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    Method and device for cellular therapy
    3.
    发明申请
    Method and device for cellular therapy 审中-公开
    细胞治疗的方法和装置

    公开(公告)号：US20070065418A1

    公开(公告)日：2007-03-22

    申请号：US11524087

    申请日：2006-09-20

    申请人： Franco Vallana ,  Giovanni Rolando ,  Maria Curcio ,  Andrea Grignani

    发明人： Franco Vallana ,  Giovanni Rolando ,  Maria Curcio ,  Andrea Grignani

    IPC分类号： A61M31/00 ,  A61M37/00 ,  A61K35/12

    CPC分类号： A61M25/1011 ,  A61K35/12 ,  A61M25/1027 ,  A61M2025/1086 ,  A61M2025/1088

    摘要： A device and method for performing a therapeutic treatment at a treatment site in a patient's vessel, the device configured to be introduced by means of a catheter, the device including an expandable portion capable of being expanded between a contracted position and a deployed position at the treatment site, such as to achieve an angioplasty treatment at the site, and a conveyor portion capable of receiving cells for cellular therapy and delivering the cells to the treatment site such that the angioplasty and cellular therapy procedures are performed substantially simultaneously.

    摘要翻译： 一种用于在患者血管的治疗部位进行治疗性处置的装置和方法，所述装置被构造成通过导管引入，所述装置包括能够在收缩位置和展开位置之间扩张的可扩张部分 治疗部位，例如在现场实现血管成形术治疗，以及能够接收细胞用于细胞治疗并将细胞递送到治疗部位的输送部分，使得血管成形术和细胞治疗程序基本上同时进行。

    Stent for angioplasty and a production process therefor
    4.
    发明授权
    Stent for angioplasty and a production process therefor 失效
    用于血管成形术的支架及其生产工艺

    公开(公告)号：US06645243B2

    公开(公告)日：2003-11-11

    申请号：US09004376

    申请日：1998-01-08

    申请人： Franco Vallana ,  Benito Chinaglia ,  Maria Curcio ,  Giovanni Rolando

    发明人： Franco Vallana ,  Benito Chinaglia ,  Maria Curcio ,  Giovanni Rolando

    IPC分类号： A61F206

    CPC分类号： A61F2/91 ,  A61F2/915 ,  A61F2002/91516 ,  A61F2002/91541 ,  A61F2210/0095 ,  A61N5/1002

    摘要： The stent for angioplasty has a body in the form of a generally tubular casing capable of being dilated in use from a radially-contracted position to a radially-expanded position. The body includes a support structure made from a first material capable of withstanding this dilation without losing its structural integrity. A structure made from a second material which has been rendered radioactive following the exposure of the stent itself to a neutron flux is associated with at least a portion of the carrying structure.

    摘要翻译： 用于血管成形术的支架具有大体管状外壳形式的本体，其能够在使用中从径向收缩位置扩张到径向扩张位置。 主体包括由能够承受该膨胀而不失去其结构完整性的第一材料制成的支撑结构。 由支架本身暴露于中子通量后被放射性的第二材料制成的结构与承载结构的至少一部分相关联。

    Stents for angioplasty
    5.
    发明授权
    Stents for angioplasty 有权
    血管成形术支架

    公开(公告)号：US06451049B2

    公开(公告)日：2002-09-17

    申请号：US09410303

    申请日：1999-10-01

    申请人： Franco Vallana ,  Giovanni Rolando ,  Maria Curcio ,  Paolo Gaschino

    发明人： Franco Vallana ,  Giovanni Rolando ,  Maria Curcio ,  Paolo Gaschino

    IPC分类号： A61F206

    CPC分类号： A61F2/915 ,  A61F2/91 ,  A61F2002/91541 ,  A61F2002/9155 ,  A61F2002/91583 ,  A61F2230/0054 ,  A61F2250/0036

    摘要： This invention is a stent having a substantially tubular body defining a longitudinal axis comprising first and second adjacent annular segments, each segment defining a substantially sinusoidal shape having a plurality of peaks and valleys, the peaks of the first segment extending toward the second segment and being aligned longitudinally with the valleys of the second segment. The stent has a plurality of bridge elements having a U-shaped portion between first and second connector arms, the first connector arm of one bridge element being connected between a first peak and a first valley of the first segment and the second connector arm being connected between a first peak and a first valley of the second segment in a manner such that the U-shaped portion extends in the direction of the first peak of the first segment and the first valley of the second segment. The bridge elements may be connected to the segments at points spaced 360° apart along the sinusoidal shape of the segments. The segments and bridge elements are configured such that when compression, flexure, and torsion forces are applied to the stent they generate first maximum stress regions, second maximum stress regions and third maximum stress regions which do not overlap.

    摘要翻译： 本发明是一种支架，其具有限定纵向轴线的基本上管状的主体，该纵向轴线包括第一和第二相邻的环形段，每个段限定具有多个峰和谷的基本正弦形状，第一段的峰向第二段延伸， 与第二段的谷部纵向对齐。 支架具有在第一和第二连接器臂之间具有U形部分的多个桥接元件，一个桥接元件的第一连接臂连接在第一段的第一峰与第一谷之间，第二连接臂连接 在第二段的第一峰和第一谷之间以使得U形部分沿第一段的第一峰和第二段的第一谷的方向延伸的方式。 桥接元件可以沿着分段的正弦形状间隔360°的点处连接到段。 段和桥元件构造成使得当压缩，弯曲和扭转力施加到支架时，它们产生不重叠的第一最大应力区域，第二最大应力区域和第三最大应力区域。

    Cardiac valve prosthesis with valve flaps of biological tissue
    6.
    发明授权
    Cardiac valve prosthesis with valve flaps of biological tissue 失效
    心脏瓣膜假体与瓣瓣瓣生物组织

    公开(公告)号：US4666442A

    公开(公告)日：1987-05-19

    申请号：US711942

    申请日：1985-03-15

    申请人： Piero Arru ,  Gioachino Bona ,  Maria Curcio ,  Franco Vallana

    发明人： Piero Arru ,  Gioachino Bona ,  Maria Curcio ,  Franco Vallana

    IPC分类号： A61F2/00 ,  A61F2/24 ,  A61L27/30

    CPC分类号： A61F2/2412 ,  A61F2/2409 ,  A61L27/303 ,  A61F2220/0075 ,  A61F2310/00574

    摘要： A cardiac valve prosthesis comprises an annular frame and a valve sleeve with a plurality of valve flaps which are forced apart by the blood passing through the prosthesis in one direction and which are mutually coapted by blood flow in the opposite direction. The frame of the prosthesis includes a rigid or semi-rigid stent constituted by a tubular body with a ring of apertures and with first and second end edges which, in the implanted position of the prosthesis, are respectively upstream and downstream with respect to the direction of flow of the blood through the prosthesis. Biocompatible textile completely covers the rigid stent: the covering has associated suture stitches some of which extend through the apertures of the said ring to attach the covering to the stent itself. The valve sleeve includes two sheets of biological tissue sutured together and wound into a tube, the radially outermost one having a shape which substantially reproduces the shape of the stent of the frame and the radially innermost one whereof, carrying the valve flaps, has a collar end portion which can be turned outwardly of the frame at the first end edge of the stent. The valve sleeve is fixed to the frame by further suture stitches, sone of which extend through the apertures in the ends of the appendages of the frame stent. Other suture stitches connect the end edge of the collar end portion of the radially inner sheet to the covering of biocompatible textile.

    摘要翻译： 心脏瓣膜假体包括环形框架和具有多个瓣膜的阀套，所述阀瓣被血液在一个方向上穿过假体而被迫使其隔开，并且通过相反方向上的血流相互叠加。 假体的框架包括刚性或半刚性支架，其由具有孔环的管状体构成，并且具有第一和第二端边缘，其在假体的植入位置中相对于方向分别在上游和下游 血液通过假体流动。 生物相容性织物完全覆盖刚性支架：覆盖物具有相关联的缝合线迹，其中一些线延伸穿过所述环的孔，以将覆盖物附着到支架本身。 阀套包括缝合在一起并缠绕在管中的两片生物组织，径向最外侧的一个生物组织具有基本上再现框架的支架形状的形状，并且承载阀瓣的径向最内侧的形状具有凸缘 端部可以在支架的第一端边缘处向框架外侧转动。 阀套通过进一步的缝合线缝合到框架上，其中的一个缝合线延伸穿过框架支架的附件的端部中的孔。 其他缝合针迹将径向内片的颈圈端部的端缘连接到生物相容性织物的覆盖物上。

    Methods for manufacture of valve flaps for cardiac valve prostheses
    9.
    发明授权
    Methods for manufacture of valve flaps for cardiac valve prostheses 失效
    用于制造心脏瓣膜假体瓣瓣的方法

    公开(公告)号：US4624822A

    公开(公告)日：1986-11-25

    申请号：US634085

    申请日：1984-07-25

    申请人： Pietro Arru ,  Gioacchino Bona ,  Maria Curcio ,  Franco Vallana

    发明人： Pietro Arru ,  Gioacchino Bona ,  Maria Curcio ,  Franco Vallana

    IPC分类号： A61F2/00 ,  A61F2/24 ,  A61L27/08 ,  A61L27/36 ,  B29C51/10

    CPC分类号： A61L27/507 ,  A61F2/2415 ,  A61L27/08 ,  A61L27/3683 ,  A61F2220/0075 ,  A61F2310/00161 ,  Y10S623/901

    摘要： Sheets of incompletely fixed biological tissue comprising portions for defining valve flaps of a cardiac valve prosthesis are mounted on forming means which can separate in a substantially fluid-tight manner the opposite faces of such portions. These opposite faces are subjected to a fluid pressure difference which produces deformation of the portions towards a conformation substantially identical with the conformation of the valve flaps when mounted in the prosthesis. The biological tissue is finally fixed while the portions defining the valve flaps of the prosthesis are maintained in the said conformation. The sheets of biological tissue are then separated from the forming means to be subsequently mounted in the frame of the prosthesis.

    摘要翻译： 包括用于限定心脏瓣膜假体的瓣膜的部分的不完全固定的生物组织的片材被安装在形成装置上，该装置可以以基本上流体密封的方式分离这些部分的相对面。 这些相对的面受到流体压力差，当安装在假体中时，该压力差导致部分朝向与瓣瓣的构象基本相同的构象的变形。 生物组织最后被固定，而限定假体瓣瓣的部分保持在所述构型中。 然后将生物组织片与成形装置分离，随后安装在假体的框架中。