摘要:
Dihydrodesoxygriseolic acid, which has the formula ##STR1## and salts and esters thereof may be prepared by cultivating a suitable strain of Streptomyces, e.g. Streptomyces griseoaurantiacus No. 43894, and, if necessary, salifying or esterifying the free acid. These compounds inhibit the activity of various cyclic nucleotide phosphodiesterases, particularly cAMP PDE, and, as a result of this, have a variety of physiological activities and uses.
摘要:
A new compound, named "Griseolic acid", and its salts and can be prepared by the cultivation of Streptomyces griseoaurantiacus SANK 63479 (FERM-P 5223). Griseolic acid and its salts inhibit the activity of the enzyme cyclic adenosine monophosphate phosphodiesterase and, as a result of this, have variety of physiological activities and uses.
摘要:
Griseolic acid derivatives of formula (I): ##STR1## wherein A represents: ##STR2## have enzyme-inhibitory activity, especially against cAMP PDE and cGMP PDE. When formulated as compositions with appropriate carriers or diluents, they may be used for the treatment of a variety of organic disorders and show toxicities less than griseolic acid itself.
摘要:
An ornamental panel for automobiles has a synthetic resin cover. An attaching base is molded separately from the cover and disposed opposite a rear surface of the cover. The cover is molded of a translucent material. The cover has its outer surface made smooth and its inner surface formed with a fine rugged pattern such as crimps. The base has a surface with a rugged pattern of a dimension larger than a dimension of the crimps of the cover. The pattern of the base may be hemispheric concave fisheyes which are two-dimensionally arranged side by side, for example. A metallic film is coated on the pattern of the base.
摘要:
To provide a therapeutic agent for inflammatory bowel disease.The therapeutic agent for inflammatory bowel disease contains, as an active ingredient, a uracil derivative or a pharmaceutically acceptable salt thereof, represented by formula (1).
摘要:
In an anti-skid brake control system incorporated with dual hydraulic braking circuits for independently controlling respective braking fluids supplied to the right and left rear-wheel brake cylinders from a tandem master cylinder, an electronic anti-skid brake control apparatus is incorporated with one of the hydraulic braking circuits for decreasing the pressure applied to one of the rear-wheel brake cylinders from the master cylinder in response to an electric signal indicative of a predetermined wheel locking condition, and a modulator valve assembly is incorporated with the other hydraulic braking circuit to cooperate with the anti-skid brake control apparatus so as to control the pressure applied to the other rear-wheel brake cylinder in response to activation of the anti-skid brake control apparatus.
摘要:
The efficiency of silver recovery from photographic processing solutions is improved by the installation of a silver recovery water tank between the fix or blix tank and the wash water tank, which is provided with a mechanism for maintaining the silver concentration of said recovery tank at a substantially constant value, said mechanism comprising a detecting means for measuring the amount of the photographic material treated by the processing line involved and a means to supply water thereto operatable by signal from said detecting means.
摘要:
A braking system of a motor vehicle including an accumulator, being coupled to a to motor-driven pump, for accumulating a hydraulic pressure which is supplied to a braking device to brake a wheel of the motor vehicle and a control valve provided between the accumulator and the braking device for regulating the hydraulic pressure to be applied from the accumulator to the braking device. Also included in the braking system is a control unit for controlling the control valve in accordance with the condition of the wheel. The control unit controls the motor-driven pump on the basis of the control time of the control valve.
摘要:
A bucket cooled by circulating water and scrap preheating apparatus incorporating the bucket are disclosed. The bucket comprises a bucket-shaped container which contains scrap to be preheated and through which an exhaust gas from an electric furnace is passed to preheat the scrap contained therein, a cooling water passageway which surrounds the periphery of said container, and water supply and exhaust ports which are connected to said cooling water passageway, cooling water being supplied to and exhausted from the bucket during preheating of the scrap contained therein.
摘要:
A regulator valve for a hydraulic anti-skid apparatus and which includes a housing provided with a first inlet port for connection to a fluid pump and the anti-skid apparatus, a second inlet port for connection to a master cylinder, and an outlet port for connection to a fluid reservoir, a regulator piston reciprocably disposed within the housing to form a first fluid chamber in open communication with the first inlet and outlet ports and a second fluid chamber in open communication with the second inlet port, and a spring loaded annular valve seat member arranged within the first fluid chamber to cooperate with a valve part of the piston so as to control the fluid flow from the first inlet port to the outlet port in response to the difference in pressure between the fluid chambers. A support member is arranged within the first fluid chamber formed therein with an axial bore in which a large diameter portion of the piston is slidably disposed to form a third annular fluid chamber. The support member is further formed with an orifice for effecting the fluid flow between the first and third fluid chambers in response to axial movement of the piston.