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    Fluorescence detector, filter device and related methods
    1.
    发明申请
    Fluorescence detector, filter device and related methods 有权
    荧光检测器，过滤装置及相关方法

    公开(公告)号：US20080013092A1

    公开(公告)日：2008-01-17

    申请号：US11804112

    申请日：2007-05-17

    申请人： George Maltezos ,  John Lee ,  Axel Scherer ,  Emil Kartalov

    发明人： George Maltezos ,  John Lee ,  Axel Scherer ,  Emil Kartalov

    IPC分类号： G01N21/25 ,  B01D63/00 ,  F15C1/06 ,  F15C5/00

    CPC分类号： G01N21/6456 ,  G01N21/6452 ,  Y10T137/2224

    摘要： Microfluidic assay detectors and microfluidic assay detection methods are disclosed. A microfluidic chip is coupled to a light emitting device, emission filters and excitation filters. Excited fluorescent light is detected by a camera and a lens. The correspondent reading allows parallel detection of features such as antigens and biomarkers. A microfluidic filter and related methods are also disclosed. The filter can be used with on-chip fluid filtration such as whole blood filtration for microfluidic blood analysis. The filter is able to filter the necessary volume of fluid and in particular blood in an acceptable time frame.

    摘要翻译： 公开了微流控测定检测器和微流控测定检测方法。 微流控芯片耦合到发光器件，发射滤光器和激发滤光器。 激发的荧光灯由相机和透镜检测。 通讯阅读允许并行检测抗原和生物标志物等特征。 还公开了微流体过滤器和相关方法。 过滤器可用于片上流体过滤，如全血过滤用于微流体血液分析。 过滤器能够在可接受的时间范围内过滤所需体积的流体，特别是血液。

    Fluorescence detector, filter device and related methods
    4.
    发明授权
    Fluorescence detector, filter device and related methods 有权
    荧光检测器，过滤装置及相关方法

    公开(公告)号：US08137626B2

    公开(公告)日：2012-03-20

    申请号：US11804112

    申请日：2007-05-17

    申请人： George Maltezos ,  John Kim Lee ,  Axel Scherer ,  Emil Kartalov

    发明人： George Maltezos ,  John Kim Lee ,  Axel Scherer ,  Emil Kartalov

    IPC分类号： G01N21/64

    CPC分类号： G01N21/6456 ,  G01N21/6452 ,  Y10T137/2224

    摘要： Microfluidic assay detectors and microfluidic assay detection methods are disclosed. A microfluidic chip is coupled to a light emitting device, emission filters and excitation filters. Excited fluorescent light is detected by a camera and a lens. The correspondent reading allows parallel detection of features such as antigens and biomarkers. A microfluidic filter and related methods are also disclosed. The filter can be used with on-chip fluid filtration such as whole blood filtration for microfluidic blood analysis. The filter is able to filter the necessary volume of fluid and in particular blood in an acceptable time frame.

    摘要翻译： 公开了微流控测定检测器和微流控测定检测方法。 微流控芯片耦合到发光器件，发射滤光器和激发滤光器。 激发的荧光灯由相机和透镜检测。 通讯阅读允许并行检测抗原和生物标志物等特征。 还公开了微流体过滤器和相关方法。 过滤器可用于片上流体过滤，如全血过滤用于微流体血液分析。 过滤器能够在可接受的时间范围内过滤所需体积的流体，特别是血液。

    Microfluidic autoregulator devices and arrays for operation with newtonian fluids
    6.
    发明授权
    Microfluidic autoregulator devices and arrays for operation with newtonian fluids 有权
    用于牛顿流体操作的微流控自动调节器和阵列

    公开(公告)号：US07992587B2

    公开(公告)日：2011-08-09

    申请号：US11606312

    申请日：2006-11-28

    申请人： Emil Kartalov ,  Axel Scherer ,  W. French Anderson ,  Christopher I. Walker

    发明人： Emil Kartalov ,  Axel Scherer ,  W. French Anderson ,  Christopher I. Walker

    IPC分类号： F16K31/36

    CPC分类号： G05D7/0694 ,  B01L3/5027 ,  F16K99/0001 ,  F16K99/0015 ,  F16K99/0026 ,  F16K99/0057 ,  F16K2099/008 ,  F16K2099/0084 ,  Y10T137/218 ,  Y10T137/2202 ,  Y10T137/7796

    摘要： By use of the vias a microfluidic autoregulator is fabricated comprising an origin of a fluid, a sink for the fluid, a main flow channel coupling the origin and the sink, a valve communicated to the main flow channel to selectively control flow of fluid therethrough, and means dependent on flow through the main flow channel for creating a pressure differential across the valve to at least partially activate the valve to control flow of fluid through the main flow channel. The means for dependent on flow for creating a pressure differential comprises either a dead-end detour channel from the flow channel to the valve, or a loop channel fed back to the control chamber of the valve.

    摘要翻译： 通过使用通孔，制造微流体自动调节器，该微流控自动调节器包括流体的来源，用于流体的水槽，连接原点和水槽的主流动通道，连通到主流动通道的阀，以选择性地控制流体的流动， 并且取决于通过主流动通道的流动的装置，用于在阀门两端产生压差，至少部分地启动阀门，以控制通过主流动通道的流体流动。 用于产生压力差的用于依赖于流动的装置包括从流动通道到阀门的死端迂回通道或反馈到阀的控制室的回路通道。

    High throughput multi-antigen microfluidic fluorescence immunoassays
    8.
    发明申请
    High throughput multi-antigen microfluidic fluorescence immunoassays 审中-公开
    高通量多抗原微流体荧光免疫测定

    公开(公告)号：US20060263818A1

    公开(公告)日：2006-11-23

    申请号：US11439288

    申请日：2006-05-22

    申请人： Axel Scherer ,  Emil Kartalov ,  W. Anderson ,  Clive Taylor

    发明人： Axel Scherer ,  Emil Kartalov ,  W. Anderson ,  Clive Taylor

    IPC分类号： C12Q1/68 ,  G01N33/53 ,  C12M1/34

    CPC分类号： G01N33/582 ,  B01L3/502707 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2200/0605 ,  B01L2200/0621 ,  B01L2300/0636 ,  B01L2300/0861 ,  B01L2400/0481 ,  B01L2400/0487 ,  B01L2400/0655

    摘要： The development of a high-throughput multi-antigen microfluidic fluorescence immunoassay system is illustrated in a 100-chamber PDMS (polydimethylsiloxane) chip which performs up to 5 tests for each of 10 samples. Specificity of detection is demonstrated and calibration curves produced for C-Reactive Protein (CRP), Prostate Specific Antigen (PSA), ferritin, and Vascular Endothelial Growth Factor (VEGF). The measurements show sensitivity at and below levels that are significant in current clinical laboratory practice (with SIN>8 at as low as 10 pM antigen concentration). The chip uses 100 nL per sample for all four tests and provides an improved instrument for use in scientific research and “point-of-care” testing in medicine.

    摘要翻译： 高通量多抗原微流体荧光免疫测定系统的开发在100个腔室PDMS（聚二甲基硅氧烷）芯片中进行了说明，该芯片对10个样品中的每一个进行多达5次测试。 证明了检测的特异性，并为C-反应蛋白（CRP），前列腺特异性抗原（PSA），铁蛋白和血管内皮生长因子（VEGF）产生了校准曲线。 测量显示当前临床实验室实践中显着的敏感度和水平以下（SIN> 8，低至10 pM抗原浓度）。 该芯片用于所有四个测试，每个样品使用100nL，并提供用于医学科学研究和“点护理”测试的改进仪器。

    Microfluidic autoregulator devices and arrays for operation with newtonian fluids
    10.
    发明申请
    Microfluidic autoregulator devices and arrays for operation with newtonian fluids 有权
    用于牛顿流体操作的微流控自动调节器和阵列

    公开(公告)号：US20070119510A1

    公开(公告)日：2007-05-31

    申请号：US11606312

    申请日：2006-11-28

    申请人： Emil Kartalov ,  Axel Scherer ,  W. Anderson

    发明人： Emil Kartalov ,  Axel Scherer ,  W. Anderson

    IPC分类号： F15C1/04

    CPC分类号： G05D7/0694 ,  B01L3/5027 ,  F16K99/0001 ,  F16K99/0015 ,  F16K99/0026 ,  F16K99/0057 ,  F16K2099/008 ,  F16K2099/0084 ,  Y10T137/218 ,  Y10T137/2202 ,  Y10T137/7796

    摘要： By use of the vias a microfluidic autoregulator is fabricated comprising an origin of a fluid, a sink for the fluid, a main flow channel coupling the origin and the sink, a valve communicated to the main flow channel to selectively control flow of fluid therethrough, and means dependent on flow through the main flow channel for creating a pressure differential across the valve to at least partially activate the valve to control flow of fluid through the main flow channel. The means for dependent on flow for creating a pressure differential comprises either a dead-end detour channel from the flow channel to the valve, or a loop channel fed back to the control chamber of the valve.

    摘要翻译： 通过使用通孔，制造微流体自动调节器，该微流控自动调节器包括流体的来源，用于流体的水槽，连接原点和水槽的主流动通道，连通到主流动通道的阀，以选择性地控制流体的流动， 并且取决于通过主流动通道的流动的装置，用于在阀门两端产生压差，至少部分地启动阀门，以控制通过主流动通道的流体流动。 用于产生压力差的用于依赖于流动的装置包括从流动通道到阀门的死端迂回通道或反馈到阀的控制室的回路通道。