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公开(公告)号:US20140045802A1
公开(公告)日:2014-02-13
申请号:US13612435
申请日:2012-09-12
申请人: Franz Von Nussbaum , Dagmar Karthaus , Sonja Anlauf , Martina Delbeck , Volkhart Min-Jian Li , Daniel Meibom , Klemens Lustig , Jens Schamberger
发明人: Franz Von Nussbaum , Dagmar Karthaus , Sonja Anlauf , Martina Delbeck , Volkhart Min-Jian Li , Daniel Meibom , Klemens Lustig , Jens Schamberger
IPC分类号: C07D239/22 , A61K31/5377 , C07D409/12 , C07D403/06 , C07D401/06 , A61K31/519 , C07D487/04 , A61K31/541 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07D405/12 , A61K45/06 , C07D413/06 , C07D417/12 , A61K31/513
CPC分类号: C07D487/04 , A61K31/513 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D239/22 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/06 , C07D413/12 , C07D417/12
摘要: The present invention relates to novel 4-(4-cyano-2-thioaryl)dihydropyrimidin-2-one derivatives, to processes for their preparation, to their use alone or in combination for the treatment and/or prevention of diseases and also to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of disorders of the lung and the cardiovascular system.
摘要翻译: 本发明涉及新的4-(4-氰基-2-硫代芳基)二氢嘧啶-2-酮衍生物,其制备方法,单独使用或组合用于治疗和/或预防疾病,以及它们 用于制备治疗和/或预防疾病的药物,特别是用于治疗和/或预防肺和心血管系统疾病。
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公开(公告)号:US08288402B2
公开(公告)日:2012-10-16
申请号:US12809781
申请日:2008-12-09
申请人: Franz Von Nussbaum , Dagmar Karthaus , Sonja Anlauf , Martina Delbeck , Volkhart Min-Jian Li , Daniel Meibom , Klemens Lustig , Jens Schamberger
发明人: Franz Von Nussbaum , Dagmar Karthaus , Sonja Anlauf , Martina Delbeck , Volkhart Min-Jian Li , Daniel Meibom , Klemens Lustig , Jens Schamberger
IPC分类号: A01N43/54 , A61K31/505
CPC分类号: C07D487/04 , A61K31/513 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D239/22 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/06 , C07D413/12 , C07D417/12
摘要: The present invention relates to novel 4-(4-cyano-2-thioaryl)dihydropyrimidin-2-one derivatives, to processes for their preparation, to their use alone or in combination for the treatment and/or prevention of diseases and also to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of disorders of the lung and the cardiovascular system.
摘要翻译: 本发明涉及新的4-(4-氰基-2-硫代芳基)二氢嘧啶-2-酮衍生物,其制备方法,单独使用或组合用于治疗和/或预防疾病,以及它们 用于制备治疗和/或预防疾病的药物,特别是用于治疗和/或预防肺和心血管系统疾病。
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公开(公告)号:US08889700B2
公开(公告)日:2014-11-18
申请号:US13612435
申请日:2012-09-12
申请人: Franz Von Nussbaum , Dagmar Karthaus , Sonja Anlauf , Martina Delbeck , Volkhart Min-Jian Li , Daniel Meibom , Klemens Lustig , Jens Schamberger
发明人: Franz Von Nussbaum , Dagmar Karthaus , Sonja Anlauf , Martina Delbeck , Volkhart Min-Jian Li , Daniel Meibom , Klemens Lustig , Jens Schamberger
IPC分类号: A01N43/54 , A61K31/505 , C07D413/06 , C07D401/06 , C07D403/06 , A61K31/541 , C07D403/12 , C07D405/12 , C07D487/04 , C07D239/22 , A61K31/513 , C07D401/14 , A61K31/5377 , C07D417/12 , A61K31/519 , C07D401/12 , A61K45/06 , C07D413/12 , C07D409/12
CPC分类号: C07D487/04 , A61K31/513 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D239/22 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/06 , C07D413/12 , C07D417/12
摘要: The present invention relates to novel 4-(4-cyano-2-thioaryl)dihydropyrimidin-2-one derivatives, to processes for their preparation, to their use alone or in combination for the treatment and/or prevention of diseases and also to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of disorders of the lung and the cardiovascular system.
摘要翻译: 本发明涉及新的4-(4-氰基-2-硫代芳基)二氢嘧啶-2-酮衍生物,其制备方法,单独使用或组合用于治疗和/或预防疾病,以及它们 用于制备治疗和/或预防疾病的药物,特别是用于治疗和/或预防肺和心血管系统疾病。
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公开(公告)号:US20110034433A1
公开(公告)日:2011-02-10
申请号:US12809781
申请日:2008-12-09
申请人: Franz Von Nussbaum , Dagmar Karthaus , Sonja Anlauf , Martina Delbeck , Volkhart Min-Jian Li , Daniel Meibom , Klemens Lustig , Jens Schamberger
发明人: Franz Von Nussbaum , Dagmar Karthaus , Sonja Anlauf , Martina Delbeck , Volkhart Min-Jian Li , Daniel Meibom , Klemens Lustig , Jens Schamberger
IPC分类号: A61K31/513 , C07D239/22 , C07D413/12 , A61K31/5377 , C07D409/12 , C07D403/12 , C07D401/12 , C07D487/04 , A61K31/519 , C07D417/06 , A61K31/541 , C07D401/14 , C07D405/12 , A61P9/12 , A61P9/00 , A61P11/00
CPC分类号: C07D487/04 , A61K31/513 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D239/22 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/06 , C07D413/12 , C07D417/12
摘要: The present invention relates to novel 4-(4-cyano-2-thioaryl)dihydropyrimidin-2-one derivatives, to processes for their preparation, to their use alone or in combination for the treatment and/or prevention of diseases and also to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of disorders of the lung and the cardiovascular system.
摘要翻译: 本发明涉及新的4-(4-氰基-2-硫代芳基)二氢嘧啶-2-酮衍生物,其制备方法,单独使用或组合用于治疗和/或预防疾病,以及它们 用于制备治疗和/或预防疾病的药物,特别是用于治疗和/或预防肺和心血管系统疾病。
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公开(公告)号:US08143411B2
公开(公告)日:2012-03-27
申请号:US12676568
申请日:2008-08-26
申请人: Lars Bärfacker , Barbara Albrecht-Küpper , Peter Kolkhof , Yolanda Cancho Grande , Adam Nitsche , Heinrich Meier , Carsten Schmeck , Jens Schamberger , Klemens Lustig
发明人: Lars Bärfacker , Barbara Albrecht-Küpper , Peter Kolkhof , Yolanda Cancho Grande , Adam Nitsche , Heinrich Meier , Carsten Schmeck , Jens Schamberger , Klemens Lustig
IPC分类号: C07D211/78 , A61K31/44
CPC分类号: C07D213/80
摘要: The present application relates to novel substituted 6-phenylnicotinic acid derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prophylaxis of cardiovascular disorders, in particular dyslipidaemias, arteriosclerosis and heart failure.
摘要翻译: 本申请涉及新的取代的6-苯基烟酸衍生物,其制备方法,其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病的药物的用途,优选用于 治疗和/或预防心血管疾病,特别是血脂异常,动脉硬化和心力衰竭。
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公开(公告)号:US20100234432A1
公开(公告)日:2010-09-16
申请号:US12676568
申请日:2008-08-26
申请人: Lars Baerfacker , Barbara Albrecht-Kuepper , Peter Kolkhof , Yolanda Cancho Grande , Adam Nitsche , Heinrich Meier , Carsten Schmeck , Jens Schamberger , Klemens Lustig
发明人: Lars Baerfacker , Barbara Albrecht-Kuepper , Peter Kolkhof , Yolanda Cancho Grande , Adam Nitsche , Heinrich Meier , Carsten Schmeck , Jens Schamberger , Klemens Lustig
IPC分类号: A61K31/44 , C07D213/55 , C07D213/78 , A61P9/10
CPC分类号: C07D213/80
摘要: The present application relates to novel substituted 6-phenylnicotinic acid derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prophylaxis of cardiovascular disorders, in particular dyslipidaemias, arteriosclerosis and heart failure.
摘要翻译: 本申请涉及新的取代的6-苯基烟酸衍生物,其制备方法,其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病的药物的用途,优选用于 治疗和/或预防心血管疾病,特别是血脂异常,动脉硬化和心力衰竭。
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7.
公开(公告)号:US20070099927A1
公开(公告)日:2007-05-03
申请号:US10576698
申请日:2004-10-12
申请人: Achim Feurer , Sara Bosio , Stephan Bulat , Silvia Cerezo-Galvez , Victor Matassa , Inge Ott , Michael Papadopoulos , Claudia Rosenbaum , Jens Schamberger , Gunther Metz
发明人: Achim Feurer , Sara Bosio , Stephan Bulat , Silvia Cerezo-Galvez , Victor Matassa , Inge Ott , Michael Papadopoulos , Claudia Rosenbaum , Jens Schamberger , Gunther Metz
IPC分类号: A61K31/497 , A61K31/4965 , A61K31/506 , A61K31/4745 , C07D403/02 , C07D401/02 , A61K31/4709
CPC分类号: C07D401/12 , C07D241/20 , C07D401/14 , C07D409/12 , C07D409/14
摘要: The invention relates to compounds of formula (I) wherein A, B, X, R1, R2, G, R3, D and E have the meaning as cited in the description and the claims. Said compounds are useful as coagulants. The invention also relates to the production and use thereof as medicament.
摘要翻译: 本发明涉及式(I)化合物,其中A,B,X,R 1,R 2,G,R 3,D 和E具有在说明书和权利要求书中引用的含义。 所述化合物可用作凝结剂。 本发明还涉及其作为药物的生产和使用。
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