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16 条记录 (耗时 0.055 秒)

    Substituted benzene derivatives or salts thereof
    5.
    发明授权
    Substituted benzene derivatives or salts thereof 失效
    取代的苯衍生物或其盐

    公开(公告)号：US07786106B2

    公开(公告)日：2010-08-31

    申请号：US12356376

    申请日：2009-01-20

    申请人： Tsukasa Ishihara ,  Fukushi Hirayama ,  Keizo Sugasawa ,  Yuji Koga ,  Takeshi Kadokura ,  Takeshi Shigenaga

    发明人： Tsukasa Ishihara ,  Fukushi Hirayama ,  Keizo Sugasawa ,  Yuji Koga ,  Takeshi Kadokura ,  Takeshi Shigenaga

    IPC分类号： A61K31/551 ,  C07D243/08

    CPC分类号： C07D401/12 ,  C07D211/26 ,  C07D401/14 ,  C07H15/203 ,  C07H15/26

    摘要： There are provided compounds having an anticoagulant action on the basis of inhibition of activated blood coagulation factor X and being useful as anticoagulants or preventive/therapeutic agents for diseases induced by thrombosis or embolism. Effective ingredients are the compounds such as 4′-bromo-2′-[(5-chloro-2-pyridyl) carbamoyl]-6′-β-D-galactopyranosyloxy-1-isopropylpiperidine-4-carboxanilide, 2′-(2-acetamido-2-deoxy-β-D-glucopyranosyloxy)-4′-bromo-6′-[(5-chloro-2-pyridyl)carbamoyl]-1-isopropylpiperidine-4-carboxanilide, etc. or salts thereof.

    摘要翻译： 提供了基于活化凝血因子X的抑制具有抗凝血作用的化合物，并且可用作血栓形成或栓塞引起的疾病的抗凝剂或预防/治疗剂。 有效成分是诸如4'-溴-2' - [（5-氯-2-吡啶基）氨基甲酰基] -6' - （b-）-D-吡喃半乳糖氧基-1-异丙基哌啶-4-甲酰苯胺，2' - （ -2'-乙酰氨基-2-脱氧-α-D-吡喃葡萄糖基氧基）-4'-溴-6' - [（5-氯-2-吡啶基）氨基甲酰基] -1-异丙基哌啶-4-甲酰苯胺等或其盐 。

    SUBSTITUTED BENZENE DERIVATIVES OR SALTS THEREOF
    6.
    发明申请
    SUBSTITUTED BENZENE DERIVATIVES OR SALTS THEREOF 失效
    取代的苯甲酸衍生物或其盐

    公开(公告)号：US20090137498A1

    公开(公告)日：2009-05-28

    申请号：US12356376

    申请日：2009-01-20

    申请人： Tsukasa Ishihara ,  Fukushi Hirayama ,  Keizo Sugasawa ,  Yuji Koga ,  Takeshi Kadokura ,  Takeshi Shigenaga

    发明人： Tsukasa Ishihara ,  Fukushi Hirayama ,  Keizo Sugasawa ,  Yuji Koga ,  Takeshi Kadokura ,  Takeshi Shigenaga

    IPC分类号： A61K31/704 ,  C07D211/26

    CPC分类号： C07D401/12 ,  C07D211/26 ,  C07D401/14 ,  C07H15/203 ,  C07H15/26

    摘要： There are provided compounds having an anticoagulant action on the basis of inhibition of activated blood coagulation factor X and being useful as anticoagulants or preventive/therapeutic agents for diseases induced by thrombosis or embolism. Effective ingredients are the compounds such as 4′-bromo-2′-[(5-chloro-2-pyridyl)carbamoyl]-6′-β-D-galactopyranosyloxy-1-isopropylpiperidine-4-carboxanilide, 2′-(2-acetamido-2-deoxy-β-D-glucopyranosyloxy)-4′-bromo-6′-[(5-chloro-2-pyridyl)carbamoyl]-1-isopropylpiperidine-4-carboxanilide, etc. or salts thereof.

    摘要翻译： 提供了基于活化凝血因子X的抑制具有抗凝血作用的化合物，并且可用作血栓形成或栓塞引起的疾病的抗凝剂或预防/治疗剂。 有效成分是诸如4'-溴-2' - [（5-氯-2-吡啶基）氨基甲酰基] -6'-β-D-吡喃半乳糖氧基-1-异丙基哌啶-4-甲酰苯胺，2' - （2 - 乙酰氨基-2-脱氧-β-D-吡喃葡萄糖基氧基）-4'-溴-6' - [（5-氯-2-吡啶基）氨基甲酰基] -1-异丙基哌啶-4-甲酰苯胺等或其盐。

    Hexahydro-1,4-diazepine derivatives or salts thereof
    7.
    发明授权
    Hexahydro-1,4-diazepine derivatives or salts thereof 失效
    六氢-1,4-二氮杂衍生物或其盐

    公开(公告)号：US06333320B1

    公开(公告)日：2001-12-25

    申请号：US09463017

    申请日：2000-01-19

    申请人： Hiroyuki Koshio ,  Fukushi Hirayama ,  Tsukasa Ishihara ,  Masashi Funatsu ,  Tomihisa Kawasaki ,  Yuzo Matsumoto

    发明人： Hiroyuki Koshio ,  Fukushi Hirayama ,  Tsukasa Ishihara ,  Masashi Funatsu ,  Tomihisa Kawasaki ,  Yuzo Matsumoto

    IPC分类号： A61K3155

    CPC分类号： C07D405/12 ,  C07D243/08

    摘要： Hexahydro-1,4-diazepine derivatives represented by general formula (I); pharmaceutically acceptable salts thereof; and drugs containing the same as the active ingredient, such as activated blood coagulation factor X inhibitor, wherein A: phenylene, pyridylene, or the like; B: a 5- or 6-membered aryl or heteroaryl ring; X: —CO—, —CONH—, —CSNH—, —SO2—, —SO2NH—, or the like; Y: a bond or alkylene; R1: hydrogen, alkyl, —Y—(hetero) aryl, or the like; R2: hydrogen, alkoxy, —COOH, or the like; R3: amidino or a group capable of being converted into amidino; and R4, R5: each independently hydrogen or lower alkyl.

    摘要翻译： 由通式（I）表示的六氢-1,4-二氮杂衍生物; 其药学上可接受的盐; 以及与活性成分相同的药物，例如活化凝血因子X抑制剂，其中A：亚苯基，亚吡啶基等; B：5-或6-元芳基或杂芳基环; X：-CO - ， - CONH - ， - CSH - ， - SO 2 - ， - SO 2 NH-等; Y：一个键或亚烷基; R1：氢，烷基，-Y-（杂）芳基等; R2：氢，烷氧基，-COOH等; R3：脒基或能够转化为脒基的基团; 和R 4，R 5：各自独立地为氢或低级烷基。

    Porous material production method
    10.
    发明授权
    Porous material production method 有权
    多孔材料生产方法

    公开(公告)号：US08518490B2

    公开(公告)日：2013-08-27

    申请号：US12749921

    申请日：2010-03-30

    申请人： Koju Ito ,  Tsukasa Ishihara ,  Hidekazu Yamazaki

    发明人： Koju Ito ,  Tsukasa Ishihara ,  Hidekazu Yamazaki

    IPC分类号： B05D5/00

    CPC分类号： C08J5/18 ,  C08J9/28

    摘要： In a coating zone, a cylindrical tube is soaked in and taken out from a solution, such that a coating film is formed on a curved surface of the tube. In a wet gas zone, while a first gas feeding nozzle having a gas outlet moves in a state where the gas outlet faces an outer peripheral surface of the tube, wet gas is blown toward the coating film through the gas outlet. Water drops are generated on the coating film and grown up. In a dry gas zone, as in the case of the first gas feeding nozzle, while a second gas feeding nozzle having a gas outlet moves, dry gas is blown toward the coating film through the gas outlet. Solvent and water drops are evaporated from the coating film. Pores form from the water drops as a template for the porous material on the coating film.

    摘要翻译： 在涂布区域中，将圆筒形管浸泡并从溶液中取出，使得在管的弯曲表面上形成涂膜。 在湿气区域中，具有气体出口的第一气体供给喷嘴在气体出口朝向管的外周面的状态下移动，湿气通过气体出口吹向涂膜。 在涂膜上产生水滴并长大。 在干燥气体区域中，与第一气体供给喷嘴的情况相同，当具有气体出口的第二气体供给喷嘴移动时，干燥气体通过气体出口吹向涂膜。 溶剂和水滴从涂膜中蒸发掉。 从水滴形成孔，作为涂膜上的多孔材料的模板。