公开(公告)号：US12031003B2

公开(公告)日：2024-07-09

申请号：US17076448

申请日：2020-10-21

Applicant: Gen-Probe Incorporated

Inventor： Byron J. Knight ,  David Opalsky

IPC: C08J7/048 ,  B01L3/00 ,  C08J7/043 ,  C08J7/06 ,  C08J7/12 ,  C08J7/18 ,  C12Q1/686 ,  G01N3/303

CPC classification number: C08J7/048 ,  B01L3/5085 ,  C08J7/043 ,  C08J7/065 ,  C08J7/123 ,  C08J7/18 ,  C12Q1/686 ,  B01L2200/12 ,  B01L2200/16 ,  B01L2300/161 ,  C08J2345/00 ,  G01N3/303

Abstract: The disclosure provides solid compositions such as lyophilisates adhered to surfaces such as plasma-treated surfaces and related methods, uses, kits, intermediates, starting materials, and downstream products.

公开(公告)号：US11966086B2

公开(公告)日：2024-04-23

申请号：US17830115

申请日：2022-06-01

Applicant: Gen-Probe Incorporated

Inventor： David Buse ,  David Howard Combs ,  Norbert D. Hagen ,  David Opalsky ,  Bruce Richardson ,  Anita Prasad ,  Keith Moravick ,  Tyler Moore

IPC: G02B6/36 ,  G01N21/25 ,  G01N21/64 ,  G02B6/06 ,  G02B6/08 ,  G02B6/42

CPC classification number: G02B6/3668 ,  G01N21/253 ,  G01N21/6452 ,  G02B6/06 ,  G02B6/08 ,  G02B6/3672 ,  G02B6/4214 ,  G02B6/4246 ,  G02B6/4269 ,  G01N2021/6484

Abstract: A first time/temperature data set includes temperatures and time stamps recorded at time intervals during a first thermal cycling process and a time stamp for each time interval, and a second time/temperature data set includes temperatures and time stamps recorded at time intervals during a second thermal cycling process. Signal emissions at different signal detecting positions are sequentially measured at different time intervals to generate first and second time/signal emission data sets for receptacles subject to the first and second thermal cycling processes, respectively. Signal emissions of receptacles subject to the first thermal cycling process are synchronized with specific temperatures of the first thermal cycling process by comparing time stamps of the first time/signal emission data set for each receptacle with the time stamps of the first time/temperature data set that correspond with the specific temperature. Signal emissions of receptacles subject to the second thermal cycling process are synchronized with specific temperatures of the second thermal cycling process by comparing time stamps of the second time/signal emission data set for each receptacle with the time stamps of the second time/temperature data set that correspond with the specific temperature.

公开(公告)号：US11840727B2

公开(公告)日：2023-12-12

申请号：US17028367

申请日：2020-09-22

Applicant: Gen-Probe Incorporated

Inventor： David Buse ,  David Howard Combs ,  Norbert D. Hagen ,  David Opalsky ,  Bruce Richardson ,  Anita Prasad ,  Keith Moravick ,  Tyler Moore ,  Byron J. Knight

IPC: C12Q1/686 ,  B01L7/00 ,  G01N21/64 ,  B01L9/06

CPC classification number: C12Q1/686 ,  B01L7/52 ,  G01N21/6452 ,  B01L9/06 ,  B01L2200/141 ,  B01L2200/142 ,  B01L2300/042 ,  B01L2300/0654 ,  B01L2300/0829 ,  B01L2300/0851 ,  B01L2300/1822 ,  G01N2021/6482 ,  G01N2021/6484

Abstract: Multiple receptacles containing a reaction mixture are transported to corresponding receptacle wells of a thermally-conductive receptacle holder in thermal communication with a support that is in thermal communication with a heat sink. The heat sink is pre-heated to a temperature above ambient temperature, and the temperature of the receptacle holder is cycled. Optical communication is established between each of the receptacle wells and an excitation signal source and an emission signal detector during cycling, and whether an emission signal is emitted from any of the receptacles is determined as an indication of the presence of a target nucleic acid.

公开(公告)号：US11746373B2

公开(公告)日：2023-09-05

申请号：US17847096

申请日：2022-06-22

Applicant: GEN-PROBE INCORPORATED

Inventor： Byron J. Knight ,  David A. Buse ,  Norbert D. Hagen ,  David Opalsky ,  Tyler Moore ,  Anita Prasad ,  Bruce Richardson

IPC: B01L3/00 ,  B01L7/00 ,  G01N35/04 ,  C12Q1/6806 ,  C12Q1/686

CPC classification number: C12Q1/6806 ,  B01L3/50825 ,  B01L3/565 ,  B01L7/5255 ,  C12Q1/686 ,  G01N35/04 ,  B01L3/527 ,  B01L2200/026 ,  B01L2200/0689 ,  B01L2300/046 ,  G01N2035/0418 ,  G01N2035/0436

Abstract: A cap and a processing vial configured for interlocking engagement. The processing vial includes a locking collar surrounding an open upper end of the processing vial with lateral through holes formed through the locking collar. The vial also includes a latch hook located above each through hole. The cap includes a latch collar extending about a lower portion of the cap, where the latch collar is configured to snap in beneath the latch hooks of the processing vial when the lower portion of the cap is inserted into the open upper end of the processing vial to lock the cap to the processing vial.

公开(公告)号：US11493445B2

公开(公告)日：2022-11-08

申请号：US16910414

申请日：2020-06-24

Applicant: Gen-Probe Incorporated

Inventor： Haitao Li ,  David Opalsky ,  R. Eric Heinz ,  Norbert D. Hagen

IPC: G01N21/64 ,  G01N21/27

Abstract: A system for monitoring reactions with a plurality of receptacle vessels that includes: an incubator; a movable receptacle carrier contained within a temperature-controlled chamber of the incubator; one or more fixed fluorometers configured to measure a fluorescent emission and positioned with respect to the receptacle carrier to measure fluorescent emissions from receptacle vessels carried on the receptacle carrier into an operative position with respect to each fluorometer; one or more fluorescent reference standards mounted on the receptacle carrier; and a controller configured to control operation of the receptacle carrier and the one or more fluorometers to determine if a fluorescent emission intensity of one or more of the fluorescent reference standards deviates from an expected fluorescent emission intensity.

公开(公告)号：US20220291454A1

公开(公告)日：2022-09-15

申请号：US17830115

申请日：2022-06-01

Applicant: Gen-Probe Incorporated

Inventor： David Buse ,  David Combs ,  Norbert D. Hagen ,  David Opalsky ,  Bruce Richardson ,  Anita Prasad ,  Keith Moravick ,  Tyler Moore

IPC: G02B6/36 ,  G02B6/06 ,  G02B6/08 ,  G01N21/25 ,  G01N21/64 ,  G02B6/42

Abstract: A first time/temperature data set includes temperatures and time stamps recorded at time intervals during a first thermal cycling process and a time stamp for each time interval, and a second time/temperature data set includes temperatures and time stamps recorded at time intervals during a second thermal cycling process. Signal emissions at different signal detecting positions are sequentially measured at different time intervals to generate first and second time/signal emission data sets for receptacles subject to the first and second thermal cycling processes, respectively. Signal emissions of receptacles subject to the first thermal cycling process are synchronized with specific temperatures of the first thermal cycling process by comparing time stamps of the first time/signal emission data set for each receptacle with the time stamps of the first time/temperature data set that correspond with the specific temperature. Signal emissions of receptacles subject to the second thermal cycling process are synchronized with specific temperatures of the second thermal cycling process by comparing time stamps of the second time/signal emission data set for each receptacle with the time stamps of the second time/temperature data set that correspond with the specific temperature.

公开(公告)号：US11009458B2

公开(公告)日：2021-05-18

申请号：US16658482

申请日：2019-10-21

Applicant: Gen-Probe Incorporated

Inventor： Norbert D. Hagen ,  David Opalsky ,  George T. Walker ,  Byron J. Knight

IPC: G01N21/64 ,  G01N21/27

Abstract: Optical reference devices for calibrating or monitoring the performance of an optical measurement device, such as a fluorometer, are made from thermoplastics from the polyaryletherketone (PAEK) family of semi-crystalline thermoplastics, including polyether ether ketone (PEEK). The reference device may be made as a master reference device having a known emission output—as determined by a standard optical measurement device—that is used to calibrate other optical measurement devices against the standard. The reference device may be made in the shape of a receptacle vial so that the reference device can be placed in the receptacle holding structure of an instrument in which the optical measurement device is installed and used to calibrate or monitor the optical measurement device within the instrument. The reference device may be part of the probe of a pipettor or pick and place mechanism or it may be a cap that can be secured to the end of such a probe.

公开(公告)号：US10921338B2

公开(公告)日：2021-02-16

申请号：US16127939

申请日：2018-09-11

Applicant: Gen-Probe Incorporated

Inventor： Rolf Silbert ,  David Opalsky ,  David Aaron Buse ,  Robert J. Rosati ,  Olev Tammer ,  Richard Capella ,  Matthias Merten

IPC: G01N1/28 ,  G01N1/31 ,  G01N35/10 ,  G01N35/02 ,  G01N35/00 ,  G01F23/26 ,  G01N35/04 ,  C40B60/12

Abstract: A sample processing station includes two or more container holders on a platform that is rotatable about a central axis of rotation. Each holder is configured to rotate about a secondary axis of rotation. The station includes a capping/decapping mechanism to cap or decap a container held in one of the container holders and a drip tray movable between a first position not under the capping/decapping mechanism and a second position under the capping/decamping mechanism.

公开(公告)号：US10739263B2

公开(公告)日：2020-08-11

申请号：US16219388

申请日：2018-12-13

Applicant: GEN-PROBE INCORPORATED

Inventor： David Opalsky ,  Srajan Raghuwanshi ,  James Bui

IPC: G01N21/64 ,  G01N21/03 ,  G01N21/27 ,  G01N21/75 ,  G01N35/02 ,  G01N35/00 ,  G01N35/04

Abstract: A system including an optical signal detector and a controller operatively coupled to the optical signal detector and configured to determine an operational performance status of the optical signal detector. The optical signal detector includes a detection channel having a light source and a sensor, where the detection channel is configured to emit and focus light generated by the light source at a detection zone and to receive and focus light on the sensor. The optical performance status of the optical signal detector is based on a measured characteristic of light focused on the sensor while a non-fluorescent surface is in the detection zone and/or a measured characteristic of light focused on the sensor while a void is in the detection zone.

公开(公告)号：US10451550B2

公开(公告)日：2019-10-22

申请号：US15176861

申请日：2016-06-08

Applicant: Gen-Probe Incorporated

Inventor： Norbert D. Hagen ,  David Opalsky ,  George T. Walker ,  Byron J. Knight

IPC: G01N21/64 ,  G01N21/27

Abstract: Optical reference devices for calibrating or monitoring the performance of an optical measurement device, such as a fluorometer, are made from thermoplastics from the polyaryletherketone (PAEK) family of semi-crystalline thermoplastics, including polyether ether ketone (PEEK). The reference device may be made as a master reference device having a known emission output—as determined by a standard optical measurement device—that is used to calibrate other optical measurement devices against the standard. The reference device may be made in the shape of a receptacle vial so that the reference device can be placed in the receptacle holding structure of an instrument in which the optical measurement device is installed and used to calibrate or monitor the optical measurement device within the instrument. The reference device may be part of the probe of a pipettor or pick and place mechanism or it may be a cap that can be secured to the end of such a probe.