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公开(公告)号:US10596168B2
公开(公告)日:2020-03-24
申请号:US16096868
申请日:2017-04-26
发明人: Gerd Krause , Inna Hoyer , Edgar Specker , Jens Furkert , Patrick Marcinkowski , Jens-Peter Von Kries , Martin Neuenschwander , Marc Nazare
IPC分类号: A61K31/429 , A61K31/495 , A61P5/14 , A61P35/00
摘要: Chemical compounds are useful in the treatment of a subject afflicted by a thyroid disease. The compounds exhibit activity as thyroid-stimulating hormone receptor (TSHR) antagonists and can be used in the treatment of hyperthyroidism, Graves' disease, Graves' Ophthalmopathy and thyroid cancer.
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公开(公告)号:US11028084B2
公开(公告)日:2021-06-08
申请号:US16349580
申请日:2017-11-14
申请人: Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft , Forschungsverbund Berlin e.V.
发明人: Claus Scheidereit , Michael Willenbrock , Peter Lindemann , Silke Radetzki , Jens-Peter Von Kries , Marc Nazare
IPC分类号: C07D471/04 , A61P35/00 , C07D209/56 , C07D221/06 , C07D471/14 , C07D487/04 , C07D471/16
摘要: A method is for treatment of a disease associated with genotoxic stress-induced inhibitor of nuclear factor-κB kinase/nuclear factor kappa-light chain enhancer of activated B cells (IKK/NF-κB) signaling. The method can include administering a compound to a subject having a cancer exhibiting genotoxic stress induced IKK/NF-κB activation.
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公开(公告)号:US20190276452A1
公开(公告)日:2019-09-12
申请号:US16349580
申请日:2017-11-14
申请人: Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft , Forschungsverbund Berlin e.V.
发明人: Claus Scheidereit , Michael Willenbrock , Peter Lindemann , Silke Radetzki , Jens-Peter Von Kries , Marc Nazare
IPC分类号: C07D471/04 , C07D471/14 , C07D209/56 , C07D487/04 , C07D221/06 , A61P35/00
摘要: A method is for treatment of a disease associated with genotoxic stress-induced inhibitor of nuclear factor-κB kinase/nuclear factor kappa-light chain enhancer of activated B cells (IKK/NF-κB) signaling. The method can include administering a compound to a subject having a cancer exhibiting genotoxic stress induced IKK/NF-κB activation.
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