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1.Thyazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene A4 hydrolase 有权
标题翻译: 噻唑并吡啶-2-基氧基 - 苯基和噻唑并吡嗪-2-基氧基 - 苯胺作为白三烯A4水解酶的调节剂公开(公告)号:US20110159563A1
公开(公告)日:2011-06-30
申请号:US13039017
申请日:2011-03-02
申请人: Genesis M. Bacani , Diego Broggini , Eugene Y. Cheung , Christa C. Chrovian , Xiaohu Deng , Anne M. Fourie , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Jimmy T. Liang , Susanne Lochner , Neelakandha S. Mani , Alejandro Santillán, JR. , Kathleen Sappey , Kia Sepassi , Virginia M. Tanis , Alvah T. Wickboldt , John J. M. Wiener , Hartmut Zinser
发明人: Genesis M. Bacani , Diego Broggini , Eugene Y. Cheung , Christa C. Chrovian , Xiaohu Deng , Anne M. Fourie , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Jimmy T. Liang , Susanne Lochner , Neelakandha S. Mani , Alejandro Santillán, JR. , Kathleen Sappey , Kia Sepassi , Virginia M. Tanis , Alvah T. Wickboldt , John J. M. Wiener , Hartmut Zinser
IPC分类号: C12N9/99 , C07D513/04
CPC分类号: C07D498/04 , C07D451/02
摘要: Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amine compounds are described, which are useful as LTA4 hydrolase (LTA4H) modulators. Such compounds may be used in pharmaceutical compositions and methods for modulation of LTA4H and for the treatment of disease states, disorders, and conditions mediated by LTA4 hydrolase activity.
摘要翻译: 描述了噻唑并吡啶-2-基氧基 - 苯基和噻唑并吡嗪-2-基氧基 - 苯基胺化合物,其可用作LTA4水解酶(LTA4H)调节剂。 这样的化合物可以用于调节LTA4H的药物组合物和方法以及用于治疗由LTA4水解酶活性介导的疾病状态,障碍和病症。
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公开(公告)号:US07939527B2
公开(公告)日:2011-05-10
申请号:US12421406
申请日:2009-04-09
申请人: Genesis M. Bacani , Diego Broggini , Eugene Y. Cheung , Christa C. Chrovian , Xiaohu Deng , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Jimmy T. Liang , Susanne Lochner , Neelakandha S. Mani , Alejandro Santillán, Jr. , Kathleen Sappey , Kia Sepassi , Virginia M. Tanis , Alvah T. Wickboldt , John J. M. Wiener , Hartmut Zinser
发明人: Genesis M. Bacani , Diego Broggini , Eugene Y. Cheung , Christa C. Chrovian , Xiaohu Deng , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Jimmy T. Liang , Susanne Lochner , Neelakandha S. Mani , Alejandro Santillán, Jr. , Kathleen Sappey , Kia Sepassi , Virginia M. Tanis , Alvah T. Wickboldt , John J. M. Wiener , Hartmut Zinser
IPC分类号: A61K31/5355 , A61K31/4985 , A61K31/516 , A61K31/497 , A61K31/4365 , C07D413/14 , C07D239/34 , C07D513/04
CPC分类号: C07D498/04 , C07D451/02
摘要: Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amine compounds are described, which are useful as LTA4 hydrolase (LTA4H) modulators. Such compounds may be used in pharmaceutical compositions and methods for modulation of LTA4H and for the treatment of disease states, disorders, and conditions mediated by LTA4 hydrolase activity.
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3.Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene A4 hydrolase 有权
标题翻译: 噻唑并吡啶-2-基氧基 - 苯基和噻唑并吡嗪-2-基氧基 - 苯胺作为白三烯A4水解酶的调节剂公开(公告)号:US20090258854A1
公开(公告)日:2009-10-15
申请号:US12421406
申请日:2009-04-09
申请人: Genesis M. Bacani , Diego Broggini , Eugene Y. Cheung , Christa C. Chrovian , Xiaohu Deng , Anne M. Fourie , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearny , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Jimmy T. Liang , Susanne Lochner , Neelakandha S. Mani , Alejandro Santillan, JR. , Kathleen Sappey , Kia Sepassi , Virginia M. Tanis , Alvah T. Wickboldt , John J. M. Wiener , Hartmut Zinser
发明人: Genesis M. Bacani , Diego Broggini , Eugene Y. Cheung , Christa C. Chrovian , Xiaohu Deng , Anne M. Fourie , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearny , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Jimmy T. Liang , Susanne Lochner , Neelakandha S. Mani , Alejandro Santillan, JR. , Kathleen Sappey , Kia Sepassi , Virginia M. Tanis , Alvah T. Wickboldt , John J. M. Wiener , Hartmut Zinser
IPC分类号: A61K31/437 , C07D513/04 , A61K31/506 , A61K31/5377 , A61K31/4985 , A61P29/00 , C12N9/50 , C07D453/02
CPC分类号: C07D498/04 , C07D451/02
摘要: Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amine compounds are described, which are useful as LTA4 hydrolase (LTA4H) modulators. Such compounds may be used in pharmaceutical compositions and methods for modulation of LTA4H and for the treatment of disease states, disorders, and conditions mediated by LTA4 hydrolase activity.
摘要翻译: 描述了噻唑并吡啶-2-基氧基 - 苯基和噻唑并吡嗪-2-基氧基 - 苯基胺化合物,其可用作LTA4水解酶(LTA4H)调节剂。 这样的化合物可以用于调节LTA4H的药物组合物和方法以及用于治疗由LTA4水解酶活性介导的疾病状态,障碍和病症。
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4.Thyazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene A4 hydrolase 有权
标题翻译: 噻唑并吡啶-2-基氧基 - 苯基和噻唑并吡嗪-2-基氧基 - 苯胺作为白三烯A4水解酶的调节剂公开(公告)号:US08357684B2
公开(公告)日:2013-01-22
申请号:US13039017
申请日:2011-03-02
申请人: Genesis M. Bacani , Eugene Y. Cheung , Christa C. Chrovian , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Alejandro Santillán, Jr. , Kathleen Sappey , Kia Sepassi , Virginia M. Tanis , Alvah T. Wickboldt , John J. M. Wiener
发明人: Genesis M. Bacani , Eugene Y. Cheung , Christa C. Chrovian , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Alejandro Santillán, Jr. , Kathleen Sappey , Kia Sepassi , Virginia M. Tanis , Alvah T. Wickboldt , John J. M. Wiener
IPC分类号: A61K31/5355 , A61K31/4985 , A61K31/506 , A61K31/497 , A61K31/4365 , C07D413/14 , C07D239/34 , C07D513/04
CPC分类号: C07D498/04 , C07D451/02
摘要: Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amine compounds are described, which are useful as LTA4 hydrolase (LTA4H) modulators. Such compounds may be used in pharmaceutical compositions and methods for modulation of LTA4H and for the treatment of disease states, disorders, and conditions mediated by LTA4 hydrolase activity.
摘要翻译: 描述了噻唑并吡啶-2-基氧基 - 苯基和噻唑并吡嗪-2-基氧基 - 苯基胺化合物,其可用作LTA4水解酶(LTA4H)调节剂。 这样的化合物可以用于调节LTA4H的药物组合物和方法以及用于治疗由LTA4水解酶活性介导的疾病状态,障碍和病症。
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5.COMPOUNDS WITH TWO FUSED BICYCLIC HETEROARYL MOIETIES AS MODULATORS OF LEUKOTRIENE A4 HYDROLASE 有权
标题翻译: 具有两个双熔体双组分杂化物的化合物作为LEUKOTRIENE A4水解产物的调节剂公开(公告)号:US20100292208A1
公开(公告)日:2010-11-18
申请号:US12778646
申请日:2010-05-12
申请人: Genesis Bacani , Christa C. Chrovian , Wendy Eccles , Anne M. Fourie , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Alejandro Santillán, JR. , Virginia M. Tanis , John J. M. Wiener
发明人: Genesis Bacani , Christa C. Chrovian , Wendy Eccles , Anne M. Fourie , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Alejandro Santillán, JR. , Virginia M. Tanis , John J. M. Wiener
IPC分类号: A61K31/397 , C07D417/14 , A61K31/428 , A61K31/454 , A61K31/5377 , A61K31/537 , A61K31/551 , A61P11/06 , A61P17/06 , A61P17/02 , A61P17/00 , A61P3/10 , A61P19/02 , A61P35/00 , A61P1/00 , A61P9/00
CPC分类号: C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D493/04 , C07D495/04 , C07D498/04 , C07D513/04 , C07D519/00
摘要: Compounds with two fused bicyclic heteroaryl moieties and their pharmaceutical compositions, and methods of using them as leukotriene A4 hydrolase (LTA4H) modulators and for the treatment of diseases, disorders and conditions mediated by LTA4H.
摘要翻译: 具有两个稠合双环杂芳基部分的化合物及其药物组合物,以及将其用作白三烯A4水解酶(LTA4H)调节剂并用于治疗由LTA4H介导的疾病,病症和状况的方法。
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6.Compounds with two fused bicyclic heteroaryl moieties as modulators of leukotriene A4 hydrolase 有权
标题翻译: 具有两个稠合双环杂芳基部分的化合物作为白三烯A4水解酶的调节剂公开(公告)号:US08399465B2
公开(公告)日:2013-03-19
申请号:US12778646
申请日:2010-05-12
申请人: Genesis Bacani , Christa C. Chrovian , Wendy Eccles , Anne M. Fourie , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Alejandro Santillán, Jr. , Virginia M. Tanis , John J. M. Wiener
发明人: Genesis Bacani , Christa C. Chrovian , Wendy Eccles , Anne M. Fourie , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Alejandro Santillán, Jr. , Virginia M. Tanis , John J. M. Wiener
IPC分类号: A61K31/535 , A61K31/47 , A61K31/445 , A61K31/425 , C07D417/14 , C07D417/12
CPC分类号: C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D493/04 , C07D495/04 , C07D498/04 , C07D513/04 , C07D519/00
摘要: Compounds with two fused bicyclic heteroaryl moieties and their pharmaceutical compositions, and methods of using them as leukotriene A4 hydrolase (LTA4H) modulators and for the treatment of diseases, disorders and conditions mediated by LTA4H.
摘要翻译: 具有两个稠合双环杂芳基部分的化合物及其药物组合物,以及将其用作白三烯A4水解酶(LTA4H)调节剂并用于治疗由LTA4H介导的疾病,病症和状况的方法。
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7.CARBON-LINKED TETRAHYDRO-PYRAZOLO-PYRIDINE MODULATORS OF CATHEPSIN S 审中-公开
标题翻译: 碳氢化合物的联苯四唑 - 吡唑并吡啶调节剂公开(公告)号:US20080200454A1
公开(公告)日:2008-08-21
申请号:US12031010
申请日:2008-02-14
申请人: Michael K. Ameriks , Frank U. Axe , James P. Edwards , Cheryl A. Grice , Hui Cai , Elizabeth Ann Gleason , Steven P. Meduna , Kevin L. Tays , John J. M. Wiener , Alvah T. Wickboldt
发明人: Michael K. Ameriks , Frank U. Axe , James P. Edwards , Cheryl A. Grice , Hui Cai , Elizabeth Ann Gleason , Steven P. Meduna , Kevin L. Tays , John J. M. Wiener , Alvah T. Wickboldt
IPC分类号: A61K31/437 , A61P37/00 , A61P29/00 , A61P1/00 , A61P25/00 , A61P35/00 , A61K31/496 , A61K31/541 , A61K31/55 , A61P17/00 , A61P3/10 , A61P11/00 , C07D471/04 , A61K31/53
CPC分类号: C07D471/04 , C07D519/00
摘要: Carbon-linked tetrahydro-pyrazolo-pyridine compounds are described, which are useful as cathepsin S modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by cathepsin S activity, such as psoriasis, pain, multiple sclerosis, atherosclerosis, and rheumatoid arthritis.
摘要翻译: 描述了碳连接的四氢 - 吡唑并 - 吡啶化合物,其可用作组织蛋白酶S调节剂。 这些化合物可用于治疗由组织蛋白酶S活性介导的疾病状态,病症和病症的药物组合物和方法,例如银屑病,疼痛,多发性硬化,动脉粥样硬化和类风湿性关节炎。
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公开(公告)号:US08232391B2
公开(公告)日:2012-07-31
申请号:US12833682
申请日:2010-07-09
申请人: Brett D. Allison , Laurent Gomez , Cheryl A. Grice , Michael D. Hack , Brian J. Morrow , S. Timothy Motley , Alejandro Santillan, Jr. , Karen J. Shaw , Kimberly L. Schwarz , Liu Y. Tang , Hariharan Venkatesan , John J. M. Wiener
发明人: Brett D. Allison , Laurent Gomez , Cheryl A. Grice , Michael D. Hack , Brian J. Morrow , S. Timothy Motley , Alejandro Santillan, Jr. , Karen J. Shaw , Kimberly L. Schwarz , Liu Y. Tang , Hariharan Venkatesan , John J. M. Wiener
IPC分类号: C07D279/10 , A61K31/54
CPC分类号: A61K31/4375 , A61K31/444 , A61K31/4453 , A61K31/4709 , A61K31/498 , A61K31/538 , A61K31/5383 , A61K31/5415 , A61K31/55 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/12 , C07D417/14 , C07D471/04
摘要: Antibacterial compounds, compositions containing them, and methods of use for the inhibition of bacterial activity and the treatment, prevention or inhibition of bacterial infection.
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公开(公告)号:US08242275B2
公开(公告)日:2012-08-14
申请号:US12833621
申请日:2010-07-09
申请人: Brett D. Allison , Laurent Gomez , Cheryl A. Grice , Michael D. Hack , Brian J. Morrow , S. Timothy Motley , Alejandro Santillan, Jr. , Karen J. Shaw , Kimberly L. Schwarz , Liu Y. Tang , Hariharan Venkatesan , John J. M. Wiener
发明人: Brett D. Allison , Laurent Gomez , Cheryl A. Grice , Michael D. Hack , Brian J. Morrow , S. Timothy Motley , Alejandro Santillan, Jr. , Karen J. Shaw , Kimberly L. Schwarz , Liu Y. Tang , Hariharan Venkatesan , John J. M. Wiener
IPC分类号: C07D471/02
CPC分类号: A61K31/4375 , A61K31/444 , A61K31/4453 , A61K31/4709 , A61K31/498 , A61K31/538 , A61K31/5383 , A61K31/5415 , A61K31/55 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/12 , C07D417/14 , C07D471/04
摘要: Antibacterial compounds, compositions containing them, and methods of use for the inhibition of bacterial activity and the treatment, prevention or inhibition of bacterial infection.
摘要翻译: 抗菌化合物,含有它们的组合物,以及用于抑制细菌活性和治疗,预防或抑制细菌感染的方法。
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公开(公告)号:US07842810B2
公开(公告)日:2010-11-30
申请号:US11393558
申请日:2006-03-30
申请人: Brett D. Allison , Laurent Gomez , Cheryl A. Grice , Michael D. Hack , Alejandro Santillan, Jr. , Kimberly L. Schwarz , Liu Y. Tang , Hariharan Venkatesan , John J. M. Wiener
发明人: Brett D. Allison , Laurent Gomez , Cheryl A. Grice , Michael D. Hack , Alejandro Santillan, Jr. , Kimberly L. Schwarz , Liu Y. Tang , Hariharan Venkatesan , John J. M. Wiener
IPC分类号: C07D215/00
CPC分类号: A61K31/4375 , A61K31/444 , A61K31/4453 , A61K31/4709 , A61K31/498 , A61K31/538 , A61K31/5383 , A61K31/5415 , A61K31/55 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/12 , C07D417/14 , C07D471/04
摘要: Antibacterial compounds, compositions containing them, and methods of use for the inhibition of bacterial activity and the treatment, prevention or inhibition of bacterial infection.
摘要翻译: 抗菌化合物,含有它们的组合物,以及用于抑制细菌活性和治疗,预防或抑制细菌感染的方法。
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