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公开(公告)号:US06828327B2
公开(公告)日:2004-12-07
申请号:US10008982
申请日:2001-12-06
申请人: Gee-Hong Kuo , Han-Cheng Zhang , Catherine Prouty , Alan DeAngelis , Peter Connolly , William V. Murray , Lan Shen , Bruce Conway , Keith Demarest , Chandra R. Shah , Bruce E. Maryanoff , Kimberly B. White
发明人: Gee-Hong Kuo , Han-Cheng Zhang , Catherine Prouty , Alan DeAngelis , Peter Connolly , William V. Murray , Lan Shen , Bruce Conway , Keith Demarest , Chandra R. Shah , Bruce E. Maryanoff , Kimberly B. White
IPC分类号: A61K3144
CPC分类号: C07D471/22 , C07D487/22 , C07D498/22 , C07D515/22
摘要: This invention is directed to macroheterocyclic compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
摘要翻译: 本发明涉及可用作激酶或双重激酶抑制剂的大量杂环化合物,用于制备此类化合物的方法和用于治疗或改善激酶或双重激酶介导的病症的方法。
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公开(公告)号:US06710048B2
公开(公告)日:2004-03-23
申请号:US09955780
申请日:2001-09-19
申请人: Gee-Hong Kuo , Peter J. Connolly , Catherine Prouty , Alan DeAngelis , Aihua Wang , Linda Jolliffe , Steve Middleton , Stuart Emanuel
发明人: Gee-Hong Kuo , Peter J. Connolly , Catherine Prouty , Alan DeAngelis , Aihua Wang , Linda Jolliffe , Steve Middleton , Stuart Emanuel
IPC分类号: A61K31505
CPC分类号: C07D401/04 , C07D401/14 , C07D405/14
摘要: The present invention provides pyrazine derivatives that inhibit tyrosine kinase activity. Certain pyrazine derivatives are selective inhibitors of vascular endothelial growth factor (VEGF) receptor tyrosine kinase. The present invention also provides pharmaceutical formulations containing the pyrazine derivatives and methods of use of these formulations as anti-tumor agents and to treat solid-tumor cancers, angiogenesis, diabetic retinopathy, rheumatoid arthritis, endometriosis and psoriasis.
摘要翻译: 本发明提供抑制酪氨酸激酶活性的吡嗪衍生物。 某些吡嗪衍生物是血管内皮生长因子(VEGF)受体酪氨酸激酶的选择性抑制剂。 本发明还提供含有吡嗪衍生物的药物制剂以及这些制剂用作抗肿瘤剂并用于治疗实体瘤,血管生成,糖尿病性视网膜病,类风湿性关节炎,子宫内膜异位和银屑病的方法。
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公开(公告)号:US20090318332A1
公开(公告)日:2009-12-24
申请号:US12549426
申请日:2009-08-28
申请人: Gee-Hong Kuo , Rui Zhang , Aihua Wang , Alan DeAngelis , Keith Demarest , Patricia Pelton
发明人: Gee-Hong Kuo , Rui Zhang , Aihua Wang , Alan DeAngelis , Keith Demarest , Patricia Pelton
CPC分类号: C07C59/68 , C07C323/20
摘要: The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR modulators to treat or inhibit the progression of, for example, dyslipidemia.
摘要翻译: 本发明具有4 - ((苯氧基烷基)硫基) - 苯氧基乙酸及其类似物,含有它们的组合物,以及使用它们作为PPAR调节剂来治疗或抑制例如血脂异常进展的方法。
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公开(公告)号:US20060058382A1
公开(公告)日:2006-03-16
申请号:US11226645
申请日:2005-09-14
申请人: Gee-Hong Kuo , Rui Zhang , Aihua Wang , Alan DeAngelis , Keith Demarest , Patricia Pelton
发明人: Gee-Hong Kuo , Rui Zhang , Aihua Wang , Alan DeAngelis , Keith Demarest , Patricia Pelton
IPC分类号: A61K31/277 , A61K31/192 , A61K31/195 , C07C255/40 , C07C59/64
CPC分类号: C07C59/68 , C07C323/20
摘要: The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR modulators to treat or inhibit the progression of, for example, dyslipidemia.
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公开(公告)号:US20080269336A1
公开(公告)日:2008-10-30
申请号:US12144061
申请日:2008-06-23
申请人: Gee-Hong Kuo , Rui Zhang , Aihua Wang , Alan DeAngelis , Keith Demarest , Patricia Pelton
发明人: Gee-Hong Kuo , Rui Zhang , Aihua Wang , Alan DeAngelis , Keith Demarest , Patricia Pelton
IPC分类号: A61K31/192 , C07C59/13 , A61P9/10 , A61P3/06 , A61P3/10
CPC分类号: C07C59/68 , C07C323/20
摘要: The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR modulators to treat or inhibit the progression of, for example, dyslipidemia.
摘要翻译: 本发明具有4 - ((苯氧基烷基)硫基) - 苯氧基乙酸及其类似物,含有它们的组合物,以及使用它们作为PPAR调节剂来治疗或抑制例如血脂异常进展的方法。
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公开(公告)号:US20060058393A1
公开(公告)日:2006-03-16
申请号:US11226179
申请日:2005-09-14
申请人: Alan DeAngelis , Keith Demarest , Gee-Hong Kuo , Patricia Pelton , Aihua Wang , Rui Zhang
发明人: Alan DeAngelis , Keith Demarest , Gee-Hong Kuo , Patricia Pelton , Aihua Wang , Rui Zhang
IPC分类号: A61K31/192 , C07C323/22
CPC分类号: C07C323/60 , C07C59/68 , C07C323/20
摘要: The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR modulators to treat or inhibit the progression of, for example, dyslipidemia.
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公开(公告)号:US07875744B2
公开(公告)日:2011-01-25
申请号:US12549426
申请日:2009-08-28
申请人: Gee-Hong Kuo , Rui Zhang , Aihua Wang , Alan DeAngelis , Keith Demarest , Patricia Pelton
发明人: Gee-Hong Kuo , Rui Zhang , Aihua Wang , Alan DeAngelis , Keith Demarest , Patricia Pelton
IPC分类号: C07C59/00 , C07C53/135 , C07C255/00 , A61K31/275 , A61K31/20 , A61K31/195
CPC分类号: C07C59/68 , C07C323/20
摘要: The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR modulators to treat or inhibit the progression of, for example, dyslipidemia.
摘要翻译: 本发明具有4 - ((苯氧基烷基)硫基) - 苯氧基乙酸及其类似物,含有它们的组合物,以及使用它们作为PPAR调节剂来治疗或抑制例如血脂异常进展的方法。
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公开(公告)号:US07425649B2
公开(公告)日:2008-09-16
申请号:US11226645
申请日:2005-09-14
申请人: Gee-Hong Kuo , Rui Zhang , Aihua Wang , Alan DeAngelis , Keith Demarest , Patricia Pelton
发明人: Gee-Hong Kuo , Rui Zhang , Aihua Wang , Alan DeAngelis , Keith Demarest , Patricia Pelton
IPC分类号: C07C59/00 , C07C53/134 , C07C255/00 , A61K31/275 , A61K31/20 , A61K31/195
CPC分类号: C07C59/68 , C07C323/20
摘要: The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR modulators to treat or inhibit the progression of, for example, dyslipidemia.
摘要翻译: 本发明具有4 - ((苯氧基烷基)硫基) - 苯氧基乙酸及其类似物,含有它们的组合物,以及使用它们作为PPAR调节剂来治疗或抑制例如血脂异常进展的方法。
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公开(公告)号:US07598416B2
公开(公告)日:2009-10-06
申请号:US12144061
申请日:2008-06-23
申请人: Gee-Hong Kuo , Rui Zhang , Aihua Wang , Alan DeAngelis , Keith Demarest , Patricia Pelton
发明人: Gee-Hong Kuo , Rui Zhang , Aihua Wang , Alan DeAngelis , Keith Demarest , Patricia Pelton
IPC分类号: C07C59/13 , C07C53/134 , C07C255/00 , A61K31/275 , A61K31/20 , A61K31/195
CPC分类号: C07C59/68 , C07C323/20
摘要: The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR modulators to treat or inhibit the progression of, for example, dyslipidemia.
摘要翻译: 本发明具有4 - ((苯氧基烷基)硫基) - 苯氧基乙酸及其类似物,含有它们的组合物,以及使用它们作为PPAR调节剂来治疗或抑制例如血脂异常进展的方法。
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10.
公开(公告)号:US08242173B2
公开(公告)日:2012-08-14
申请号:US12873383
申请日:2010-09-01
申请人: Alan DeAngelis , Keith T Demarest , Gee-Hong Kuo , Patricia Pelton , Aihua Wang , Rui Zhang
发明人: Alan DeAngelis , Keith T Demarest , Gee-Hong Kuo , Patricia Pelton , Aihua Wang , Rui Zhang
IPC分类号: A61K31/275 , A61K31/192 , C07C59/135 , C07C255/41 , A61P3/10 , A61P1/00 , A61P3/06 , A61P3/04 , A61P9/10 , A61P9/00 , A61P13/12
CPC分类号: C07C323/60 , C07C59/68 , C07C323/20
摘要: The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR modulators to treat or inhibit the progression of, for example, dyslipidemia.
摘要翻译: 本发明具有4 - ((苯氧基烷基)硫基) - 苯氧基乙酸及其类似物,含有它们的组合物,以及使用它们作为PPAR调节剂来治疗或抑制例如血脂异常进展的方法。
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