公开(公告)号：US20230383008A1

公开(公告)日：2023-11-30

申请号：US18048763

申请日：2022-10-21

Applicant: Genentech, Inc.

Inventor： Robert F. KELLEY ,  Daniel K. Kirchhofer ,  Joyce Lai ,  Chingwei V. Lee ,  Wei-Ching Liang ,  Michael T. Lipari ,  Kelly M. Loyet ,  Tao Sai ,  Menno Van Lookeren Campagne ,  Yan Wu ,  Germaine Fuh

IPC: C07K16/40 ,  A61K39/395

CPC classification number: C07K16/40 ,  A61K39/3955 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  A61K2039/507

Abstract: The present invention provides anti-HtrA1 antibodies (including bispecific anti-HtrA1 anti-Factor D antibodies) and methods of making and using the same, for example, in methods of treating HtrA1-associated disorders, ocular disorders, and/or complement-associated disorders.

公开(公告)号：US11702479B2

公开(公告)日：2023-07-18

申请号：US16872631

申请日：2020-05-12

Applicant: Genentech, Inc.

Inventor： Christian W. Siebel ,  Yan Wu

IPC: A61K39/395 ,  C07K16/18 ,  C07K16/22 ,  C07K16/28 ,  C07K16/30 ,  A61K47/68 ,  C07K16/24 ,  A61K39/00

CPC classification number: C07K16/2896 ,  A61K39/3955 ,  A61K47/6849 ,  C07K16/18 ,  C07K16/24 ,  C07K16/28 ,  C07K16/30 ,  A61K39/395 ,  A61K2039/505 ,  C07K16/22 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

Abstract: The invention provides anti-Jagged antibodies and methods of using the same.

公开(公告)号：US11512143B2

公开(公告)日：2022-11-29

申请号：US16543818

申请日：2019-08-19

Applicant: Genentech, Inc.

Inventor： Robert F. Kelley ,  Daniel K. Kirchhofer ,  Joyce Lai ,  Chingwei V. Lee ,  Wei-Ching Liang ,  Michael T. Lipari ,  Kelly M. Loyet ,  Tao Sai ,  Menno Van Lookeren Campagne ,  Yan Wu ,  Germaine Fuh

IPC: C07K16/40 ,  A61K39/395 ,  A61K39/00

Abstract: The present invention provides anti-HtrA1 antibodies (including bispecific anti-HtrA1 anti-Factor D antibodies) and methods of making and using the same, for example, in methods of treating HtrA1-associated disorders, ocular disorders, and/or complement-associated disorders.

公开(公告)号：US20220135701A1

公开(公告)日：2022-05-05

申请号：US17500741

申请日：2021-10-13

Applicant: Genentech, Inc.

Inventor： Wei-Ching LIANG ,  WeiYu Lin ,  Yan Wu ,  Minhong Yan

IPC: C07K16/40 ,  A61P35/00

Abstract: The present disclosure provides anti-MerTK antibodies and methods of use thereof. The methods comprise administering an anti-MerTK antibody or an immunoconjugate thereof.

公开(公告)号：US20210206877A1

公开(公告)日：2021-07-08

申请号：US17113711

申请日：2020-12-07

Applicant: Genentech, Inc. ,  Adimab LLC

Inventor： Yichin Liu ,  Jasvinder Atwal ,  Cecilia Pui Chi Chiu ,  Ryan J. Watts ,  Yan Wu ,  Eric Krauland ,  Michael Feldhaus

IPC: C07K16/40 ,  A61K47/68 ,  G01N33/573

Abstract: The invention provides antagonistic antibodies to BACE1 and methods of using the same for the treatment of neurological disease and disorders

公开(公告)号：US20210206871A1

公开(公告)日：2021-07-08

申请号：US17085750

申请日：2020-10-30

Applicant: Genentech, Inc.

Inventor： Yvonne Chinn ,  Julie Q. Hang ,  Christian W. Siebel ,  Yan Wu ,  Daniel Lafkas

IPC: C07K16/28 ,  A61K47/68 ,  A61K39/395

Abstract: The invention provides anti-Jagged1 antibodies and methods of using the same.

公开(公告)号：US20190248903A1

公开(公告)日：2019-08-15

申请号：US16250398

申请日：2019-01-17

Applicant: Genentech, Inc.

Inventor： Bing ZHENG ,  Andrew Polson ,  Cecilia Chiu ,  Wei-Ching Liang ,  Yan Wu

IPC: C07K16/28 ,  A61K31/5517 ,  A61K47/68 ,  A61K51/10 ,  A61K31/706 ,  C07K16/30 ,  G01N33/574

CPC classification number: C07K16/2851 ,  A61K31/5517 ,  A61K31/706 ,  A61K47/68 ,  A61K47/6817 ,  A61K47/6867 ,  A61K47/6889 ,  A61K51/1069 ,  A61K51/1093 ,  C07K16/3061 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/52 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  C07K2317/94 ,  G01N33/57426 ,  G01N2333/7056

Abstract: The invention provides anti-CLL-1 antibodies and immunoconjugates and methods of using the same.

公开(公告)号：US10150813B2

公开(公告)日：2018-12-11

申请号：US14773334

申请日：2014-03-13

Applicant: Genentech, Inc.

Inventor： Steven R. Leong ,  Andrew Polson ,  Paul Polakis ,  Yan Wu ,  Wei-Ching Liang ,  Ron Firestein

IPC: C07K16/28 ,  A61K39/395 ,  A61K38/08 ,  A61K51/10 ,  C07K16/30 ,  G01N33/569 ,  A61K47/65 ,  A61K47/68 ,  A61K39/00

Abstract: The disclosure provides anti-B7-H4 antibodies and immunoconjugates and methods of using the same.

公开(公告)号：US10047158B2

公开(公告)日：2018-08-14

申请号：US15895741

申请日：2018-02-13

Applicant: Genentech, Inc.

Inventor： Jane L. Grogan ,  Robert J. Johnston ,  Yan Wu ,  Wei-Ching Liang ,  Patrick Lupardus ,  Mahesh Yadav ,  Dhaya Seshasayee ,  Meredith Hazen

IPC: C07K16/00 ,  C07K16/28 ,  A61K38/17 ,  A61K45/06 ,  A61K39/395 ,  C07K16/30 ,  A61K39/00

CPC classification number: C07K16/28 ,  A61K38/177 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/2818 ,  C07K16/2827 ,  C07K16/2878 ,  C07K16/3061 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/567 ,  C07K2317/70 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/90 ,  C07K2317/92 ,  C07K2317/94 ,  Y02A50/466

Abstract: The invention provides anti-TIGIT (T-cell immunoreceptor with Ig and ITIM domains) antibodies and methods of using the same.

公开(公告)号：US10035854B2

公开(公告)日：2018-07-31

申请号：US15349757

申请日：2016-11-11

Applicant: Genentech, Inc.

Inventor： Yan Wu ,  Weilan Ye ,  Jeremy Bryant Burton ,  Cecilia Chiu

IPC: A61P9/10 ,  A61P27/02 ,  A61K39/395 ,  C07K16/28 ,  C07H21/04 ,  A61K47/68 ,  A61K39/00

CPC classification number: C07K16/28 ,  A61K39/395 ,  A61K47/6849 ,  A61K2039/505 ,  A61P9/10 ,  A61P27/02 ,  C07H21/04 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/567 ,  C07K2317/75 ,  C07K2317/92

Abstract: The invention provides anti-LRP5 antibodies and methods of making and using the same.