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    Method of producing labeled antibody
    3.
    发明授权
    Method of producing labeled antibody 有权

    公开(公告)号：US10466234B2

    公开(公告)日：2019-11-05

    申请号：US14816836

    申请日：2015-08-03

    Applicant: FURUKAWA ELECTRIC CO., LTD.

    Inventor： Nobumitsu Yamanaka ,  Hideki Aizawa ,  Michio Ohkubo ,  Kazutomi Miyoshi

    IPC: G01N33/53 ,  G01N33/543 ,  G01N33/533 ,  G01N33/552 ,  G01N33/532

    Abstract: A method of producing a labeled antibody, including the steps of: a) allowing silica nanoparticles containing a functional molecule and having a thiol group on a surface thereof, and a linker molecule containing a maleimido group and an amino group, to coexist in a solvent to form a thioether bond between the thiol group and the maleimido group, thereby obtaining functional molecule-containing silica nanoparticles on which the linker molecule is bonded; and b) allowing the functional molecule-containing silica nanoparticles on which the linker molecule is bonded, carbodiimide and an antibody to coexist in an aqueous solvent to form an amide bond between the amino group of the linker molecule and a carboxyl group of the antibody.

    Fluorescence immuno-chromatography, kit and test strip for the same
    5.
    发明授权
    Fluorescence immuno-chromatography, kit and test strip for the same 有权

    公开(公告)号：US09726605B2

    公开(公告)日：2017-08-08

    申请号：US13830435

    申请日：2013-03-14

    Applicant: FURUKAWA ELECTRIC CO., LTD.

    Inventor： Hideki Aizawa ,  Michio Ohkubo

    IPC: G01N31/00 ,  G01N33/53 ,  G01N21/64 ,  G01N33/543 ,  G01N33/558 ,  G01N21/84

    CPC classification number: G01N21/6428 ,  G01N21/8483 ,  G01N33/54373 ,  G01N33/558

    Abstract: The invention is directed to a fluorescence immunochromatography method carried out by illuminating a fluorescent substance in a membrane with excitation light and detecting fluorescence emitted from the fluorescent substance, by applying a sample to a test strip having a membrane and a transparent film attached to the surface of the membrane, wherein the transparent film satisfies Formula (1) Formula (1) nFf>nWf (nFf: refractive index of transparent film at wavelength λf of the fluorescence) (nWf: refractive index of analyte liquid at wavelength λf of the fluorescence), and wherein the membrane contains a fluorescent labeling reagent which binds to target substance contained in the sample; binding the fluorescent labeling reagent to the target substance; immobilizing the fluorescent labeling reagent bound to the target substance in the membrane; detecting the presence of target substance.

    CONNECTION STRUCTURE OF CARBON NANOTUBE WIRE
    6.
    发明申请
    CONNECTION STRUCTURE OF CARBON NANOTUBE WIRE 有权

    公开(公告)号：US20230014073A1

    公开(公告)日：2023-01-19

    申请号：US17933752

    申请日：2022-09-20

    Applicant: FURUKAWA ELECTRIC CO., LTD.

    Inventor： Kazuki Sugihara ,  Hideki Aizawa

    IPC: H01B1/04

    Abstract: A connection structure of a carbon nanotube wire is provided, which includes a joint between the carbon nanotube wire and the connection target having excellent electrical connectivity and mechanical connectivity. The present disclosure provides a connection structure of a carbon nanotube wire, including: a carbon nanotube wire formed by twisting and bundling carbon nanotube aggregates; a connection target to which the carbon nanotube wire is connected; a conducting wire with higher solder wettability than the carbon nanotube wire; a penetrating part of the conducting wire formed along a cross section having a component orthogonal to a longitudinal direction of the carbon nanotube wire; and solder that connects the carbon nanotube wire and the connection target, in which the solder penetrates the penetrating part formed along the conducting wire.

    Method of producing functional molecule-containing silica nanoparticles on which biomolecules are bonded
    8.
    发明授权
    Method of producing functional molecule-containing silica nanoparticles on which biomolecules are bonded 有权
    制备生物分子结合的含功能分子的二氧化硅纳米粒子的方法

    公开(公告)号：US08993345B2

    公开(公告)日：2015-03-31

    申请号：US14063666

    申请日：2013-10-25

    Applicant: Furukawa Electric Co., Ltd.

    Inventor： Hideki Aizawa ,  Michio Ohkubo ,  Masataka Nishida

    IPC: G01N33/532 ,  C07K17/14 ,  G01N33/543 ,  G01N33/552 ,  G01N33/558

    CPC classification number: C07K17/14 ,  G01N33/54346 ,  G01N33/54353 ,  G01N33/552 ,  G01N33/558 ,  Y10T436/143333

    Abstract: A method of producing functional molecule-containing silica nanoparticles on which a biomolecule is bonded, containing the steps of: allowing silica nanoparticles containing a functional molecule and having a thiol group on a surface thereof to coexist with a linker molecule having a maleimido group and a carboxyl group in an aprotic solvent, thereby allowing formation of a thioether bond between the thiol group and the maleimido group, and obtaining functional molecule-containing silica nanoparticles on which the linker molecule is bonded; and allowing the functional molecule-containing silica nanoparticles on which the linker molecule is bonded to coexist with carbodiimide and a biomolecule having an amino group in an aqueous solvent, thereby allowing formation of an amide bond between the carboxyl group active esterified by the carbodiimide, and the amino group of the biomolecule.

    Abstract translation: 一种制备其上结合有生物分子的含有功能分子的二氧化硅纳米颗粒的方法，包括以下步骤：使含有功能分子的二氧化硅纳米粒子与其表面上的硫醇基团共存于具有马来酰亚胺基和 羧基在非质子溶剂中，从而在硫醇基和马来酰亚胺基之间形成硫醚键，并获得其上键合有连接分子的含功能分子的二氧化硅纳米颗粒; 并且使含有连接体分子的功能性分子的二氧化硅纳米粒子与碳二亚胺和在水性溶剂中具有氨基的生物分子共存，由此可以在由碳二亚胺酯化的羧基之间形成酰胺键，和 生物分子的氨基。

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