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    Vaccine for avian influenza and methods of use
    2.
    发明授权
    Vaccine for avian influenza and methods of use 有权
    禽流感疫苗及使用方法

    公开(公告)号：US07993655B2

    公开(公告)日：2011-08-09

    申请号：US12296729

    申请日：2007-04-20

    申请人： Steven Robert Webb ,  Matthew J. Henry

    发明人： Steven Robert Webb ,  Matthew J. Henry

    IPC分类号： A61K39/145

    CPC分类号： A61K39/145 ,  A61K39/12 ,  A61K2039/552 ,  A61K2039/55555 ,  A61K2039/55577 ,  C12N15/8258 ,  C12N2760/16134

    摘要： The subject invention pertains to influenza vaccines and particularly avian influenza vaccines (AIV). The invention includes methods for preparing transgenic plant cells to express know HA1 polypeptides having specified homologies that are used to prepare vaccine compositions and methods for inducing protective immunity in an individual, animal, mammal or human.

    摘要翻译： 本发明涉及流感疫苗，特别是禽流感疫苗（AIV）。 本发明包括用于制备转基因植物细胞以表达具有用于制备疫苗组合物的具有特定同源性的已知HA1多肽的方法和在个体，动物，哺乳动物或人中诱导保护性免疫的方法。

    INDUCTION OF MUCOSAL IMMUNE RESPONSES BY MUCOSAL DELIVERY PENTABODY COMPLEX (MDPC)
    4.
    发明申请
    INDUCTION OF MUCOSAL IMMUNE RESPONSES BY MUCOSAL DELIVERY PENTABODY COMPLEX (MDPC) 审中-公开
    通过粘膜递送复合物（MDPC）诱导粘膜免疫应答

    公开(公告)号：US20110318348A1

    公开(公告)日：2011-12-29

    申请号：US13124062

    申请日：2009-10-13

    申请人： Jianbing Zhang ,  Matthew J. Henry ,  Wangxue Chen ,  Steven R. Webb

    发明人： Jianbing Zhang ,  Matthew J. Henry ,  Wangxue Chen ,  Steven R. Webb

    IPC分类号： A61K39/395 ,  A61P31/00 ,  A61P37/08 ,  A61P37/04

    CPC分类号： A61K39/395 ,  A61K2039/541 ,  A61K2039/6037 ,  A61K2039/6056 ,  A61K2039/645 ,  C07K16/18 ,  C07K2317/565 ,  C07K2317/569 ,  C07K2317/92

    摘要： The subject invention provides, for example, a novel approach to specifically induce intranasal and/or oral mucosal as well as humoral antibody response by administrating a mucosal delivery pentabody complex (MDPC). The MDPC is a complex formed by mixing a target antigen and a mucosal delivery pentabody (MDP) that has a strong affinity to the target antigen. The MDP is a fusion protein of a single domain antibody (sdAb; which binds to the target antigen specifically) to a pentamerization domain (which can include the B-subunit of an AB5 toxin family, including the B subunit of cholera toxin (CT) or heat-labile toxin (LT)). The pentamerization domain can self-assemble into a pentamer, through which a pentameric single domain antibody, or a pentabody, is formed.

    摘要翻译： 本发明提供了例如通过施用粘膜递送五抗体复合物（MDPC）来特异性诱导鼻内和/或口腔粘膜以及体液抗体应答的新方法。 MDPC是通过混合目标抗原和对靶抗原具有强亲和力的粘膜递送五抗体（MDP）形成的复合物。 MDP是单结构域抗体（sdAb，其特异性结合靶抗原）与五聚体结构域（其可以包括AB5毒素家族的B亚基，包括霍乱毒素（CT）的B亚基）的融合蛋白， 或热不稳定毒素（LT））。 五聚体结构域可以自组装成五聚体，五聚体单结构域抗体或五肽形成。

    PHAGE RECEPTOR BINDING PROTEINS FOR ANTIBACTERIAL THERAPY AND OTHER NOVEL USES
    10.
    发明申请
    PHAGE RECEPTOR BINDING PROTEINS FOR ANTIBACTERIAL THERAPY AND OTHER NOVEL USES 审中-公开
    PHAGE受体结合蛋白抗菌治疗及其他新用途

    公开(公告)号：US20110143997A1

    公开(公告)日：2011-06-16

    申请号：US12593949

    申请日：2008-03-28

    申请人： Matthew J. Henry ,  Roger C. Mackenzie ,  Christine Szymanski ,  Jamshid Tanha

    发明人： Matthew J. Henry ,  Roger C. Mackenzie ,  Christine Szymanski ,  Jamshid Tanha

    IPC分类号： A61K38/16 ,  A61P31/04 ,  A01N37/18 ,  C07K14/005 ,  A01P1/00

    CPC分类号： C07K14/005 ,  A23K20/147 ,  A23K50/10 ,  A23K50/75 ,  A61K38/00 ,  C12N2795/10222

    摘要： The subject invention relates in part to novel uses of bacteriophage tail spike proteins (TSPs). Some preferred uses are therapeutic uses in animals, such as chickens, against pathogenic bacteria, such as Salmonella. Fragments of the TSPs can also be used according to the subject invention, particularly protein fragments comprising the phage receptor binding domains (PRBDs), which recognize their hosts and facilitate infection. The binding domains are specific to unique surface structures on bacteria and may be used for a variety of applications according to the subject invention. We have shown that by utilizing these PRBDs, it is possible to exploit the long-established evolutionary relationship between bacteria and their viruses (ie bacteriophages) that specifically infect them. The subject invention also relates in part to novel, synthetic forms of tail spike proteins. In some preferred embodiments, these are hexamers.

    摘要翻译： 本发明部分涉及噬菌体尾尖蛋白（TSPs）的新用途。 一些优选的用途是用于动物（例如鸡）中针对致病细菌如沙门氏菌的治疗用途。 也可以根据本发明使用TSP片段，特别是包含识别其宿主并促进感染的噬菌体受体结合结构域（PRBD）的蛋白质片段。 结合域对于细菌上的独特表面结构是特异性的，并且可以用于根据本发明的各种应用。 我们已经表明，通过利用这些PRBD，可以利用细菌与其特异性感染它们的病毒（即噬菌体）之间长期存在的进化关系。 本发明还部分涉及新颖的尾合蛋白的合成形式。 在一些优选的实施方案中，这些是六聚体。