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公开(公告)号：US20120171678A1
公开(公告)日：2012-07-05
申请号：US13417121
申请日：2012-03-09
CPC分类号： G01N21/645 , B01L3/50851 , B01L3/50853 , B01L7/52 , B01L7/54 , B01L2200/147 , B01L2300/0829 , B01L2300/0838 , B01L2300/12 , B01L2300/168 , B01L2300/1822 , B01L2300/1827 , B01L2300/185 , B01L2300/1861
摘要： This invention provides a system for performing PCR, and real time PCR in particular, with great speed and specificity. The system employs a heat block containing a liquid composition to rapidly transfer heat to and from reaction vessels. The system makes use of the reflective properties of the liquid metal to reflect signal from the PCR into the vessel and out the top. In this way, the signal can be measured by an optical assembly in real time without removing the vessels from the heat block.
摘要翻译： 本发明提供了一种用于特别快速和特异性地进行PCR和实时PCR的系统。 该系统采用含有液体组合物的热块来快速地将热量传递到反应容器和从其返回。 该系统利用液态金属的反射特性，将来自PCR的信号反射入容器并排出顶部。 以这种方式，可以通过光学组件实时地测量信号，而不从容器中取出容器。
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公开(公告)号：US20090275113A1
公开(公告)日：2009-11-05
申请号：US12335448
申请日：2008-12-15
CPC分类号： G01N21/645 , B01L3/50851 , B01L3/50853 , B01L7/52 , B01L7/54 , B01L2200/147 , B01L2300/0829 , B01L2300/0838 , B01L2300/12 , B01L2300/168 , B01L2300/1822 , B01L2300/1827 , B01L2300/185 , B01L2300/1861
摘要： This invention provides an apparatus for providing heating and cooling of samples in sample vessels having uniform temperature profiles. The apparatus can be used for performing PCR, and real time PCR in particular, with control and uniformity. The system employs a heat block containing a liquid composition to efficiently transfer heat to and from reaction vessels.
摘要翻译： 本发明提供了一种用于在具有均匀温度分布的样品容器中提供样品的加热和冷却的装置。 该装置可用于进行PCR，特别是具有控制和均匀性的实时PCR。 该系统采用含有液体组合物的热块以有效地将热量传递到反应容器和从其返回。
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公开(公告)号：US20130164754A1
公开(公告)日：2013-06-27
申请号：US13407644
申请日：2012-02-28
申请人： Imran R. MALIK , Axel SCHERER
发明人： Imran R. MALIK , Axel SCHERER
CPC分类号： B01L3/502784 , B01L3/502 , B01L3/502715 , B01L3/502753 , B01L3/502776 , B01L7/52 , B01L2200/0621 , B01L2200/10 , B01L2300/0681 , B01L2300/0867 , B01L2300/087 , B01L2300/165 , B01L2400/0478 , B01L2400/0481 , B01L2400/0487 , B01L2400/0644 , C12Q1/68 , F17D3/00 , G01N35/1097 , G01N2001/4088 , Y10T137/0318 , Y10T137/8593 , Y10T137/85978
摘要： Devices and system for preparing samples are described. Such devices can comprise fluidic chambers, reservoirs, and movable structures for controlling the movement of samples. The device can also comprise functional elements for performing specific operations.
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公开(公告)号：US20120175441A1
公开(公告)日：2012-07-12
申请号：US13427672
申请日：2012-03-22
申请人： Aditya RAJAGOPAL , Axel SCHERER , Mladen BARBIC
发明人： Aditya RAJAGOPAL , Axel SCHERER , Mladen BARBIC
IPC分类号： C12N1/06
摘要： Methods and arrangements to lyse a biological sample are described. The arrangements comprise a lysis tube containing the sample, one or more electromagnets generating a magnetic field, and one or more permanent magnets inside the lysis tube. The permanent magnets move and lyse the sample when a magnetic field is generated by the electromagnets.
摘要翻译： 描述了裂解生物样品的方法和布置。 该装置包括含有样品的裂解管，产生磁场的一个或多个电磁体和裂解管内的一个或多个永磁体。 当电磁铁产生磁场时，永久磁铁移动并裂开样品。
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公开(公告)号：US20100186840A1
公开(公告)日：2010-07-29
申请号：US12636086
申请日：2009-12-11
申请人： Emil P. KARTALOV , John LIU , Axel SCHERER , Clive R. TAYLOR
发明人： Emil P. KARTALOV , John LIU , Axel SCHERER , Clive R. TAYLOR
IPC分类号： F15C1/04
CPC分类号： G05D7/0694 , F16K99/0001 , F16K99/0015 , F16K99/0026 , F16K99/0057 , F16K2099/008 , Y10T137/0318 , Y10T137/218 , Y10T137/2202 , Y10T137/2224 , Y10T137/7795 , Y10T137/7796
摘要： Multi-valve autoregulatory microfluidic devices and methods are described. The described devices and methods offer improved performance and new means of tuning autoregulatory effects in microfluidic devices.
摘要翻译： 描述了多瓣膜自动调节微流体装置和方法。 所描述的装置和方法提供改进的性能和调整微流体装置中的自动调节效应的新手段。
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公开(公告)号：US20120267239A1
公开(公告)日：2012-10-25
申请号：US13448810
申请日：2012-04-17
申请人： Samson CHEN , Aditya RAJAGOPAL , Axel SCHERER
发明人： Samson CHEN , Aditya RAJAGOPAL , Axel SCHERER
CPC分类号： H05K3/10 , B01L3/502707 , B01L3/502715 , B01L2300/0645 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , H01L23/473 , H01L2924/0002 , H05K1/0272 , H05K3/284 , H05K2201/10189 , H05K2203/1327 , Y10T29/49 , Y10T29/49002 , Y10T29/49155 , Y10T29/49165 , Y10T137/85938 , Y10T436/11 , Y10T436/25 , Y10T436/2575 , H01L2924/00
摘要： A printed circuit board structure is coated with an encapsulant within which microfluidic channels have been formed. The microfluidic channels are formed by soldering fluidic connections to metal traces on a surface of the printed circuit board structure prior to encapsulation. The metal traces are removed by etching after encapsulation to form microchannels within the encapsulant.
摘要翻译： 印刷电路板结构涂覆有已经形成微流体通道的密封剂。 在封装之前，通过将流体连接焊接到印刷电路板结构的表面上的金属迹线来形成微流体通道。 在封装后通过蚀刻去除金属迹线，以在密封剂内形成微通道。
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公开(公告)号：US20120180882A1
公开(公告)日：2012-07-19
申请号：US13336717
申请日：2011-12-23
申请人： Imran R. MALIK , Axel SCHERER
发明人： Imran R. MALIK , Axel SCHERER
CPC分类号： B01L3/502707 , B01L7/52 , B01L2200/027 , B01L2200/04 , B01L2200/0689 , B01L2200/10 , B01L2200/12 , B01L2300/0861 , B01L2300/0877 , B01L2300/0887 , B01L2300/16 , B29C65/486 , B32B3/02 , B32B3/30 , Y10T137/8593
摘要： A method of fabricating a fluidic device comprises providing a fluidic device including a body having a surface and one or more channels located in the body. Recesses are defined on said surface. The one or more channels can have respective boundaries. A layer of adhesive including one or more panel-shaped pieces having a pattern based on the pattern of boundaries of the channels can be formed and applied on the surface of the body. It is further controlled that the layer of adhesive has respective boundaries surrounding the boundaries of the one or more channels.
摘要翻译： 制造流体装置的方法包括提供流体装置，其包括具有表面的主体和位于主体中的一个或多个通道。 凹槽被定义在所述表面上。 一个或多个通道可以具有相应的边界。 可以形成包括一个或多个基于通道边界图案的图案的一个或多个面板形件的粘合剂层，并施加到主体的表面上。 进一步控制粘合剂层具有围绕一个或多个通道的边界的相应边界。
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公开(公告)号：US20120153260A1
公开(公告)日：2012-06-21
申请号：US13314688
申请日：2011-12-08
申请人： Seheon KIM , Axel SCHERER , Jingqing HUANG , Dong Yoon OH
发明人： Seheon KIM , Axel SCHERER , Jingqing HUANG , Dong Yoon OH
IPC分类号： H01L29/06 , H01L21/306 , B82Y40/00
CPC分类号： B82Y40/00 , B82Y20/00 , G02B6/1225 , G02F1/01708 , G02F2202/32 , H01S5/105 , H01S5/2081 , H01S5/3412
摘要： A method of etching active quantum nanostructures provides the step of laterally etching of an intermediate active quantum nanostructure layer interposed between cladding layers. The lateral etching can be carried out on at least one side of the intermediate active quantum nanostructure layer selectively, with respect to the cladding layers to define at least one lateral recess or spacing in the intermediate active quantum nanostructure layer and respective lateral protrusions of cladding layers protruding with respect to the intermediate active quantum nanostructure layer. This method can be applied to create devices including active quantum nanostructures such as, for example, three-dimensional photonic crystals, a photonic crystal double-slab and a photonic crystal laser.
摘要翻译： 蚀刻活性量子纳米结构的方法提供了横向蚀刻介于包层之间的中间活性量子纳米结构层的步骤。 横向蚀刻可以相对于包层选择性地在中间活性量子纳米结构层的至少一侧进行，以限定中间有源量子纳米结构层中的至少一个横向凹槽或间隔，并且包覆层的相应侧向突起 相对于中间活性量子纳米结构层突出。 该方法可以应用于产生包括有源量子纳米结构的器件，例如三维光子晶体，光子晶体双板和光子晶体激光器。
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公开(公告)号：US20120152902A1
公开(公告)日：2012-06-21
申请号：US13299332
申请日：2011-11-17
申请人： Sameer WALAVALKAR , Axel SCHERER , Andrew P. HOMYK
发明人： Sameer WALAVALKAR , Axel SCHERER , Andrew P. HOMYK
IPC分类号： C23F1/00
CPC分类号： C23F4/00 , B81B2203/0127 , B81B2203/0353 , B81B2207/056 , B81C1/00031 , B81C2201/0132 , B82Y30/00 , B82Y40/00 , H01L21/3065 , H01L21/31116
摘要： A method for forming nanometer-sized patterns and pores in a membrane is described. The method comprises incorporating a reactive material onto the membrane, the reactive material being a material capable of lowering an amount of energy required for forming a pore and/or pattern by irradiating the membrane material with an electron beam, thus leading to a faster pore and/or pattern formation.
摘要翻译： 描述了在膜中形成纳米尺寸图案和孔的方法。 该方法包括将反应性材料结合到膜上，反应性材料是能够通过用电子束照射膜材料来降低形成孔和/或图案所需的能量的材料，从而导致更快的孔和 /或图案形成。
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公开(公告)号：US20100321696A1
公开(公告)日：2010-12-23
申请号：US12820104
申请日：2010-06-21
申请人： Imran R. MALIK , Axel SCHERER
发明人： Imran R. MALIK , Axel SCHERER
CPC分类号： B01L3/5085 , B01L3/502715 , B01L2300/0654 , B01L2300/0816 , B01L2300/0829 , G01N21/645 , G01N21/6452 , G01N2021/6482 , G01N2201/062
摘要： Optical devices and methods for measuring samples while minimizing stray light are described. Such methods and devices are applicable to multiple fluid chambers with multiple sources as an integrated optical element. Light sources can be embedded onto a chip or microarray with multiple chambers, or can be part of an instrument arrangement.
摘要翻译： 描述了在最小化杂散光的同时测量样品的光学装置和方法。 这种方法和装置可应用于具有多个源的多个流体室作为集成的光学元件。 光源可以嵌入到具有多个室的芯片或微阵列上，或者可以是仪器装置的一部分。
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