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公开(公告)号:US20220106356A1
公开(公告)日:2022-04-07
申请号:US17460791
申请日:2021-08-30
发明人: Christian Hackenberger , Marc André Kasper , Maria Glanz , Tom Sauer , Dominik Schumacher , Jonas Helma-Smets , Heinrich Leonhardt , Andreas Stengl
摘要: Disclosed are novel conjugates and processes for the preparation thereof. A process for the preparation of alkene- or alkyne-phosphonamidates comprises the steps of (I) reacting a compound of formula (III) with an azide of formula (IV) to prepare a compound of formula (V) (II) reacting a compound of formula (V) with a thiol-containing molecule of formula (VI) resulting in a compound of formula (VII)
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公开(公告)号:US20190330264A1
公开(公告)日:2019-10-31
申请号:US16328199
申请日:2017-09-01
发明人: Christian Hackenberger , Marc André Kasper , Maria Glanz , Tom Sauer , Dominik Schumacher , Jonas Helma-Smets , Heinrich Leonhardt , Andreas Stengl
摘要: Disclosed are novel conjugates and processes for the preparation thereof. A process for the preparation of alkene- or alkyne-phosphonamidates comprises the steps of (I) reacting a compound of formula (III), with an azide of formula (IV), to prepare a compound of formula (V), reacting a compound of formula (V) with a thiol-containing molecule of formula (VI), resulting in a compound of formula (VII).
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公开(公告)号:US11161873B2
公开(公告)日:2021-11-02
申请号:US16328199
申请日:2017-09-01
发明人: Christian Hackenberger , Marc André Kasper , Maria Glanz , Tom Sauer , Dominik Schumacher , Jonas Helma-Smets , Heinrich Leonhardt , Andreas Stengl
摘要: Disclosed are novel conjugates and processes for the preparation thereof. A process tor the preparation of alkene- or alkyne-phosphonamidates comprises the steps of (I) reacting a compound of formula (III), with an azide of formula (IV), to prepare a compound of formula (V), reacting a compound of formula (V) with a thiol-containing molecule of formula (VI), resulting in a compound of formula (VII).
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公开(公告)号:US11572384B2
公开(公告)日:2023-02-07
申请号:US16096787
申请日:2017-04-27
摘要: The present invention provides means and methods for functionalizing a polypeptide of interest at its C-terminus with an amino acid derivative.
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公开(公告)号:US10745437B2
公开(公告)日:2020-08-18
申请号:US16225522
申请日:2018-12-19
摘要: The present invention provides means and methods for equipping a polypeptide of interest at its C-terminus with a versatile adaptor amino acid that allows the functionalization of the polypeptide of interest.
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公开(公告)号:US10208084B2
公开(公告)日:2019-02-19
申请号:US15521675
申请日:2015-10-29
摘要: The present invention provides means and methods for equipping a polypeptide of interest at its C-terminus with a versatile adaptor amino acid that allows the functionalization of the polypeptide of interest.
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公开(公告)号:US20170349625A1
公开(公告)日:2017-12-07
申请号:US15521675
申请日:2015-10-29
CPC分类号: C07K1/1075 , C12P21/005 , C12P21/02 , C12Y603/02025
摘要: The present invention provides means and methods for equipping a polypeptide of interest at its C-terminus with a versatile adaptor amino acid that allows the functionalization of the polypeptide of interest.
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