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公开(公告)号：US20240409517A1
公开(公告)日：2024-12-12
申请号：US18699783
申请日：2022-10-13
Applicant: GIVAUDAN SA
Inventor： Stephan HAIBER , Esther Maria VREMAN , Adri DE KLERK , Luis IBANEZ GONZALEZ , Abdelmajid KAOUAS , Eric KOHLEN , Jose LHERONDEL , Lisa Maria WIJNEN , Cornelis WINKEL
IPC: C07D233/90 , A23L27/00 , A23L27/20 , C07D239/28 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12
Abstract: The invention relates to the use of compounds of formula (I) and edible salts thereof, wherein R1 is selected from the group consisting of 2-(1H-4-imidazolyl)-ethenyl, 1H-5-indolyl, 2-(1H-5-imidazolyl)-ethenyl, 1-amino-2-(1H-4-imidazolyl)-ethyl, (1,3-thiazol-2-yl)-ethenyl, 2,3-dihydro-1H-indol-2-yl, 2-(pyrimidin-2-yl)ethenyl, heptadecanyl, 1-heptadec-8-enyl, heptadeca-8,11-dienyl, heptadeca-8,11,14-trienyl, 2-(4H-imidazol-2-yl)-ethenyl, 2-(4H-imidazol-2-yl)-ethyl, 2-phenyl-ethenyl, 2-(furan-2-yl)-ethenyl, 2-(thiophen-2-yl)-ethenyl, 2-(thiophen-3-yl)-ethenyl, 2-but-2-enoyl, 2-butyl, 2,6-dimethylhepta-1,5-dienyl, 1,3-benzothiazol-6-yl; R2 is selected from the group consisting of (1H-imidazol-4-yl)-methyl, (1H-3-indol-3-yl)-methyl, 4-hydroxybenzyl, methylsulfanylethyl, hydroxymethyl, CH2—COOH, (pyridin-4-yl)methyl, (pyridin-2-yl)methyl, 1-(2,6-dimethylhepta-1,5-dienyl), 2-(pyrimidin-2-yl)methyl, (1H-imidazol-5-yl)-methyl, (1H-imidazol-2-yl)-methyl, (1H-pyrrol-2-yl)-methyl, phenyl, pyrimidin-5-yl, pyrazin-2-yl; R3 is selected from the group consisting of H, COOH, or a compound selected from the group consisting of 3-(1H-imidazol-4-yl) prop-2-enamide, methyl 2,3-dihydro-1H-indole-2-carboxylate, and 3,6-bis[(1H-imidazol-4-yl)methyl]piperazine-2,5-dione, as flavor modulating compound, and to flavor compositions and consumer products comprising said compounds.
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2.发明申请
公开(公告)号：US20210022376A1
公开(公告)日：2021-01-28
申请号：US17068367
申请日：2020-10-12
Applicant: GIVAUDAN SA
Inventor： Feng SHI , Harry RENES , Esther VAN OMMEREN , Susanna Magdalena VORSTER , Yili WANG , Adri DE KLERK , Jenifer AUGELLI
IPC: A23L7/161 , A23L2/56 , A23F5/24 , A23C11/10 , C12G3/06 , A23L27/21 , A23L27/00 , A23L27/50 , A23L23/10 , A23L19/18 , A23L11/00 , A23L27/60 , A23L19/20
Abstract: The use of a compound according to formula (I) or the edible salts thereof in an edible composition to mask or modulate an undesired taste or off-taste contained in the edible composition wherein R1 is an alkyl residue containing 6 to 20 carbon atoms, or an alkene residue containing from 9 to 25 carbon atoms with 1 to 6 double bonds, R1 together with the carbonyl group to which it is attached is a residue of a carboxylic acid, and NR2R3, in which R3 is H or together with R2 and the N-atom to which they are attached, a 5-membered ring, is a residue of an amino acid, in particular a proteinogenic amino acid, ornithine, gamma-aminobutyric acid or beta alanine, or a 1-amino cycloalkyl carboxylic acid.
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公开(公告)号：US20210147345A1
公开(公告)日：2021-05-20
申请号：US17157522
申请日：2021-01-25
Applicant: GIVAUDAN SA
Inventor： Adri DE KLERK , Cornelis WINKEL
IPC: C07C237/16 , C07C237/06 , C07C323/60 , C07C233/58 , A23L27/20 , A23L27/00 , C07C323/41 , C07D207/16
Abstract: This disclosure relates to flavour modification and to compounds of formula (I) or edible salts thereof, wherein R1 is selected from C6-C20 alkyl, and C9-C25 alkenyl, and i) R3 and R4 are hydrogen and R2 the residue of a proteinogenic amino acid; ii) R2 and R3 are methyl and R4 is hydrogen; or R4 is hydrogen and R2 and R3 form together with the carbon atom to which they are attached cyclopropyl; iii) R2 is hydrogen, and R3 and R4 together are —CH2—CH2—CH2— useful in modifying flavours.
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公开(公告)号：US20220332675A1
公开(公告)日：2022-10-20
申请号：US17641468
申请日：2020-09-29
Applicant: Givaudan SA
Inventor： Stefan Michael FURRER , Adri DE KLERK , Abdelmajid KAOUAS , Jay Patrick SLACK , Cornelis WINKEL
IPC: C07C233/11 , A23L27/20 , A23L27/00
Abstract: The use of compounds according to formula (I) and with X, Y═—NH— or —O—, wherein at least X or Y is —NH—, in the form of any one of its stereoisomers or a mixture thereof, wherein is indicating a carbon-carbon single or double bond, and wherein one carbon-carbon double bond is present either at C2 or C3, the wavy bond is indicating an unspecified configuration of the adjacent double bond, as umami tastant.
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5.发明申请
公开(公告)号：US20200229470A1
公开(公告)日：2020-07-23
申请号：US16838192
申请日：2020-04-02
Applicant: GIVAUDAN SA
Inventor： Feng SHI , Harry RENES , Esther VAN OMMEREN , Susanna Magdalena VORSTER , Yili WANG , Adri DE KLERK , Chris WINKEL
IPC: A23L2/39 , C12C5/02 , C12G3/06 , C07C233/49 , C07C233/47 , A23L2/56 , A23C19/09 , A23C11/10 , A23C9/156 , A23C9/13 , A23L19/20 , A23L11/00 , A23L23/10 , A23L27/50 , C07C321/14 , A23L27/20 , A23L27/60 , A23L19/18 , A23L27/21 , A23L7/161 , A23C15/16 , A23F5/24
Abstract: A flavour composition comprising a compound according to the formula (I) edible salts thereof, wherein R1 is an alkyl residue containing 6 to 20 carbon atoms, or an alkene residue containing from 9 to 25 carbon atoms with 1 to 6 double bonds, R1 together with the carbonyl group to which it is attached is a residue of a carboxylic acid, and m is 0 or 1.
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公开(公告)号：US20160242444A1
公开(公告)日：2016-08-25
申请号：US14916861
申请日：2013-10-02
Applicant: GIVAUDAN SA
Inventor： Adri DE KLERK , Harry RENES , Cornelis WINKEL
IPC: A23L1/226 , C07C233/49 , C07D207/16 , A23L2/56 , A23L1/229 , A23L1/227 , A23L1/228
Abstract: This disclosure relates to flavour modification and to compounds of formula (I) wherein R1 is selected from C6-C20 alkyl, and C9-C25 alkenyl, R5 is C1-C3 alkyl, and a) n is 1; and i) R3 and R4 are hydrogen and R2 is the residue of a proteinogenic amino acid; ii) R2 and R3 are methyl and R4 is hydrogen; or R4 is hydrogen and R2 and R3 form together with the carbon atom to which they are attached cyclopropyl; iii) R2 is hydrogen, and R3 and R4 together are —CH2—CH2—CH2—; b) n is 2 or 3 and R2, R3 and R4 are hydrogen, useful in modifying flavours.
Abstract translation: 本公开涉及风味改性和式（I）化合物，其中R 1选自C 6 -C 20烷基，C 9 -C 25烯基，R 5是C 1 -C 3烷基，和a）n是1; 和i）R3和R4是氢，R2是蛋白质氨基酸的残基; ii）R2和R3是甲基，R4是氢; 或R 4为氢，R 2和R 3与它们所连接的碳原子一起形成环丙基; iii）R 2是氢，R 3和R 4一起是-CH 2 -CH 2 -CH 2 - ; b）n是2或3，R2，R3和R4是氢，可用于改变风味。
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公开(公告)号：US20160227825A1
公开(公告)日：2016-08-11
申请号：US14916846
申请日：2013-10-02
Applicant: GIVAUDAN SA
Inventor： Adri DE KLERK , Cornelis WINKEL
IPC: A23L1/226 , C07C237/06 , C07D207/16 , C07C323/41 , C07C237/16 , A23L1/228 , A23L1/229
CPC classification number: C07C237/16 , A23L27/202 , A23L27/2022 , A23L27/203 , A23L27/204 , A23L27/2054 , A23L27/88 , A23V2002/00 , C07C233/58 , C07C237/06 , C07C323/41 , C07C323/60 , C07D207/16
Abstract: This disclosure relates to flavour modification and to compounds of formula (I) or edible salts thereof, wherein R1 is selected from C6-C20 alkyl, and C9-C25 alkenyl, and i) R3 and R4 are hydrogen and R2 the residue of a proteinogenic amino acid; ii) R2 and R3 are methyl and R4 is hydrogen; or R4 is hydrogen and R2 and R3 form together with the carbon atom to which they are attached cyclopropyl; iii) R2 is hydrogen, and R3 and R4 together are —CH2—CH2—CH2— useful in modifying flavours.
Abstract translation: 本公开涉及风味改性和式（I）化合物或其食用盐，其中R1选自C6-C20烷基和C9-C25烯基，i）R3和R4是氢，R2是蛋白质的残基 氨基酸; ii）R2和R3是甲基，R4是氢; 或R 4为氢，R 2和R 3与它们所连接的碳原子一起形成环丙基; iii）R 2是氢，并且R 3和R 4一起是-CH 2 -CH 2 -CH 2 - ，可用于改变风味。
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公开(公告)号：US20200299229A1
公开(公告)日：2020-09-24
申请号：US16887416
申请日：2020-05-29
Applicant: Givaudan SA
Inventor： Feng SHI , Harry RENES , Esther VAN OMMEREN , Susanna Magdalena VORSTER , Yili WANG , Adri DE KLERK , Xiaogen YANG
IPC: C07C235/74 , A23L2/56 , C07C233/47 , C07C233/49 , C07C233/52 , C07D207/16 , A23C9/13 , A23C9/156 , A23C11/10 , A23C15/12 , A23C19/09 , C12G3/06 , C12C5/02 , A23L27/20 , A23L27/50 , A23L11/00 , A23L27/60 , A23L23/10 , A23F5/24 , A23L19/18 , A23L27/21 , C07C323/59 , A23L19/20 , A23L7/161 , C07C237/22 , C07C233/18
Abstract: A flavour composition comprising a compound according to the formula (I) or edible salts thereof, wherein R1 is an alkyl residue containing 6 to 20 carbon atoms, or an alkene residue containing from 9 to 25 carbon atoms with 1 to 6 double bonds, R1 together with the carbonyl group to which it is attached is a residue of a carboxylic acid, and NR2R3, in which R3 is H or together with R2 and the N-atom to which they are attached, a 5-membered ring, is a residue of an amino acid, in particular a proteinogenic amino acid, ornithine, gamma-aminobutyric acid or beta alanine, or a 1-amino cycloalkyl carboxylic acid.
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公开(公告)号：US20200290952A1
公开(公告)日：2020-09-17
申请号：US16887367
申请日：2020-05-29
Applicant: Givaudan SA
Inventor： Feng SHI , Harry RENES , Esther VAN OMMEREN , Susanna Magdalena VORSTER , Yili WANG , Adri DE KLERK , Xiaogen YANG
IPC: C07C235/74 , A23L2/56 , C07C233/47 , C07C233/49 , C07C233/52 , C07D207/16 , A23C9/13 , A23C9/156 , A23C11/10 , A23C15/12 , A23C19/09 , C12G3/06 , C12C5/02 , A23L27/20 , A23L27/50 , A23L11/00 , A23L27/60 , A23L23/10 , A23F5/24 , A23L19/18 , A23L27/21 , C07C323/59 , A23L19/20 , A23L7/161 , C07C237/22 , C07C233/18
Abstract: A flavour composition comprising a compound according to the formula (I) or edible salts thereof, whereinR1 is alkyl residue containing 6 to 20 carbon atoms, or an alkene residue containing from 9 to 25 carbon atoms with 1 to 6 double bonds, R1 together with the carbonyl to which it is attached is a residue carboxylic acid, and NR2R3, in which R2 is H or together with R2 and the N-atom to which they are attached, a 5-membered ring, is a residue of an amino acid, in particular proteinogenic amino acid, ornithine, gamma-aminobutyric acid or beta alanine, or a 1-amino cycloalkyl carboxylic acid.
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公开(公告)号：US20200290951A1
公开(公告)日：2020-09-17
申请号：US16887264
申请日：2020-05-29
Applicant: Givaudan SA
Inventor： Feng SHI , Harry RENES , Esther VAN OMMEREN , Susanna Magdalena VORSTER , Yili WANG , Adri DE KLERK , Xiaogen YANG
IPC: C07C235/74 , A23L2/56 , C07C233/47 , C07C233/49 , C07C233/52 , C07D207/16 , A23C9/13 , A23C9/156 , A23C11/10 , A23C15/12 , A23C19/09 , C12G3/06 , C12C5/02 , A23L27/20 , A23L27/50 , A23L11/00 , A23L27/60 , A23L23/10 , A23F5/24 , A23L19/18 , A23L27/21 , C07C323/59 , A23L19/20 , A23L7/161 , C07C237/22 , C07C233/18
Abstract: A flavour composition comprising a compound according to the formula (1) or edible salts thereof, wherein R1 is an alkyl residue containing 6 to 20 carbon atoms, or an alkene residue containing from 9 to 25 carbon atoms with 1 to 6 double bonds, R1 together with the carbonyl group to which it is attached is a residue of a carboxylic acid, and NR2R3, in which R3 is H or together with R2 and the N-atom to which they are attached, a 5-membered ring, is a residue of an amino acid, in particular a proteinogenic amino acid, ornithine, gamma-aminobutyric acid or beta alanine, or a 1-amino cycloalkyl carboxylic acid.
