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公开(公告)号：US20230013598A1
公开(公告)日：2023-01-19
申请号：US17936162
申请日：2022-09-28
发明人： Vasile Bogdan Neculaes , Andrew Soliz Torres , Antonio Caiafa , Brian Duh-Lan Lee , Allen Lawrence Garner
IPC分类号： A61K38/18 , A61K35/19 , G01N33/49 , C12N13/00 , G01N33/487
摘要： Methods and systems for releasing growth factors are disclosed. In certain embodiments, a blood sample is exposed to a sequence of one or more electric pulses to trigger release of a growth factor in the sample. In certain embodiments, the growth factor release is not accompanied by clotting within the blood sample.
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公开(公告)号：US20190264160A1
公开(公告)日：2019-08-29
申请号：US15905463
申请日：2018-02-26
摘要： Disclosed herein are multi-cuvette cartridges, flow cells, and electrical pulse systems for treatment of large volumes of biological samples with pulsed electric fields. The multi-cuvette cartridges systems may include mechanical motors for automatic positioning and alignment between the cuvettes and the electrodes of the electrical pulse systems. The flow cell systems may include fluidic systems, such as pumps, nozzles and valves, which may operate in coordination with the electrical systems for efficient exposition of biological samples. Embodiments having flow cell systems that allow “on-demand” production of activated sample are also disclosed.
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公开(公告)号：US10383915B2
公开(公告)日：2019-08-20
申请号：US15251990
申请日：2016-08-30
发明人： Vasile Bogdan Neculaes , Andrew Soliz Torres , Antonio Caiafa , Brian Dun-Lan Lee , Allen Lawrence Garner
摘要： Methods and systems for releasing growth factors are disclosed. In certain embodiments, a blood sample is exposed to a sequence of one or more electric pulses to trigger release of a growth factor in the sample. In certain embodiments, the growth factor release is not accompanied by clotting within the blood sample.
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公开(公告)号：US20190181857A1
公开(公告)日：2019-06-13
申请号：US16121216
申请日：2018-09-04
摘要： A gate drive circuit device includes positive and negative pulse circuit portions each including a pulse diode and a pulse assembly connected in parallel with each other. The pulse assemblies each include another pulse diode and a resistor-capacitor assembly connected in series. The resistor-capacitor assembly includes a pulse resistor and a pulse capacitor connected in parallel. Each pulse circuit portion is connected with a different switch. Each pulse circuit portion is a passive device that is configured to activate a different switch responsive to receiving one or more voltage pulses from a power supply.
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公开(公告)号：US10262829B2
公开(公告)日：2019-04-16
申请号：US15249030
申请日：2016-08-26
摘要： A circuit assembly and method use a breakover device that changes states in response to a change in electric energy in a helper circuit that supplies current from a power source to a powered system. The helper circuit includes an inductive element connected with the powered system. The breakover device is in a non-conducting state prior to a discharge event from the powered system to prevent the current from the power source from being conducted through the resistive element. The breakover device changes to a conducting state responsive to the powered system discharging current into the helper circuit. The breakover device conducts the current that is discharged from the powered system through the resistive element to reduce the electric energy in the helper circuit from the current that is discharged.
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公开(公告)号：US10110013B2
公开(公告)日：2018-10-23
申请号：US14808783
申请日：2015-07-24
摘要： A switch assembly includes one or more solid state semiconductor switches configured to be disposed within a downhole pipe assembly. The one or more switches are configured to operate in a closed state to conduct electric current supplied by a power source disposed above a surface to pumps disposed beneath the surface to cause the pumps to extract a resource from beneath the surface via the pipe assembly. The one or more switches also are configured to operate in an open state to stop conducting the electric current from the power source to the pumps.
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公开(公告)号：US20180191268A1
公开(公告)日：2018-07-05
申请号：US15399309
申请日：2017-01-05
发明人： Antonio Caiafa
CPC分类号： H02M1/14 , H02M1/12 , H02M1/143 , H02M3/285 , H02M3/33569 , H02M3/33576 , H02M3/33592 , H02M3/3376 , H02M7/483 , H02M7/49 , H02M2001/0058 , H02M2001/0077 , H02M2001/0083 , Y02B70/1433 , Y02B70/1475 , Y02B70/1491
摘要： A power system includes a first unit block having first resonant circuitry that receives power from a DC bus, a first controlled rectifier that provides a first portion of power to one or more loads at a first voltage level, and a first transformer coupled between the first resonant circuitry and the first controlled rectifier. A second unit block includes second resonant circuitry that receives power from the DC bus, a second controlled rectifier configured to provide a second portion of power to the one or more loads at a second voltage level, and a second transformer coupled between the resonant circuitry and the controlled rectifier. The first and second unit blocks are coupled in series to output a summation waveform.
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公开(公告)号：US20160105018A1
公开(公告)日：2016-04-14
申请号：US14510575
申请日：2014-10-09
发明人： Ruxi Wang , William James Premerlani , Antonio Caiafa , Yan Pan
IPC分类号： H02H9/02
CPC分类号： H03K17/92 , H01H9/541 , H01H9/542 , H01H2009/543
摘要： A circuit breaking system includes a first branch including at least one solid-state snubber; a second branch coupled in parallel to the first branch and including a superconductor and a cryogenic contactor coupled in series; and a controller operatively coupled to the at least one solid-state snubber and the cryogenic contactor and programmed to, when a fault occurs in the load circuit, activate the at least one solid-state snubber for migrating flow of the electrical current from the second branch to the first branch, and, when the fault is cleared in the load circuit, activate the cryogenic contactor for migrating the flow of the electrical current from the first branch to the second branch.
摘要翻译： 断路系统包括包括至少一个固态缓冲器的第一分支; 第二分支并联耦合到第一分支并且包括串联耦合的超导体和低温接触器; 以及控制器，其可操作地耦合到所述至少一个固态缓冲器和所述低温接触器，并且被编程为当所述负载电路中发生故障时，激活所述至少一个固态缓冲器，用于使所述电流从所述第二 分支到第一分支，并且当故障在负载电路中被清除时，激活用于将电流从第一分支移动到第二分支的低温接触器。
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公开(公告)号：US20150264789A1
公开(公告)日：2015-09-17
申请号：US14211894
申请日：2014-03-14
CPC分类号： H03K17/56 , H03K2217/0081 , H05G1/58 , Y10T307/76
摘要： Methods and systems for controlling voltage switching are provided. One system includes a transformer having primary and second windings, and a plurality of switching devices, wherein at least two of the switching devices are configured to produce different voltage outputs from a voltage input generated at the transformer. The plurality of switches are electrically referenced to one or more voltages. The system also includes a drive arrangement connected to the plurality of switches and configured to receive one or more voltage control pulses through the primary windings of the transformer, wherein the drive arrangement switches one or more of the plurality of switches based on the one or more voltage control pulses.
摘要翻译： 提供了用于控制电压切换的方法和系统。 一个系统包括具有主绕组和第二绕组的变压器和多个开关装置，其中至少两个开关装置被配置为从变压器处产生的电压输入产生不同的电压输出。 多个开关以一个或多个电压为基准。 该系统还包括驱动装置，其连接到多个开关并且被配置为通过变压器的初级绕组接收一个或多个电压控制脉冲，其中驱动装置基于一个或多个开关来切换多个开关中的一个或多个 电压控制脉冲。
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公开(公告)号：US09078862B2
公开(公告)日：2015-07-14
申请号：US13912050
申请日：2013-06-06
发明人： Vasile Bogdan Neculaes , Antonio Caiafa , Brian Duh-Lan Lee , Nicole Evelyn LaPlante , Andrew Soliz Torres , Allen Lawrence Garner
CPC分类号： A61K35/19 , A61K41/00 , A61N1/00 , C12N5/0644 , C12N13/00
摘要： Embodiments of the disclosure relate to platelet activation and/or aggregation using electric pulses. In one embodiment, a platelet-containing sample is exposed to electric pulses. At least one of the electric pulses has a duration greater than 1 microsecond and a field strength below 50 kV/cm. In another embodiment, the electric pulses may be designed with particular field strengths and durations.
摘要翻译： 本公开的实施方案涉及使用电脉冲的血小板活化和/或聚集。 在一个实施方案中，将含血小板的样品暴露于电脉冲。 电脉冲中的至少一个具有大于1微秒的持续时间和低于50kV / cm的场强。 在另一个实施例中，电脉冲可以被设计为具有特定的场强和持续时间。
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