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1.发明授权Process for the alkylation of 3,4-dihydroxythiophene-2,5-dicarboxylic esters 失效3,4-二羟基噻吩-2,5-二羧酸酯的烷基化方法公开(公告)号：US06750354B2
公开(公告)日：2004-06-15
申请号：US10256836
申请日：2002-09-27
IPC分类号： C07D40900
CPC分类号： C07D495/04 , C07D333/38
摘要： The invention relates to a process for the alkylation of 3,4-dihydroxythiophene-2,5-dicarboxylic esters or their alkali metal or alkaline earth metal salts with alkylating agents in a polar diluent in the presence of quaternary onium salts.
摘要翻译： 本发明涉及在季鎓盐存在下，在极性稀释剂中用烷基化剂烷基化3,4-二羟基噻吩-2,5-二羧酸酯或其碱金属或碱土金属盐的方法。
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公开(公告)号：US06825357B2
公开(公告)日：2004-11-30
申请号：US10191647
申请日：2002-07-09
IPC分类号： C07D33374
CPC分类号： C07D495/04 , C08G61/126
摘要： The invention relates to substituted or unsubstituted benzodioxinothiophenes, their preparation and their use for preparing electrically conductive oligomers or polymers, also oligomers or polymers comprising these thiophene derivatives as repeating unit.
摘要翻译： 本发明涉及取代或未取代的苯并二恶噻吩，其制备方法及其制备导电低聚物或聚合物的用途，以及包含这些噻吩衍生物作为重复单元的低聚物或聚合物。
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公开(公告)号：US07671217B2
公开(公告)日：2010-03-02
申请号：US10538995
申请日：2003-12-04
申请人： Sigurd Buchholz , Alexander Klausener , Reinhard Langer , Leslaw Mleczko , Günter Rauchschwalbe
发明人： Sigurd Buchholz , Alexander Klausener , Reinhard Langer , Leslaw Mleczko , Günter Rauchschwalbe
IPC分类号： C07D495/02
CPC分类号： C07D495/04 , C07D333/38 , Y02P20/582
摘要： The invention relates to a method for the thermal decarboxylation of dicarboxylic acids, in particular to 3,4-ethylene dioxythiophene-2,5-dicarboxylic acid as an educt. According to said method the educt is used in solid form and/or the reaction is carried out in the presence of a plurality of fluidised bed bodies. No solvents are used in the reaction and the decarboxylation product that is formed during the reaction is carried away from the reaction zone in gaseous form.
摘要翻译： 本发明涉及一种二羧酸热脱羧的方法，特别涉及作为溶出物的3,4-亚乙基二氧噻吩-2,5-二羧酸的热脱羧方法。 根据所述方法，溶出物以固体形式使用和/或反应在多个流化床体的存在下进行。 在反应中没有使用溶剂，并且在反应期间形成的脱羧产物以气态形式从反应区带走。
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4.发明授权Method for the production of 2,6-dichloro-5-fluoro-nicotinic acid and coarse and particularly pure 2,6-dichloro-5-fluoro-nicotinic acid 失效制备2,6-二氯-5-氟 - 烟酸的方法和粗的，特别纯的2,6-二氯-5-氟 - 烟酸公开(公告)号：US06441182B1
公开(公告)日：2002-08-27
申请号：US10009437
申请日：2001-12-06
IPC分类号： C07D21380
CPC分类号： C07D213/80
摘要： The invention relates to a method for the production of 2,6-dichloro-5-fluoronicotinic acid by hydrolyzing 2,6-dichloro-5-fluoro-3-cyanopyridine by (a) dissolving 2,6-dichloro-5-fluoro-3-cyanopyridine at 70 to 90° C. in sulfuric acid having a concentration of 90 to 99% by weight and hydrolyzing the 2,6-dichloro-5-fluoro-3-cyanopyridine at 70 to 100° C. to the corresponding carboxamide, (b) cooling the resultant reaction mixture to a temperature in the range from 10 to 65° C., (c) metering in water until the concentration of sulfuric acid is 55 to 75% by weight (calculated relative to the sulfuric acid employed in stage (a) and the water employed in stage (c)) while keeping the temperature between 30 and 65° C. during the addition of the first quarter of the water and keeping the temperature between 50 and 80° C. during the addition of the second quarter of the water, and (d) completing hydrolysis of the resultant mixture to 2,6-dichloro-5-fluoronicotinic acid at 70 to 110° C.
摘要翻译： 本发明涉及通过（a）将2,6-二氯-5-氟-3-氰基吡啶溶解在2,6-二氯-5-氟-3-氰基吡啶中的方法制备2,6-二氯-5-氟烟酸， 在70〜90℃，在浓度为90〜99重量％的硫酸中，在70〜100℃下将2,6-二氯-5-氟-3-氰基吡啶水解成相应的羧酰胺 ，（b）将所得反应混合物冷却至10至65℃的温度，（c）在水中计量直到硫酸浓度为55至75重量％（相对于所用的硫酸计算） 在阶段（a）和阶段（c）中使用的水），同时在添加第一季度期间保持温度在30和65℃之间，并且在添加期间保持温度在50和80℃之间 的水，和（d）在70-110℃下将所得混合物完全水解成2,6-二氯-5-氟烟酸。
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5.发明授权2-phenylbenzimidazole-5-sulphonic acid from isolated 3,4-diaminobenzenesulphonic acid and use thereof in cosmetic preparations 有权来自分离的3,4-二氨基苯磺酸的2-苯基苯并咪唑-5-磺酸及其在化妆品制剂中的用途公开(公告)号：US06888005B2
公开(公告)日：2005-05-03
申请号：US10663825
申请日：2003-09-16
IPC分类号： A61K8/46 , A61Q17/04 , C07D235/18
CPC分类号： C07D235/18 , A61K8/466 , A61Q17/04
摘要： A process for the preparation of 2-phenylbenzimidazole-5-sulphonic acid, characterized in that 3,4-diaminobenzenesulphonic acid is reacted at a pH between 4 and 7 in aqueous solution with 0.9 to 1.5 mol of benzaldehyde per mole of 3,4-diaminobenzenesulphonic acid and with 1.0 to 3.0 mol of SO2 per mole of 3,4-diaminobenzenesulphonic acid, or an agent which comprises 1.0 to 3.0 mol of SO2 per mole of 3.4-diaminobenzenesulphonic acid, is described.
摘要翻译： 一种制备2-苯基苯并咪唑-5-磺酸的方法，其特征在于3,4-二氨基苯磺酸在水溶液中的pH值为4-7之间，每摩尔3,4-二氨基苯磺酸使用0.9至1.5摩尔苯甲醛， 每摩尔3,4-二氨基苯磺酸1.0〜3.0摩尔的SO 2 N 2，或每摩尔3,4-二氨基苯磺酸1.0〜3.0摩尔的SO 2原子的试剂， 描述了3.4-二氨基苯磺酸。
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6.发明授权Bis(2-chlorothiazolyl-5-methyl)amine and its salts, and process for working up reaction mixtures comprising 5-aminomethyl-2-chlorothiazole and bis(2-chlorothiazolyl-5-methyl)amine 失效双（2-氯噻唑-5-甲基）胺及其盐，以及用于处理包含5-氨基甲基-2-氯噻唑和双（2-氯噻唑-5-甲基）胺的反应混合物的方法公开(公告)号：US06403803B1
公开(公告)日：2002-06-11
申请号：US10006539
申请日：2001-12-03
申请人： Günter Rauchschwalbe
发明人： Günter Rauchschwalbe
IPC分类号： C07D27720
CPC分类号： C07D277/32
摘要： As a result of a special precipitation, it is possible to work up reaction mixtures containing 5-aminomethyl-2-chlorothiazole and bis(2-chlorothiazolyl-5-methyl)amine in an advantageous manner and to isolate bis(2-chlorothiazolyl-5-methyl)amine or its salts.
摘要翻译： 作为特殊沉淀的结果，可以以有利的方式处理含有5-氨基甲基-2-氯噻唑和双（2-氯噻唑-5-甲基）胺的反应混合物，并分离双（2-氯噻唑基-5 - 甲基）胺或其盐。
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7.发明授权公开(公告)号：US06369239B2
公开(公告)日：2002-04-09
申请号：US09813875
申请日：2001-03-21
IPC分类号： C07D49504
CPC分类号： C07D495/04 , C07D333/32 , Y02P20/582
摘要： A process for the preparation of dialkoxythiophenes and alkylene-dioxythiophenes in high purity and very good yields by decarboxylation of dialkoxythiophene-dicarboxylic acids or alkylenedioxythiophenedicarboxylic acids, respectively, in solvents that have a higher boiling point than the product and contain no nitrogen bases.
摘要翻译： 在沸点高于不含氮基的溶剂中分别通过二烷氧基噻吩 - 二羧酸或亚烷基二氧噻吩二羧酸脱羧来制备高纯度的二烷氧基噻吩和亚烷基二氧噻吩的方法。
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公开(公告)号：US06787666B2
公开(公告)日：2004-09-07
申请号：US10663827
申请日：2003-09-16
IPC分类号： C07C30900
CPC分类号： C07C303/06 , C07C309/45
摘要： Described herein is a process for the preparation of 3,4-diaminobenzenesulphonic acid, characterized in that 1,2-diaminobenzene is reacted with anhydrous sulphuric acid which optionally comprises SO3 in up to stoichiometric amount, at a temperature in the range from 100 to 160° C. with stirring for a reaction time of from 1 to 20 hours; water or ice is added to the reaction mixture, optionally with cooling, up to a sulphuric acid concentration in the range from 30 to 75% by weight, based on the total mixture; the 3,4-diaminobenzenesulphonic acid precipitated out of the reaction mixture is filtered off, optionally washed with dilute sulphuric acid and worked up.
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