Imidazo-pyrimidines and triazolo-pyrimidines: benzodiazepine receptor ligands
    2.
    发明授权
    Imidazo-pyrimidines and triazolo-pyrimidines: benzodiazepine receptor ligands 有权
    咪唑并 - 嘧啶和三唑并嘧啶:苯并二氮杂受体配体

    公开(公告)号:US07271170B2

    公开(公告)日:2007-09-18

    申请号:US10898690

    申请日:2004-07-23

    CPC分类号: C07D487/04

    摘要: Compounds of Formula I are provided, as are methods for their preparation. The variables Z1, Z2, Z3, R4, R5, R6, R7, R8 and Ar in the above formula are defined herein. Such compounds may be used to modulate ligand binding to GABAA receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of central nervous system (CNS) disorders in humans, domesticated companion animals and livestock animals. Compounds provided herein may be administered alone or in combination with one or more other CNS agents to potentiate the effects of the other CNS agent(s). Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting GABAA receptors (e.g., receptor localization studies).

    摘要翻译: 提供了式I化合物,以及其制备方法。 变量Z 1,Z 2,Z 3,R 4,R 5,/或 >,R 6,R 7,R 8和Ar如上所定义。 这样的化合物可用于在体内或体外调节配体与GABA A A受体的结合,并且特别可用于治疗人类中的各种中枢神经系统(CNS)紊乱,驯养伴侣动物 和牲畜。 本文提供的化合物可以单独施用或与一种或多种其它CNS剂组合施用,以增强其它CNS剂的作用。 还提供了用于治疗这种病症的药物组合物和方法,以及使用这种配体检测GABA A受体的方法(例如,受体定位研究)。

    IMIDAZO-PYRIMIDINES AND TRIAZOLO-PYRIMIDINES: BENZODIAZEPINE RECEPTOR LIGANDS
    3.
    发明申请
    IMIDAZO-PYRIMIDINES AND TRIAZOLO-PYRIMIDINES: BENZODIAZEPINE RECEPTOR LIGANDS 审中-公开
    咪唑并吡啶和三唑并嘧啶:苯并咪唑受体配体

    公开(公告)号:US20080139580A1

    公开(公告)日:2008-06-12

    申请号:US11855386

    申请日:2007-09-14

    CPC分类号: C07D487/04

    摘要: Compounds of Formula I are provided, as are methods for their preparation. The variables Z1, Z2, Z3, R4, R5, R6, R7, R8 and Ar in the above formula are defined herein. Such compounds may be used to modulate ligand binding to GABAA receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of central nervous system (CNS) disorders in humans, domesticated companion animals and livestock animals. Compounds provided herein may be administered alone or in combination with one or more other CNS agents to potentiate the effects of the other CNS agent(s). Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting GABAA receptors (e.g., receptor localization studies).

    摘要翻译: 提供了式I化合物,以及其制备方法。 变量Z 1,Z 2,Z 3,R 4,R 5,/或 >,R 6,R 7,R 8和Ar如上所定义。 这样的化合物可用于在体内或体外调节配体与GABA A A受体的结合,并且特别可用于治疗人类中的各种中枢神经系统(CNS)紊乱,驯养伴侣动物 和牲畜。 本文提供的化合物可以单独施用或与一种或多种其它CNS剂组合施用,以增强其它CNS剂的作用。 还提供了用于治疗这种病症的药物组合物和方法,以及使用这种配体检测GABA A受体的方法(例如,受体定位研究)。

    Pyrazolylmethy Heteroaryl Derivatives
    4.
    发明申请
    Pyrazolylmethy Heteroaryl Derivatives 审中-公开
    吡唑基甲基杂芳基衍生物

    公开(公告)号:US20080004269A1

    公开(公告)日:2008-01-03

    申请号:US11718528

    申请日:2005-11-01

    摘要: Compounds of Formula (I) are provided, as are methods for their preparation. The variables W, X, Y, Z, R5, R8 and Ar in the above formula are defined herein. Such compounds may be used to modulate ligand binding to GABAA receptorsin vivo or in vitro, and are particularly useful in the treatment of a variety of central nervous system (CNS) disorders in humans, domesticated companion animals and livestock animals. Compounds provided herein may be administered alone or in combination with one or more other CNS agents to potentiate the effects of the other CNS agent(s). Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting GABAA receptors (e.g., receptor localization studies).

    摘要翻译: 提供式(I)的化合物,以及它们的制备方法。 上式定义了上式中的变量W,X,Y,Z,R 5,R 8和Ar。 这样的化合物可用于在体内或体外调节配体与GABA A A受体的结合,并且特别可用于治疗人类中的各种中枢神经系统(CNS)障碍,驯养的伴侣动物和 牲畜。 本文提供的化合物可以单独施用或与一种或多种其它CNS剂组合施用,以增强其它CNS剂的作用。 还提供了用于治疗这种病症的药物组合物和方法,以及使用这种配体检测GABA A受体的方法(例如,受体定位研究)。

    Imidazo-pyrimidines and triazolo-pyrimidines: benzodiazepine receptor ligands
    5.
    发明申请
    Imidazo-pyrimidines and triazolo-pyrimidines: benzodiazepine receptor ligands 有权
    咪唑并 - 嘧啶和三唑并嘧啶:苯并二氮杂受体配体

    公开(公告)号:US20050038043A1

    公开(公告)日:2005-02-17

    申请号:US10898690

    申请日:2004-07-23

    IPC分类号: C07D487/04 A61K31/519

    CPC分类号: C07D487/04

    摘要: Compounds of Formula I are provided, as are methods for their preparation. The variables Z1, Z2, Z3, R4, R5, R6, R7, R8 and Ar in the above formula are defined herein. Such compounds may be used to modulate ligand binding to GABAA receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of central nervous system (CNS) disorders in humans, domesticated companion animals and livestock animals. Compounds provided herein may be administered alone or in combination with one or more other CNS agents to potentiate the effects of the other CNS agent(s). Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting GABAA receptors (e.g., receptor localization studies).

    摘要翻译: 提供了式I化合物,以及其制备方法。 上述式中的变量Z1,Z2,Z3,R4,R5,R6,R7,R8和Ar定义如下。 这样的化合物可用于在体内或体外调节配体与GABA A受体的结合,并且特别可用于治疗人,驯养的伴侣动物和家畜中的各种中枢神经系统(CNS)障碍。 本文提供的化合物可以单独施用或与一种或多种其它CNS剂组合施用,以增强其它CNS剂的作用。 还提供了用于治疗这种病症的药物组合物和方法,以及使用这种配体检测GABA A受体的方法(例如受体定位研究)。

    Aryl acid pyrimidinyl methyl amides, pyridazinyl methyl amides and related compounds
    6.
    发明授权
    Aryl acid pyrimidinyl methyl amides, pyridazinyl methyl amides and related compounds 失效
    芳基嘧啶基甲基酰胺,哒嗪基甲基酰胺和相关化合物

    公开(公告)号:US07351826B2

    公开(公告)日:2008-04-01

    申请号:US10544882

    申请日:2004-02-16

    IPC分类号: C07D487/00 A61K31/519

    摘要: The invention provides compounds of Formula (I) that bind to GABAA receptors. In the above formula, variables are defined herein. Such compounds may be used to modulate ligand binding to GABAA receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of central nervous system (CNS) disorders in humans, domesticated companion animals, and livestock animals. Compounds provided herein may be administered alone or in combination with one or more other CNS agents to potentiate the effects of the other CNS agent(s). Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting GABAA receptors (e.g., receptor localization studies)

    摘要翻译: 本发明提供结合GABA A A受体的式(I)化合物。 在上述公式中,变量在本文中定义。 这样的化合物可用于在体内或体外调节配体与GABA A A受体的结合,并且特别可用于治疗人类中的各种中枢神经系统(CNS)紊乱,驯养伴侣动物 ,和牲畜。 本文提供的化合物可以单独施用或与一种或多种其它CNS剂组合施用,以增强其它CNS剂的作用。 提供了用于治疗这种病症的药物组合物和方法,以及使用这种配体检测GABA A受体的方法(例如,受体定位研究)

    Imidazol-1-ylmethyl pyridazine derivatives
    8.
    发明授权
    Imidazol-1-ylmethyl pyridazine derivatives 失效
    咪唑-1-基甲基哒嗪衍生物

    公开(公告)号:US07122546B2

    公开(公告)日:2006-10-17

    申请号:US10680351

    申请日:2003-10-07

    摘要: The invention provides imidazol-1-ylmethyl pyridazine derivatives of the formula: that bind to GABAA receptors. In the above formula, R1, R2 R3, R4, R5, R6 and Ar are defined herein. Such compounds may be used to modulate ligand binding to GABAA receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of central nervous system (CNS) disorders in humans, domesticated companion animals, and livestock animals. Compounds provided herein may be administered alone or in combination with one or more other CNS agents to potentiate the effects of the other CNS agent(s). Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting GABAA receptors (e.g., receptor localization studies).

    摘要翻译: 本发明提供下式的咪唑-1-基甲基哒嗪衍生物:其结合GABA A A受体。 在上式中,R 1,R 2,R 3,R 4,R 5, / SUB,R 6和Ar如本文所定义。 这样的化合物可用于在体内或体外调节配体与GABA A A受体的结合,并且特别可用于治疗人类中的各种中枢神经系统(CNS)紊乱,驯养伴侣动物 ,和牲畜。 本文提供的化合物可以单独施用或与一种或多种其它CNS剂组合施用,以增强其它CNS剂的作用。 还提供了用于治疗这种病症的药物组合物和方法,以及使用这种配体检测GABA A受体的方法(例如,受体定位研究)。