公开(公告)号：US06946173B2

公开(公告)日：2005-09-20

申请号：US10103274

申请日：2002-03-21

申请人： Florencia Lim ,  Chi Le Long ,  Charles D. Claude ,  Jeong S. Lee ,  Srinivasan Sridharan ,  Fernando Gonzalez ,  Edwin Wang

发明人： Florencia Lim ,  Chi Le Long ,  Charles D. Claude ,  Jeong S. Lee ,  Srinivasan Sridharan ,  Fernando Gonzalez ,  Edwin Wang

IPC分类号： A61L29/00 ,  A61F2/958 ,  A61L29/04 ,  A61L29/08 ,  A61L29/12 ,  A61M25/00 ,  A61M25/16 ,  B32B1/08 ,  A61M25/10 ,  A61M29/00

CPC分类号： A61M25/1034 ,  A61L29/041 ,  A61L29/085 ,  A61L29/126 ,  A61M25/1006 ,  A61M25/1025 ,  A61M25/1029 ,  A61M2025/1075 ,  Y10T428/13 ,  Y10T428/1334 ,  Y10T428/1352 ,  Y10T428/1376 ,  Y10T428/1386 ,  Y10T428/139 ,  Y10T428/1393 ,  C08L27/18

摘要： A catheter balloon formed of a polymeric material such as expanded polytetrafluoroethylene (ePTFE) bonded to a second layer formed of a low tensile set polymer and/or impregnated with a low tensile set polymer. In a presently preferred embodiment, the low tensile set polymer is a silicone-polyurethane copolymer elastomer or a diene polymer elastomer. The low tensile set polymer has high strength, low modulus, high elongation, and low tensile set. The diene or silicone-polyurethane has a low tensile set, which facilitates deflation of the balloon to a low profile deflated configuration. One aspect of the invention provides improved attachment of the diene to the ePTFE. In one embodiment, the second layer is formed of a diene mixed with a bonding promoter such as a vulcanizing agent which is covalently bonded to the diene.

摘要翻译： 由诸如膨胀聚四氟乙烯（ePTFE）的聚合物材料形成的导管球囊结合到由低拉伸凝固聚合物形成的第二层和/或用低拉伸固化聚合物浸渍。 在目前优选的实施方案中，低拉伸固化聚合物是硅氧烷 - 聚氨酯共聚物弹性体或二烯聚合物弹性体。 低强度聚合物具有高强度，低模量，高伸长率和低拉伸强度。 二烯或硅氧烷聚氨酯具有低拉伸组合，其有利于将气囊放气至低剖面放气构型。 本发明的一个方面提供了改进的二烯与ePTFE的连接。 在一个实施方案中，第二层由与二烯混合的二烯混合形成，所述二烯与粘合促进剂例如硫化剂混合。

公开(公告)号：US20060029756A1

公开(公告)日：2006-02-09

申请号：US11198623

申请日：2005-08-05

申请人： Florencia Lim ,  Chi Long ,  Charles Claude ,  Jeong Lee ,  Srinivasan Sridharan ,  Fernando Gonzalez ,  Edwin Wang

发明人： Florencia Lim ,  Chi Long ,  Charles Claude ,  Jeong Lee ,  Srinivasan Sridharan ,  Fernando Gonzalez ,  Edwin Wang

IPC分类号： B32B27/32

CPC分类号： A61M25/1034 ,  A61L29/041 ,  A61L29/085 ,  A61L29/126 ,  A61M25/1006 ,  A61M25/1025 ,  A61M25/1029 ,  A61M2025/1075 ,  Y10T428/13 ,  Y10T428/1334 ,  Y10T428/1352 ,  Y10T428/1376 ,  Y10T428/1386 ,  Y10T428/139 ,  Y10T428/1393 ,  C08L27/18

摘要： A catheter balloon formed of a polymeric material such as expanded polytetrafluoroethylene (ePTFE) bonded to a second layer formed of a low tensile set polymer and/or impregnated with a low tensile set polymer. In a presently preferred embodiment, the low tensile set polymer is an elastomer selected from the group consisting of a silicone-polyurethane copolymer and a diene polymer. The low tensile set polymer has high strength, low modulus, high elongation, and low tensile set, to provide improved balloon performance. The diene or silicone-polyurethane has a low tensile set, which facilitates deflation of the balloon to a low profile deflated configuration. One aspect of the invention provides improved attachment of the diene to the ePTFE. In one embodiment, the second layer is formed of a diene mixed with a bonding promoter such as a vulcanizing agent which is covalently bonded to the diene.

公开(公告)号：US06939321B2

公开(公告)日：2005-09-06

申请号：US10255487

申请日：2002-09-26

申请人： Edwin Wang ,  Florencia Lim ,  Huong Chung ,  Chi Le Long ,  Nadine Ding

发明人： Edwin Wang ,  Florencia Lim ,  Huong Chung ,  Chi Le Long ,  Nadine Ding

IPC分类号： A61F2/958 ,  A61M25/00 ,  A61M31/00 ,  A61F2/06 ,  A61M29/00 ,  A61M37/00

CPC分类号： A61M25/1034 ,  A61M25/10 ,  A61M25/1006 ,  A61M2025/1075 ,  Y10T428/1334

摘要： A balloon catheter and a method of making the balloon catheter, having a balloon which is bonded to an elongated shaft, and which has a first layer and a second layer and an improved strong bond between the balloon and the shaft. One aspect of the invention is directed to a balloon in which the balloon first layer has at least a section with a gas plasma-etched or chemical solution-etched surface for improved bondability. Another aspect of the invention is directed to a balloon in which the balloon first layer has a proximal end section bonded to an outer surface of the shaft and the balloon second layer has a proximal end section bonded to an inner surface of the shaft, and, in one embodiment, at least a section of the balloon first layer has a gas plasma-etched or chemical solution-etched surface.

摘要翻译： 气囊导管和制造气囊导管的方法，具有结合到细长轴的气球，并且具有第一层和第二层以及在球囊和轴之间改善的强结合。 本发明的一个方面涉及一种球囊，其中球囊第一层具有至少一个具有气体等离子体蚀刻或化学溶液蚀刻表面的部分，以提高粘合性。 本发明的另一方面涉及一种球囊，其中球囊第一层具有接合到轴的外表面的近端部分，球囊第二层具有接合到轴的内表面的近端部分， 在一个实施例中，气囊第一层的至少一部分具有气体等离子体蚀刻或化学溶液蚀刻表面。

公开(公告)号：US07981244B2

公开(公告)日：2011-07-19

申请号：US11585071

申请日：2006-10-23

申请人： Florencia Lim ,  Jeong S Lee ,  Edwin Wang

发明人： Florencia Lim ,  Jeong S Lee ,  Edwin Wang

IPC分类号： B29C65/00 ,  B32B37/00

CPC分类号： A61M25/104 ,  A61L29/06 ,  A61L29/085 ,  A61M2025/1075 ,  C08L79/02 ,  C08L75/04

摘要： A balloon catheter and a method of making a balloon catheter, having a balloon with a first layer and a second layer, the first layer having at least one impregnated section impregnated with a polymeric material compatible with a polymeric material forming the catheter shaft. At least a portion of the impregnated section is fusion bonded to the shaft. In a presently preferred embodiment, the impregnated section is adjacent to a section of the first layer which is not impregnated with the compatible polymeric material. The impregnated section provides improved bonding of the balloon to the catheter shaft while minimizing the effect of the bond on catheter performance characteristics such as profile and flexibility.

摘要翻译： 气囊导管和制造球囊导管的方法，具有具有第一层和第二层的气囊，所述第一层具有浸渍有与形成导管轴的聚合物材料相容的聚合材料的至少一个浸渍部分。 浸渍部分的至少一部分熔合在轴上。 在目前优选的实施方案中，浸渍的部分邻近第一层的不被相容的聚合物材料浸渍的部分。 浸渍部分提供了球囊与导管轴的改善的粘合，同时最小化粘合对导管性能特征如轮廓和柔性的影响。

公开(公告)号：US07147619B2

公开(公告)日：2006-12-12

申请号：US10200274

申请日：2002-07-22

申请人： Florencia Lim ,  Jeong S. Lee ,  Edwin Wang

发明人： Florencia Lim ,  Jeong S. Lee ,  Edwin Wang

IPC分类号： A61M29/02

CPC分类号： A61M25/104 ,  A61L29/06 ,  A61L29/085 ,  A61M2025/1075 ,  C08L79/02 ,  C08L75/04

摘要： A balloon catheter and a method of making a balloon catheter, having a balloon with a first layer and a second layer, the first layer having at least one impregnated section impregnated with a polymeric material compatible with a polymeric material forming the catheter shaft. At least a portion of the impregnated section is fusion bonded to the shaft. In a presently preferred embodiment, the impregnated section is adjacent to a section of the first layer which is not impregnated with the compatible polymeric material. The impregnated section provides improved bonding of the balloon to the catheter shaft while minimizing the effect of the bond on catheter performance characteristics such as profile and flexibility.

摘要翻译： 气囊导管和制造球囊导管的方法，具有具有第一层和第二层的气囊，所述第一层具有浸渍有与形成导管轴的聚合物材料相容的聚合材料的至少一个浸渍部分。 浸渍部分的至少一部分熔合在轴上。 在目前优选的实施方案中，浸渍的部分邻近第一层的不被相容的聚合物材料浸渍的部分。 浸渍部分提供了球囊与导管轴的改善的粘合，同时最小化粘合对导管性能特征如轮廓和柔性的影响。

公开(公告)号：US20070118076A1

公开(公告)日：2007-05-24

申请号：US11642294

申请日：2006-12-20

申请人： Florencia Lim ,  Edwin Wang

发明人： Florencia Lim ,  Edwin Wang

IPC分类号： A61M29/00

CPC分类号： A61M25/1029 ,  A61M25/1034 ,  A61M2025/1075

摘要： A method of making a catheter balloon, and a balloon catheter formed thereby, in which a layer of a catheter balloon is formed by providing a tubular member to serve as a non porous liner for cooperation with a polymeric tube, and enlarging radially a central or working section of the tubular member such that a first end of the tubular member is smaller in the radial direction with respect to the working section. The tubular member may also have a thickness at the working section that is less than a thickness of the first and second end portions. The first end section of the tubular member is bonded to a catheter shaft having a first outer diameter to form at least a portion of a skirt section of the balloon, and the second end section is bonded to the catheter shaft having a second outer diameter to form a portion of a skirt section, where the skirt sections have an improved high rupture pressure.

摘要翻译： 一种制造导管球囊的方法和由此形成的气囊导管，其中通过提供用于与聚合物管配合的无孔衬垫的管状构件形成导管球囊层，并且径向扩大中心或 所述管状构件的工作部分使得所述管状构件的第一端相对于所述工作部在径向方向上较小。 管状构件还可以具有在工作部分处的厚度小于第一和第二端部的厚度。 管状构件的第一端部结合到具有第一外径的导管轴，以形成气囊的裙部的至少一部分，并且第二端部接合到具有第二外径的导管轴 形成裙部的一部分，其中裙部具有改善的高破裂压力。

公开(公告)号：US07175607B2

公开(公告)日：2007-02-13

申请号：US10382965

申请日：2003-03-06

申请人： Florencia Lim ,  Edwin Wang

发明人： Florencia Lim ,  Edwin Wang

IPC分类号： A61M29/00

CPC分类号： A61M25/1029 ,  A61M25/1034 ,  A61M2025/1075

摘要： A method of making a catheter balloon, and a balloon catheter formed thereby, in which a layer of a catheter balloon is formed by providing a tubular member to serve as a non porous liner for cooperation with a polymeric tube, and enlarging radially a central or working section of the tubular member such that a first end of the tubular member is smaller in the radial direction with respect to the working section. The tubular member may also have a thickness at the working section that is less than a thickness of the first and second end portions. The first end section of the tubular member is bonded to a catheter shaft having a first outer diameter to form at least a portion of a skirt section of the balloon, and the second end section is bonded to the catheter shaft having a second outer diameter to form a portion of a skirt section, where the skirt sections have an improved high rupture pressure.

公开(公告)号：US07172575B2

公开(公告)日：2007-02-06

申请号：US10382330

申请日：2003-03-05

申请人： Fozan El-Nounou ,  Timothy Owens ,  Florencia Lim ,  Edwin Wang

发明人： Fozan El-Nounou ,  Timothy Owens ,  Florencia Lim ,  Edwin Wang

IPC分类号： A61M29/00 ,  A61M31/00 ,  B32B3/26 ,  B32B3/06 ,  B32B9/00

CPC分类号： A61M25/104 ,  A61F2/958 ,  A61M2025/1075 ,  Y10T428/249953 ,  Y10T428/249955 ,  Y10T428/249958 ,  Y10T428/249972 ,  Y10T428/249987 ,  Y10T428/3154

摘要： A balloon for a catheter and a method of making the balloon, having a layer of a porous polymeric material with a modified outer surface and a lubricious coating bonded to the modified outer surface. In one embodiment, the modified outer surface is formed by a polymer impregnated in the porous polymeric material, and the subsequently applied lubricious coating bonds to the impregnating polymer. In another embodiment, the modified outer surface is formed by a functionality deposited on the porous polymeric material which bonds to the subsequently applied lubricious coating. The modified outer surface provides an improved strong bond between the lubricious coating and the balloon, for improved catheter performance.

公开(公告)号：US20070038240A1

公开(公告)日：2007-02-15

申请号：US11585071

申请日：2006-10-23

申请人： Florencia Lim ,  Jeong Lee ,  Edwin Wang

发明人： Florencia Lim ,  Jeong Lee ,  Edwin Wang

IPC分类号： A61M29/00

CPC分类号： A61M25/104 ,  A61L29/06 ,  A61L29/085 ,  A61M2025/1075 ,  C08L79/02 ,  C08L75/04

摘要： A balloon catheter and a method of making a balloon catheter, having a balloon with a first layer and a second layer, the first layer having at least one impregnated section impregnated with a polymeric material compatible with a polymeric material forming the catheter shaft. At least a portion of the impregnated section is fusion bonded to the shaft. In a presently preferred embodiment, the impregnated section is adjacent to a section of the first layer which is not impregnated with the compatible polymeric material. The impregnated section provides improved bonding of the balloon to the catheter shaft while minimizing the effect of the bond on catheter performance characteristics such as profile and flexibility.

摘要翻译： 气囊导管和制造球囊导管的方法，具有具有第一层和第二层的气囊，所述第一层具有浸渍有与形成导管轴的聚合物材料相容的聚合材料的至少一个浸渍部分。 浸渍部分的至少一部分熔合在轴上。 在目前优选的实施方案中，浸渍的部分邻近第一层的不被相容的聚合物材料浸渍的部分。 浸渍部分提供了球囊与导管轴的改善的粘合，同时最小化粘合对导管性能特征如轮廓和柔性的影响。

公开(公告)号：US07951413B2

公开(公告)日：2011-05-31

申请号：US11582580

申请日：2006-10-18

申请人： Fozan El-Nounou ,  Timothy Owens ,  Florencia Lim ,  Edwin Wang

发明人： Fozan El-Nounou ,  Timothy Owens ,  Florencia Lim ,  Edwin Wang

IPC分类号： B05D3/10 ,  B32B3/26 ,  A61M25/10

CPC分类号： A61M25/104 ,  A61F2/958 ,  A61M2025/1075 ,  Y10T428/249953 ,  Y10T428/249955 ,  Y10T428/249958 ,  Y10T428/249972 ,  Y10T428/249987 ,  Y10T428/3154

摘要： A balloon for a catheter and a method of making the balloon, having a layer of a porous polymeric material with a modified outer surface and a lubricious coating bonded to the modified outer surface. In one embodiment, the modified outer surface is formed by a polymer impregnated in the porous polymeric material, and the subsequently applied lubricious coating bonds to the impregnating polymer. In another embodiment, the modified outer surface is formed by a functionality deposited on the porous polymeric material which bonds to the subsequently applied lubricious coating. The modified outer surface provides an improved strong bond between the lubricious coating and the balloon, for improved catheter performance.

摘要翻译： 用于导管的球囊和制造球囊的方法，具有一层具有改良的外表面的多孔聚合物材料和与改性外表面结合的润滑涂层。 在一个实施方案中，改性的外表面由浸渍在多孔聚合物材料中的聚合物形成，随后施加的润滑涂层与浸渍聚合物结合。 在另一个实施方案中，改性的外表面由沉积在多孔聚合物材料上的官能团形成，其结合到随后施加的光滑涂层上。 改进的外表面在光滑涂层和球囊之间提供改进的强结合，以改善导管性能。