35/34 , A61K38/1709 , A61P3/00 , C12N15/87 , G01N33/15 , A61K9/0029
Abstract: Therapeutic chondrisome compositions and related methods are described.
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公开(公告)号：US20200060980A1
公开(公告)日：2020-02-27
申请号：US16611768
申请日：2018-05-08
Applicant: FLAGSHIP PIONEERING INNOVATIONS V, INC.
Inventor： Geoffrey A. von Maltzahn , John Miles Milwid , Michael Travis Mee , Jacob Rosenblum Rubens , Nathan Wilson Stebbins , Molly Krisann Gibson , Neal Francis Gordon , Bo Zhang , Kyle Marvin Trudeau , Brigham Jay Hartley , Tamar Rose Putiri , Kiana Mahdaviani , Matthew Milnes Dobbin
IPC: A61K9/50 , A61K9/127 , C12N15/88 , A61K48/00 , A61K38/17 , C12N15/113 , A61K38/45 , C12N9/22 , C12N15/11
Abstract: In some aspects, fusosome compositions and methods are described herein that comprise membrane enclosed preparations, comprising a fusogen. In some embodiments, the fusosome can the target cell, thereby delivering complex biologic agents to the target cell cytoplasm.
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公开(公告)号：US20240279685A1
公开(公告)日：2024-08-22
申请号：US18004403
申请日：2021-07-06
Applicant: FLAGSHIP PIONEERING INNOVATIONS V, INC.
Inventor： Benhur Lee , Michael Travis Mee , Jagesh V. Shah , Kyle Marvin Trudeau
IPC: C12N15/88 , A61K9/51 , C07K14/005 , C12N5/071 , C12N7/00
CPC classification number: C12N15/88 , A61K9/5184 , C07K14/005 , C12N5/0602 , C12N7/00 , C12N2740/16043 , C12N2760/18222
Abstract: The present disclosure provides, at least in part, methods and compositions for producing fusosomes. In some embodiments, a producer cell for producing fusosomes comprises an exogenous or overexpresed cathepsin molecule. In some embodiments, these cells generate an increased level of active fusogen, leading to a higher proportion of fusogenically active fusosomes.
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公开(公告)号：US20220160784A1
公开(公告)日：2022-05-26
申请号：US17651056
申请日：2022-02-14
Inventor： Geoffrey A. von Maltzahn , John Miles Milwid , Michael Travis Mee , Jacob Rosenblum Rubens , David Chess , Kyle Marvin Trudeau , Kiana Mahdaviani , Jacob Feala , James D. McCully , Douglas B. Cowan
IPC: A61K35/35 , A61K35/34 , A61K35/14 , A61K35/19 , A61K38/17 , A61K35/33 , G01N33/15 , C12N15/87 , A61K35/12 , A61P3/00
Abstract: Therapeutic chondrisome compositions and related methods are described.
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公开(公告)号：US11903975B2
公开(公告)日：2024-02-20
申请号：US15779754
申请日：2016-11-30
Inventor： Geoffrey A. von Maltzahn , John Miles Milwid , Michael Travis Mee , Jacob Rosenblum Rubens , David Chess , Kyle Marvin Trudeau , Kiana Mahdaviani , Jacob Feala , James D. McCully , Douglas B. Cowan
IPC: A61K35/35 , A61K35/34 , A61K35/14 , A61K35/19 , A61K38/17 , A61K35/33 , G01N33/15 , C12N15/87 , A61K35/12 , A61P3/00 , A61K9/00
CPC classification number: A61K35/35 , A61K35/12 , A61K35/14 , A61K35/19 , A61K35/33 , A61K35/34 , A61K38/1709 , A61P3/00 , C12N15/87 , G01N33/15 , A61K9/0029
Abstract: Therapeutic chondrisome and mitoplast compositions and related methods are described.
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公开(公告)号：US20240033227A1
公开(公告)日：2024-02-01
申请号：US18154618
申请日：2023-01-13
Applicant: FLAGSHIP PIONEERING INNOVATIONS V, INC.
Inventor： Geoffrey A. von Maltzahn , John Miles Milwid , Michael Travis Mee , Jacob Rosenblum Rubens , Nathan Wilson Stebbins , Molly Krisann Gibson , Neal Francis Gordon , Bo Zhang , Kyle Marvin Trudeau , Brigham Jay Hartley , Tamar Rose Putiri , Kiana Mahdaviani , Matthew Milnes Dobbin
IPC: A61K9/50 , A61K9/127 , A61K38/17 , A61K38/45 , A61K48/00 , C12N9/22 , C12N15/11 , C12N15/113 , C12N15/88
CPC classification number: A61K9/5068 , C12N2800/80 , A61K9/1277 , A61K38/177 , A61K38/45 , A61K48/0008 , C12N9/22 , C12N15/11 , C12N15/113 , C12N15/88 , C12Y207/07 , C12N2310/20 , C12N2310/14 , C12N2310/141 , C12N2320/32 , A61K9/1271
Abstract: In some aspects, fusosome compositions and methods are described herein that comprise membrane enclosed preparations, comprising a fusogen. In some embodiments, the fusosome can fuse to the target cell, thereby delivering complex biologic agents to the target cell cytoplasm.
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公开(公告)号：US20210228627A1
公开(公告)日：2021-07-29
申请号：US17055077
申请日：2019-05-15
Applicant: FLAGSHIP PIONEERING INNOVATIONS V, INC.
Inventor： Geoffrey A. von Maltzahn , Jacob Rosenblum Rubens , Michael Travis Mee , John Miles Milwid , Neal Francis Gordon , Jagesh Vijaykumar Shah , Kyle Marvin Trudeau , Brigham Jay Hartley , Peter Anthony Jones
IPC: A61K35/15 , C07K14/005 , C12N15/88 , A61K48/00
Abstract: The present disclosure provides, at least in part, methods and compositions for in vivo fusosome delivery. In some embodiments, the fusosome comprises a combination of elements that promote specificity for target cells, e.g., one or more of a re-targeted fusogen, a positive target cell-specific regulatory element, and a non-target cell-specific regulatory element. In some embodiments, the fusosome comprises one or more modifications that decrease an immune response against the fusosome.
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公开(公告)号：US20230068547A1
公开(公告)日：2023-03-02
申请号：US17293830
申请日：2019-11-14
Applicant: FLAGSHIP PIONEERING INNOVATIONS V, INC.
Inventor： Geoffrey A. von Maltzahn , John Miles Milwid , Jacob Rosenblum Rubens , Michael Travis Mee , Neal Francis Gordon , Jagesh Vijaykumar Shah , Kyle Marvin Trudeau , Brigham Jay Hartley
Abstract: Fusosome compositions and methods are described herein.
