中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

13 records (took 0.016 seconds)

    Method for propagating adenoviral vectors encoding inhibitory gene products
    2.
    发明授权
    Method for propagating adenoviral vectors encoding inhibitory gene products 有权
    繁殖编码抑制性基因产物的腺病毒载体的方法

    公开(公告)号：US09388429B2

    公开(公告)日：2016-07-12

    申请号：US14288493

    申请日：2014-05-28

    Applicant: GenVec, Inc.

    Inventor： Jason G. D. Gall ,  Douglas E. Brough ,  C. Richter King

    IPC: C12N7/01 ,  C12N15/861 ,  C12N15/86 ,  C12N7/00 ,  C12N15/63

    CPC classification number: C12N15/635 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/10343 ,  C12N2710/10352 ,  C12N2830/006

    Abstract: The invention provides a method of propagating an adenoviral vector. The method comprises (a) providing a cell comprising a cellular genome comprising a nucleic acid sequence encoding a tetracycline operon repressor protein (tetR), and (b) contacting the cell with an adenoviral vector comprising a heterologous nucleic acid sequence encoding a toxic protein. The heterologous nucleic acid sequence is operably linked to a promoter and one or more tetracycline operon operator sequences (tetO), and expression of the heterologous nucleic acid sequence is inhibited in the presence of tetR, such that the adenoviral vector is propagated. The invention also provides a system comprising the aforementioned cell and adenoviral vector.

    Abstract translation: 本发明提供了一种繁殖腺病毒载体的方法。 该方法包括（a）提供包含细胞基因组的细胞，所述细胞基因组包含编码四环素操纵子阻遏蛋白（tetR）的核酸序列，和（b）使细胞与包含编码毒性蛋白质的异源核酸序列的腺病毒载体接触。 异源核酸序列可操作地连接到启动子和一个或多个四环素操纵子操纵子序列（tetO），并且异源核酸序列的表达在tetR存在下被抑制，使得腺病毒载体被繁殖。 本发明还提供了包含上述细胞和腺病毒载体的系统。

    Adenoviral vector-based respiratory syncytial virus (RSV) vaccine
    7.
    发明授权
    Adenoviral vector-based respiratory syncytial virus (RSV) vaccine 有权
    基于腺病毒载体的呼吸道合胞病毒（RSV）疫苗

    公开(公告)号：US09580476B2

    公开(公告)日：2017-02-28

    申请号：US14349735

    申请日：2012-10-05

    Applicant: GenVec, Inc.

    Inventor： Douglas E. Brough ,  Jason G. D. Gall ,  Duncan McVey

    IPC: C07K14/005 ,  C12N15/86

    CPC classification number: C07K14/005 ,  C12N15/86 ,  C12N2710/10322 ,  C12N2710/10333 ,  C12N2710/10343 ,  C12N2760/18034 ,  C12N2799/022

    Abstract: The invention provides an adenovirus or adenoviral vector characterized by comprising a nucleic acid sequence encoding one or more Respiratory Syncytial Virus (RSV) antigens and one or more particular nucleic acid sequences or one or more particular amino acid sequences, or portions thereof, pertaining to, for example, an adenoviral pIX protein, DNA polymerase protein, penton protein, hexon protein, and/or fiber protein, as well as a method of inducing an immune response against RSV in a mammal by administering the adenovirus or adenoviral vector to the mammal.

    Abstract translation: 本发明提供了腺病毒或腺病毒载体，其特征在于包含编码一种或多种呼吸道合胞病毒（RSV）抗原和一种或多种特定核酸序列或一个或多个特定氨基酸序列或其部分的核酸序列， 例如腺病毒pIX蛋白，DNA聚合酶蛋白，penton蛋白，六邻体蛋白和/或纤维蛋白，以及通过向哺乳动物施用腺病毒或腺病毒载体而在哺乳动物中诱导针对RSV的免疫应答的方法。

Patent Agency Ranking