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25 条记录 (耗时 0.055 秒)

    ORGANIC COMPOUNDS
    1.
    发明申请
    ORGANIC COMPOUNDS 有权
    有机化合物

    公开(公告)号：US20130005770A1

    公开(公告)日：2013-01-03

    申请号：US13616081

    申请日：2012-09-14

    申请人： Fumiaki Yokokawa ,  Takeru Ehara ,  Shimpei Kawakami ,  Osamu Irie ,  Masaki Suzuki ,  Yuko Hitomi ,  Atsushi Toyao

    发明人： Fumiaki Yokokawa ,  Takeru Ehara ,  Shimpei Kawakami ,  Osamu Irie ,  Masaki Suzuki ,  Yuko Hitomi ,  Atsushi Toyao

    IPC分类号： A61K31/4545 ,  A61P9/12 ,  A61P9/10 ,  A61P9/04 ,  A61P27/02 ,  A61P13/12 ,  A61P1/16 ,  A61P25/28 ,  A61P25/22 ,  C07D401/12 ,  A61P9/00

    CPC分类号： C07D401/12

    摘要： The present invention relates to a compound of the formula I wherein R1, R2, R3, R4 and R5 are as defined in the specification, for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations a compound of that class; a method of treatment comprising administering a compound of that class and a method for its manufacture.

    摘要翻译： 本发明涉及式I化合物，其中R1，R2，R3，R4和R5如说明书中所定义，用于诊断和治疗温血动物，特别是用于治疗疾病 （=无效），依赖于肾素的活性; 使用该类化合物制备用于治疗依赖于肾素活性的疾病的药物制剂; 使用该类化合物治疗依赖于肾素活性的疾病; 药物制剂是该类化合物; 一种治疗方法，包括施用该类化合物及其制备方法。

    Organic compounds
    2.
    发明授权
    Organic compounds 有权
    有机化合物

    公开(公告)号：US08497286B2

    公开(公告)日：2013-07-30

    申请号：US13616081

    申请日：2012-09-14

    申请人： Fumiaki Yokokawa ,  Takeru Ehara ,  Shimpei Kawakami ,  Osamu Irie ,  Masaki Suzuki ,  Yuko Hitomi ,  Atsushi Toyao

    发明人： Fumiaki Yokokawa ,  Takeru Ehara ,  Shimpei Kawakami ,  Osamu Irie ,  Masaki Suzuki ,  Yuko Hitomi ,  Atsushi Toyao

    IPC分类号： A61K31/444 ,  C07D211/32

    CPC分类号： C07D401/12

    摘要： The present invention relates to a compound of the formula I wherein R1, R2, R3, R4 and R5 are as defined in the specification, for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations a compound of that class; a method of treatment comprising administering a compound of that class and a method for its manufacture.

    摘要翻译： 本发明涉及式I化合物，其中R1，R2，R3，R4和R5如说明书中所定义，用于诊断和治疗温血动物，特别是用于治疗疾病 （=无效），依赖于肾素的活性; 使用该类化合物制备用于治疗依赖于肾素活性的疾病的药物制剂; 使用该类化合物治疗依赖于肾素活性的疾病; 药物制剂是该类化合物; 一种治疗方法，包括施用该类化合物及其制备方法。

    ORGANIC COMPOUNDS
    4.
    发明申请
    ORGANIC COMPOUNDS 有权
    有机化合物

    公开(公告)号：US20080319018A1

    公开(公告)日：2008-12-25

    申请号：US12146073

    申请日：2008-06-25

    申请人： Fumiaki Yokokawa ,  Takeru Ehara ,  Shimpei Kawakami ,  Osamu Irie ,  Masaki Suzuki ,  Yuku Hitomi ,  Atsushi Toyao

    发明人： Fumiaki Yokokawa ,  Takeru Ehara ,  Shimpei Kawakami ,  Osamu Irie ,  Masaki Suzuki ,  Yuku Hitomi ,  Atsushi Toyao

    IPC分类号： A61K31/4545 ,  C07D401/12 ,  A61P43/00

    CPC分类号： C07D401/12

    摘要： The present invention relates to a compound of the formula I wherein R1, R2, R3, R4 and R5 are as defined in the specification, for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations a compound of that class; a method of treatment comprising administering a compound of that class and a method for its manufacture.

    摘要翻译： 本发明涉及式I化合物，其中R1，R2，R3，R4和R5如说明书中所定义，用于诊断和治疗温血动物，特别是用于治疗疾病 （=无效），依赖于肾素的活性; 使用该类化合物制备用于治疗依赖于肾素活性的疾病的药物制剂; 使用该类化合物治疗依赖于肾素活性的疾病; 药物制剂是该类化合物; 一种治疗方法，包括施用该类化合物及其制备方法。

    3, 4, 5 - Substituted Piperidine Compounds
    7.
    发明申请
    3, 4, 5 - Substituted Piperidine Compounds 审中-公开
    3，4，5 - 取代的哌啶化合物

    公开(公告)号：US20100160305A1

    公开(公告)日：2010-06-24

    申请号：US11908182

    申请日：2006-03-07

    申请人： Keiichi Masuya ,  Fumiaki Yokokawa ,  Osamu Irie ,  Atsuko Nihonyanagi ,  Takeru Ehara ,  Kazuhide Konishi ,  Takanori Kanazawa ,  Masaki Suzuki

    发明人： Keiichi Masuya ,  Fumiaki Yokokawa ,  Osamu Irie ,  Atsuko Nihonyanagi ,  Takeru Ehara ,  Kazuhide Konishi ,  Takanori Kanazawa ,  Masaki Suzuki

    IPC分类号： A61K31/451 ,  A61K31/538 ,  A61K31/454 ,  C07D413/12 ,  C07D401/12 ,  C07D211/60 ,  A61P43/00

    CPC分类号： C07D401/12 ,  C07D211/60 ,  C07D413/12

    摘要： 3,4,5-substituted piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations comprising a 3,4,5-substituted piperidine compound, and/or a method of treatment comprising administering a 3,4,5-substituted piperidine compound, a method for the manufacture of a 3,4,5-substituted piperidine compound, and novel intermediates and partial steps for its synthesis.The compounds are of the formula I, wherein the substitutents are as defined in the specification.

    摘要翻译： 3,4,5-取代的哌啶化合物，这些化合物用于诊断和治疗温血动物，特别是用于治疗依赖于肾素活性的疾病（=病症）; 使用该类化合物制备用于治疗依赖于肾素活性的疾病的药物制剂; 使用该类化合物治疗依赖于肾素活性的疾病; 包含3,4,5-取代的哌啶化合物的药物制剂和/或治疗方法，包括给予3,4,5-取代的哌啶化合物，制备3,4,5-取代哌啶化合物的方法 ，以及其合成的新型中间体和部分步骤。 化合物是式I，其中取代基如说明书中所定义。