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公开(公告)号：US06946173B2
公开(公告)日：2005-09-20
申请号：US10103274
申请日：2002-03-21
申请人： Florencia Lim , Chi Le Long , Charles D. Claude , Jeong S. Lee , Srinivasan Sridharan , Fernando Gonzalez , Edwin Wang
发明人： Florencia Lim , Chi Le Long , Charles D. Claude , Jeong S. Lee , Srinivasan Sridharan , Fernando Gonzalez , Edwin Wang
IPC分类号： A61L29/00 , A61F2/958 , A61L29/04 , A61L29/08 , A61L29/12 , A61M25/00 , A61M25/16 , B32B1/08 , A61M25/10 , A61M29/00
CPC分类号： A61M25/1034 , A61L29/041 , A61L29/085 , A61L29/126 , A61M25/1006 , A61M25/1025 , A61M25/1029 , A61M2025/1075 , Y10T428/13 , Y10T428/1334 , Y10T428/1352 , Y10T428/1376 , Y10T428/1386 , Y10T428/139 , Y10T428/1393 , C08L27/18
摘要： A catheter balloon formed of a polymeric material such as expanded polytetrafluoroethylene (ePTFE) bonded to a second layer formed of a low tensile set polymer and/or impregnated with a low tensile set polymer. In a presently preferred embodiment, the low tensile set polymer is a silicone-polyurethane copolymer elastomer or a diene polymer elastomer. The low tensile set polymer has high strength, low modulus, high elongation, and low tensile set. The diene or silicone-polyurethane has a low tensile set, which facilitates deflation of the balloon to a low profile deflated configuration. One aspect of the invention provides improved attachment of the diene to the ePTFE. In one embodiment, the second layer is formed of a diene mixed with a bonding promoter such as a vulcanizing agent which is covalently bonded to the diene.
摘要翻译： 由诸如膨胀聚四氟乙烯（ePTFE）的聚合物材料形成的导管球囊结合到由低拉伸凝固聚合物形成的第二层和/或用低拉伸固化聚合物浸渍。 在目前优选的实施方案中，低拉伸固化聚合物是硅氧烷 - 聚氨酯共聚物弹性体或二烯聚合物弹性体。 低强度聚合物具有高强度，低模量，高伸长率和低拉伸强度。 二烯或硅氧烷聚氨酯具有低拉伸组合，其有利于将气囊放气至低剖面放气构型。 本发明的一个方面提供了改进的二烯与ePTFE的连接。 在一个实施方案中，第二层由与二烯混合的二烯混合形成，所述二烯与粘合促进剂例如硫化剂混合。
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公开(公告)号：US20120219521A1
公开(公告)日：2012-08-30
申请号：US13468956
申请日：2012-05-10
申请人： Eugene T. Michal , Evgenia Mandrusov , Charles D. Claude , Ni Ding , Murthy Simhambhatia , Syed Faiyez Ahmed Hossainy , Srinivasan Sridharan , Paul Consigny
发明人： Eugene T. Michal , Evgenia Mandrusov , Charles D. Claude , Ni Ding , Murthy Simhambhatia , Syed Faiyez Ahmed Hossainy , Srinivasan Sridharan , Paul Consigny
IPC分类号： A61K31/765 , A61M25/00
CPC分类号： A61K9/0019 , A61K9/0024 , A61K31/7088
摘要： Methods, devices, kits and compositions to treat a myocardial infarction. In one embodiment, the method includes the prevention of remodeling of the infarct zone of the ventricle. In other embodiments, the method includes the introduction of structurally reinforcing agents. In other embodiments, agents are introduced into a ventricle to increase compliance of the ventricle. In an alternative embodiment, the prevention of remodeling includes the prevention of thinning of the ventricular infarct zone. In another embodiment, the prevention of remodeling and thinning of the infarct zone involves the cross-linking of collagen and prevention of collagen slipping. In other embodiments, the structurally reinforcing agent may be accompanied by other therapeutic agents. These agents may include but are not limited to pro-fibroblastic and angiogenic agents.
摘要翻译： 用于治疗心肌梗塞的方法，装置，试剂盒和组合物。 在一个实施例中，该方法包括防止脑室梗死区的重塑。 在其它实施方案中，该方法包括引入结构上增强剂。 在其它实施方案中，将药剂引入心室以增加心室的依从性。 在替代实施例中，预防重塑包括防止心室梗塞区变薄。 在另一个实施方案中，预防梗塞区的重塑和变薄包括胶原蛋白的交联和预防胶原蛋白滑脱。 在其它实施方案中，结构上增强剂可以伴随其它治疗剂。 这些药剂可以包括但不限于前成纤维细胞和血管生成剂。
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公开(公告)号：US08747385B2
公开(公告)日：2014-06-10
申请号：US13468956
申请日：2012-05-10
申请人： Eugene T. Michal , Evgenia Mandrusov , Charles D. Claude , Ni Ding , Murthy Simhambhatla , Syed Faiyez Ahmed Hossainy , Srinivasan Sridharan , Paul Consigny
发明人： Eugene T. Michal , Evgenia Mandrusov , Charles D. Claude , Ni Ding , Murthy Simhambhatla , Syed Faiyez Ahmed Hossainy , Srinivasan Sridharan , Paul Consigny
IPC分类号： A61M31/00
CPC分类号： A61K9/0019 , A61K9/0024 , A61K31/7088
摘要： Methods, devices, kits and compositions to treat a myocardial infarction. In one embodiment, the method includes the prevention of remodeling of the infarct zone of the ventricle. In other embodiments, the method includes the introduction of structurally reinforcing agents. In other embodiments, agents are introduced into a ventricle to increase compliance of the ventricle. In an alternative embodiment, the prevention of remodeling includes the prevention of thinning of the ventricular infarct zone. In another embodiment, the prevention of remodeling and thinning of the infarct zone involves the cross-linking of collagen and prevention of collagen slipping. In other embodiments, the structurally reinforcing agent may be accompanied by other therapeutic agents. These agents may include but are not limited to pro-fibroblastic and angiogenic agents.
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公开(公告)号：US08383158B2
公开(公告)日：2013-02-26
申请号：US10414602
申请日：2003-04-15
申请人： Eugene T. Michal , Evgenia Mandrusov , Charles D. Claude , Ni Ding , Murthy Simhambhatla , Syed Faiyez Ahmed Hossainy , Srinivasan Sridharan , Paul Consigny
发明人： Eugene T. Michal , Evgenia Mandrusov , Charles D. Claude , Ni Ding , Murthy Simhambhatla , Syed Faiyez Ahmed Hossainy , Srinivasan Sridharan , Paul Consigny
IPC分类号： A61K9/14
CPC分类号： A61N1/3625 , A61K9/0024 , A61K31/00 , A61K31/728 , A61K31/732 , A61K31/734 , A61K31/78 , A61K31/79 , A61K36/886 , A61K38/40 , A61K41/0042 , A61K45/06 , A61K47/02 , A61K47/34 , A61K47/60 , A61K47/62 , A61K49/0404 , A61L24/043 , A61L27/20 , A61L27/50 , A61L27/54 , A61L2430/20 , A61N1/36521 , A61K2300/00
摘要： Methods, devices, kits and compositions to treat a myocardial infarction. In one embodiment, the method includes the prevention of remodeling of the infarct zone of the ventricle. In other embodiments, the method includes the introduction of structurally reinforcing agents. In other embodiments, agents are introduced into a ventricle to increase compliance of the ventricle. In an alternative embodiment, the prevention of remodeling includes the prevention of thinning of the ventricular infarct zone. In another embodiment, the prevention of remodeling and thinning of the infarct zone involves the cross-linking of collagen and prevention of collagen slipping. In other embodiments, the structurally reinforcing agent may be accompanied by other therapeutic agents. These agents may include, but are not, limited to pro-fibroblastic and angiogenic agents.
摘要翻译： 用于治疗心肌梗塞的方法，装置，试剂盒和组合物。 在一个实施例中，该方法包括防止脑室梗死区的重塑。 在其它实施方案中，该方法包括引入结构上增强剂。 在其它实施方案中，将药剂引入心室以增加心室的依从性。 在替代实施例中，预防重塑包括防止心室梗塞区变薄。 在另一个实施方案中，预防梗塞区的重塑和变薄包括胶原蛋白的交联和预防胶原蛋白滑脱。 在其它实施方案中，结构上增强剂可以伴随其它治疗剂。 这些试剂可以包括但不限于前成纤维细胞和血管生成剂。
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公开(公告)号：US20100144635A1
公开(公告)日：2010-06-10
申请号：US12632612
申请日：2009-12-07
申请人： Eugene T. Michal , Evgenia Mandrusov , Charles D. Claude , Ni Ding , Murthy Simhambhatla , Syed Faiyaz Ahmed Hossainy , Srinivasan Sridharan , Paul Consigny
发明人： Eugene T. Michal , Evgenia Mandrusov , Charles D. Claude , Ni Ding , Murthy Simhambhatla , Syed Faiyaz Ahmed Hossainy , Srinivasan Sridharan , Paul Consigny
CPC分类号： A61K9/0019 , A61K9/0024 , A61K31/7088
摘要： Methods, devices, kits and compositions to treat a myocardial infarction. In one embodiment, the method includes the prevention of remodeling of the infarct zone of the ventricle. In other embodiments, the method includes the introduction of structurally reinforcing agents. In other embodiments, agents are introduced into a ventricle to increase compliance of the ventricle. In an alternative embodiment, the prevention of remodeling includes the prevention of thinning of the ventricular infarct zone. In another embodiment, the prevention of remodeling and thinning of the infarct zone involves the cross-linking of collagen and prevention of collagen slipping. In other embodiments, the structurally reinforcing agent may be accompanied by other therapeutic agents. These agents may include but are not limited to pro-fibroblastic and angiogenic agents.
摘要翻译： 用于治疗心肌梗塞的方法，装置，试剂盒和组合物。 在一个实施例中，该方法包括防止脑室梗死区的重塑。 在其它实施方案中，该方法包括引入结构上增强剂。 在其它实施方案中，将药剂引入心室以增加心室的依从性。 在替代实施例中，预防重塑包括防止心室梗塞区变薄。 在另一个实施方案中，预防梗塞区的重塑和变薄包括胶原蛋白的交联和预防胶原蛋白滑脱。 在其它实施方案中，结构上增强剂可以伴随其它治疗剂。 这些药剂可以包括但不限于前成纤维细胞和血管生成剂。
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公开(公告)号：US08821473B2
公开(公告)日：2014-09-02
申请号：US12632612
申请日：2009-12-07
申请人： Eugene T. Michal , Evgenia Mandrusov , Charles D. Claude , Ni Ding , Murthy Simhambhatla , Syed Faiyaz Ahmed Hossainy , Srinivasan Sridharan , Paul Consigny
发明人： Eugene T. Michal , Evgenia Mandrusov , Charles D. Claude , Ni Ding , Murthy Simhambhatla , Syed Faiyaz Ahmed Hossainy , Srinivasan Sridharan , Paul Consigny
IPC分类号： A61M31/00 , A61K31/7088 , A61K9/00
CPC分类号： A61K9/0019 , A61K9/0024 , A61K31/7088
摘要： Methods, devices, kits and compositions to treat a myocardial infarction. In one embodiment, the method includes the prevention of remodeling of the infarct zone of the ventricle. In other embodiments, the method includes the introduction of structurally reinforcing agents. In other embodiments, agents are introduced into a ventricle to increase compliance of the ventricle. In an alternative embodiment, the prevention of remodeling includes the prevention of thinning of the ventricular infarct zone. In another embodiment, the prevention of remodeling and thinning of the infarct zone involves the cross-linking of collagen and prevention of collagen slipping. In other embodiments, the structurally reinforcing agent may be accompanied by other therapeutic agents. These agents may include but are not limited to pro-fibroblastic and angiogenic agents.
摘要翻译： 用于治疗心肌梗塞的方法，装置，试剂盒和组合物。 在一个实施例中，该方法包括防止脑室梗死区的重塑。 在其它实施方案中，该方法包括引入结构上增强剂。 在其它实施方案中，将药剂引入心室以增加心室的依从性。 在替代实施例中，预防重塑包括防止心室梗塞区变薄。 在另一个实施方案中，预防梗塞区的重塑和变薄包括胶原蛋白的交联和预防胶原蛋白滑脱。 在其它实施方案中，结构上增强剂可以伴随其它治疗剂。 这些药剂可以包括但不限于前成纤维细胞和血管生成剂。
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公开(公告)号：US07641643B2
公开(公告)日：2010-01-05
申请号：US10414767
申请日：2003-04-15
申请人： Eugene T. Michal , Evgenia Mandrusov , Charles D. Claude , Nadine Ding , Murthy Simhambhatla , Syed Faiyez Ahmed Hossainy , Srinivasan Sridharan , Paul Consigny
发明人： Eugene T. Michal , Evgenia Mandrusov , Charles D. Claude , Nadine Ding , Murthy Simhambhatla , Syed Faiyez Ahmed Hossainy , Srinivasan Sridharan , Paul Consigny
IPC分类号： A61M31/00
CPC分类号： A61N1/3625 , A61K9/0024 , A61K31/00 , A61K31/728 , A61K31/732 , A61K31/734 , A61K31/78 , A61K31/79 , A61K36/886 , A61K38/40 , A61K41/0042 , A61K45/06 , A61K47/02 , A61K47/34 , A61K47/60 , A61K47/62 , A61K49/0404 , A61L24/043 , A61L27/20 , A61L27/50 , A61L27/54 , A61L2430/20 , A61N1/36521 , A61K2300/00
摘要： Methods, devices, kits and compositions to treat a myocardial infarction. In one embodiment, the method includes the prevention of remodeling of the infarct zone of the ventricle. In other embodiments, the method includes the introduction of structurally reinforcing agents. In other embodiments, agents are introduced into a ventricle to increase compliance of the ventricle. In an alternative embodiment, the prevention of remodeling includes the prevention of thinning of the ventricular infarct zone. In another embodiment, the prevention of remodeling and thinning of the infarct zone involves the cross-linking of collagen and prevention of collagen slipping. In other embodiments, the structurally reinforcing agent may be accompanied by other therapeutic agents. These agents may include but are not limited to pro-fibroblastic and angiogenic agents.
摘要翻译： 用于治疗心肌梗塞的方法，装置，试剂盒和组合物。 在一个实施例中，该方法包括防止脑室梗死区的重塑。 在其它实施方案中，该方法包括引入结构上增强剂。 在其它实施方案中，将药剂引入心室以增加心室的依从性。 在替代实施例中，预防重塑包括防止心室梗塞区变薄。 在另一个实施方案中，预防梗塞区的重塑和变薄包括胶原蛋白的交联和预防胶原蛋白滑脱。 在其它实施方案中，结构上增强剂可以伴随其它治疗剂。 这些药剂可以包括但不限于前成纤维细胞和血管生成剂。
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公开(公告)号：US20080245474A1
公开(公告)日：2008-10-09
申请号：US12139263
申请日：2008-06-13
申请人： Charles D. Claude , Jeong S. Lee
发明人： Charles D. Claude , Jeong S. Lee
CPC分类号： C08J7/123 , A61L29/085 , A61L31/10 , A61M25/0009 , A61M25/0014 , A61M25/1027 , A61M25/1029 , A61M25/1034 , B05D1/62 , Y10S623/926 , Y10T428/26 , Y10T428/263 , Y10T428/265 , Y10T428/31504 , Y10T428/3154 , Y10T428/31544 , Y10T428/31551 , Y10T428/31663 , Y10T428/31721 , Y10T428/31855
摘要： Medical devices, and particularly intracorporeal devices for therapeutic or diagnostic uses, having a component chemically modified by plasma polymerization. The medical device comprises a substrate with a plasma polymerized functionality bonded to a surface of at least a section thereof. The plasma polymerized film on a first component of the medical device allows for bonding an agent or a second component to the first component. In one embodiment, the plasma polymerized film facilitates fusion or adhesive bonding of a first component to a second component formed of a material which is dissimilar to, incompatible with, or otherwise not readily bondable to the substrate material of the first component. In another embodiment, a bioactive agent is bonded to the plasma polymerized film on the component, for presenting or delivering the bioactive agent within a body lumen of the patient.
摘要翻译： 医疗装置，特别是用于治疗或诊断用途的体内装置，其具有通过等离子体聚合化学改性的组分。 医疗装置包括具有等离子体聚合功能性的基底，其结合至少部分的表面。 医疗装置的第一部件上的等离子体聚合膜允许将试剂或第二组分粘合到第一组分。 在一个实施方案中，等离子体聚合膜促进第一组分与由与第一组分的衬底材料不相容，不相容或不容易粘合的材料形成的第二组分的熔融或粘合。 在另一个实施方案中，生物活性剂与组分上的等离子体聚合膜结合，用于在患者的体腔内呈递或递送生物活性剂。
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公开(公告)号：US07396582B2
公开(公告)日：2008-07-08
申请号：US09827887
申请日：2001-04-06
申请人： Charles D. Claude , Jeong S. Lee
发明人： Charles D. Claude , Jeong S. Lee
CPC分类号： C08J7/123 , A61L29/085 , A61L31/10 , A61M25/0009 , A61M25/0014 , A61M25/1027 , A61M25/1029 , A61M25/1034 , B05D1/62 , Y10S623/926 , Y10T428/26 , Y10T428/263 , Y10T428/265 , Y10T428/31504 , Y10T428/3154 , Y10T428/31544 , Y10T428/31551 , Y10T428/31663 , Y10T428/31721 , Y10T428/31855
摘要： Medical devices, and particularly intracorporeal devices for therapeutic or diagnostic uses, having a component chemically modified by plasma polymerization. The medical device comprises a substrate with a plasma polymerized functionality bonded to a surface of at least a section thereof. The plasma polymerized film on a first component of the medical device allows for bonding an agent or a second component to the first component. In one embodiment, the plasma polymerized film facilitates fusion or adhesive bonding of a first component to a second component formed of a material which is dissimilar to, incompatible with, or otherwise not readily bondable to the substrate material of the first component. In another embodiment, a bioactive agent is bonded to the plasma polymerized film on the component, for presenting or delivering the bioactive agent within a body lumen of the patient.
摘要翻译： 医疗装置，特别是用于治疗或诊断用途的体内装置，其具有通过等离子体聚合化学改性的组分。 医疗装置包括具有等离子体聚合功能性的基底，其结合至少部分的表面。 医疗装置的第一部件上的等离子体聚合膜允许将试剂或第二组分粘合到第一组分。 在一个实施方案中，等离子体聚合膜促进第一组分与由与第一组分的衬底材料不相容，不相容或不容易粘合的材料形成的第二组分的熔融或粘合。 在另一个实施方案中，生物活性剂与组分上的等离子体聚合膜结合，用于在患者的体腔内呈递或递送生物活性剂。
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公开(公告)号：US20120289932A1
公开(公告)日：2012-11-15
申请号：US13559438
申请日：2012-07-26
CPC分类号： A61K9/0024 , A61K9/06
摘要： A method including introducing a treatment agent at a treatment site within a mammalian host; and introducing a bioerodable gel material at the treatment site. An apparatus including a first annular member having a first lumen disposed about a length of the first annular member and a first entry port at a proximal end of the first annular member, and a second annular member coupled to the first annular member having a second lumen disposed about a length of the second annular member and a second entry port at a proximal end of the second annular member, wherein the first annular member and the second annular member are positioned to allow a combining of treatment agents introduced through each annular member at the treatment site.
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