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13 条记录 (耗时 0.031 秒)

    Dimethoxy quinazolines for treating diabetes
    2.
    发明授权
    Dimethoxy quinazolines for treating diabetes 失效
    用于治疗糖尿病的二甲氧基喹唑啉

    公开(公告)号：US06495556B2

    公开(公告)日：2002-12-17

    申请号：US09812098

    申请日：2001-03-19

    申请人： Fatih M. Uckun ,  Elise A. Sudbeck ,  Marina Cetkovic ,  Ravi Malaviya ,  Xing-Ping Liu

    发明人： Fatih M. Uckun ,  Elise A. Sudbeck ,  Marina Cetkovic ,  Ravi Malaviya ,  Xing-Ping Liu

    IPC分类号： A61K3152

    CPC分类号： A61K31/00 ,  A61K31/505 ,  A61K31/517 ,  C07D239/74 ,  C07D239/94

    摘要： The invention provides novel JAK-3 inhibitors that are useful for treating leukemia and lymphoma. The compounds are also useful to treat or prevent skin cancer, as well as sunburn and UVB-induced skin inflammation. In addition, the compounds of the present invention prevent the immunosuppressive effects of UVB radiation, and are useful to treat or prevent autoimmune diseases, inflammation, and transplant rejection. The invention also provides pharmaceutical compositions comprising compounds of the invention, as well as therapeutic methods for their use.

    摘要翻译： 本发明提供了可用于治疗白血病和淋巴瘤的新型JAK-3抑制剂。 这些化合物也可用于治疗或预防皮肤癌，以及晒伤和UVB诱导的皮肤炎症。 此外，本发明的化合物可防止UVB辐射的免疫抑制作用，并且可用于治疗或预防自身免疫性疾病，炎症和移植排斥。 本发明还提供了包含本发明化合物的药物组合物，以及它们使用的治疗方法。

    Therapeutic compounds
    4.
    发明授权
    Therapeutic compounds 失效
    治疗化合物

    公开(公告)号：US06313129B1

    公开(公告)日：2001-11-06

    申请号：US09378093

    申请日：1999-08-20

    申请人： Fatih M. Uckun ,  Elise A. Sudbeck ,  Marina Cetkovic ,  Ravi Malaviya ,  Xing-Ping Liu

    发明人： Fatih M. Uckun ,  Elise A. Sudbeck ,  Marina Cetkovic ,  Ravi Malaviya ,  Xing-Ping Liu

    IPC分类号： A61K31517

    CPC分类号： A61K31/00 ,  A61K31/505 ,  A61K31/517 ,  C07D239/74 ,  C07D239/94

    摘要： The invention provides novel JAK-3 inhibitors that are useful for treating leukemia and lymphoma. The compounds are also useful to treat or prevent skin cancer, as well as sunburn and UVB-induced skin inflammation. In addition, the compounds of the present invention prevent the immunosuppressive effects of UVB radiation, and are useful to treat or prevent autoimmune diseases, inflammation, and transplant rejection. The invention also provides pharmaceutical compositions comprising compounds of the invention, as well as therapeutic methods for their use.

    摘要翻译： 本发明提供了可用于治疗白血病和淋巴瘤的新型JAK-3抑制剂。 这些化合物也可用于治疗或预防皮肤癌，以及晒伤和UVB诱导的皮肤炎症。 此外，本发明的化合物可防止UVB辐射的免疫抑制作用，并且可用于治疗或预防自身免疫性疾病，炎症和移植排斥。 本发明还提供了包含本发明化合物的药物组合物，以及它们使用的治疗方法。

    Treatment of inflammation with 2,4,6-trihydroxy-alpha-rho-methoxyphenylacetophenone, or its pharmaceutically acceptable derivatives
    8.
    发明授权
    Treatment of inflammation with 2,4,6-trihydroxy-alpha-rho-methoxyphenylacetophenone, or its pharmaceutically acceptable derivatives 失效
    用2,4,6-三羟基-α-对甲氧基苯乙酮或其药学上可接受的衍生物治疗炎症

    公开(公告)号：US06248790B1

    公开(公告)日：2001-06-19

    申请号：US09606926

    申请日：2000-06-29

    申请人： Fatih M. Uckun ,  Ravi Malaviya

    发明人： Fatih M. Uckun ,  Ravi Malaviya

    IPC分类号： A61K3112

    CPC分类号： A61K31/12

    摘要： 2,4,6-trihydroxy-&agr;-p-methoxyphenylacetophenone (also identified herein as “D-58”), or its pharmaceutically acceptable derivatives such as salt and ester forms, is administered for inhibiting inflammatory reactions. The treatment can be remedial or prophylactic. Examples of the conditions that can be treated include acute inflammatory reactions and allergic inflammatory reactions, and specific examples include allergy, asthma, arthritis, psoriasis, skin sunburn, inflammatory pelvic disease, inflammatory bowel disease, urethritis, uvitis, senusitis, pneumonitis, encephalitis, meningitis, myocarditis, nephritis, osteomyelitis, myositis, hepatitis, gastritis, enteritis, dermatitis, gingivitis, appendicitis, pancreatitis, cholocystitis and cholangitis. The 2,4,6-trihydroxy-&agr;-p-methoxyphenylacetophenone can be administered by various routes as needed.

    摘要翻译： 施用2,4,6-三羟基-α-对甲氧基苯乙酮（本文中也称为“D-58”）或其药学上可接受的衍生物如盐和酯形式用于抑制炎性反应。 治疗可以是补救或预防。 可以治疗的病症的实例包括急性炎症反应和过敏性炎症反应，具体实例包括过敏，哮喘，关节炎，牛皮癣，皮肤晒伤，炎性骨盆疾病，炎性肠病，尿道炎，尿毒症，肾炎，肺炎，脑炎， 脑膜炎，心肌炎，肾炎，骨髓炎，肌炎，肝炎，胃炎，肠炎，皮炎，牙龈炎，阑尾炎，胰腺炎，胆囊炎和胆管炎。 2,4,6-三羟基-α-对甲氧基苯乙酮可以根据需要通过各种途径施用。

    Treatment of inflammation with 2,4,6-trihydroxy-&agr;-para-methoxyphenylacetophenone, or its pharmaceutically acceptable derivatives
    9.
    发明授权
    Treatment of inflammation with 2,4,6-trihydroxy-&agr;-para-methoxyphenylacetophenone, or its pharmaceutically acceptable derivatives 有权

    公开(公告)号：US06391921B1

    公开(公告)日：2002-05-21

    申请号：US09884245

    申请日：2001-06-19

    申请人： Fatih M. Uckun ,  Ravi Malaviya

    发明人： Fatih M. Uckun ,  Ravi Malaviya

    IPC分类号： A61K3112

    摘要： 2,4,6-trihydroxy-&agr;-p-methoxyphenylacetophenone (also identified herein as “D-58”), or its pharmaceutically acceptable derivatives such as salt and ester forms, is administered for inhibiting inflammatory reactions. The treatment can be remedial or prophylactic. Examples of the conditions that can be treated include acute inflammatory reactions and allergic inflammatory reactions, and specific examples include allergy, asthma, arthritis, psoriasis, skin sunburn, inflammatory pelvic disease, inflammatory bowel disease, urethritis, uvitis, senusitis, pneumonitis, encephalitis, meningitis, myocarditis, nephritis, osteomyelitis, myositis, hepatitis, gastritis, enteritis, dermatitis, gingivitis, appendicitis, pancreatitis, cholocystitis and cholangitis. The 2,4,6-trihydroxy-&agr;-p-methoxyphenylacetophenone can be administered by various routes as needed.