摘要:
A rifamycin derivative having the formula (I): ##STR1## wherein R.sup.1 is hydrogen atom, methyl group or ethyl group, R.sup.2 is an alkyl group having 1 to 4 carbon atoms, and A is a group having the formula: ##STR2## in which n is an integer of 3 to 5, or group having the formula: ##STR3## in which R.sup.3 is a alkyl group having 1 to 5 carbon atoms; or a salt thereof. The rifamycin derivative (I) exhibits a strong antibacterial activity against Gram-positive bacteria and acid-fast bacteria, and also exhibits a strong antibacterial activity against tubercle bacilli.
摘要:
A new anti-inflammatory, analgesic, and antipyretic pharmaceutical composition is disclosed which contains a 3,5-di-tert-butyl-4-hydroxystyrene derivative of the formula: ##STR1## wherein R.sup.1 stands for a group represented by COR.sup.3 [R.sup.3 denotes a group of OR.sup.4 (R.sup.4 is a hydrogen atom or an alkyl group with C.sub.1 .about.C.sub.4), an alkyl group with C.sub.1 .about.C.sub.3, a phenyl group, or an amino group], a nitro group, or an alkylsulfonyl group represented by SO.sub.2 R.sup.5 (R.sup.5 is an alkyl group with C.sub.1 .about.C.sub.3); and R.sup.2 stands for a hydrogen atom, an alkyl group with C.sub.1 .about.C.sub.4, a hydroxyalkyl group with C.sub.1 .about.C.sub.4, a cyano group, or an acyl group represented by COR.sup.6 (R.sup.6 is an alkyl group with C.sub.1 .about.C.sub.3),or its pharmaceutically acceptable salt as an active ingredient in association with pharmaceutical excipients. The pharmaceutical composition has excellent anti-inflammatory, analgesic, and antipyretic activities and low toxicity.
摘要:
Novel compounds, 3,5-di-tert-butylstyrene derivatives and their salts, are disclosed, which derivatives are represented by the general formula: ##STR1## wherein R.sup.1 stands for an acyloxy group represented by R.sup.3 COO (R.sup.3 is a hydrogen atom or an alkyl group with C.sub.1 -C.sub.6), an alkoxyl group of R.sub.4 O (R.sup.4 is an alkyl group with C.sub.1 -C.sub.4), a hydroxyl group, or a hydrogen atom; R.sup.2 stands for ##STR2## (R.sup.5 is a hydrogen atom or an alkyl group with C.sub.1 -C.sub.3 and X.sup.1 is CH.sub.2 or an oxygen atom), ##STR3## (R.sup.5 and X.sup.1 are each the same as defined above), or ##STR4## (X.sup.2 is an oxygen or sulfur atom). There are also disclosed an anti-inflammatory, analgesic, and antipyretic pharmaceutical composition and an anti-platelet aggregation pharmaceutical composition, both pharmaceutical compositions comprising the foregoing 3,5-di-tert-butylstyrene derivative or its pharmaceutically acceptable salt as an active ingredient in association with pharmaceutical excipients.
摘要:
A process is disclosed wherein an optically active N-mercaptoalkanoylamino acid is prepared by(1) reacting an optically active .beta.-hydroxyalkanoic acid, with a halogenating reagent to prepare an optically active .beta.-haloalkanoyl halide(2) reacting the .beta.-haloalkanoyl halide with an amino acid to produce an optically active N-.beta.-haloalkanoylamino acid and(3) reacting the N-.beta.-haloalkanoylamino acid with a reagent capable of converting the halogen into the thiol group, the configuration of the formulas (II), (III), (IV), (V), and (VI) being retained in all the optically active compounds throughout the process to prepare the compound represented by formula (I). The product of the present invention, for example, N-(3-mercapto-2-D-methylpropanoyl)-L-proline inhibits the enzymatic conversion of angiotensin I into angiotensin II and therefore is useful for relieving angiotensin-related hypertension.
摘要:
The invention is directed to decreasing the power consumption of a remote control signal receiving circuit. A receiving circuit includes a timing signal generation circuit generating a timing signal, a power supply circuit intermittently operating a light receiving element receiving a remote control signal by supplying power to the light receiving element when the timing signal is at a first level and by halting supplying power to the light receiving element when the timing signal is at a second level, a sampling signal generation circuit generating a sampling signal during the operation of the light receiving element corresponding to the timing signal, a sampling circuit sampling an output signal from the light receiving element corresponding to the sampling signal, and a detection circuit detecting the output signal sent from the light receiving element and sampled by the sampling circuit.
摘要:
A remaining battery power calculation circuit includes: a detection unit configured to detect an output voltage of a battery; a data storage unit configured to store data in an associated manner with each of a plurality of current values for charge or discharge of the battery, the data indicating a relationship between the output voltage and a ratio of remaining power of the battery to a capacity of the battery in a case where the battery is charged or discharged with each of the plurality of current values; and a first calculation unit configured to calculate a charging/discharging current of the battery based on the data and the output voltage.
摘要:
A support mechanism of a steering system that supports a steering column to a part of a vehicle body includes an energy absorbing member mounted on the side of a steering column or the vehicle body, a support pin mounted on the side of the vehicle body or the steering column, that deforms the energy absorbing member when the steering column moves relative to the vehicle body, and an actuator mounted on the side of the steering column or the vehicle body, that changes deformation characteristics of the energy absorbing member.
摘要:
The invention reduces unnecessary electromagnetic radiation noise associated with a step pulse of an output signal. A random number control register is a register for controlling start, standby, stop, timing or the like of output of random number data from a random number generation circuit. Random number data outputted by the random number generation circuit is stored in a rise/fall time variable data register. The data stored in the rise/fall time variable data register is replaced by random number data sequentially generated by the random number generation circuit. An output circuit is a circuit for outputting a signal from an internal circuit of a microcomputer to an external device, and the rise/fall times of the output signal from the output circuit are variably controlled in response to the random number data stored in the rise/fall time variable data register.
摘要:
This invention makes it possible to reduce a power consumption of an electronic circuit (microcomputer, for example) while preventing malfunctioning of an oscillator by appropriately setting a power supply impedance of a low frequency oscillator corresponding to an operation mode. A high frequency oscillator, a medium frequency oscillator and a low frequency oscillator are provided as sources of system clocks. In addition, there is provided a quartz oscillator to generate a clock for a timepiece. When the high frequency oscillator is in operation, a power supply impedance of the quartz oscillator is reduced to improve a noise tolerance. In a waiting period during which the high frequency oscillator, the medium frequency oscillator and the low frequency oscillator are halted, on the other hand, the power supply impedance of the quartz oscillator is increased to suppress the power consumption.
摘要:
At least one caisson which is part or all of a breakwater forms a water chamber therein whose closure is a pendulum having a natural period in rocking or oscillating the same as a period of stationary wave surges caused in the water chamber by rocking movement of the pendulum owing to wave force impinging against the pendulum. At least one double-acting piston and cylinder assembly is connected to the pendulum, so that when a piston of the assembly is reciprocatively moved by the pendulum, pressure difference between cylinder chambers on both sides of the piston of the assembly controls a change-over valve which in turn controls hydraulic pressure discharged from the cylinder chambers to be supplied to a plurality of hydraulic motors respectively having accumulators of a type wherein accumulated pressure and volume of the hydraulic liquid are proportional to each other, whereby driving a common generator alternately by the hydraulic motors.