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公开(公告)号:US07056925B2
公开(公告)日:2006-06-06
申请号:US10640615
申请日:2003-08-13
申请人: Gaoquan Li , Qun Li , Tongmei Li , Nan-Horng Lin , Robert A. Mantei , Hing L. Sham , Gary T. Wang
发明人: Gaoquan Li , Qun Li , Tongmei Li , Nan-Horng Lin , Robert A. Mantei , Hing L. Sham , Gary T. Wang
IPC分类号: A61K31/4965 , C07D241/00 , C07D241/02 , C07D211/90 , C07D211/78
CPC分类号: C07D239/42 , C07D401/12
摘要: Compounds having the formula are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
摘要翻译: 具有该式的化合物可用于抑制蛋白激酶。 还公开了制备化合物,含有化合物的组合物和使用该化合物的处理方法的方法。
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公开(公告)号:US07323570B2
公开(公告)日:2008-01-29
申请号:US11459745
申请日:2006-07-25
申请人: Akiyo K. Claiborne , Stephen L. Gwaltney, II , Lisa A. Hasvold , Qun Li , Tongmei Li , Nan-Horng Lin , Robert A. Mantei , Todd W. Rockway , Hing L. Sham , Gerard M. Sullivan , Yunsong Tong , Gary Wang , Le Wang , Xilu Wang , Wei-Bo Wang
发明人: Akiyo K. Claiborne , Stephen L. Gwaltney, II , Lisa A. Hasvold , Qun Li , Tongmei Li , Nan-Horng Lin , Robert A. Mantei , Todd W. Rockway , Hing L. Sham , Gerard M. Sullivan , Yunsong Tong , Gary Wang , Le Wang , Xilu Wang , Wei-Bo Wang
IPC分类号: C07D401/10 , C07D401/12 , A61K31/44
CPC分类号: C07D233/64 , C07D401/12 , C07D405/12 , C07D409/12
摘要: Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.
摘要翻译: 具有下式的取代的咪唑和噻唑可用于抑制法呢基转移酶。 还公开了法呢基转移酶抑制组合物和在患者体内抑制法尼基转移酶的方法。
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公开(公告)号:US07211595B2
公开(公告)日:2007-05-01
申请号:US09997323
申请日:2001-11-30
申请人: Akiyo K. Claiborne , Stephen L. Gwaltney, II , Lisa A. Hasvold , Qun Li , Tongmei Li , Nan-Horng Lin , Robert A. Mantei , Todd W. Rockway , Hing L. Sham , Gerard M. Sullivan , Yunsong Tong , Gary Wang , Le Wang , Xilu Wang , Wei-Bo Wang
发明人: Akiyo K. Claiborne , Stephen L. Gwaltney, II , Lisa A. Hasvold , Qun Li , Tongmei Li , Nan-Horng Lin , Robert A. Mantei , Todd W. Rockway , Hing L. Sham , Gerard M. Sullivan , Yunsong Tong , Gary Wang , Le Wang , Xilu Wang , Wei-Bo Wang
IPC分类号: A61K31/415 , C07D401/04 , C07D401/12 , C07D233/32
CPC分类号: C07D233/64 , C07D401/12 , C07D405/12 , C07D409/12
摘要: Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.
摘要翻译: 具有下式的取代的咪唑和噻唑可用于抑制法呢基转移酶。 还公开了法呢基转移酶抑制组合物和在患者体内抑制法尼基转移酶的方法。
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公开(公告)号:US07320986B2
公开(公告)日:2008-01-22
申请号:US10792564
申请日:2004-03-03
申请人: Yunsong Tong , Akiyo K. Claiborne , Gaoquan Li , Nan-Horng Lin , Hing L. Sham , Thomas J. Sowin , Zhi-Fu Tao
发明人: Yunsong Tong , Akiyo K. Claiborne , Gaoquan Li , Nan-Horng Lin , Hing L. Sham , Thomas J. Sowin , Zhi-Fu Tao
IPC分类号: A61K31/4745 , A61K31/4162 , C07D487/14
CPC分类号: C07D249/08 , C07D231/12 , C07D231/54 , C07D233/56 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/14 , C07D417/14
摘要: Compounds having the formula (I) are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
摘要翻译: 具有式(I)的化合物可用于抑制蛋白激酶。 还公开了制备化合物,含有化合物的组合物和使用该化合物的处理方法的方法。
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公开(公告)号:US06797825B2
公开(公告)日:2004-09-28
申请号:US10317336
申请日:2002-12-12
申请人: Nan-Horng Lin , Hing L. Sham , Ping Xia
发明人: Nan-Horng Lin , Hing L. Sham , Ping Xia
IPC分类号: C07D47102
CPC分类号: C07D401/06 , C07D209/34 , C07D403/06 , C07D471/04
摘要: Compounds having the formula or therapeutically acceptable salts thereof, are protein kinase inhibitors. Preparation of the compounds, compositions containing the compounds, and treatment of diseases using the compounds are disclosed.
摘要翻译: 具有其配方的具有治疗上可接受的盐的化合物是蛋白激酶抑制剂。 公开了化合物的制备,含有该化合物的组合物以及使用该化合物治疗疾病。
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公开(公告)号:US5268374A
公开(公告)日:1993-12-07
申请号:US700185
申请日:1991-05-22
申请人: Anthony K. L. Fung , William R. Baker , Yoek-Lin Armiger , Saul H. Rosenberg , Biswanath De , Jacob J. Plattner , Steven A. Boyd , Dale J. Kempf , Hing L. Sham , Hollis D. Kleinert , Robert A. Mantei
发明人: Anthony K. L. Fung , William R. Baker , Yoek-Lin Armiger , Saul H. Rosenberg , Biswanath De , Jacob J. Plattner , Steven A. Boyd , Dale J. Kempf , Hing L. Sham , Hollis D. Kleinert , Robert A. Mantei
IPC分类号: C07C237/08 , C07C317/28 , C07C323/58 , C07D203/18 , C07D211/44 , C07D211/62 , C07D211/96 , C07D233/54 , C07D295/185 , C07D401/12 , C07D407/12 , C07D413/12 , A61K37/43 , C07K5/08
CPC分类号: C07D233/64 , C07C237/08 , C07C317/28 , C07C323/58 , C07D203/18 , C07D211/44 , C07D211/62 , C07D211/96 , C07D295/185 , C07D401/12 , C07D407/12 , C07D413/10 , C07C2101/14
摘要: The present invention relates to renin inhibiting compounds of the formula: ##STR1##
摘要翻译: 本发明涉及下式的肾素抑制化合物:
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7.
公开(公告)号:US06518305B1
公开(公告)日:2003-02-11
申请号:US09422093
申请日:1999-10-19
申请人: Clarence J. Maring , Yuanwei Chen , David A. Degoey , Vincent L. Giranda , David J. Grampovnik , Yu Gui Gu , Warren M. Kati , Dale J. Kempf , April Kennedy , Allan C. Krueger , Zhen Lin , Darold L. Madigan , Steven W. Muchmore , Hing L. Sham , Kent D. Stewart , Vincent S. Stoll , Minghua Sun , Gary T. Wang , Sheldon Wang , Ming C. Yeung , Chen Zhao
发明人: Clarence J. Maring , Yuanwei Chen , David A. Degoey , Vincent L. Giranda , David J. Grampovnik , Yu Gui Gu , Warren M. Kati , Dale J. Kempf , April Kennedy , Allan C. Krueger , Zhen Lin , Darold L. Madigan , Steven W. Muchmore , Hing L. Sham , Kent D. Stewart , Vincent S. Stoll , Minghua Sun , Gary T. Wang , Sheldon Wang , Ming C. Yeung , Chen Zhao
IPC分类号: A61K31195
CPC分类号: C07D233/64 , C07B2200/07 , C07B2200/09 , C07C233/48 , C07C237/24 , C07C271/22 , C07C271/24 , C07C279/16 , C07C2601/08 , C07C2601/10 , C07D263/32 , C07D307/24 , C07D317/30 , C07D405/04
摘要: Disclosed are compounds of the formula: which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.
摘要翻译: 公开了下式的化合物:其可用于抑制致病微生物,特别是流感神经氨酸酶的神经氨酸酶。 还公开了用于预防和治疗由具有神经氨酸酶的微生物引起的疾病的组合物和方法,用于制备这些方法中使用的化合物和合成中间体的方法。
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公开(公告)号:US06831096B2
公开(公告)日:2004-12-14
申请号:US10253152
申请日:2002-09-24
申请人: Clarence J. Maring , Yu Gui Gu , Hui-Ju Chen , Yuanwei Chen , David A. Degoey , William J. Flosi , Vincent L. Giranda , David J. Grampovnik , Warren M. Kati , Dale J. Kempf , April Kennedy , Larry L. Klein , Allan C. Krueger , Zhen Lin , Darold L. Madigan , Keith F. McDaniel , Steven W. Muchmore , Hing L. Sham , Kent D. Stewart , Vincent S. Stoll , Minghua Sun , Noah P. Tu , Frank L. Wagenaar , Gary T. Wang , Sheldon Wang , Paul E. Wiedeman , Yibo Xu , Ming C. Yeung , Chen Zhao , Stephen Hanessian , Malken Bayrakdarian , Xuehong Luo
发明人: Clarence J. Maring , Yu Gui Gu , Hui-Ju Chen , Yuanwei Chen , David A. Degoey , William J. Flosi , Vincent L. Giranda , David J. Grampovnik , Warren M. Kati , Dale J. Kempf , April Kennedy , Larry L. Klein , Allan C. Krueger , Zhen Lin , Darold L. Madigan , Keith F. McDaniel , Steven W. Muchmore , Hing L. Sham , Kent D. Stewart , Vincent S. Stoll , Minghua Sun , Noah P. Tu , Frank L. Wagenaar , Gary T. Wang , Sheldon Wang , Paul E. Wiedeman , Yibo Xu , Ming C. Yeung , Chen Zhao , Stephen Hanessian , Malken Bayrakdarian , Xuehong Luo
IPC分类号: A61K3140
CPC分类号: C07D207/16 , C07D207/26 , C07D207/327 , C07D207/38 , C07D207/46 , C07D231/12 , C07D233/56 , C07D249/08 , C07D303/16 , C07D403/04 , C07D405/04 , C07D405/06 , C07D409/06 , C07D413/04 , C07D417/04 , C07D417/06
摘要: Disclosed are compounds of the formula: which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.
摘要翻译: 公开了下式的化合物:其可用于抑制致病微生物,特别是流感神经氨酸酶的神经氨酸酶。 还公开了用于预防和治疗由具有神经氨酸酶的微生物引起的疾病的组合物和方法,用于制备这些方法中使用的化合物和合成中间体的方法。
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公开(公告)号:US06455571B1
公开(公告)日:2002-09-24
申请号:US09421787
申请日:1999-10-19
申请人: Clarence J. Maring , Yu Gui Gu , Hui-Ju Chen , Yuanwei Chen , David A. Degoey , William J. Flosi , Vincent L. Giranda , David J. Grampovnik , Warren M. Kati , Dale J. Kempf , April Kennedy , Larry L. Klein , Allan C. Krueger , Zhen Lin , Darold L. Madigan , Keith F. McDaniel , Steven W. Muchmore , Hing L. Sham , Kent D. Stewart , Vincent S. Stoll , Minghua Sun , Noah P. Tu , Frank L. Wagenaar , Gary T. Wang , Sheldon Wang , Paul E. Wiedeman , Yibo Xu , Ming C. Yeung , Chen Zhao , Stephen Hanessian , Malken Bayrakdarian , Xuehong Luo
发明人: Clarence J. Maring , Yu Gui Gu , Hui-Ju Chen , Yuanwei Chen , David A. Degoey , William J. Flosi , Vincent L. Giranda , David J. Grampovnik , Warren M. Kati , Dale J. Kempf , April Kennedy , Larry L. Klein , Allan C. Krueger , Zhen Lin , Darold L. Madigan , Keith F. McDaniel , Steven W. Muchmore , Hing L. Sham , Kent D. Stewart , Vincent S. Stoll , Minghua Sun , Noah P. Tu , Frank L. Wagenaar , Gary T. Wang , Sheldon Wang , Paul E. Wiedeman , Yibo Xu , Ming C. Yeung , Chen Zhao , Stephen Hanessian , Malken Bayrakdarian , Xuehong Luo
IPC分类号: A61K3140
CPC分类号: C07D207/16 , C07D207/26 , C07D207/327 , C07D207/38 , C07D207/46 , C07D231/12 , C07D233/56 , C07D249/08 , C07D303/16 , C07D403/04 , C07D405/04 , C07D405/06 , C07D409/06 , C07D413/04 , C07D417/04 , C07D417/06
摘要: Disclosed are compounds of the formula: which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.
摘要翻译: 公开了下式的化合物:其可用于抑制致病微生物,特别是流感神经氨酸酶的神经氨酸酶。 还公开了用于预防和治疗由具有神经氨酸酶的微生物引起的疾病的组合物和方法,用于制备这些方法中使用的化合物和合成中间体的方法。
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公开(公告)号:US06228868B1
公开(公告)日:2001-05-08
申请号:US09360463
申请日:1999-07-23
申请人: Stephen L. Gwaltney, II , Hwan-Soo Jae , Douglas M. Kalvin , Gang Liu , Hing L. Sham , Qun Li , Akiyo K. Claiborne , Le Wang , Kenneth J. Barr , Keith W. Woods
发明人: Stephen L. Gwaltney, II , Hwan-Soo Jae , Douglas M. Kalvin , Gang Liu , Hing L. Sham , Qun Li , Akiyo K. Claiborne , Le Wang , Kenneth J. Barr , Keith W. Woods
IPC分类号: A61K31421
CPC分类号: C07D413/04 , C07D263/14
摘要: Compounds having Formula I are useful for treating cancer. Also disclosed are pharmaceutical compositions comprising compounds of Formula I, and methods of treating cancer in a mammal.
摘要翻译: 具有式Iare的化合物可用于治疗癌症。 还公开了包含式I化合物的药物组合物和治疗哺乳动物癌症的方法。
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