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    Biodegradable polymeric materials providing controlled release of hydrophobic drugs from implantable devices
    6.
    发明申请
    Biodegradable polymeric materials providing controlled release of hydrophobic drugs from implantable devices 审中-公开
    提供可植入式设备的疏水性药物的控制释放的可生物降解的聚合材料

    公开(公告)号：US20090110713A1

    公开(公告)日：2009-04-30

    申请号：US11982160

    申请日：2007-10-31

    申请人： Florencia Lim ,  Michael H. Ngo ,  Yiwen Tang ,  Syed F.A. Hossainy ,  Mikael O. Trollsas

    发明人： Florencia Lim ,  Michael H. Ngo ,  Yiwen Tang ,  Syed F.A. Hossainy ,  Mikael O. Trollsas

    IPC分类号： A61F2/82 ,  C08L5/00 ,  C08L5/06 ,  C08L3/00 ,  C08L1/00 ,  C08G63/00 ,  C08G63/08 ,  A61K47/30 ,  A61K31/4353

    CPC分类号： C08G63/08 ,  A61L31/06 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/602 ,  C08L67/04

    摘要： The present invention is directed to polymeric materials (e.g., coatings) comprising biodegradable copolymers and implantable devices (e.g., drug-delivery stents) formed of such materials. The biodegradable copolymers are derived from at least two relatively polar monomers and at least one relatively nonpolar monomer. Incorporation of at least one relatively nonpolar monomer into the copolymer improves controlled release of a hydrophobic drug from the polymeric material by increasing the copolymer's miscibility with and permeability to the hydrophobic drug. The polymeric materials can also contain at least one biocompatible moiety, at least one non-fouling moiety, at least one biobeneficial material, at least one bioactive agent, or a combination thereof. The polymeric materials are designed to improve the mechanical, physical and biological properties of implantable devices formed thereof.

    摘要翻译： 本发明涉及包含由这种材料形成的可生物降解的共聚物和可植入装置（例如药物递送支架）的聚合物材料（例如包衣）。 可生物降解的共聚物衍生自至少两种相对极性的单体和至少一种相对非极性的单体。 将至少一种相对非极性的单体掺入共聚物中，通过增加共聚物与疏水性药物的混溶性和渗透性，可以改善疏水性药物从聚合物材料的受控释放。 聚合物材料还可含有至少一种生物相容部分，至少一种非结垢部分，至少一种生物有益材料，至少一种生物活性剂或其组合。 聚合材料被设计成改善由其形成的可植入装置的机械，物理和生物学特性。