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公开(公告)号:US20170325708A1
公开(公告)日:2017-11-16
申请号:US15589615
申请日:2017-05-08
申请人: Lenny Dang , Valeria Fantin , Stefan Gross , Hyun G. Jang , Shengfang Jin , Francesco G. Salituro , Jeffrey O. Saunders , Shin-San Michael Su , Katharine Yen
发明人: Lenny Dang , Valeria Fantin , Stefan Gross , Hyun G. Jang , Shengfang Jin , Francesco G. Salituro , Jeffrey O. Saunders , Shin-San Michael Su , Katharine Yen
IPC分类号: A61B5/055 , G01N33/574 , C12Q1/68 , A61K31/426 , C12Q1/32 , C12N15/113 , A61K45/06 , G06F19/00 , A61K31/41
CPC分类号: A61B5/055 , A61K31/41 , A61K31/426 , A61K45/06 , C12N15/1137 , C12N2310/14 , C12Q1/32 , C12Q1/6886 , C12Y101/01042 , G01N33/574 , G06F19/328 , Y02A90/24 , Y02A90/26 , A61K2300/00
摘要: Methods of treating and evaluating subjects having neoactive mutants are described herein.
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公开(公告)号:US09303002B2
公开(公告)日:2016-04-05
申请号:US14085947
申请日:2013-11-21
申请人: Rene M. Lemieux , Janeta Popovici-Muller , Francesco G. Salituro , Jeffrey O. Saunders , Jeremy Travins , Shunqi Yan
发明人: Rene M. Lemieux , Janeta Popovici-Muller , Francesco G. Salituro , Jeffrey O. Saunders , Jeremy Travins , Shunqi Yan
IPC分类号: C07D285/135 , C07D417/14 , C07D285/12 , C07D417/12 , C07D471/04
CPC分类号: C07D285/135 , C07D285/12 , C07D417/12 , C07D417/14 , C07D471/04
摘要: Compounds and compositions comprising compounds that inhibit glutaminase are described herein. Also described herein are methods of using the compounds that inhibit glutaminase in the treatment of cancer.
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公开(公告)号:US20150183760A1
公开(公告)日:2015-07-02
申请号:US14505866
申请日:2014-10-03
IPC分类号: C07D401/12 , C07D413/14 , C07D405/14 , C07D417/14 , C07D215/06 , C07D401/14
CPC分类号: C07D401/12 , C07D215/06 , C07D241/04 , C07D401/06 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D487/08
摘要: Compounds and compositions comprising compounds that modulate pyruvate kinase M2 (PKM2) are described herein. Also described herein are methods of using the compounds that modulate PKM2 in the treatment of cancer.
摘要翻译: 包含调节丙酮酸激酶M2(PKM2)的化合物的化合物和组合物在本文中描述。 本文还描述了使用调节PKM2的化合物治疗癌症的方法。
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公开(公告)号:US20140213580A1
公开(公告)日:2014-07-31
申请号:US14126763
申请日:2012-06-18
申请人: Sheldon Cao , Janeta Popovici-Muller , Francesco G. Salituro , Jeffrey O. Saunders , Xuefei Tan , Jeremy Travins , Shunqi Yan , Zhixiong Ye
发明人: Sheldon Cao , Janeta Popovici-Muller , Francesco G. Salituro , Jeffrey O. Saunders , Xuefei Tan , Jeremy Travins , Shunqi Yan , Zhixiong Ye
IPC分类号: C07D401/04 , A61K31/496 , C07D401/14 , C07D413/14 , C07D213/85 , C07D471/04 , C07D405/14 , C07D409/14 , C07D417/14 , C07D487/04 , A61K31/4985 , A61K31/517 , A61K31/501 , A61K31/506 , A61K31/502 , A61K31/498
CPC分类号: C07F9/650952 , A61K31/496 , A61K31/498 , A61K31/4985 , A61K31/501 , A61K31/502 , A61K31/506 , A61K31/517 , A61K31/5377 , A61K31/675 , C07D213/85 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D498/04 , C07F9/65583
摘要: Provided are compounds with the following structure, formula (I) pharmaceutically acceptable salts thereof, use of those compounds for treating cancer and pharmaceutical compositions comprising those compounds.
摘要翻译: 提供具有以下结构的化合物,式(I)其药学上可接受的盐,这些化合物用于治疗癌症的用途和包含那些化合物的药物组合物。
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公开(公告)号:US20140206673A1
公开(公告)日:2014-07-24
申请号:US14126791
申请日:2012-06-18
申请人: Sheldon Cao , Janeta Popovici-Muller , Francesco G. Salituro , Jeffrey O. Saunders , Xuefei Tan , Jeremy Travins , Shunqi Yan , Zhixiong Ye
发明人: Sheldon Cao , Janeta Popovici-Muller , Francesco G. Salituro , Jeffrey O. Saunders , Xuefei Tan , Jeremy Travins , Shunqi Yan , Zhixiong Ye
IPC分类号: C07D491/052 , C07D401/04 , C07D519/00 , C07D217/22 , A61K31/551 , C07D471/04 , C07D405/12 , A61K31/496 , A61K31/519
CPC分类号: C07D491/052 , A61K31/496 , A61K31/519 , A61K31/551 , C07D217/22 , C07D217/26 , C07D401/04 , C07D405/12 , C07D413/04 , C07D471/04 , C07D519/00
摘要: Provided are compounds of formula (I), wherein X, Y, Z, W, V, R2, R3 and m are defined as in the description. Their pharmaceutical compositions and their uses for treating cancers are also provided.
摘要翻译: 提供式(I)化合物,其中X,Y,Z,W,V,R 2,R 3和m如描述中所定义。 还提供了它们的药物组合物及其用于治疗癌症的用途。
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6.Pyruvate kinase M2 modulators, therapeutic compositions and related methods of use 有权
标题翻译: 丙酮酸激酶M2调节剂,治疗组合物和相关使用方法公开(公告)号:US08742119B2
公开(公告)日:2014-06-03
申请号:US13267494
申请日:2011-10-06
IPC分类号: C07D401/04 , C07D401/14 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/4196 , A61K31/4439 , A61P35/00
CPC分类号: C07D405/14 , C07D401/04 , C07D403/04 , C07D409/04 , C07D417/04
摘要: Compositions comprising compounds that modulate pyruvate kinase M2 (PKM2) are described herein. Also described herein are methods of using the compounds that modulate PKM2 in the treatment of cancer.
摘要翻译: 包含调节丙酮酸激酶M2(PKM2)的化合物的组合物在本文中描述。 本文还描述了使用调节PKM2的化合物治疗癌症的方法。
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公开(公告)号:US20140142146A1
公开(公告)日:2014-05-22
申请号:US14085947
申请日:2013-11-21
申请人: Rene M. Lemieux , Janeta Popovici-Muller , Francesco G. Salituro , Jeffrey O. Saunders , Jeremy Travins , Shunqi Yan
发明人: Rene M. Lemieux , Janeta Popovici-Muller , Francesco G. Salituro , Jeffrey O. Saunders , Jeremy Travins , Shunqi Yan
IPC分类号: C07D285/135 , C07D417/14
CPC分类号: C07D285/135 , C07D285/12 , C07D417/12 , C07D417/14 , C07D471/04
摘要: Compounds and compositions comprising compounds that inhibit glutaminase are described herein. Also described herein are methods of using the compounds that inhibit glutaminase in the treatment of cancer.
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8.NOVEL N-(4-(AZETIDINE-1-CARBONYL) PHENYL) - (HETERO-) ARYLSULFONAMIDE DERIVATIVES AS PYRUVATE KINASE M2 (PMK2) MODULATORS 有权
标题翻译: 新型N-(4-(亚甲基-1-羰基)苯基) - (异丁基)芳基磺酰胺衍生物作为吡咯类激酶M2(PMK2)调节剂公开(公告)号:US20140073625A1
公开(公告)日:2014-03-13
申请号:US13994398
申请日:2011-12-16
IPC分类号: C07D401/12 , C07D401/14
CPC分类号: C07D401/12 , A61K31/4709 , C07D215/36 , C07D401/14
摘要: Compounds of general Formula (I), and compositions comprising compounds of general formula I that modulate pyruvate kinase M2 (PKM2) are described herein. Also described herein are methods of using the compounds that modulate PKM2 in the treatment of cancer.
摘要翻译: 本文描述了通式(I)的化合物和包含调节丙酮酸激酶M2(PKM2)的通式I化合物的组合物。 本文还描述了使用调节PKM2的化合物治疗癌症的方法。
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9.
公开(公告)号:US20120121515A1
公开(公告)日:2012-05-17
申请号:US13256396
申请日:2010-03-12
申请人: Lenny Dang , Valeria Fantin , Stefan Gross , Hyun Gyung Jang , Shengfang Jin , Francesco G. Salituro , Jeffrey O. Saunders , Shinsan Su , Katharine Yen
发明人: Lenny Dang , Valeria Fantin , Stefan Gross , Hyun Gyung Jang , Shengfang Jin , Francesco G. Salituro , Jeffrey O. Saunders , Shinsan Su , Katharine Yen
CPC分类号: A61B5/055 , A61K31/41 , A61K31/426 , A61K45/06 , C12N15/1137 , C12N2310/14 , C12Q1/32 , C12Q1/6886 , C12Y101/01042 , G01N33/574 , G06F19/328 , Y02A90/24 , Y02A90/26 , A61K2300/00
摘要: Methods of treating and evaluating subjects having neoactive mutants are described herein.
摘要翻译: 本文描述了治疗和评估具有新生突变体的受试者的方法。
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10.N-(4-(azetidine-1-carbonyl) phenyl)-(hetero-) arylsulfonamide derivatives as pyruvate kinase M2 (PMK2) modulators 有权
标题翻译: 丙酮酸激酶M2(PMK2)调节剂N-(4-(氮杂环丁烷-1-羰基)苯基) - (异 - )芳基磺酰胺衍生物公开(公告)号:US09221792B2
公开(公告)日:2015-12-29
申请号:US13994398
申请日:2011-12-16
IPC分类号: A61K31/397 , A61K31/00 , C07D205/00 , C07D215/36 , C07D401/12 , C07D401/14 , A61K31/4709
CPC分类号: C07D401/12 , A61K31/4709 , C07D215/36 , C07D401/14
摘要: Compounds of general Formula (I), and compositions comprising compounds of general formula I that modulate pyruvate kinase M2 (PKM2) are described herein. Also described herein are methods of using the compounds that modulate PKM2 in the treatment of cancer.
摘要翻译: 本文描述了通式(I)的化合物和包含调节丙酮酸激酶M2(PKM2)的通式I化合物的组合物。 本文还描述了使用调节PKM2的化合物治疗癌症的方法。
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