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公开(公告)号：US20100305033A1
公开(公告)日：2010-12-02
申请号：US12747981
申请日：2008-12-15
申请人： Frank Hacket , Thomas Hey , Franziska Hauschild , Helmut Knoller , Martin Schimmel , Klaus Sommermeyer
发明人： Frank Hacket , Thomas Hey , Franziska Hauschild , Helmut Knoller , Martin Schimmel , Klaus Sommermeyer
IPC分类号： A61K31/718 , A61P19/10 , A61P7/04 , A61P37/04 , A61P35/00 , A61P35/02 , A61P7/06 , A61P29/00 , A61P43/00 , A61P11/00 , C08B31/00 , C07K17/10
CPC分类号： C08B31/00 , A61K47/61 , C08B31/125
摘要： The invention relates to a method for the preparation of a hydroxyalkyl starch derivative which comprises reacting hydroxyalkyl starch (HAS) via the optionally oxidised reducing end of the HAS with the amino group M of a crosslinking compound which, apart from the amino group, comprises a specifically protected carbonyl group, namely an acetal group or a ketal group.
摘要翻译： 本发明涉及一种制备羟烷基淀粉衍生物的方法，其包括将羟烷基淀粉（HAS）经由任选氧化的HAS还原端与交联化合物的氨基M反应，所述交联化合物除氨基以外还包含 特别保护的羰基，即缩醛基或缩酮基。
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公开(公告)号：US08404834B2
公开(公告)日：2013-03-26
申请号：US12747981
申请日：2008-12-15
申请人： Frank Hacket , Thomas Hey , Franziska Hauschild , Helmut Knoller , Martin Schimmel , Klaus Sommermeyer
发明人： Frank Hacket , Thomas Hey , Franziska Hauschild , Helmut Knoller , Martin Schimmel , Klaus Sommermeyer
CPC分类号： C08B31/00 , A61K47/61 , C08B31/125
摘要： The invention relates to a method for the preparation of a hydroxyalkyl starch derivative which comprises reacting hydroxyalkyl starch (HAS) via the optionally oxidized reducing end of the HAS with the amino group M of a crosslinking compound which, apart from the amino group, comprises a specifically protected carbonyl group, namely an acetal group or a ketal group.
摘要翻译： 本发明涉及一种制备羟烷基淀粉衍生物的方法，其包括将羟烷基淀粉（HAS）经由任选氧化的HAS还原端与交联化合物的氨基M反应，所述交联化合物除了氨基外，还包含 特别保护的羰基，即缩醛基或缩酮基。
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公开(公告)号：US08426357B2
公开(公告)日：2013-04-23
申请号：US12525902
申请日：2008-02-11
申请人： Ralf Kraehmer , Frank Leenders , Erik Fiedler , Thomas Hey , Ulrike Fiedler , Markus Fiedler
发明人： Ralf Kraehmer , Frank Leenders , Erik Fiedler , Thomas Hey , Ulrike Fiedler , Markus Fiedler
IPC分类号： A61K38/18 , A61K38/00 , A61K39/11 , A61K35/00 , A61K47/30 , C08G63/00 , C08G71/00 , C08G69/00 , C08G75/00 , C08G73/00 , C07K17/02 , C07K17/08
摘要： The present invention is directed to a multimeric agent and a multimeric conjugate formed from this multimeric agent and a biologically active agent. Said multimeric conjugates have a longer life time in vivo and an increased avidity compared to the unmodified biologically agent. The present invention is further directed to a pharmaceutical or diagnostic composition containing said conjugate as well as to a method of its production. The invention additionally provides the use of said conjugates for the detection, determination, separation and/or isolation of a specific binding partner and for the diagnosis, prophylaxis and treatment of diseases in which the specific binding partner is directly or indirectly involved.
摘要翻译： 本发明涉及由该多聚体试剂和生物活性剂形成的多聚体试剂和多聚体缀合物。 所述多聚体缀合物与未修饰的生物学试剂相比在体内具有更长的使用寿命和更高的亲合力。 本发明还涉及含有所述缀合物的药物或诊断组合物以及其制备方法。 本发明还提供所述缀合物用于特异性结合配偶体的检测，测定，分离和/或分离以及用于诊断，预防和治疗特异性结合配偶体直接或间接参与的疾病的用途。
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4.发明授权Ubiquitin or gamma-crystalline conjugates for use in therapy, diagnosis and chromatography 有权泛素或γ-结晶共轭物，用于治疗，诊断和色谱公开(公告)号：US07838629B2
公开(公告)日：2010-11-23
申请号：US11732632
申请日：2007-04-04
申请人： Erik Fiedler , Hilmar Ebersbach , Thomas Hey , Ulrike Fiedler
发明人： Erik Fiedler , Hilmar Ebersbach , Thomas Hey , Ulrike Fiedler
IPC分类号： C07K14/00
摘要： The present invention relates to conjugates containing a covalent linkage between one or more polypeptide molecules based on gamma-crystallin or ubiquitin and one or more functional components. Furthermore, the present invention relates to a method for the preparation of such a conjugate as well as to the use of the conjugate in diagnostics, therapy and chromatography.
摘要翻译： 本发明涉及含有基于γ-晶状蛋白或泛素的一种或多种多肽分子和一种或多种功能组分之间的共价键的缀合物。 此外，本发明涉及制备这种缀合物的方法以及在诊断，治疗和层析中使用该缀合物。
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公开(公告)号：US20100143387A1
公开(公告)日：2010-06-10
申请号：US12525902
申请日：2008-02-11
申请人： Ralf Kraehmer , Frank Leenders , Erik Fiedler , Thomas Hey , Ulrike Fiedler , Markus Fiedler
发明人： Ralf Kraehmer , Frank Leenders , Erik Fiedler , Thomas Hey , Ulrike Fiedler , Markus Fiedler
IPC分类号： A61K39/395 , C07D403/14 , C07C235/06 , C07K2/00 , C07K14/475 , C07H21/00 , C07K16/00 , A61K38/00 , A61K31/7088 , A61K31/4025 , A61K31/16
摘要： The present invention is directed to a multimeric agent and a multimeric conjugate formed from this multimeric agent and a biologically active agent. Said multimeric conjugates have a longer life time in vivo and an increased avidity compared to the unmodified biologically agent. The present invention is further directed to a pharmaceutical or diagnostic composition containing said conjugate as well as to a method of its production. The invention additionally provides the use of said conjugates for the detection, determination, separation and/or isolation of a specific binding partner and for the diagnosis, prophylaxis and treatment of diseases in which the specific binding partner is directly or indirectly involved.
摘要翻译： 本发明涉及由该多聚体试剂和生物活性剂形成的多聚体试剂和多聚体缀合物。 所述多聚体缀合物与未修饰的生物学试剂相比在体内具有更长的使用寿命和更高的亲合力。 本发明还涉及含有所述缀合物的药物或诊断组合物以及其制备方法。 本发明还提供所述缀合物用于特异性结合配偶体的检测，测定，分离和/或分离以及用于诊断，预防和治疗特异性结合配偶体直接或间接参与的疾病的用途。
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6.发明申请Ubiquitin or gamma-crystalline conjugates for use in therapy, diagnosis and chromatography 有权泛素或γ-结晶共轭物，用于治疗，诊断和色谱公开(公告)号：US20070248536A1
公开(公告)日：2007-10-25
申请号：US11732632
申请日：2007-04-04
申请人： Erik Fiedler , Hilmar Ebersbach , Thomas Hey , Ulrike Fiedler
发明人： Erik Fiedler , Hilmar Ebersbach , Thomas Hey , Ulrike Fiedler
摘要： The present invention relates to conjugates containing a covalent linkage between one or more polypeptide molecules based on gamma-crystallin or ubiquitin and one or more functional components. Furthermore, the present invention relates to a method for the preparation of such a conjugate as well as to the use of the conjugate in diagnostics, therapy and chromatography.
摘要翻译： 本发明涉及含有基于γ-晶状蛋白或泛素的一种或多种多肽分子和一种或多种功能组分之间的共价键的缀合物。 此外，本发明涉及制备这种缀合物的方法以及在诊断，治疗和层析中使用该缀合物。
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